50% develop arthropathy

Hemochromatosis is called a form of .. erythrocytosis .. increased red
blood cells.

Showing .. again .. increased red blood cell production linked to
arthritis .. and coincidentally .. hyperviscosity exists IN ..
rheumatoid arthritis AND .. lupus .. and it seems ..
**indistinguishable** .. FROM .. rheumatoid arthritis.

"These patients had been treated for rheumatoid arthritis and other
rheumatologic disorders over several years."

Meaning .. 'they' .. screwed up.

Erythrocytosis leads to hyperviscosity.

Z Rheumatol. 1997 May-Jun;56(3):156-62. Links
[Hemochromatosis arthropathy--an early manifestation of genetic
hemochromatosis][Article in German]
Gottschalk R, Neeck G, Wigand R, Vogtherr B, Kaltwasser JP.
Medizinische Klinik III Hamato-/Onkologie, Rheumatologie,
Infektiologie, Johann-Wolfgang-Goethe Universitat, Frankfurt am Main.

Recent studies have shown a high frequency of genetic hemochromatosis
in the Caucasian population. In addition, the well known organ
involvement of genetic hemochromatosis was evident; more than 50% of
patients develop a typical arthropathy which may result in severe
physical disability. Among approximately 5000 patients referred to the
rheumatology outpatient clinics of Bad Nauheim and Frankfurt with
different rheumatologic diagnoses, 11 patients with typical signs of
hemochromatotic arthropathy were identified. In none of those cases
had the diagnosis "genetic hemochromatosis" been previously
established. These patients had been treated for rheumatoid arthritis
and other rheumatologic disorders over several years. All showed
severe organ dysfunction due to iron overload, resulting in a reduced
life expectancy. This investigation shows that knowledge of the
typical signs of hemochromatotic arthropathy could lead to an earlier
diagnosis of genetic hemochromatosis which is necessary to prevent the
complications of iron overload in those patients.

PMID: 9340956 [PubMed - indexed for MEDLINE]


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