Phytate Decreased TNF-alpha

Miraculous .. stuff.

This would be my .. freeee .. bisphosphonate .. aaaa gain.

Remember .. ? .. the one that is **better** than those .. expensive
**unaffordable** .. other bisphosphonates .. like etidronate .. ?

http://tinyurl.com/2wuhuk

The influence of phytic acid on TNF-alpha and its receptors genes'
expression in colon cancer Caco-2 cells.
Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E,
Kierot J, Weglarz L
Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9.


Inositol hexaphosphate (IP6, phytic acid) is a naturally occurring
carbohydrate abundantly present in high-fiber diets and it is also
contained in almost all mammalian cells.
It plays an important role in signal transduction, cell proliferation
and differentiation.
Some natural substances have been shown to elicit an impact on the
expression of TNF-alpha and its receptors in cancer cells.
TNF-alpha represents cytokine very often deregulated at the level of
both gene expression and signal transmission through TNF-alpha
receptors (TNFRI and TNFRII).
The aim of the present study was to analyze the IP6 influence on the
transcription of genes coding for TNF-alpha and its receptors in human
colon cancer cells line Caco-2.
Real-time QRT-PCR based on TaqMan methodology was applied to analyze
quantitatively the transcript levels of these genes.
Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2
cells stimulation for 1, 6, 12 and 24 h.
The results showed that IP6 modulated the expression of the listed
genes at transcription level in a dose and time dependent manner.
The enhanced TNFRI and decreased TNF-alpha and TNFRII transcription in
Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive
evidence for anti-inflammatory and antitumor activity of IP6.


Acta poloniae pharmaceutica [Acta Pol Pharm]
---------------------------------------------------------------------------------
The last study found there was not enough evidence to say one
bisphosphonate was better than another.
This study found .. phyate IS .. **better**.


"No evidence currently available to definitely confirm that
one bisphosphonate is better than another"


"Phytate found to be the most effective"


Phytate inhibits bovine pericardium calcification in vitro
Cardiovascular Pathology, Volume 17, Issue 3, May-June 2008, Pages
139-145
F¨¦lix Grases, Pilar Sanchis, Antonia Costa-Bauz¨¢, Oriol Bonnin,
Bernat Isern, Joan Perell¨®, Rafael M. Prieto

Objective
The present study examined the inhibitory effects of pyrophosphate,
etidronate, and phytate on bovine pericardium calcification in vitro.
Methods
Bovine pericardium was glutaraldehyde fixed and then placed in a flow
chamber in the presence of a synthetic physiological fluid alone
(control) or the fluid plus various concentrations of pyrophosphate,
etidronate, or phytate.
Following a 96-h incubation, fragments were removed and assayed for
calcification by measuring calcium and phosphorus levels.

Results
The data indicated that both pyrophosphate and etidronate at 1 mg/l
(5.75 and 4.95 ¦ÌM, respectively) inhibited bovine pericardium
calcification, whereas neither agent had an effect at 0.5 mg/l (2.87
and 2.47 ¦ÌM, respectively).
Phytate was the most potent inhibitor of calcification, and the
effects of this agent were apparent at levels as low as 0.25 mg/l
(0.39 ¦ÌM).

Conclusions
While pyrophosphate, etidronate, and phytate were all able to inhibit
bovine pericardium calcification in vitro, phytate was found to be the
most effective.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk