Bloodletting Alone Is Necessary and Sufficient

On Jul 2, 12:08*pm, DKGBee...@webtv.net (Donna G.) wrote:
Look, rustbucket, you are the ONLY one here who has been proven to be
stalking others, <<

Stalking .. ?

I have yet to stalk anyone ..

You kinda make sht up as you go along .. eh ..

On Jul 2, 12:08 pm, DKGBee...@webtv.net (Donna G.) wrote:resorting to
low life tactics <<

Low - life tactics.

YOU .. and your .. ilk .. **attack** .. ME ..

Get it right you stupid .. cow ..

I bite .. back ..

Don't like it .. ?

DON'T .. post to **my** .. threads ..

**MY** .. threads ..

IF .. you wish to post to**MY** threads .. contribute .. do NOT
attempt to abuse ..

This thread is .. thrombosis .. and has been changed to shtbags by
someone ..

Someone thinks you are a bunch of shtbags ..

Simple .. question .. screwball ..

ARE YOU HERE TO ABUSE .. **me** ..

Answer .. it ..

Are you here to abuse a .. specific .. poster ..

On Jul 2, 12:08 pm, DKGBee...@webtv.net (Donna G.) wrote:you are the
only one here who is dangerous <<

I can make your computer blow up in your .. face.

Did you know that .. ?

On Jul 2, 12:08 pm, DKGBee...@webtv.net (Donna G.) wrote: has had run
ins with the police, etc etc etc <<

Many .. men .. have ..

Harv .. hasn't ..

Donna G. wrote:
"The whole post is littered with sentences like seems to, may help,
suggests, possible usefulness, etc"

You use tired old tricks to attempt to make people NOT .. look into
stuff .. medical studies .. conducted by reputable .. researchers ..
because .. ?

YOU 'don't like the poster' ..

You attempt by .. any means necessary .. to TARGET .. **me** / my
posts specifically ..

Keep it up ..

It will begin to be even MORE .. obvious .


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




, been kicked off repeatedly various ISP's because you can't abide by
rules, you are the only one here who is dangerous, has had run ins
with the police, etc etc
etc <<


Donna G. wrote:
>> The whole post is littered with sentences like seems to, may help,
>> suggests, possible usefulness, etc.
resorting to low life tactics, been kicked off
> repeatedly various ISP's because you can't abide by rules, you are the
> only one here who is dangerous, has had run ins with the police, etc etc
> etc.
>
> EVERYTHING you post can be discredited. *Everything you post always has
> the words might, may, could possibly, that doesn't prove anything! *You
> say you post on topic, yet you post in an arthritis group about diabetes
> and other OFF TOPIC ilk!
>
> You have NO desire to really help anyone, only to feed your need for
> attention, harass, stalk, cause harm and danger, shove your views down
> others throats when they have asked you not to, practice medicine
> without a license, like to spout off your foul foul language, break the
> rules, break the law, cause problems, etc.
> Is your life really that empty and pathetic that the only thing you know
> how to do is cause trouble for people and break the rules and break the
> law?
>
> Do you even know how to have a thought of your own instead of stealing
> others works to harass news groups with?
>
> You really need to seek some serious help for yourself and *the
> delusional world you live in!!!
>
> My goodness, to have to keep posting the same thing 30, 40, 50 times
> really says something about you and your demented, sick, delusional,
> mind. * Perhaps you have bled yourself a little too much and need to
> take an iron supplement to get your sanity back!
>
> This is a PUBLIC forum, not your forum, so get a life for petes sake!!!
> .
> .
> .
> .
> .
> .

On Jun 30, 12:02Â*pm, ironjustice <ironjust...@aol.com> wrote:
thrombosis <<

"Iron markedly accelerates thrombus formation"

(Circulation. 2003;107:2601.)
© 2003 American Heart Association, Inc.

--------------------------------------------------------------------------------

Basic Science Reports


Chronic Iron Administration Increases Vascular Oxidative Stress and
Accelerates Arterial Thrombosis
Sharlene M. Day, MD; Damon Duquaine, BS; Lakshmi V. Mundada, MS; Rekha
G. Menon, MD; Bobby V. Khan, MD, PhD; Sanjay Rajagopalan, MD; William
P. Fay, MD
From the University of Michigan Medical School, Division of
Cardiology, Ann Arbor (S.M.D., D.D., L.V.M., S.R., W.P.F.); and Emory
University School of Medicine, Division of Cardiology, Atlanta, Ga
(R.G.M., B.V.K.).

Correspondence to Sharlene M. Day, MD, University of Michigan Medical
Center, 7301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI
48109-0644. E-mail sday@umich.edu

Background— Iron overload has been implicated in the pathogenesis of
ischemic cardiovascular events. However, the effects of iron excess on
vascular function and the thrombotic response to vascular injury are
not well understood.

Methods and Results— We examined the effects of chronic iron dextran
administration (15 mg over 6 weeks) on thrombosis, systemic and
vascular oxidative stress, and endothelium-dependent vascular
reactivity in mice. Thrombus generation after photochemical carotid
artery injury was accelerated in iron-loaded mice (mean time to
occlusive thrombosis, 20.4±8.5 minutes; n=10) compared with control
mice (54.5±35.5 minutes, n=10, P=0.009). Iron loading had no effect on
plasma clotting, vessel wall tissue factor activity, or ADP-induced
platelet aggregation. Acute administration of DL-cysteine, a reactive
oxygen species scavenger, completely abrogated the effects of iron
loading on thrombus formation, suggesting that iron accelerated
thrombosis through a pro-oxidant mechanism. Iron loading enhanced both
systemic and vascular reactive oxygen species production. Endothelium-
dependent vasorelaxation was impaired in iron-loaded mice, indicating
reduced NO bioavailability.

Conclusions— Moderate iron loading markedly accelerates thrombus
formation after arterial injury, increases vascular oxidative stress,
and impairs vasoreactivity. Iron-induced vascular dysfunction may
contribute to the increased incidence of ischemic cardiovascular
events that have been associated with chronic iron overload.


Key Words: thrombosis • free radicals • arteries


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


> On Jun 30, 11:50Â*am, ironjustice <ironjust...@aol.com> wrote: Arginine
> butyrate <<
>
> This would be your plant food.
>
> "Effects of short-chain fatty acids on head and neck squamous"
>
> "Arginine butyrate and α-lipoic acid are the most effective in
> suppressing growth"
>
> Titre du document / Document title
> Differential effects of short-chain fatty acids on head and neck
> squamous carcinoma cells
> Auteur(s) / Author(s)
> KRISHNA Srinivasan (1) ; BROWN Neil (1) ; FALLER Douglas V. (2) ;
> SPANJAARD Remco A. (1) ;
> Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
> (1) Department of Otolaryngology-Head and Neck Surgery, Cancer
> Research Center, Boston University School of Medicine, Boston,
> Massachusetts, ETATS-UNIS
> (2) Department of Medicine, Cancer Research Center, Boston University
> School of Medicine, Boston, Massachusetts, ETATS-UNIS
>
> Résumé / Abstract
> Objectives/Hypothesis:
> Head and neck squamous cell carcinoma (HNSCC) is a major cause of
> mortality. Despite advances in therapeutic modalities, recurrences and
> second primaries are commonly observed.
> Biological agents that can suppress growth of tumors that are
> otherwise difficult to treat are greatly needed.
> The present study examined the effects of short-chain fatty acids on
> HNSCC cell lines.
> Study Design:
> The effects of short-chain fatty acids on HNSCC cells was examined
> using tissue culture and immunoblotting techniques.
> Methods:
> The effects of four short-chain fatty acids, arginine butyrate, α-
> methyl hydrocinnamic acid, 2,2-dimethylbutyrate, and α-lipoic acid,
> were evaluated on four HNSCC cell lines (FaDu, SCC9, SCC25, and
> Detroit-562).
> Proliferation assays were performed by means of spectrophotometric
> techniques. Histone deacetylase activity was assessed by identifying
> the amount of acetylated histone H4.
> Involucrin expression was determined to assess cellular
> differentiation.
> Results:
> Inhibition of cellular proliferation was determined after 5 days of
> incubation with increasing doses with short-chain fatty acids.
> Arginine butyrate and α-lipoic acid were most effective in suppressing
> growth. Arginine butyrate demonstrated strong histone deacetylase
> inhibition in FaDu cells, while not inducing cellular
> differentiation.
> The short-chain fatty acid α-lipoic acid demonstrated weak histone
> deacetylase inhibition but was the only short-chain fatty acid that
> induced involucrin expression in at least two of the cell lines.
> Histone deacetylase inhibitory activity or induction of involucrin
> expression correlated with suppression of cell growth.
> Conclusions:
> Short-chain fatty acids have variable effects on HNSCC cells.
> Arginine butyrate and α-lipoic acid are the most effective in
> suppressing growth and appear to do so through different biochemical
> mechanisms.
> These compounds warrant further research as chemotherapeutic or
> chemopreventive agents in HNSCC.
> Revue / Journal Title
> The Laryngoscope Â* ISSN 0023-852X Â* CODEN LARYA8
> Source / Source
> 2002, vol. 112, no4, pp. 645-650 (46 ref.)
> Langue / Language
> Anglais
>
> Editeur / Publisher
> Lippincott, Hagerstown, MD, ETATS-UNIS (1896) (Revue)
>
> Mots-clés anglais / English Keywords
> ENT disease ; Malignant tumor ; Cell culture ; Cell line ; Biological
> effect ; Experimental study ; Immunoblotting assay ; Fatty acids ;
> Short chain ; Head and neck ; Squamous cell carcinoma ;
> Mots-clés français / French Keywords
> ORL pathologie ; Tumeur maligne ; Culture cellulaire ; Lignée
> cellulaire ; Effet biologique ; Etude expérimentale ; Méthode
> immunoblotting ; Acide gras ; Chaîne courte ; Tête cou ; Carcinome
> épidermoïde ;
> Mots-clés espagnols / Spanish Keywords
> ORL patologÃ*a ; Tumor maligno ; Cultivo celular ; LÃ*nea celular;
> Efecto biológico ; Estudio experimental ; Western blotting ; Acido
> graso ; Cadena corta ; Cabeza cuello ; Carcinoma epidermoide ;
> Localisation / Location
> INIST-CNRS, Cote INIST : 3102, 35400010053073.0100
>
> Copyright 2007 INIST-CNRS. All rights reserved
>
> Toute reproduction ou diffusion même partielle, par quelque procédé ou
> sur tout support que ce soit, ne pourra être faite sans l'accord
> préalable écrit de l'INIST-CNRS.
> No part of these records may be reproduced of distributed, in any form
> or by any means, without the prior written permission of INIST-CNRS.
>
> Nº notice refdoc (ud4) : 13609728
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > On Jun 30, 10:44Â*am, "ironjust...@aol.com" <ironjust...@aol.com>
> > wrote: thrombosis <<
>
> > Curious thing here is ,, there was a question of Â*"the hemolysis in
> > blood donor bags" someone ventured .. "add arginine to offset the
> > hemolysis".
>
> > -------------------------------------------
>
> > Arginine Butyrate Heals Sickle Cell Leg Ulcers
>
> > Jane Salodof MacNeil
>
> > Dec. 10, 2002 (Philadelphia) — Researchers working with an
> > experimental drug for sickle cell anemia noticed an unexpected side
> > effect: the incidental healing of debilitating leg ulcers in seven
> > patients.
>
> > That serendipitous observation led to a 25-patient phase II study in
> > which treatment with the compound, arginine butyrate, healed 17 of 37
> > leg ulcers. In contrast, among 24 ulcers that received standard local
> > care for wounds, complete healing was documented for one ulcer.
>
> > Several of the participants had suffered with large open sores for
> > decades, according to investigator Susan Perrine, MD, of Boston
> > University School of Medicine in Massachusetts. One woman had leg
> > ulcers for 30 years, Dr. Perrine reported in a presentation here at
> > the American Society of Hematology annual meeting.
>
> > The investigator showed dramatic before and after photographs of legs
> > from several patients who benefited from the treatment. The mean
> > initial area of ulcers in the arginine butyrate arm of the study was
> > 50.8 cm2 — nearly twice the 26.4 cm2 in the control group.
>
> > Within three months of treatment, the area had been reduced by 53% in
> > patients who received arginine butyrate, but the area was reduced by
> > 9% in the control arm. Dr. Perrine said the researchers don't know why
> > the compound heals these ulcers.
>
> > H. Grant Prentice, MD, of the London Clinic in the U.K., called the
> > study "extremely important." The former head of hematology at the
> > Royal Free Hospital in London, Dr. Prentice said the most common
> > therapy for leg ulcers associated with sickle cell disease is
> > hydroxyurea. "It's not very effective, and the patients don't like to
> > take it," he told Medscape.
>
> > About 25% of sickle cell patients suffer from leg ulcers, according to
> > an earlier study of 2,000 patients that Dr. Perrine cited at the start
> > of her talk. In the United States, she said, the typical sickle cell
> > ulcer lasts as long as three years; in the Caribbean more than nine
> > years is common. Even if they are cured, between a quarter and a half
> > of these ulcers will recur.
>
> > Despite their prevalence, the ulcers are not well known, even in the
> > sickle cell community, according to Dr. Perrine. They tend to occur in
> > adults, she said, explaining she had little experience with them
> > because she works in pediatrics.
>
> > Patients in the treatment arm of the trial received 500 mg/kg of
> > arginine butyrate six hours a day three days a week for twelve weeks.
> > Although hydroxyurea is used, she said there is no standard regimen
> > for these sores. The control group was treated aggressively according
> > to local standards for wound healing, but no particular protocol was
> > used in the six-center study.
>
> > Although the study ended after three months, patients were allowed to
> > continue for 16 weeks if their ulcers were closing with arginine
> > butryate. Within five to seven months, a 10-fold increase in wound
> > healing was reported.
>
> > Dr. Perrine said the investigators plan to seek funds for a phase III
> > trial. The pilot study was conducted with support from the U.S. Food
> > and Drug Administration's orphan drug program, she said. Arginine
> > butryate is an experimental compound and is not yet commercially
> > available.
>
> > ASH 44th Annual Meeting: Abstract 26. Presented Dec. 8, 2002.
>
> > Reviewed by Gary D. Vogin, MD
>
> > Jane Salodof MacNeil is a freelance writer for Medscape.
> > Conference Coverage
> > 44th Annual Meeting of the American Society of Hematology
>
> > -------------------
>
> > THE IDEA THAT DRUGS MIGHT SAFELY SWITCH ON NONWORKING GENES RECEIVED
> > ABOOST FROM RESEARCHERS DEVELOPING TREATMENTS FOR A GROUP OF GENETIC
> > BLOODDISORDERS
>
> > THE BLOOD DISORDERS INVOLVE RED BLOOD CELLS' FAILURE TO PRODUCE
> > HEMOGLOBIN OR PRODUCTION OF A DEFECTIVE FORM OF THE OXYGEN CARRYING
> > PROTEIN.
> > THE DISORDERS INCLUDE SICKLE CELL ANEMIA WHICH MOSTLY AFFLICTS
> > AFRICAN AMERICANS AND COOLEY'S ANEMIA WHICH MOSTLY AFFLICTS ITALIANS
> > GREEKS AND OTHER MEDITERRANEAN GROUPS.
>
> > BLOOD SPECIALISTS HAVE BEEN TRYING FOR A DECADE TO FIND A NEW WAY TO
> > TREAT THESE DISORDERS BY TURNING ON A HEMOGLOBIN GENE THAT ORDINARILY
> > QUITS WORKING AFTER BIRTH.
> > THE FEW DRUGS THAT HAVE PULLED OFF THIS TRICK HAVE BEEN
> > TOO TOXIC FOR THE LIFETIME USE THAT THE ANEMIC PATIENTS WOULD REQUIRE.
>
> > NOW A TEAM OF RESEARCHERS IN OAKLAND CALIF REPORTED PRELIMINARY
> > RESULTS IN WHICH A FOOD ADDITIVE A FATTY ACID CALLED ARGININE BUTYRATE
> > APPEARED TO STIMULATE THE NONWORKING GENE TO BEGIN MAKING NORMAL
> > HEMOGLOBIN IN SIX PATIENTS THEIR REPORT APPEARS IN THIS WEEK'S ISSUE
> > OF THE NEW ENGLAND JOURNAL OF MEDICINE.
>
> > THE MAIN PROBLEM IS THAT THE DRUG MUST BE GIVEN INTRAVENOUSLY BUT ONE
> > OF THE RESEARCHERS SAID AN ORAL FORM OF THE DRUG IS BEING DEVELOPED.
>
> > THE TWO ANEMIAS ARE IDEAL CANDIDATES FOR GENE ACTIVATION THERAPY.
> > BOTH INVOLVE DEFECTS IN HEMOGLOBIN THE IRON CONTAINING PROTEIN THAT
> > RED BLOOD CELLS USE TO CARRY OXYGEN TO BODY TISSUES.
> > OF THE TWO GENES CAPABLE OF MAKING HEMOGLOBIN ONE FUNCTIONS ONLY
> > DURING FETAL LIFE WHEN THE FETUS MUST PULL OXYGEN CARRYING BLOOD
> > ACROSS THE PLACENTA.
> > Â*THIS FETAL GENE
>
> ...
>
> read more »- Hide quoted text -
>
> - Show quoted text -

Alan S wrote:
> On Wed, 2 Jul 2008 13:49:57 -0400, "DeeTee"
> <ke3iu_nospam@hotmail.com> wrote:
>
>> I can kill-file him each time he changes his address. LOL
>>
>> DeeTee
>
> Just use the word ironjustice in the kf terms. Gets most of
> them. Until people respond to him and remind me he's still
> around.
>
Yep same here, he lives in my kill file along with that Chinese guy,
can't remember his name what was it again:-)

(- -)
=m=(_)=m=
RodS T2
Australia



> Cheers, Alan, T2, Australia.
> --
> d&e, metformin 1500mg, ezetrol 10mg
> Everything in Moderation - Except Laughter.
> http://loraldiabetes.blogspot.com
> http://www.flickr.com/photos/alan_s/
> http://loraltravel.blogspot.com (On Indian Roads)
>
>

Reported for being off topic in Alt.support.arthritis,,,, cross posting
after being warned not to do it.

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Subject: Re: Phlebotomy Prevents Thrombosis
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On Jun 30, 12:02=C2=A0pm, ironjustice <ironjust...@aol.com> wrote:
thrombosis <<

"Iron markedly accelerates thrombus formation"

(Circulation. 2003;107:2601.)
=C2=A9 2003 American Heart Association, Inc.

---------------------------------------------------------------------------=
-----

Basic Science Reports


Chronic Iron Administration Increases Vascular Oxidative Stress and
Accelerates Arterial Thrombosis
Sharlene M. Day, MD; Damon Duquaine, BS; Lakshmi V. Mundada, MS; Rekha
G. Menon, MD; Bobby V. Khan, MD, PhD; Sanjay Rajagopalan, MD; William
P. Fay, MD
=46rom the University of Michigan Medical School, Division of
Cardiology, Ann Arbor (S.M.D., D.D., L.V.M., S.R., W.P.F.); and Emory
University School of Medicine, Division of Cardiology, Atlanta, Ga
(R.G.M., B.V.K.).

Correspondence to Sharlene M. Day, MD, University of Michigan Medical
Center, 7301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI
48109-0644. E-mail sday@umich.edu

Background=E2=80=94 Iron overload has been implicated in the pathogenesis o=
f
ischemic cardiovascular events. However, the effects of iron excess on
vascular function and the thrombotic response to vascular injury are
not well understood.

Methods and Results=E2=80=94 We examined the effects of chronic iron dextra=
n
administration (15 mg over 6 weeks) on thrombosis, systemic and
vascular oxidative stress, and endothelium-dependent vascular
reactivity in mice. Thrombus generation after photochemical carotid
artery injury was accelerated in iron-loaded mice (mean time to
occlusive thrombosis, 20.4=C2=B18.5 minutes; n=3D10) compared with control
mice (54.5=C2=B135.5 minutes, n=3D10, P=3D0.009). Iron loading had no effec=
t on
plasma clotting, vessel wall tissue factor activity, or ADP-induced
platelet aggregation. Acute administration of DL-cysteine, a reactive
oxygen species scavenger, completely abrogated the effects of iron
loading on thrombus formation, suggesting that iron accelerated
thrombosis through a pro-oxidant mechanism. Iron loading enhanced both
systemic and vascular reactive oxygen species production. Endothelium-
dependent vasorelaxation was impaired in iron-loaded mice, indicating
reduced NO bioavailability.

Conclusions=E2=80=94 Moderate iron loading markedly accelerates thrombus
formation after arterial injury, increases vascular oxidative stress,
and impairs vasoreactivity. Iron-induced vascular dysfunction may
contribute to the increased incidence of ischemic cardiovascular
events that have been associated with chronic iron overload.


Key Words: thrombosis =E2=80=A2 free radicals =E2=80=A2 arteries


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

"ironjustice" <teamtanner@hotmail.com> wrote in message
news:9d51be37-5f04-4068-ae3d-23d3d76a387f@l64g2000hse.googlegroups.com...
On Jun 30, 12:02 pm, ironjustice <ironjust...@aol.com> wrote:
thrombosis <<

"Iron markedly accelerates thrombus formation"

(Circulation. 2003;107:2601.)
© 2003 American Heart Association, Inc.

--------------------------------------------------------------------------------

Basic Science Reports


Chronic Iron Administration Increases Vascular Oxidative Stress and
Accelerates Arterial Thrombosis
Sharlene M. Day, MD; Damon Duquaine, BS; Lakshmi V. Mundada, MS; Rekha
G. Menon, MD; Bobby V. Khan, MD, PhD; Sanjay Rajagopalan, MD; William
P. Fay, MD
From the University of Michigan Medical School, Division of
Cardiology, Ann Arbor (S.M.D., D.D., L.V.M., S.R., W.P.F.); and Emory
University School of Medicine, Division of Cardiology, Atlanta, Ga
(R.G.M., B.V.K.).

Correspondence to Sharlene M. Day, MD, University of Michigan Medical
Center, 7301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI
48109-0644. E-mail sday@umich.edu

Background- Iron overload has been implicated in the pathogenesis of
ischemic cardiovascular events. However, the effects of iron excess on
vascular function and the thrombotic response to vascular injury are
not well understood.

Methods and Results- We examined the effects of chronic iron dextran
administration (15 mg over 6 weeks) on thrombosis, systemic and
vascular oxidative stress, and endothelium-dependent vascular
reactivity in mice. Thrombus generation after photochemical carotid
artery injury was accelerated in iron-loaded mice (mean time to
occlusive thrombosis, 20.4±8.5 minutes; n=10) compared with control
mice (54.5±35.5 minutes, n=10, P=0.009). Iron loading had no effect on
plasma clotting, vessel wall tissue factor activity, or ADP-induced
platelet aggregation. Acute administration of DL-cysteine, a reactive
oxygen species scavenger, completely abrogated the effects of iron
loading on thrombus formation, suggesting that iron accelerated
thrombosis through a pro-oxidant mechanism. Iron loading enhanced both
systemic and vascular reactive oxygen species production. Endothelium-
dependent vasorelaxation was impaired in iron-loaded mice, indicating
reduced NO bioavailability.

Conclusions- Moderate iron loading markedly accelerates thrombus
formation after arterial injury, increases vascular oxidative stress,
and impairs vasoreactivity. Iron-induced vascular dysfunction may
contribute to the increased incidence of ischemic cardiovascular
events that have been associated with chronic iron overload.


Key Words: thrombosis . free radicals . arteries


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


> On Jun 30, 11:50 am, ironjustice <ironjust...@aol.com> wrote: Arginine
> butyrate <<
>
> This would be your plant food.
>
> "Effects of short-chain fatty acids on head and neck squamous"
>
> "Arginine butyrate and ?-lipoic acid are the most effective in
> suppressing growth"
>
> Titre du document / Document title
> Differential effects of short-chain fatty acids on head and neck
> squamous carcinoma cells
> Auteur(s) / Author(s)
> KRISHNA Srinivasan (1) ; BROWN Neil (1) ; FALLER Douglas V. (2) ;
> SPANJAARD Remco A. (1) ;
> Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
> (1) Department of Otolaryngology-Head and Neck Surgery, Cancer
> Research Center, Boston University School of Medicine, Boston,
> Massachusetts, ETATS-UNIS
> (2) Department of Medicine, Cancer Research Center, Boston University
> School of Medicine, Boston, Massachusetts, ETATS-UNIS
>
> Résumé / Abstract
> Objectives/Hypothesis:
> Head and neck squamous cell carcinoma (HNSCC) is a major cause of
> mortality. Despite advances in therapeutic modalities, recurrences and
> second primaries are commonly observed.
> Biological agents that can suppress growth of tumors that are
> otherwise difficult to treat are greatly needed.
> The present study examined the effects of short-chain fatty acids on
> HNSCC cell lines.
> Study Design:
> The effects of short-chain fatty acids on HNSCC cells was examined
> using tissue culture and immunoblotting techniques.
> Methods:
> The effects of four short-chain fatty acids, arginine butyrate, ?-
> methyl hydrocinnamic acid, 2,2-dimethylbutyrate, and ?-lipoic acid,
> were evaluated on four HNSCC cell lines (FaDu, SCC9, SCC25, and
> Detroit-562).
> Proliferation assays were performed by means of spectrophotometric
> techniques. Histone deacetylase activity was assessed by identifying
> the amount of acetylated histone H4.
> Involucrin expression was determined to assess cellular
> differentiation.
> Results:
> Inhibition of cellular proliferation was determined after 5 days of
> incubation with increasing doses with short-chain fatty acids.
> Arginine butyrate and ?-lipoic acid were most effective in suppressing
> growth. Arginine butyrate demonstrated strong histone deacetylase
> inhibition in FaDu cells, while not inducing cellular
> differentiation.
> The short-chain fatty acid ?-lipoic acid demonstrated weak histone
> deacetylase inhibition but was the only short-chain fatty acid that
> induced involucrin expression in at least two of the cell lines.
> Histone deacetylase inhibitory activity or induction of involucrin
> expression correlated with suppression of cell growth.
> Conclusions:
> Short-chain fatty acids have variable effects on HNSCC cells.
> Arginine butyrate and ?-lipoic acid are the most effective in
> suppressing growth and appear to do so through different biochemical
> mechanisms.
> These compounds warrant further research as chemotherapeutic or
> chemopreventive agents in HNSCC.
> Revue / Journal Title
> The Laryngoscope ISSN 0023-852X CODEN LARYA8
> Source / Source
> 2002, vol. 112, no4, pp. 645-650 (46 ref.)
> Langue / Language
> Anglais
>
> Editeur / Publisher
> Lippincott, Hagerstown, MD, ETATS-UNIS (1896) (Revue)
>
> Mots-clés anglais / English Keywords
> ENT disease ; Malignant tumor ; Cell culture ; Cell line ; Biological
> effect ; Experimental study ; Immunoblotting assay ; Fatty acids ;
> Short chain ; Head and neck ; Squamous cell carcinoma ;
> Mots-clés français / French Keywords
> ORL pathologie ; Tumeur maligne ; Culture cellulaire ; Lignée
> cellulaire ; Effet biologique ; Etude expérimentale ; Méthode
> immunoblotting ; Acide gras ; Chaîne courte ; Tête cou ; Carcinome
> épidermoïde ;
> Mots-clés espagnols / Spanish Keywords
> ORL patología ; Tumor maligno ; Cultivo celular ; Línea celular ;
> Efecto biológico ; Estudio experimental ; Western blotting ; Acido
> graso ; Cadena corta ; Cabeza cuello ; Carcinoma epidermoide ;
> Localisation / Location
> INIST-CNRS, Cote INIST : 3102, 35400010053073.0100
>
> Copyright 2007 INIST-CNRS. All rights reserved
>
> Toute reproduction ou diffusion même partielle, par quelque procédé ou
> sur tout support que ce soit, ne pourra être faite sans l'accord
> préalable écrit de l'INIST-CNRS.
> No part of these records may be reproduced of distributed, in any form
> or by any means, without the prior written permission of INIST-CNRS.
>
> Nº notice refdoc (ud4) : 13609728
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > On Jun 30, 10:44 am, "ironjust...@aol.com" <ironjust...@aol.com>
> > wrote: thrombosis <<
>
> > Curious thing here is ,, there was a question of "the hemolysis in
> > blood donor bags" someone ventured .. "add arginine to offset the
> > hemolysis".
>
> > -------------------------------------------
>
> > Arginine Butyrate Heals Sickle Cell Leg Ulcers
>
> > Jane Salodof MacNeil
>
> > Dec. 10, 2002 (Philadelphia) - Researchers working with an
> > experimental drug for sickle cell anemia noticed an unexpected side
> > effect: the incidental healing of debilitating leg ulcers in seven
> > patients.
>
> > That serendipitous observation led to a 25-patient phase II study in
> > which treatment with the compound, arginine butyrate, healed 17 of 37
> > leg ulcers. In contrast, among 24 ulcers that received standard local
> > care for wounds, complete healing was documented for one ulcer.
>
> > Several of the participants had suffered with large open sores for
> > decades, according to investigator Susan Perrine, MD, of Boston
> > University School of Medicine in Massachusetts. One woman had leg
> > ulcers for 30 years, Dr. Perrine reported in a presentation here at
> > the American Society of Hematology annual meeting.
>
> > The investigator showed dramatic before and after photographs of legs
> > from several patients who benefited from the treatment. The mean
> > initial area of ulcers in the arginine butyrate arm of the study was
> > 50.8 cm2 - nearly twice the 26.4 cm2 in the control group.
>
> > Within three months of treatment, the area had been reduced by 53% in
> > patients who received arginine butyrate, but the area was reduced by
> > 9% in the control arm. Dr. Perrine said the researchers don't know why
> > the compound heals these ulcers.
>
> > H. Grant Prentice, MD, of the London Clinic in the U.K., called the
> > study "extremely important." The former head of hematology at the
> > Royal Free Hospital in London, Dr. Prentice said the most common
> > therapy for leg ulcers associated with sickle cell disease is
> > hydroxyurea. "It's not very effective, and the patients don't like to
> > take it," he told Medscape.
>
> > About 25% of sickle cell patients suffer from leg ulcers, according to
> > an earlier study of 2,000 patients that Dr. Perrine cited at the start
> > of her talk. In the United States, she said, the typical sickle cell
> > ulcer lasts as long as three years; in the Caribbean more than nine
> > years is common. Even if they are cured, between a quarter and a half
> > of these ulcers will recur.
>
> > Despite their prevalence, the ulcers are not well known, even in the
> > sickle cell community, according to Dr. Perrine. They tend to occur in
> > adults, she said, explaining she had little experience with them
> > because she works in pediatrics.
>
> > Patients in the treatment arm of the trial received 500 mg/kg of
> > arginine butyrate six hours a day three days a week for twelve weeks.
> > Although hydroxyurea is used, she said there is no standard regimen
> > for these sores. The control group was treated aggressively according
> > to local standards for wound healing, but no particular protocol was
> > used in the six-center study.
>
> > Although the study ended after three months, patients were allowed to
> > continue for 16 weeks if their ulcers were closing with arginine
> > butryate. Within five to seven months, a 10-fold increase in wound
> > healing was reported.
>
> > Dr. Perrine said the investigators plan to seek funds for a phase III
> > trial. The pilot study was conducted with support from the U.S. Food
> > and Drug Administration's orphan drug program, she said. Arginine
> > butryate is an experimental compound and is not yet commercially
> > available.
>
> > ASH 44th Annual Meeting: Abstract 26. Presented Dec. 8, 2002.
>
> > Reviewed by Gary D. Vogin, MD
>
> > Jane Salodof MacNeil is a freelance writer for Medscape.
> > Conference Coverage
> > 44th Annual Meeting of the American Society of Hematology
>
> > -------------------
>
> > THE IDEA THAT DRUGS MIGHT SAFELY SWITCH ON NONWORKING GENES RECEIVED
> > ABOOST FROM RESEARCHERS DEVELOPING TREATMENTS FOR A GROUP OF GENETIC
> > BLOODDISORDERS
>
> > THE BLOOD DISORDERS INVOLVE RED BLOOD CELLS' FAILURE TO PRODUCE
> > HEMOGLOBIN OR PRODUCTION OF A DEFECTIVE FORM OF THE OXYGEN CARRYING
> > PROTEIN.
> > THE DISORDERS INCLUDE SICKLE CELL ANEMIA WHICH MOSTLY AFFLICTS
> > AFRICAN AMERICANS AND COOLEY'S ANEMIA WHICH MOSTLY AFFLICTS ITALIANS
> > GREEKS AND OTHER MEDITERRANEAN GROUPS.
>
> > BLOOD SPECIALISTS HAVE BEEN TRYING FOR A DECADE TO FIND A NEW WAY TO
> > TREAT THESE DISORDERS BY TURNING ON A HEMOGLOBIN GENE THAT ORDINARILY
> > QUITS WORKING AFTER BIRTH.
> > THE FEW DRUGS THAT HAVE PULLED OFF THIS TRICK HAVE BEEN
> > TOO TOXIC FOR THE LIFETIME USE THAT THE ANEMIC PATIENTS WOULD REQUIRE.
>
> > NOW A TEAM OF RESEARCHERS IN OAKLAND CALIF REPORTED PRELIMINARY
> > RESULTS IN WHICH A FOOD ADDITIVE A FATTY ACID CALLED ARGININE BUTYRATE
> > APPEARED TO STIMULATE THE NONWORKING GENE TO BEGIN MAKING NORMAL
> > HEMOGLOBIN IN SIX PATIENTS THEIR REPORT APPEARS IN THIS WEEK'S ISSUE
> > OF THE NEW ENGLAND JOURNAL OF MEDICINE.
>
> > THE MAIN PROBLEM IS THAT THE DRUG MUST BE GIVEN INTRAVENOUSLY BUT ONE
> > OF THE RESEARCHERS SAID AN ORAL FORM OF THE DRUG IS BEING DEVELOPED.
>
> > THE TWO ANEMIAS ARE IDEAL CANDIDATES FOR GENE ACTIVATION THERAPY.
> > BOTH INVOLVE DEFECTS IN HEMOGLOBIN THE IRON CONTAINING PROTEIN THAT
> > RED BLOOD CELLS USE TO CARRY OXYGEN TO BODY TISSUES.
> > OF THE TWO GENES CAPABLE OF MAKING HEMOGLOBIN ONE FUNCTIONS ONLY
> > DURING FETAL LIFE WHEN THE FETUS MUST PULL OXYGEN CARRYING BLOOD
> > ACROSS THE PLACENTA.
> > THIS FETAL GENE
>
> ...
>
> read more »- Hide quoted text -
>
> - Show quoted text -

"Iron markedly accelerates thrombus formation"

(Circulation. 2003;107:2601.)
© 2003 American Heart Association, Inc.

Basic Science Reports

Chronic Iron Administration Increases Vascular Oxidative Stress and
Accelerates Arterial Thrombosis
Sharlene M. Day, MD; Damon Duquaine, BS; Lakshmi V. Mundada, MS;
Rekha
G. Menon, MD; Bobby V. Khan, MD, PhD; Sanjay Rajagopalan, MD; William
P. Fay, MD
From the University of Michigan Medical School, Division of
Cardiology, Ann Arbor (S.M.D., D.D., L.V.M., S.R., W.P.F.); and Emory
University School of Medicine, Division of Cardiology, Atlanta, Ga
(R.G.M., B.V.K.).


Correspondence to Sharlene M. Day, MD, University of Michigan Medical
Center, 7301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI
48109-0644. E-mail s...@umich.edu


Background— Iron overload has been implicated in the pathogenesis of
ischemic cardiovascular events. However, the effects of iron excess
on
vascular function and the thrombotic response to vascular injury are
not well understood.

Methods and Results— We examined the effects of chronic iron dextran
administration (15 mg over 6 weeks) on thrombosis, systemic and
vascular oxidative stress, and endothelium-dependent vascular
reactivity in mice. Thrombus generation after photochemical carotid
artery injury was accelerated in iron-loaded mice (mean time to
occlusive thrombosis, 20.4±8.5 minutes; n=10) compared with control
mice (54.5±35.5 minutes, n=10, P=0.009). Iron loading had no effect
on
plasma clotting, vessel wall tissue factor activity, or ADP-induced
platelet aggregation. Acute administration of DL-cysteine, a reactive
oxygen species scavenger, completely abrogated the effects of iron
loading on thrombus formation, suggesting that iron accelerated
thrombosis through a pro-oxidant mechanism. Iron loading enhanced
both
systemic and vascular reactive oxygen species production.
Endothelium-
dependent vasorelaxation was impaired in iron-loaded mice, indicating
reduced NO bioavailability.

Conclusions— Moderate iron loading markedly accelerates thrombus
formation after arterial injury, increases vascular oxidative stress,
and impairs vasoreactivity. Iron-induced vascular dysfunction may
contribute to the increased incidence of ischemic cardiovascular
events that have been associated with chronic iron overload.

Key Words: thrombosis • free radicals • arteries

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

"Harvey R. Stone" <hrstone@swbell.net> wrote in message
newsr3bk.6309$LG4.1736@nlpi065.nbdc.sbc.com...
> Reported for being off topic in Alt.support.arthritis,,,, cross posting
> after being warned not to do it.
>
> Path:
> nlpi059.nbdc.sbc.com!nlpi062.nbdc.sbc.com!prodigy. com!nlpi057.nbdc.sbc.com!prodigy.net!border1.nntp. dca.giganews.com!nntp.giganews.com!postnews.google .com!l64g2000hse.googlegroups.com!not-for-mail
> From: ironjustice <teamtanner@hotmail.com>
[snip]
Off topic in alt.support.diabetes too. Has ignored requests not to
post off topic messages there.

Note that groups-abuse@google.com is slow and not very effective
at responding to reports of spam posted through Google groups, so
I would expect them to be unlikely to act on reports of being off topic.
However, it does help to report the same spammers over and over
for different messages for at least 6 weeks, so perhaps
groups-abuse@google.com just can't keep up with reading all their
incoming mail.

On Jul 3, 7:28*am, "Robert Miles" <robertmi...@bellsouthNOSPAM.net>
wrote:thrombosis <<

"Iron markedly accelerates thrombus formation"


(Circulation. 2003;107:2601.)
© 2003 American Heart Association, Inc.


---------------------------------------------------------------------------*-----


Basic Science Reports


Chronic Iron Administration Increases Vascular Oxidative Stress and
Accelerates Arterial Thrombosis
Sharlene M. Day, MD; Damon Duquaine, BS; Lakshmi V. Mundada, MS;
Rekha
G. Menon, MD; Bobby V. Khan, MD, PhD; Sanjay Rajagopalan, MD; William
P. Fay, MD
From the University of Michigan Medical School, Division of
Cardiology, Ann Arbor (S.M.D., D.D., L.V.M., S.R., W.P.F.); and Emory
University School of Medicine, Division of Cardiology, Atlanta, Ga
(R.G.M., B.V.K.).


Correspondence to Sharlene M. Day, MD, University of Michigan Medical
Center, 7301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI
48109-0644. E-mail s...@umich.edu


Background— Iron overload has been implicated in the pathogenesis of
ischemic cardiovascular events. However, the effects of iron excess
on
vascular function and the thrombotic response to vascular injury are
not well understood.


Methods and Results— We examined the effects of chronic iron dextran
administration (15 mg over 6 weeks) on thrombosis, systemic and
vascular oxidative stress, and endothelium-dependent vascular
reactivity in mice. Thrombus generation after photochemical carotid
artery injury was accelerated in iron-loaded mice (mean time to
occlusive thrombosis, 20.4±8.5 minutes; n=10) compared with control
mice (54.5±35.5 minutes, n=10, P=0.009). Iron loading had no effect
on
plasma clotting, vessel wall tissue factor activity, or ADP-induced
platelet aggregation. Acute administration of DL-cysteine, a reactive
oxygen species scavenger, completely abrogated the effects of iron
loading on thrombus formation, suggesting that iron accelerated
thrombosis through a pro-oxidant mechanism. Iron loading enhanced
both
systemic and vascular reactive oxygen species production.
Endothelium-
dependent vasorelaxation was impaired in iron-loaded mice, indicating
reduced NO bioavailability.


Conclusions— Moderate iron loading markedly accelerates thrombus
formation after arterial injury, increases vascular oxidative stress,
and impairs vasoreactivity. Iron-induced vascular dysfunction may
contribute to the increased incidence of ischemic cardiovascular
events that have been associated with chronic iron overload.


Key Words: thrombosis • free radicals • arteries


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


> "Harvey R. Stone" <hrst...@swbell.net> wrote in messagenewsr3bk.6309$LG4.1736@nlpi065.nbdc.sbc.c om...> Reported for being off topic in Alt.support..arthritis,,,, cross posting
> > after being warned not to do it.
>
> > Path:
> > nlpi059.nbdc.sbc.com!nlpi062.nbdc.sbc.com!prodigy. com!nlpi057.nbdc.sbc.com!*prodigy.net!border1.nntp .dca.giganews.com!nntp.giganews.com!postnews..goog le*.com!l64g2000hse.googlegroups.com!not-for-mail
> > From: ironjustice <teamtan...@hotmail.com>
>
> [snip]
> Off topic in alt.support.diabetes too. *Has ignored requests not to
> post off topic messages there.
>
> Note that groups-ab...@google.com is slow and not very effective
> *at responding to reports of spam posted through Google groups, so
> I would expect them to be unlikely to act on reports of being off topic.
> However, it does help to report the same spammers over and over
> for different messages for at least 6 weeks, so perhaps
> groups-ab...@google.com just can't keep up with reading all their
> incoming mail.

On Jul 3, 7:28*am, "Robert Miles" <robertmi...@bellsouthNOSPAM.net>
wrote:[snip] Off topic in alt.support.diabetes too.<<

Meet Robert .. he knows NOTHING about diabetes .. he only .. has
diabetes.
Through .. stupidity .. evidentally ..
--------------------------------
Diabetes Raises the Risk of Thrombosis in Atheromatous Coronary
Arteries

A study was undertaken at the Massachusetts General Hospital to
quantify the lipid composition and macrophage infiltration in
atheromatous plaques of culprit coronary arteries removed from 47
patients diagnosed with diabetes who were subjected to atherectomy for
acute ischemic events. Lesions were also studied from 48 nondiabetic
patients matched clinically and demographically with the diabetic
patients.

Four types of tissue in atheromatous plaque were identified by
staining: tissue with few cells and densely-stained collagen; tissue
with abundant smooth muscle cells and a loose connective tissue
matrix; lipid-rich atheroma with acellular debris, cholesterol clefts,
and no preserved connective tissue matrix; and thrombus.

It was found that lipid-rich atheroma and macrophages occupied larger
percentages of total area of specimens from diabetic than nondiabetic
patients. The incidence of thrombus was greater in diabetic than in
nondiabetic subjects (62% vs 40%, P=0.04). Whether diabetic patients
had been treated with insulin, a sulfonylurea, or diet had no effect
on plaque composition, macrophage infiltration, or thrombus presence.

The finding that coronary tissue from patients diagnosed with diabetes
exhibits a larger content of lipid-rich atheroma, macrophage
infiltration, and subsequent thrombosis than tissue from patients
without diabetes suggests that diabetes increases vulnerability for
coronary thrombosis.

Moreno PR, Murcia AM, Palacios IF, et al. Coronary composition and
macrophage infiltration in atherectomy specimens from patients with
diabetes mellitus. Circulation. 2000;102:2180-2184.
The above summary is adapted from the cited reference.

--------------------------------------------------------------------------------
Additional Information
Diabetes Accelerates Smooth Muscle Accumulation in Lesions of
Atherosclerosis: Lack of Direct Growth-Promoting Effects of High
Glucose Levels


Cardiologists Should Become as Familiar With Diabetes as They Are
With Dyslipidemia and Hypertension


Coronary Atherosclerosis in Type 2 Diabetes: Angiographic Findings
and Clinical Outcome


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




> "Harvey R. Stone" <hrst...@swbell.net> wrote in messagenewsr3bk.6309$LG4.1736@nlpi065.nbdc.sbc.c om...> Reported for being off topic in Alt.support..arthritis,,,, cross posting
> > after being warned not to do it.
>
> > Path:
> > nlpi059.nbdc.sbc.com!nlpi062.nbdc.sbc.com!prodigy. com!nlpi057.nbdc.sbc.com!*prodigy.net!border1.nntp .dca.giganews.com!nntp.giganews.com!postnews..goog le*.com!l64g2000hse.googlegroups.com!not-for-mail
> > From: ironjustice <teamtan...@hotmail.com>
>
> [snip]
> Off topic in alt.support.diabetes too. *Has ignored requests not to
> post off topic messages there.
>
> Note that groups-ab...@google.com is slow and not very effective
> *at responding to reports of spam posted through Google groups, so
> I would expect them to be unlikely to act on reports of being off topic.
> However, it does help to report the same spammers over and over
> for different messages for at least 6 weeks, so perhaps
> groups-ab...@google.com just can't keep up with reading all their
> incoming mail.

With some trolls, it helps to killfile them by name instead of
return address,

"Shelley" <noway@nohow.com> wrote in message
newsDQak.6945$3q7.6662@newsfe15.lga...
> I've done it twice (already) today... and I don't feel bad at all!!!
>
> Nasty little rusty troll... delete!!! Great fun!!!
>
> Shelley
>>
>>>I can kill-file him each time he changes his address. LOL
>>
>> I just did, fun isn't it?
>>
>> Joan
>
>

ironjustice wrote:
>
> On Jul 2, 5:21 pm, percy <vbeausol...@nowhere.bum> wrote: percy <<
>
> Yep ..
>
> It does sound gay ..

you must mean happy and lighthearted, right?

otherwise, it means you've reverted to homophobic slurs once again -

are you homophobic tommy?

since you do this so often, is it that you're just afraid of your own
impulses?
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!
> http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
>
> > Harvey R. Stone wrote:
> > > "DeeTee" <ke3iu_nos...@hotmail.com> wrote in message
> > >news:g4gf4j$o51$1@registered.motzarella.org...
> > >> I can kill-file him each time he changes his address. LOL
> >
> > >> DeeTee
> >
> > > Yes, that does clean up your computer but does it do anything for anyone
> > > elses. Aaah, I can hear morst of the replies to this. Atleast, I did not
> > > makes things worse... My reply would be,,,, how do you spell support?
> > > Harv
> >
> > ab...@telus.net

gosh tommy - are you being a gay basher again?

tell everyone tommy - are you homophobic?

just why are you so afraid of gays tommy? are you really afraid? or is
it that you get excited?

just what is it that you are remembering when you write these unfounded
slurs about folks?

go ahead tommy - 'fesh up - tell everyone what you think about as you
write such things...

what are those images that you carry around in your mind...just how
vivid are they?

ironjustice wrote:
>
> On Jul 2, 5:20 pm, percy <vbeausol...@nowhere.bum> wrote: here <<
>
> I always disliked the name .. percy ..
>
> Percy .. kinda sounds .. gay ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!
> http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk

On Jul 3, 11:45*am, "Robert Miles" <robertmi...@bellsouthNOSPAM.net>
wrote:
it helps <<

It helps to know just a smidgen about your disease.

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




>
> "Shelley" <no...@nohow.com> wrote in message
>
> newsDQak.6945$3q7.6662@newsfe15.lga...
>
>
>
> > I've done it twice (already) today... and I don't feel bad at all!!!
>
> > Nasty little rusty troll... delete!!! *Great fun!!!
>
> > Shelley
>
> >>>I can kill-file him each time he changes his address. LOL
>
> >> I just did, fun isn't it?
>
> >> Joan- Hide quoted text -
>
> - Show quoted text -

On Jul 3, 1:23*pm, "Paul T. Holland" <pholl...@bellatlantic.net>
wrote:long winded whack <<


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Jul 3, 1:10*pm, "Paul T. Holland" <pholl...@bellatlantic.net>
wrote: long winded whack <<


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Jul 3, 7:46*am, ironjustice <ironjust...@cashette.com> wrote:
thrombosis <<

Increased red blood cells cause thrombosis.
THAT is **precisely** WHY .. epo .. 'fell from grace'.
Epo builds red blood cells and it causes .. thrombosis.

Black Box Warning Ordered for Aranesp, Epogen, and Procrit
By Peggy Peck, Managing Editor, MedPage Today
Published: March 09, 2007
Reviewed by Robert Jasmer, MD; Associate Clinical Professor of
Medicine, University of California, San Francisco Earn CME/CE credit
for reading medical news

http://www.medpagetoday.com/ProductA...ptions/tb/5231

ROCKVILLE, Md., March 9 -- The FDA warned today that aggressive use of
erythropoiesis-stimulating agents to raise hemoglobin to a target of
12 g/dL or higher was associated with "serious and life-threatening
side-effects and/or death."

The warning states:

Avoid serious cardiovascular and arterial and venous thromboembolic
events by using the lowest dose of Aranesp, Epogen, or Procrit that
will gradually raise the hemoglobin concentration to the lowest level
sufficient to avoid the need for blood transfusion.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


> On Jul 3, 7:28*am, "Robert Miles" <robertmi...@bellsouthNOSPAM.net>
> wrote:[snip] Off topic in alt.support.diabetes too.<<
>
> Meet Robert .. he knows NOTHING about diabetes .. he only .. has
> diabetes.
> Through .. stupidity .. evidentally ..
> --------------------------------
> Diabetes Raises the Risk of Thrombosis in Atheromatous Coronary
> Arteries
>
> A study was undertaken at the Massachusetts General Hospital to
> quantify the lipid composition and macrophage infiltration in
> atheromatous plaques of culprit coronary arteries removed from 47
> patients diagnosed with diabetes who were subjected to atherectomy for
> acute ischemic events. Lesions were also studied from 48 nondiabetic
> patients matched clinically and demographically with the diabetic
> patients.
>
> Four types of tissue in atheromatous plaque were identified by
> staining: tissue with few cells and densely-stained collagen; tissue
> with abundant smooth muscle cells and a loose connective tissue
> matrix; lipid-rich atheroma with acellular debris, cholesterol clefts,
> and no preserved connective tissue matrix; and thrombus.
>
> It was found that lipid-rich atheroma and macrophages occupied larger
> percentages of total area of specimens from diabetic than nondiabetic
> patients. The incidence of thrombus was greater in diabetic than in
> nondiabetic subjects (62% vs 40%, P=0.04). Whether diabetic patients
> had been treated with insulin, a sulfonylurea, or diet had no effect
> on plaque composition, macrophage infiltration, or thrombus presence.
>
> The finding that coronary tissue from patients diagnosed with diabetes
> exhibits a larger content of lipid-rich atheroma, macrophage
> infiltration, and subsequent thrombosis than tissue from patients
> without diabetes suggests that diabetes increases vulnerability for
> coronary thrombosis.
>
> Moreno PR, Murcia AM, Palacios IF, et al. Coronary composition and
> macrophage infiltration in atherectomy specimens from patients with
> diabetes mellitus. Circulation. 2000;102:2180-2184.
> The above summary is adapted from the cited reference.
>
> ---------------------------------------------------------------------------*-----
> * *Additional Information
> * Diabetes Accelerates Smooth Muscle Accumulation in Lesions of
> Atherosclerosis: Lack of Direct Growth-Promoting Effects of High
> Glucose Levels
>
> *Cardiologists Should Become as Familiar With Diabetes as They Are
> With Dyslipidemia and Hypertension
>
> *Coronary Atherosclerosis in Type 2 Diabetes: Angiographic Findings
> and Clinical Outcome
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > "Harvey R. Stone" <hrst...@swbell.net> wrote in messagenewsr3bk.6309$LG4.1736@nlpi065.nbdc.sbc.c om...> Reported for being off topic in Alt.support.arthritis,,,, cross posting
> > > after being warned not to do it.
>
> > > Path:
> > > nlpi059.nbdc.sbc.com!nlpi062.nbdc.sbc.com!prodigy. com!nlpi057.nbdc.sbc.com!**prodigy.net!border1.nnt p.dca.giganews.com!nntp.giganews.com!postnews.goog l*e*.com!l64g2000hse.googlegroups.com!not-for-mail
> > > From: ironjustice <teamtan...@hotmail.com>
>
> > [snip]
> > Off topic in alt.support.diabetes too. *Has ignored requests not to
> > post off topic messages there.
>
> > Note that groups-ab...@google.com is slow and not very effective
> > *at responding to reports of spam posted through Google groups, so
> > I would expect them to be unlikely to act on reports of being off topic..
> > However, it does help to report the same spammers over and over
> > for different messages for at least 6 weeks, so perhaps
> > groups-ab...@google.com just can't keep up with reading all their
> > incoming mail.- Hide quoted text -
>
> - Show quoted text -

questioning your homophobic slurs is whack? then so be it -

do tell us how it 'feels' each time you write a slur tommy -

does it excite you to say those things?

are you afraid of your own impulses tom?

it that why you write bigoted things?

have you always been a bigot?

ironjustice wrote:
>
> On Jul 3, 1:10 pm, "Paul T. Holland" <pholl...@bellatlantic.net>
> wrote: long winded whack <<
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!
> http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!
> http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk

indeed tommy


ironjustice wrote:
>
> On Jul 3, 1:23 pm, "Paul T. Holland" <pholl...@bellatlantic.net>
> wrote:long winded whack <<

bigoted statements like the ones you post deserve a good 'whack' when
you write them...



>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!
> http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!
> http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk

On Jul 3, 4:11*pm, "Paul T. Holland" <pholl...@bellatlantic.net>
wrote:long winded whack <<

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Jul 3, 4:08*pm, "Paul T. Holland" <pholl...@bellatlantic.net>
wrote:long winded whack <<

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk