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  #1  
Old 07-21-2008, 10:58 AM
jay
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Default Rheumatoid Arthritis & Dioxin & Smoking

[A role for the aryl hydrocarbon receptor and the dioxin TCDD in
rheumatoid arthritis]
Objective. Environmental factors are involved in RA pathogenesis and
epidemiological studies have suggested that smoking is an
environmental risk factor for RA. The 2,3,7,8-tetrachlorodibenzo-p-
dioxin (TCDD) is one of the major toxic components in
cigarettes ...Results. Higher AhR mRNA and protein levels were
observed in RA synovial tissue than in OA tissue. TCDD up-regulated
the expression of IL-1beta, IL-6 and IL-8 through binding to AhR, and
this effect was transmitted via the NF-kappaB and ERK signalling
cascades. AhR expression in synovial cells was up-regulated by TNF-
alpha. Conclusion. TNF-alpha activates AhR expression in RA synovial
tissue, and that cigarette smoking and exposure to TCDD enhances RA
inflammatory processes. TCDD induces inflammatory cytokines via its
association with AhR, resulting in stimulation of the NF-kappaB and
ERK signalling cascades. Thus TCDD exposure, such as smoking
exacerbates RA pathophysiology. PMID: 18617548

Note: Besides cigarette smoke, the most concentrated source of dioxins
are dietary animal fats.
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  #2  
Old 07-21-2008, 10:58 AM
erach27@gmail.com
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Default Re: Rheumatoid Arthritis & Dioxin & Smoking

AH YES. BUT DOES URINE THERAPY HELP IN ARTHRITIS.
Erach


On Jul 21, 10:20*am, jay <jaym1...@hotmail.com> wrote:
> [A role for the aryl hydrocarbon receptor and the dioxin TCDD in
> rheumatoid arthritis]
> Objective. Environmental factors are involved in RA pathogenesis and
> epidemiological studies have suggested that smoking is an
> environmental risk factor for RA. The 2,3,7,8-tetrachlorodibenzo-p-
> dioxin (TCDD) is one of the major toxic components in
> cigarettes ...Results. Higher AhR mRNA and protein levels were
> observed in RA synovial tissue than in OA tissue. TCDD up-regulated
> the expression of IL-1beta, IL-6 and IL-8 through binding to AhR, and
> this effect was transmitted via the NF-kappaB and ERK signalling
> cascades. AhR expression in synovial cells was up-regulated by TNF-
> alpha. Conclusion. TNF-alpha activates AhR expression in RA synovial
> tissue, and that cigarette smoking and exposure to TCDD enhances RA
> inflammatory processes. TCDD induces inflammatory cytokines via its
> association with AhR, resulting in stimulation of the NF-kappaB and
> ERK signalling cascades. Thus TCDD exposure, such as smoking
> exacerbates RA pathophysiology. PMID: 18617548
>
> Note: Besides cigarette smoke, the most concentrated source of dioxins
> are dietary animal fats.


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  #3  
Old 07-21-2008, 03:59 PM
ironjustice
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Default Re: Rheumatoid Arthritis & Dioxin & Smoking

On Jul 20, 10:31*pm, "erac...@gmail.com" <erac...@gmail.com> wrote:
AH YES. *BUT DOES URINE THERAPY HELP IN ARTHRITIS.
Erach <<

Title: PhD/B.Tech IIT Mumbai Computer Science
"Are all intellectuals dumb and cowards"

I would say since YOU have a PhD that would make YOU a .. stupid ..
pussy .. ?

Yep ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

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  #4  
Old 07-22-2008, 01:14 AM
aka_velcro
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Posts: n/a
Default Re: Rheumatoid Arthritis & Dioxin & Smoking

Who loves ya. =CAUSE NO ONE WANTS TO BE AROUND THIS CREATURE, LET
ALONE READ THE SHIT SPEWED FORTH BY HIM REPETITIVELY.
Tom= REALLY A HERMAPHRODITIC NEANDERTHAL THAT WILL NOT GO AWAY.


Jesus Was A Vegetarian! JESUS ATE FISH. HE ATE A MEDITERRANEAN DIET.
http://tinyurl.com/2r2nkh (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)


Man Is A Herbivore! I AM MAN, I AM HUMAN, I EAT MEAT. MOST PEOPLE EAT
MEAT AND ARE NOT HERBIVORES!
http://tinyurl.com/4rq595 (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)



DEAD PEOPLE WALKING. DEAD PEOPLE CANNOT TALK, WALK, OR EAT, REGARDLESS
OF THE BULLSHIT SWIMMING AROUND IN THAT FILTHY, SICK, ANNOYING HEAD OF
YOURS.
http://tinyurl.com/zk9fk (WHY ARE YOU ADVERTISING THAT YOU HAVE A
TINY***, ARE A TINY LITTLE DUMBASS THAT WON'T GO
AWAY!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!)


STAY OFF ANY THREADS.
HOW DO YOU OWN ANYTHING?
STAY OUT OF THE NEWSGROUPS.
QUIT POSTING NONSENSE THAT NO ONE WANTS TO HEAR.
THE ONLY PURPOSE YOU HAVE IN LIFE IS TO ANNOY THOSE ACTUALLY USING
THESE SERVICES FOR THE INTENDED PURPOSE BY POSTING YOUR SHIT.
QUIT.

YOU FIT THE PROFILE OF THE CYBERSTALKER, CYBERBULLY. YOU ARE THE ONE
and ONLY PERSON DOING THAT TO THE REST OF THE NEWSGROUP SUBSCRIBERS.

GO AWAY.

WHY CAN'T YOU UNDERSTAND THAT **YOUR POSTING IS NOT WANTED HERE*****
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  #5  
Old 07-22-2008, 01:14 AM
ironjustice
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Posts: n/a
Default Re: Rheumatoid Arthritis & Dioxin & Smoking

On Jul 21, 3:38*pm, aka_velcro <Crystalarev...@gmail.com> wrote: snip
<<

I've got another .. fan ..

Where's .. Holland ..

You guys should .. meet up .. hook up .. whatever .. hep .. language
you .. guys .. are using nowadays ..


Yep ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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