Ankylosing Spondilitis and Oxidative Stress

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increased oxidant and decreased antioxidant capacity
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Rheumatol Int. 2007 Oct;27(12):1131-4. Epub 2007 Apr 19. Links
Serum oxidative-antioxidative status in patients with ankylosing
spondilitis.
Karakoc M, Altindag O, Keles H, Soran N, Selek S.
Department of Physical Medicine and Rehabilitation, Ozel Yasam
Hospital, Aksaray, Turkey.

Ankylosing spondylitis (AS) is an inflammatory disorder with unknown
etiology that mainly affects the axial skeleton as well as the
peripheral joints and extra-articular structures. The aim of this
study was to evaluate the total antioxidant status (TAS), total
oxidative status (TOS) and oxidative stress index (OSI) in patients
with ankylosing spondylitis (AS). Fifty AS patients with a mean Bath
AS Activity Index (BASDAI) 4.6 (range 4-9.3) and 26 healthy controls
were included in the study. Plasma TAS, TOS levels were determined by
using novel automated methods. The OSI was calculated. Plasma TOS
level and OSI values were significantly higher, and plasma TAS level
was lower in patients than in healthy controls (15.8 +/- 4. 9 vs. 4.3
+/- 2.8, 12.8 +/- 3. 9 vs. 9.6 +/- 5.5, 1.2 +/- 0.03 vs. 1.8 +/- 0.2,
respectively, P < 0.001 for all). There was no significant correlation
between oxidant/antioxidant parameters and disease activity. The
results of this study indicated that increased oxidant and decreased
antioxidant capacity may be associated with the pathogenesis of AS.

PMID: 17443328 [PubMed - in process]


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