This article shows .. clearly .. the TARGETING of the .. iron .. IN
those with arthritis leads to improved .. i-m-p-r-o-v-e-d ..
anemia ..
Clin Exp Rheumatol. 1986
Jan-Mar;4(1):25-9. Related Articles, Links
Antianemic and potential anti-inflammatory activity of
desferrioxamine:
possible usefulness in rheumatoid arthritis.
Giordano N, Sancasciani S, Borghi C, Fioravanti A, Marcolongo R.
In order to study the role of excessive synovial iron sequestration
in
the
production of anemia in rheumatoid arthritis (RA), the antianemic
efficacy and
anti-inflammatory effect of desferrioxamine administered in a
short-term
treatment (14 days), were evaluated in 10 patients suffering from
classic or
definite RA and hyposideremic anemia. Treatment with desferrioxamine
showed an
elevated urinary iron excretion, a significant increase of serum
iron,
UIBC and
hemoglobin, and a marked progressive decrease of serum ferritin. A
moderate
improvement of the pain intensity, morning stiffness and Ritchie's
index was
also observed. The results obtained suggest that excessive
reticuloendothelial
iron deposits occur in RA and that the iron uptake can be an
important
factor
in the production of anemia. Desferrioxamine seems to be useful in
the
treatment of patients suffering from RA and anemia, in order to
release
iron
from synovial tissue, reduce the inflammatory process and improve
anemia,
changing an anemia which is typically resistant to the martial
therapy
into an
iron-sensitive anemia.
Publication Types:
Clinical Trial
PMID: 3516495 [PubMed - indexed for MEDLINE]
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Desferrioxamine maleateDesferrioxamine is a medicine that binds to
excess iron in the body. ... In these cases, desferrioxamine may be
given at the time of the blood transfusion, ...
http://www.tiscali.co.uk/lifestyle/h...100004514.html
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Deferoxamine - Wikipedia, the free encyclopediaDeferoxamine, otherwise
known as desferrioxamine or desferal, is a chelating agent used to
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