Bucillamine / strong iron chelator / arthritis

<<snip>>
these metal ions are significantly higher in RA patients and may be
involved in oxidative stress-induced damage
<<snip>>

Antioxidant properties of bucillamine: possible mode of action.
Mazor D, Greenberg L, Shamir D, Meyerstein D, Meyerstein N
Biochem Biophys Res Commun. 2006 Oct 27; 349(3): 1171-5

The antioxidant properties of Bucillamine (BUC), a di-thiol compound
used for treatment of rheumatoid arthritis (RA) and its possible mode
of action, were investigated. BUC exhibits potent antioxidant activity
similar to those of trolox and ascorbic acid. It reduces the stable
free radical diphenyl-2-picrylhydrazyl (DPPH) with IC(50) of 18.5+/-0.1
micromol, its relative antioxidant activity by the ferric reducing
ability (FRAP) is 2.07+/-0.01 mM and by the trolox equivalent
antioxidant capacity (TEAC), 1.46+/-0.05 mM. However, its superoxide
and apparent hydroxyl radical scavenging activities are low (IC(50) at
millimolar concentrations). We found that BUC is a strong iron (II) and
copper (II) chelator. This finding is very important since these metal
ions are significantly higher in RA patients and may be involved in
oxidative stress-induced damage. Our study suggests that BUC is a
potent antioxidant which exerts its beneficial therapeutic activities
in RA patients by metal chelation rather than by scavenging free
radical species.


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Tom


Jesus Was A Vegetarian!
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Man Is A Herbivore!
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DEAD PEOPLE WALKING
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