Patiently Phlebotomizing Patients

Gout crystals WHEN iron is present.

Phosphate has an AFFINITY for iron.

"decreased clearance rate of calcium pyrophosphate dihydrate crystals
by iron"

Iron reduction seems to help.

"phlebotomy is suggested as therapy for gout patients"

Calcium Pyrophosphate Dihydrate Crystal Deposition Disease (CPPD)
(Pseudo Gout)

What Is It?

Calcium Pyrophosphate Dihydrate Crystal Deposition is a condition
that causes pain, redness, heat, and swelling in one or more joints.
Also referred to as Pseudo Gout or Chondrocalcinosis.

http://ww2.arthritis.org/conditions/...enter/cppd.asp
--------------------------------------------------------

"decreased clearance rate of calcium pyrophosphate dihydrate crystals
by iron"

Arthritis Rheum 1981 May;24(5):706-10

Clearance of calcium pyrophosphate dihydrate crystals in vivo. III.
Effects of synovial hemosiderosis.

McCarty DJ, Palmer DW, Garancis JC

Synthetic triclinic calcium pyrophosphate dihydrate crystals,
uniformly labeled with 85Sr and 45Ca, were injected into the knee
joints of 2 normal adult rabbits and 2 rabbits previously injected
repeatedly with autologous blood.

The "half clearance time" of the injected crystal mass was 20.4 and 19
days from control joints, nearly identical to previously reported
values in 6 rabbits (19.1 +/- 1.4), and 28.8 and 34 days from the
joints injected with blood, a significant difference (P less than
0.05).

Iron stains showed hemosiderin granules in the superficial synovium in
these joints.

Electron microscopy showed crystals with a molar calcium/phosphorus
ratio of 1.0 and particles containing iron within synovial cells.

We hypothesize that the decreased clearance rate from hemosiderotic
synovium is due to inhibition of one or more intracellular
pyrophosphatases by iron.

PMID: 6263291, UI: 81207376


--------------------------------------------------------------------------------

http://www.medscape.com/viewarticle/550602


<<snip>>
there was an association with higher ferritin levels in patients with
the chronic arthropathy pattern in this population
<<snip>>
<<snip>>
Subclinical anomalies in iron storage may underlie a subset of what
would be considered to be idiopathic chondrocalcinosis in some
populations
<<snip>>

------------------------------------------------------------------------------------

http://tinyurl.com/22tgjz

Therefore, phlebotomy is suggested as therapy for gout patients, in
order to
eliminate the accumulated Fe. Furthermore, yearly blood donation is
recommended for males with a family history of gout, so as to prevent
Fe accumulation and avoid gout.

PMID: 10616042, UI: 20081788

Phlebotomize \Phle*bot"o*mize\, v. t. [imp. & p. p.
Phlebotomized; p. pr. & vb. n. Phlebotomizing.] [Cf. F.
phl['e]botomiser.]
To let blood from by opening a vein; to bleed. [R.] --Howell.

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk