These 11 cases ALL showed increased .. iron stores / hyperferritinemia
..
AND .. again .. 'coincidentally' .. hypertransaminasemia WHICH .. again
... coincidentally .. is the ONLY marker which is DIAGNOSTIC of the
**lowering**
of **iron** .. in hepatitis ..
It falls as iron load falls in hepatitis patients treated for iron ..
load.
So the bottom line here is .. 'they' .. say Still's / juvenile
rheumatoid arthritis patients are ..
iron 'deficient' .. when in FACT hypertansaminasemia ..
is THE .. marker which .. DIAGNOSES .. iron **excess** in hepatitis ..
...
Throw in the fact .. Still's patients get .. RELIEF .. by .. using
chloroquine / sulfasalazine /
aspirin /
tetracycline iron binding
substances .. would give .. quite
a bit of .. **evidence** .. that **iron** is NOT .. 'deficient' .. but
is
ACTIVELY .. **involved** .. IN .. the disease .. COURSE ..
And the FACT one patient DIED .. due TO .. hepatitis MEANS the 'marker'
of Hypertransaminasemia .. {Hypertransaminasemia DIAGNOSTIC of
INCREASED iron in hepatitis] .. gives credence TO .. **excess** as
opposed to .. iron 'deficiency'.
[Adult Still's disease: study of a series of 11 cases]
Ben Taarit C, Turki S, Ben Maïz H
J Mal Vasc. 2002 Feb ; 27(1): 31-5
Adult Still's disease is a systemic disease of unknown etiology. We
report a retrospective study of 11 cases (9 females and 2 males) of
adult Still's disease collected during 25 years. The mean age was 36
years. Fever, arthritis and skin rash was constant. Adenopathies and
splenomegaly were observed in 2 patients. The laboratory findings was
characterized by a constant inflammatory syndrome and leucocytosis.
Hypertransaminasemia and hyperferritinemia were observed respectively
in 7 cases and 3 cases. Corticosteroids were prescribed in all
patients.
Methotrexate was administered in 3 patients. Outcome was
favorable in 10 cases, death incurred in one patient, secondary to
acute hepatitis.
-----------------------------------------------------------------------------------------------------------
EXPERIMENTAL BIOLOGY UPDATE: Arthritic kids' iron supplements may
hasten joint
deterioration
By Diana Swift
WWASHINGTON, D.C. - The iron supplements that many arthritic children
take to
combat concomitant anemia may be hastening the deterioration of their
joints,
Houston researchers say.
Led by biologist Roman Shypailo of the Children's Nutrition Research
Centre at
Baylor College of Medicine, a Texas team looked at eight children being
treated
for juvenile rheumatoid arthritis. The patients, aged five to 15 years,
received an intravenous radioactive tracer dose of iron (0.03
microsievert).
Iron activity in affected joints was monitored on a
position/energy-sensitive
gamma counter, while a second machine monitored whole-body iron
retention. Iron
deposition was measured two hours post-infusion and again at days
seven, 14, 28
and 56.
Anemic
"We found that iron excessively accumulates in arthritic joints and
probably
contributes to the chronic damage," said Shypailo. "That puts you
between a
rock and a hard place because many of these arthritic kids are anemic
and need
iron supplements, which may worsen the disease."
The study found a high level of agreement between the joint data and
the
whole-body data, with a greater than 90% retention rate of the infused
iron
both in joints and systemically. Furthermore, six of eight patients
showed
increased uptake at the affected joints: 165% over the first 30 days
compared
with initial uptake at two hours.
The next step, he says, is to see if there is excessive deposition of
dietary
iron in arthritic joints.
--------------------------------------------------------------------------
<<snip>>
beef and chicken muscle increased iron absorption 180%
<<snip>>
Meat Protein Fractions Enhance Nonheme Iron Absorption in Humans.
Hurrell RF, Reddy MB, Juillerat M, Cook JD
J Nutr. 2006 Nov ; 136(11): 2808-2812
The nature of the enhancing effect of muscle tissue on nonheme iron
absorption in humans is unclear but thought to be related to muscle
proteins. We conducted radioiron absorption studies to compare iron
absorption from proteins isolated from beef and chicken muscle with
that from freeze-dried beef and chicken muscle and from egg albumin.
All meals contained an equivalent amount of protein as part of a
semisynthetic liquid formula. Freeze-dried beef and chicken muscle
increased iron absorption 180% (P < 0.001) and 100% (P < 0.001),
respectively, relative to egg albumin. When added to the meal at an
equivalent protein level (15 g), the isolated beef protein and the
isolated heme-free beef protein with 94 and 98% protein content,
respectively, increased iron absorption to the same extent as the
native beef muscle. Similarly, when added to the meal at an equivalent
protein level (30 g), isolated chicken muscle protein (94% protein)
increased iron absorption similarly to native chicken muscle. Iron
absorption from the meal containing the isolated heme-free chicken
protein, however, was 120% (P < 0.01) greater than from the meal
containing freeze-dried chicken muscle, indicating that a nonprotein
component of muscle tissue with iron-binding potential may have been
removed or concentrated by the protein extraction and separation
procedures. Our results support the hypothesis that the enhancing
effect of muscle tissue on iron absorption is mainly protein related
but indicate that other factors may also play a role.
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