Oxidative Stress Confirmed In Arthritis

"Taking away iron should be considered"

Lipid, protein, DNA oxidation and antioxidant status in rheumatoid
arthritis.
Clin Biochem. 2008 May;41(7-8):538-43. Epub 2008 Feb 15. Links
Seven A, Güzel S, Aslan M, Hamuryudan V.
Department of Biochemistry, Cerrahpaºa Medical Faculty, Istanbul
University, Istanbul, Turkey. arzu_seven@hotmail.com

OBJECTIVES:
To investigate lipid, protein, DNA oxidation and antioxidant status in
blood and synovial fluid of rheumatoid arthritis (RA) patients and to
determine the importance of oxidative stress parameters in reflecting
disease activity.
DESIGN AND METHODS:
20 RA patients and 15 healthy controls were included. Lipid
peroxidation (thiobarbituric acid reactive substances (TBARS), lipid
hydroperoxide, and conjugated diene), protein oxidation (carbonyl and
thiol), DNA oxidation (8-OHdG) and antioxidant status markers
(glutathione (GSH), glutathione peroxidase (GSH Px), superoxide
dismutase (CuZn SOD), and catalase) were determined in blood and
synovial fluid.
RESULTS:
TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene
(p<0.001), carbonyl (p<0.001) and 8-OHdG (p<0.01) levels were
significantly higher; thiol (p<0.01) and GSH levels (p<0.01) and GSH
Px (p<0.001) and CuZn SOD (p<0.01) activities were significantly lower
in blood of RA patients. TBARS (p<0.001), lipid hydroperoxide
(p<0.001), conjugated diene (p<0.01), carbonyl (p<0.001) and 8-OHdG
(p<0.05) levels were significantly higher, catalase activity (p<0.001)
significantly lower in synovial fluid of RA patients.
CONCLUSIONS:
Increased lipid, protein and DNA oxidation markers and impaired
antioxidant status confirm the role of oxidative stress in the
pathogenesis of RA. Lipid peroxidation markers can serve as surrogate
markers for disease activity.

PMID: 18313405
---------------------------------------------------------------------------*-----
Biochem Pharmacol 1999 Jun 15;57(12):1345-9

Therapy by taking away: the case of iron.

Polla BS

Laboratoire de Physiologie Respiratoire, UFR Cochin Port-Royal,
Paris, France. Barbara.Po...@cochin.univ-paris5.fr

The recent finding of the beneficial effects of iron deprivation in
the outcome of muscle necrosis in an animal model of genetic myopathy
served as the basis of this commentary.
Here, "taking away" iron by controlled dietary deprivation is proposed
as a reasonable, feasible, cheap, and efficient clinical approach to
many diverse diseases, all of which have a free radical component.
Indeed, iron potentiates the generation of the highly reactive and
toxic hydroxyl radical, and, thus, of oxidative damage. Iron
deprivation may represent the first really efficient antioxidant,
preventing oxidative stress in all subcellular compartments, tissues,
and organs.
Iron/iron deprivation also modulates programmed cell death
(apoptosis), which should be the subject of further studies to better
define the mechanisms mediating these complex effects.
Finally, related to its antioxidant effects, iron deprivation may find
applications in the anti-aging field, whether programmed or premature
aging, and whether in cosmetics or in gerontology.

PMID: 10353254, UI: 99279694
--------------------------------

CONCLUSION

In conclusion, therapy by taking away (iron) has a great potential for
many different diseases, all of which share ROS-mediated mechanisms.
The development of new, non-toxic , easily administrable iron
chelators such as IRCO11 may shortly become the most efficient and
fashionable antioxidant, anti-aging, anti-infectious, and anti-
inflammatroy therapy.
In the meantime, although taking away by controlled dietary
deprivation is less attractive , it should be considered in all of the
above, as well as in the currently incurable, devastating genetic or
acquired myopathies such as DMD.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Jul 20, 9:41�am, ironjustice <teamtan...@hotmail.com> wrote:

Tom
Fe+ is an essential nutrient, however when found systemcally in excess
it induces oxidation <---> inflammation and related pathology (which
is virtually *all* pathology). This is well established. Why then do
you have to post 6,000 studies a day to reinforce the obvious......
what is your goal?
CB

On Jul 20, 7:54Â*am, Chuck <ShorThi...@aol.com> wrote:This is well
established. <<

Good ..

You don't like my post .. ?
On Jul 20, 7:54 am, Chuck <ShorThi...@aol.com> wrote:Why then do
you have to post 6,000 studies a day to reinforce the obvious......
>what is your goal? <<

If you don't know .. there is no explaining it to .. you ..

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




> On Jul 20, 9:41�am, ironjustice <teamtan...@hotmail.com> wrote:
>
> Tom
> Fe+ is an essential nutrient, however when found systemcally in excess
> it induces oxidation <---> inflammation and related pathology (which
> is virtually *all* pathology). This is well established. Why then do
> you have to post 6,000 studies a day to reinforce the obvious......
> what is your goal?
> CB

On Jul 20, 7:54Â*am, Chuck <ShorThi...@aol.com> wrote:
On Jul 20, 9:41�am, ironjustice <teamtan...@hotmail.com> wrote: Tom
Fe+ is an essential nutrient, however when found systemcally in
excess it induces oxidation <---> inflammation and related pathology
(which
is virtually *all* pathology). This is well established. Why then do
you have to post 6,000 studies a day to reinforce the obvious......
what is your goal? CB <<

Ok .. chuck .. as a "nutritionist" .. you .. "based in free radical
oxidative stress processes" .. your words .. you AGREE the oxidative
stress / rust 'theory' holds water.

If I understand you correctly.

I have heard nothing of the overwhelming **evidence** OF the
**effects** of "age-related iron accumulation" from .. you a
"nutritionist" .. you .. "based in free radical oxidative stress
processes" .

That leaves .. ?

Me ..

Doesn't .. it ..

Evidentally ..

YOU seem to have .. given up .. ON .. the 'hope' of EVER finding this
elusive cause of disease.
You seem to have taken a course of there is NO way there will ever BE
a elimination of disease and it is a .. normal .. ageing process.

I disagree and have disagreed for many years and now am enjoying the
fact iron reduction therapy leads to 10 X 1 reduction in hospital
stays in sickle cell and recommended for everyone with hepatitis and a
large clinical trial of iron reduction in diabetes.

And .. the deaths of three people in high iron in cancer and the
deaths of one person in low iron in cancer .. give or take a few
bodies.

You .. for some reason .. based on your "nutritionist" teaching
believe that somehow an animal like man would have a problem with
obtaining iron from his diet so much so that you advise people to
include iron filings in their diets.

I disagree because it adds to this "free radical theory and oxidative
stress theory of pathology of disease" ..

Evidence based medicine .. IE: noone screaming in the room .. says ..
phlebotomy works ..

How come it isn't being used .. ?

Nutritionists ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk






Now what would your .. theory .. be to the effects of lactoferrin .. ?

Fungistatic activity of iron-free bovin lactoferrin against several
fungal plant pathogens and antagonists.
Lahoz E, Pisacane A, Iannaccone M, Palumbo D, Capparelli R Nat Prod
Res 2008 Jul; 22(11):955-61.

Lactoferrin (LF) is a member of the transferrin family of iron-
binding
glycoproteins. It is also a multifunctional protein of 80 kDa that is
synthesized by glandular epithelial cells and secreted into mucosal
fluid. High levels of LF are present in colostrom and milk and low
levels in tears, saliva, and gastrointestinal and reproductive
secretions. Data regarding the antifungal effects of LF are limited.
Studies have been performed on Candida albicans, which demonstrated
that LF inhibits the growth of this fungus. This study reports the
results of experiments carried out in order to evaluate the effects
of
LF on the growth of 11 fungi, which were isolated from plants and
soils. These experiments employed the methods of amended agar
utilizing nine different concentration levels of LF (0, 0.001, 0.01,
0.1, 1, 10, 100, 1000, 5000 mg L(-1)). The effects of LF on the
growth
of these fungi were based on measures of the radial growth of the
fungal colonies expressed both as percentage of inhibition and as
IC(50) values (the concentration at which the fungal growth was
inhibited by 50% relative to controls). LF had no effects on
Alternaria alternata, Gliocladium roseum, Fusarium solani and
Colletotrichum lindemuthianum. It did, however, inhibit the growth of
Aspergillus niger, Trichoderma viride, Sclerotinia sclerotiorum,
Sclerotium rolfsii, Rhizoctonia solani and Phoma exigua to the point
that their IC(50) values ranged from 31.1 mg L(-1) for S.
sclerotiorum
to 952 mg L(-1) for T. viride.


Natural product research [Nat Prod Res]


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

URINE THERAPY ?
Have you heard of it --- 150,000 web pages on the internet.

Erach


On Jul 21, 2:57Â*am, ironjustice <teamtan...@hotmail.com> wrote:
> On Jul 20, 7:54Â*am, Chuck <ShorThi...@aol.com> wrote:
> Â*On Jul 20, 9:41�am, ironjustice <teamtan...@hotmail.com> wrote: Tom
> Â*Fe+ is an essential nutrient, however when found systemcally in
> excess it induces oxidation <---> inflammation and related pathology
> (which
> Â*is virtually *all* pathology). This is well established. Why then do
> Â*you have to post 6,000 studies a day to reinforce the obvious......
> Â*what is your goal? CB <<
>
> Ok .. Â*chuck .. as a "nutritionist" .. you .. "based in free radical
> oxidative stress processes" .. your words .. you AGREE the oxidative
> stress / rust 'theory' holds water.
>
> If I understand you correctly.
>
> I have heard nothing of the overwhelming **evidence** OF the
> **effects** of "age-related iron accumulation" from .. you a
> "nutritionist" .. you .. "based in free radical oxidative stress
> processes" .
>
> That leaves .. ?
>
> Me ..
>
> Doesn't .. it ..
>
> Evidentally ..
>
> YOU seem to have .. given up .. ON .. the 'hope' of EVER finding this
> elusive cause of disease.
> You seem to have taken a course of there is NO way there will ever BE
> a elimination of disease and it is a .. normal .. ageing process.
>
> I disagree and have disagreed for many years and now am enjoying the
> fact iron reduction therapy leads to 10 X 1 reduction in hospital
> stays in sickle cell and recommended for everyone with hepatitis and a
> large clinical trial of iron reduction in diabetes.
>
> And .. the deaths of three people in high iron in cancer and the
> deaths of one person in low iron in cancer .. give or take a few
> bodies.
>
> You .. for some reason .. based on your "nutritionist" teaching
> believe that somehow an animal like man would have a problem with
> obtaining iron from his diet so much so that you advise people to
> include iron filings in their diets.
>
> I disagree because it adds to this "free radical theory and oxidative
> stress theory of pathology of disease" ..
>
> Evidence based medicine .. IE: noone screaming in the room .. says ..
> phlebotomy works ..
>
> How come it isn't being used .. ?
>
> Nutritionists ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> Now what would your .. theory .. be to the effects of lactoferrin .. ?
>
> Fungistatic activity of iron-free bovin lactoferrin against several
> fungal plant pathogens and antagonists.
> Lahoz E, Pisacane A, Iannaccone M, Palumbo D, Capparelli R Nat Prod
> Res 2008 Jul; 22(11):955-61.
>
> Lactoferrin (LF) is a member of the transferrin family of iron-
> binding
> glycoproteins. It is also a multifunctional protein of 80 kDa that is
> synthesized by glandular epithelial cells and secreted into mucosal
> fluid. High levels of LF are present in colostrom and milk and low
> levels in tears, saliva, and gastrointestinal and reproductive
> secretions. Data regarding the antifungal effects of LF are limited.
> Studies have been performed on Candida albicans, which demonstrated
> that LF inhibits the growth of this fungus. This study reports the
> results of experiments carried out in order to evaluate the effects
> of
> LF on the growth of 11 fungi, which were isolated from plants and
> soils. These experiments employed the methods of amended agar
> utilizing nine different concentration levels of LF (0, 0.001, 0.01,
> 0.1, 1, 10, 100, 1000, 5000 mg L(-1)). The effects of LF on the
> growth
> of these fungi were based on measures of the radial growth of the
> fungal colonies expressed both as percentage of inhibition and as
> IC(50) values (the concentration at which the fungal growth was
> inhibited by 50% relative to controls). LF had no effects on
> Alternaria alternata, Gliocladium roseum, Fusarium solani and
> Colletotrichum lindemuthianum. It did, however, inhibit the growth of
> Aspergillus niger, Trichoderma viride, Sclerotinia sclerotiorum,
> Sclerotium rolfsii, Rhizoctonia solani and Phoma exigua to the point
> that their IC(50) values ranged from 31.1 mg L(-1) for S.
> sclerotiorum
> to 952 mg L(-1) for T. viride.
>
> Natural product research [Nat Prod Res]
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

LOL You know nothing about me nor my "teachings" or "learnings". I
think you do yourself and your message a huge disservice by being
obnoxious and condescending.

CB

On Jul 21, 2:52*am, Chuck <ShorThi...@aol.com> wrote:
LOL *You know nothing about me nor my "teachings" or "learnings". <<

I know you have a .. trap .. and you flap it quite .. regular ..
-----------------------
Chuck View profile
Of course not. I'm actually a Nutritionist who did his masters thesis
on antioxidants and cardiovascular disease. There is a case for iron
and oxidation as it is a first line pro-oxidant with oxidative stress
being connected with well over 200 disease processes. I just don't
understand the cut, paste and run mentality. But *mentality* may be
the key word in Doe's case ;-) CB
-------------------------

On Jul 21, 2:52 am, Chuck <ShorThi...@aol.com> wrote:I
think you do yourself and your message a huge disservice by being
obnoxious and condescending. <<

I find the fact a man who 'claims' to have some sort of .. advanced
learning in something .. doesn't have the .. foggiest .. ABOUT ..
it .. strange ..

It is either a .. lie .. or .. ? .. what .. ?

Stupidity ..

You have two choices ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Jul 21, 9:34�am, ironjustice <teamtan...@hotmail.com> wrote:

> It is either a .. lie .. or .. ? .. what .. ?
>
> Stupidity ..
>
> You have two choices ..
>
> Who loves ya.
> Tom

You need help, sir. Searching the archives to attack a virtual
stranger? I've done quite a bit of research in the arena of Fe+,
oxidation and pathology. I agree with most of the studies you cut and
paste. Instead of attacking everyone, perhaps you should make
recommendations as to *help* them. You treat someone who agree's with
your message like this, imagine how you treat anyone who disagree's.?
Unfortunate, but your message will never resonate until you learn
human decency.
BTW, there is much more to the oxidation<--> inflammation <----> NO
<---> glycation...... paradigm than just Fe+
CB

On Jul 21, 7:39Â*am, Chuck <ShorThi...@aol.com> wrote:You need help,
sir. Searching the archives to attack a virtual stranger? <<

You came onto my thread and badmouthed .. me ..

You got some sort of cognition .. problem ..

Stay away from me .. chuck ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> On Jul 21, 9:34�am, ironjustice <teamtan...@hotmail.com> wrote:
>
> > It is either a .. lie .. or .. ? .. what .. ?
>
> > Stupidity ..
>
> > You have two choices ..
>
> > Who loves ya.
> > Tom
>
> You need help, sir. Searching the archives to attack a virtual
> stranger? I've done quite a bit of research in the arena of Fe+,
> oxidation and pathology. I agree with most of the studies you cut and
> paste. Instead of attacking everyone, perhaps you should make
> recommendations as to *help* them. You treat someone who agree's with
> your message like this, imagine how you treat anyone who disagree's.?
> Unfortunate, but your message will never resonate until you learn
> human decency.
> BTW, there is much more to the oxidation<--> inflammation <----> NO
> <---> glycation...... Â* Â* Â*paradigm than just Fe+
> CB

On Jul 21, 11:15�am, "ironjust...@aol.com" <ironjust...@aol.com>
> You came onto my thread and badmouthed .. me ..
>
> You got some sort of cognition .. problem ..
>
> Stay away from me .. chuck ..

LOL Not a problem.

On Jul 21, 11:33Â*am, Chuck <ShorThi...@aol.com> wrote:
> On Jul 21, 11:15�am, "ironjust...@aol.com" <ironjust...@aol.com>
>
> > You came onto my thread and badmouthed .. me ..
>
> > You got some sort of cognition .. problem ..
>
> > Stay away from me .. chuck ..
>
> LOL Â*Not a problem.

Chuck,

The guy is a long time, well known troll. Everybody ignores him.

Evelyn

On Jul 21, 1:22�pm, Evelyn <evelyn.r...@gmail.com> wrote:

> Chuck,
>
> The guy is a long time, well known troll. � Everybody ignores him..
>
> Evelyn


Thank you. It is sad because his message, although completely
obsessive, has validity. Just packaged wrong, I now realize.
Be well,
CB

On Jul 21, 2:45Â*pm, Chuck <ShorThi...@aol.com> wrote:
> On Jul 21, 1:22�pm, Evelyn <evelyn.r...@gmail.com> wrote:
>
> > Chuck,
>
> > The guy is a long time, well known troll. � Everybody ignores him.
>
> > Evelyn
>
> Thank you. It is sad because his message, although completely
> obsessive, has validity. Just packaged wrong, I now realize.
> Be well,
> CB

I don't think anyone much cares any longer about his message, because
of the obsessive and nasty way he presents it. He trolls on several
newsgroups and gets very ugly with anyone who tries to converse with
him. I have been posting around ten years, and he has always been
around annoying people.

Evelyn

Who loves ya. =CAUSE NO ONE WANTS TO BE AROUND THIS CREATURE, LET
ALONE READ THE SHIT SPEWED FORTH BY HIM REPETITIVELY.
Tom= REALLY A HERMAPHRODITIC NEANDERTHAL THAT WILL NOT GO AWAY.


Jesus Was A Vegetarian! JESUS ATE FISH. HE ATE A MEDITERRANEAN DIET.
http://tinyurl.com/2r2nkh (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)


Man Is A Herbivore! I AM MAN, I AM HUMAN, I EAT MEAT. MOST PEOPLE EAT
MEAT AND ARE NOT HERBIVORES!
http://tinyurl.com/4rq595 (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)



DEAD PEOPLE WALKING. DEAD PEOPLE CANNOT TALK, WALK, OR EAT, REGARDLESS
OF THE BULLSHIT SWIMMING AROUND IN THAT FILTHY, SICK, ANNOYING HEAD OF
YOURS.
http://tinyurl.com/zk9fk (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)


STAY OFF ANY THREADS.
HOW DO YOU OWN ANYTHING?
STAY OUT OF THE NEWSGROUPS.
QUIT POSTING NONSENSE THAT NO ONE WANTS TO HEAR.
THE ONLY PURPOSE YOU HAVE IN LIFE IS TO ANNOY THOSE ACTUALLY USING
THESE SERVICES FOR THE INTENDED PURPOSE BY POSTING YOUR SHIT.
QUIT.

YOU FIT THE PROFILE OF THE CYBERSTALKER, CYBERBULLY. YOU ARE THE ONE
and ONLY PERSON DOING THAT TO THE REST OF THE NEWSGROUP SUBSCRIBERS.

GO AWAY.

WHY CAN'T YOU UNDERSTAND THAT **YOUR POSTING IS NOT WANTED HERE*****

Who loves ya. =CAUSE NO ONE WANTS TO BE AROUND THIS CREATURE, LET
ALONE READ THE SHIT SPEWED FORTH BY HIM REPETITIVELY.
Tom= REALLY A HERMAPHRODITIC NEANDERTHAL THAT WILL NOT GO AWAY.


Jesus Was A Vegetarian! JESUS ATE FISH. HE ATE A MEDITERRANEAN DIET.
http://tinyurl.com/2r2nkh (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)


Man Is A Herbivore! I AM MAN, I AM HUMAN, I EAT MEAT. MOST PEOPLE EAT
MEAT AND ARE NOT HERBIVORES!
http://tinyurl.com/4rq595 (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)



DEAD PEOPLE WALKING. DEAD PEOPLE CANNOT TALK, WALK, OR EAT, REGARDLESS
OF THE BULLSHIT SWIMMING AROUND IN THAT FILTHY, SICK, ANNOYING HEAD OF
YOURS.
http://tinyurl.com/zk9fk (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)


STAY OFF ANY THREADS.
HOW DO YOU OWN ANYTHING?
STAY OUT OF THE NEWSGROUPS.
QUIT POSTING NONSENSE THAT NO ONE WANTS TO HEAR.
THE ONLY PURPOSE YOU HAVE IN LIFE IS TO ANNOY THOSE ACTUALLY USING
THESE SERVICES FOR THE INTENDED PURPOSE BY POSTING YOUR SHIT.
QUIT.

YOU FIT THE PROFILE OF THE CYBERSTALKER, CYBERBULLY. YOU ARE THE ONE
and ONLY PERSON DOING THAT TO THE REST OF THE NEWSGROUP SUBSCRIBERS.

GO AWAY.

WHY CAN'T YOU UNDERSTAND THAT **YOUR POSTING IS NOT WANTED HERE*****

Who loves ya. =CAUSE NO ONE WANTS TO BE AROUND THIS CREATURE, LET
ALONE READ THE SHIT SPEWED FORTH BY HIM REPETITIVELY.
Tom= REALLY A HERMAPHRODITIC NEANDERTHAL THAT WILL NOT GO AWAY.


Jesus Was A Vegetarian! JESUS ATE FISH. HE ATE A MEDITERRANEAN DIET.
http://tinyurl.com/2r2nkh (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)


Man Is A Herbivore! I AM MAN, I AM HUMAN, I EAT MEAT. MOST PEOPLE EAT
MEAT AND ARE NOT HERBIVORES!
http://tinyurl.com/4rq595 (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)



DEAD PEOPLE WALKING. DEAD PEOPLE CANNOT TALK, WALK, OR EAT, REGARDLESS
OF THE BULLSHIT SWIMMING AROUND IN THAT FILTHY, SICK, ANNOYING HEAD OF
YOURS.
http://tinyurl.com/zk9fk (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)


STAY OFF ANY THREADS.
HOW DO YOU OWN ANYTHING?
STAY OUT OF THE NEWSGROUPS.
QUIT POSTING NONSENSE THAT NO ONE WANTS TO HEAR.
THE ONLY PURPOSE YOU HAVE IN LIFE IS TO ANNOY THOSE ACTUALLY USING
THESE SERVICES FOR THE INTENDED PURPOSE BY POSTING YOUR SHIT.
QUIT.

YOU FIT THE PROFILE OF THE CYBERSTALKER, CYBERBULLY. YOU ARE THE ONE
and ONLY PERSON DOING THAT TO THE REST OF THE NEWSGROUP SUBSCRIBERS.

GO AWAY.

WHY CAN'T YOU UNDERSTAND THAT **YOUR POSTING IS NOT WANTED HERE*****

On Jul 21, 10:22*am, Evelyn <evelyn.r...@gmail.com> wrote: The guy is
a long time, well known troll. * Everybody ignores him.<<

And it is .. coincidence .. you and chuck .. talk to each other ..
eh ..

Yep .. meet .. chuck .. again ..

YOU know by now it is impolite for YOU to post to my threads .. don't
ya .. ruut .

Everytime you post it is to say something .. anything .. negative .

Based on .. ?

"my dad has alzheimers"

Stick .. it ..

This is a .. science .. based thread ..

It is not about .. eating ..

You may have mistook my sig for a .. call to the all you can eat ..
buffet .. but you are wrong.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Jul 21, 1:28*pm, Evelyn <evelyn.r...@gmail.com> wrote:He trolls on
several
newsgroups and gets very ugly with anyone who tries to converse with
him. * I have been posting around ten years, and he has always been
around annoying people. <<

You've posted to most of my threads over the years .. haven't ya ..

And since you HAVE posted to most of my threads .. and you fully admit
that you disagree with my .. work .. means .. ?

Everytime you've posted to my threads it has been ..
noncontributive .. EVERYTIME.

JUST like this time .. twice .. eh ..

Said nothing about .. Oxidative Stress Confirmed In Arthritis but ..
does .. badmouth .. ME .. for .. ?

Posting a medical study which .. confirms .. oxidative stress in
arthritis.

Contributive .. ?

You make the call ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
>
> Evelyn

"Taking away iron should be considered"

Lipid, protein, DNA oxidation and antioxidant status in rheumatoid
arthritis.
Clin Biochem. 2008 May;41(7-8):538-43. Epub 2008 Feb 15. Links
Seven A, Güzel S, Aslan M, Hamuryudan V.
Department of Biochemistry, Cerrahpaºa Medical Faculty, Istanbul
University, Istanbul, Turkey. arzu_se...@hotmail.com


OBJECTIVES:
To investigate lipid, protein, DNA oxidation and antioxidant status
in
blood and synovial fluid of rheumatoid arthritis (RA) patients and to
determine the importance of oxidative stress parameters in reflecting
disease activity.
DESIGN AND METHODS:
20 RA patients and 15 healthy controls were included. Lipid
peroxidation (thiobarbituric acid reactive substances (TBARS), lipid
hydroperoxide, and conjugated diene), protein oxidation (carbonyl and
thiol), DNA oxidation (8-OHdG) and antioxidant status markers
(glutathione (GSH), glutathione peroxidase (GSH Px), superoxide
dismutase (CuZn SOD), and catalase) were determined in blood and
synovial fluid.
RESULTS:
TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene
(p<0.001), carbonyl (p<0.001) and 8-OHdG (p<0.01) levels were
significantly higher; thiol (p<0.01) and GSH levels (p<0.01) and GSH
Px (p<0.001) and CuZn SOD (p<0.01) activities were significantly
lower
in blood of RA patients. TBARS (p<0.001), lipid hydroperoxide
(p<0.001), conjugated diene (p<0.01), carbonyl (p<0.001) and 8-OHdG
(p<0.05) levels were significantly higher, catalase activity
(p<0.001)
significantly lower in synovial fluid of RA patients.
CONCLUSIONS:
Increased lipid, protein and DNA oxidation markers and impaired
antioxidant status confirm the role of oxidative stress in the
pathogenesis of RA. Lipid peroxidation markers can serve as surrogate
markers for disease activity.


PMID: 18313405
---------------------------------------------------------------------------**-----
Biochem Pharmacol 1999 Jun 15;57(12):1345-9


Therapy by taking away: the case of iron.


Polla BS


Laboratoire de Physiologie Respiratoire, UFR Cochin Port-Royal,
Paris, France. Barbara.Po...@cochin.univ-paris5.fr


The recent finding of the beneficial effects of iron deprivation in
the outcome of muscle necrosis in an animal model of genetic myopathy
served as the basis of this commentary.
Here, "taking away" iron by controlled dietary deprivation is
proposed
as a reasonable, feasible, cheap, and efficient clinical approach to
many diverse diseases, all of which have a free radical component.
Indeed, iron potentiates the generation of the highly reactive and
toxic hydroxyl radical, and, thus, of oxidative damage. Iron
deprivation may represent the first really efficient antioxidant,
preventing oxidative stress in all subcellular compartments, tissues,
and organs.
Iron/iron deprivation also modulates programmed cell death
(apoptosis), which should be the subject of further studies to better
define the mechanisms mediating these complex effects.
Finally, related to its antioxidant effects, iron deprivation may
find
applications in the anti-aging field, whether programmed or premature
aging, and whether in cosmetics or in gerontology.


PMID: 10353254, UI: 99279694
--------------------------------


CONCLUSION


In conclusion, therapy by taking away (iron) has a great potential
for
many different diseases, all of which share ROS-mediated mechanisms.
The development of new, non-toxic , easily administrable iron
chelators such as IRCO11 may shortly become the most efficient and
fashionable antioxidant, anti-aging, anti-infectious, and anti-
inflammatroy therapy.
In the meantime, although taking away by controlled dietary
deprivation is less attractive , it should be considered in all of
the
above, as well as in the currently incurable, devastating genetic or
acquired myopathies such as DMD.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

"Taking away iron should be considered"

Lipid, protein, DNA oxidation and antioxidant status in rheumatoid
arthritis.
Clin Biochem. 2008 May;41(7-8):538-43. Epub 2008 Feb 15. Links
Seven A, Güzel S, Aslan M, Hamuryudan V.
Department of Biochemistry, Cerrahpaºa Medical Faculty, Istanbul
University, Istanbul, Turkey. arzu_se...@hotmail.com


OBJECTIVES:
To investigate lipid, protein, DNA oxidation and antioxidant status
in
blood and synovial fluid of rheumatoid arthritis (RA) patients and to
determine the importance of oxidative stress parameters in reflecting
disease activity.
DESIGN AND METHODS:
20 RA patients and 15 healthy controls were included. Lipid
peroxidation (thiobarbituric acid reactive substances (TBARS), lipid
hydroperoxide, and conjugated diene), protein oxidation (carbonyl and
thiol), DNA oxidation (8-OHdG) and antioxidant status markers
(glutathione (GSH), glutathione peroxidase (GSH Px), superoxide
dismutase (CuZn SOD), and catalase) were determined in blood and
synovial fluid.
RESULTS:
TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene
(p<0.001), carbonyl (p<0.001) and 8-OHdG (p<0.01) levels were
significantly higher; thiol (p<0.01) and GSH levels (p<0.01) and GSH
Px (p<0.001) and CuZn SOD (p<0.01) activities were significantly
lower
in blood of RA patients. TBARS (p<0.001), lipid hydroperoxide
(p<0.001), conjugated diene (p<0.01), carbonyl (p<0.001) and 8-OHdG
(p<0.05) levels were significantly higher, catalase activity
(p<0.001)
significantly lower in synovial fluid of RA patients.
CONCLUSIONS:
Increased lipid, protein and DNA oxidation markers and impaired
antioxidant status confirm the role of oxidative stress in the
pathogenesis of RA. Lipid peroxidation markers can serve as surrogate
markers for disease activity.


PMID: 18313405
---------------------------------------------------------------------------**-----
Biochem Pharmacol 1999 Jun 15;57(12):1345-9


Therapy by taking away: the case of iron.


Polla BS


Laboratoire de Physiologie Respiratoire, UFR Cochin Port-Royal,
Paris, France. Barbara.Po...@cochin.univ-paris5.fr


The recent finding of the beneficial effects of iron deprivation in
the outcome of muscle necrosis in an animal model of genetic myopathy
served as the basis of this commentary.
Here, "taking away" iron by controlled dietary deprivation is
proposed
as a reasonable, feasible, cheap, and efficient clinical approach to
many diverse diseases, all of which have a free radical component.
Indeed, iron potentiates the generation of the highly reactive and
toxic hydroxyl radical, and, thus, of oxidative damage. Iron
deprivation may represent the first really efficient antioxidant,
preventing oxidative stress in all subcellular compartments, tissues,
and organs.
Iron/iron deprivation also modulates programmed cell death
(apoptosis), which should be the subject of further studies to better
define the mechanisms mediating these complex effects.
Finally, related to its antioxidant effects, iron deprivation may
find
applications in the anti-aging field, whether programmed or premature
aging, and whether in cosmetics or in gerontology.


PMID: 10353254, UI: 99279694
--------------------------------


CONCLUSION


In conclusion, therapy by taking away (iron) has a great potential
for
many different diseases, all of which share ROS-mediated mechanisms.
The development of new, non-toxic , easily administrable iron
chelators such as IRCO11 may shortly become the most efficient and
fashionable antioxidant, anti-aging, anti-infectious, and anti-
inflammatroy therapy.
In the meantime, although taking away by controlled dietary
deprivation is less attractive , it should be considered in all of
the
above, as well as in the currently incurable, devastating genetic or
acquired myopathies such as DMD.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

"Taking away iron should be considered"

Lipid, protein, DNA oxidation and antioxidant status in rheumatoid
arthritis.
Clin Biochem. 2008 May;41(7-8):538-43. Epub 2008 Feb 15. Links
Seven A, Güzel S, Aslan M, Hamuryudan V.
Department of Biochemistry, Cerrahpaºa Medical Faculty, Istanbul
University, Istanbul, Turkey. arzu_se...@hotmail.com


OBJECTIVES:
To investigate lipid, protein, DNA oxidation and antioxidant status
in
blood and synovial fluid of rheumatoid arthritis (RA) patients and to
determine the importance of oxidative stress parameters in reflecting
disease activity.
DESIGN AND METHODS:
20 RA patients and 15 healthy controls were included. Lipid
peroxidation (thiobarbituric acid reactive substances (TBARS), lipid
hydroperoxide, and conjugated diene), protein oxidation (carbonyl and
thiol), DNA oxidation (8-OHdG) and antioxidant status markers
(glutathione (GSH), glutathione peroxidase (GSH Px), superoxide
dismutase (CuZn SOD), and catalase) were determined in blood and
synovial fluid.
RESULTS:
TBARS (p<0.001), lipid hydroperoxide (p<0.001), conjugated diene
(p<0.001), carbonyl (p<0.001) and 8-OHdG (p<0.01) levels were
significantly higher; thiol (p<0.01) and GSH levels (p<0.01) and GSH
Px (p<0.001) and CuZn SOD (p<0.01) activities were significantly
lower
in blood of RA patients. TBARS (p<0.001), lipid hydroperoxide
(p<0.001), conjugated diene (p<0.01), carbonyl (p<0.001) and 8-OHdG
(p<0.05) levels were significantly higher, catalase activity
(p<0.001)
significantly lower in synovial fluid of RA patients.
CONCLUSIONS:
Increased lipid, protein and DNA oxidation markers and impaired
antioxidant status confirm the role of oxidative stress in the
pathogenesis of RA. Lipid peroxidation markers can serve as surrogate
markers for disease activity.


PMID: 18313405
---------------------------------------------------------------------------**-----
Biochem Pharmacol 1999 Jun 15;57(12):1345-9


Therapy by taking away: the case of iron.


Polla BS


Laboratoire de Physiologie Respiratoire, UFR Cochin Port-Royal,
Paris, France. Barbara.Po...@cochin.univ-paris5.fr


The recent finding of the beneficial effects of iron deprivation in
the outcome of muscle necrosis in an animal model of genetic myopathy
served as the basis of this commentary.
Here, "taking away" iron by controlled dietary deprivation is
proposed
as a reasonable, feasible, cheap, and efficient clinical approach to
many diverse diseases, all of which have a free radical component.
Indeed, iron potentiates the generation of the highly reactive and
toxic hydroxyl radical, and, thus, of oxidative damage. Iron
deprivation may represent the first really efficient antioxidant,
preventing oxidative stress in all subcellular compartments, tissues,
and organs.
Iron/iron deprivation also modulates programmed cell death
(apoptosis), which should be the subject of further studies to better
define the mechanisms mediating these complex effects.
Finally, related to its antioxidant effects, iron deprivation may
find
applications in the anti-aging field, whether programmed or premature
aging, and whether in cosmetics or in gerontology.


PMID: 10353254, UI: 99279694
--------------------------------


CONCLUSION


In conclusion, therapy by taking away (iron) has a great potential
for
many different diseases, all of which share ROS-mediated mechanisms.
The development of new, non-toxic , easily administrable iron
chelators such as IRCO11 may shortly become the most efficient and
fashionable antioxidant, anti-aging, anti-infectious, and anti-
inflammatroy therapy.
In the meantime, although taking away by controlled dietary
deprivation is less attractive , it should be considered in all of
the
above, as well as in the currently incurable, devastating genetic or
acquired myopathies such as DMD.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk