Sensitization, glutamate, and the link between migraine and fibromyalgia, Sarchielli P, Di Filippo M, Nardi K, Calabresi P, 2007 Oct., Curr Pain Headache Rep., related MCS studies: Murray 2007.09.29

Sensitization, glutamate, and the link between migraine and
fibromyalgia, Sarchielli P, Di Filippo M, Nardi K, Calabresi P, 2007
Oct., Curr Pain Headache Rep., related MCS studies: Murray 2007.09.29
http://groups.yahoo.com/group/aspartameNM/message/1476
http://RMForAll.blogspot.com September 29, 2007


"Of course, everyone chooses, as a natural priority,
to actively find, quickly share, and positively act
upon the facts about healthy and safe food, drink,
and environment."

Rich Murray, MA Room For All rmforall@comcast.net
505-501-2298 1943 Otowi Road, Santa Fe, New Mexico 87505

http://groups.yahoo.com/group/aspartameNM/messages
group with 82 members, 1,476 posts in a public,
searchable archive http://RMForAll.blogspot.com

http://groups.yahoo.com/group/aspartameNM/message/1454
recent research and news re aspartame and stevia: Murray 2007.08.16


Curr Pain Headache Rep. 2007 Oct; 11(5): 343-51.
Sensitization, glutamate, and the link between migraine and
fibromyalgia.
Sarchielli P,
Di Filippo M, massimilianodifilippo@virgilio.it,
Nardi K,
Calabresi P. calabre@unipg.it,
Neurologic Clinic,
Department of Medical and Surgical Specialties and Public Health,
University of Perugia, Ospedale Santa Maria della Misericordia,
Via Santa Andrea delle Fratte, San Sisto, 06158 Perugia, Italy.
neuro.pg@tiscalinet.it,
Department of Medical and Surgical Specialties and Public Health,
Neurologic Clinic, University of Perugia, Perugia, Italy.
headache@unipg.it,

Recent advances have shed insight on the pathophysiologic mechanisms
of fibromyalgia and migraine, especially in the chronic form.

A growing body of evidence supports the involvement of peripheral and
central sensitization disturbances of pain-related processes
underlying both disorders.

They involve increased glutamate transmission through interaction with
its ionotropic and metabotropic receptors.

Few studies supporting the implication of this excitatory amino acid
in chronic migraine and primary fibromyalgia demonstrated increased
levels of glutamate in the cerebrospinal fluid of affected patients.

These findings have implications for future therapies directed against
glutamate receptors (in particular, N-methyl-D-aspartate receptors).

Limited clinical experience in this regard, although promising, does
not exclude additional mechanisms contributing to the maintenance of
pain, which can be the target of therapeutic approaches in both
disorders.
PMID: 17894924

[ a reference re Martin L. Pall paradigm from
Position Statement: Multiple Chemical Sensitivity
http://mcs-america.org/MCSPositionStatement.htm
13 Vale Street, Salem, NY 12864
Phone: 213-985-3096
Lourdes Salvador, President admin@mcs-america.org
http://thetruthaboutmcs.blogspot.com/

Pall, Martin L.
Explaining 'Unexplained Illnesses': Disease Paradigm for Chronic
Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-
Traumatic Stress Disorder, and Gulf War Syndrome.
Bighampton, NY: The Hawthorne Press. 2007.

Pall, M. Community Spotlight: An Interview with Martin L. Pall, PhD.
MCS America News. 2007 Oct;2:10, 11-13.
http://thetruthaboutmcs.blogspot.com...view-with.html

See also: http://mcs-america.org/pall.pdf
Multiple Chemical Sensitivity: Towards the End of Controversy
Martin L. Pall, Ph.D.
Professor of Biochemistry and Basic Medical Sciences
Washington State University
Pullman, WA 99164-4234 USA
509-335-1246 martin_pall@wsu.edu, ]

[ Two years of items by Sarchielli P in PubMed ]

Items 1 - 20 of 81

Page 1 of 5

1:
Sarchielli P, Di Filippo M, Nardi K, Calabresi P.
Abstract
Sensitization, glutamate, and the link between migraine and
fibromyalgia.
Curr Pain Headache Rep. 2007 Oct;11(5):343-51.
PMID: 17894924 [PubMed - in process]

2:
Sarchielli P, Di Filippo M, Candeliere A, Chiasserini D, Mattioni A,
Tenaglia S, Bonucci M, Calabresi P.
Abstract
Expression of ionotropic glutamate receptor GLUR3 and effects of
glutamate on MBP- and MOG-specific lymphocyte activation and
chemotactic migration in multiple sclerosis patients.
J Neuroimmunol. 2007 Aug;188(1-2):146-58. Epub 2007 Jul 12.
PMID: 17628700 [PubMed - in process]

3:
Sandrini G, Cerbo R, Del Bene E, Ferrari A, Genco S, Grazioli I,
Martelletti P, Nappi G, Pinessi L, Sarchielli P, Tamburro P, Uslenghi
C, Zanchin G.
Efficacy of dosing and re-dosing of two oral fixed combinations of
indomethacin, prochlorperazine and caffeine compared with oral
sumatriptan in the acute treatment of multiple migraine attacks: a
double-blind, double-dummy, randomised, parallel group, multicentre
study.
Int J Clin Pract. 2007 Aug;61(8):1256-69.
PMID: 17627707 [PubMed - in process]
Free full text in PubMed Central
http://www.pubmedcentral.nih.gov/art...medid=17627707
G Sandrini, 1
R Cerbo, 2
E Del Bene, 3
A Ferrari, 4
S Genco, 5
I Grazioli, 6
P Martelletti, 7
G Nappi, 8
L Pinessi, 9
P Sarchielli, 10
P Tamburro, 11
C Uslenghi, 6
and G Zanchin1 2

1 University Centre for Adaptive Disorders and Headache (UCADH), IRCCS
'C. Mondino' Institute of Neurology Foundation, Pavia, Italy
2 Pain Centre, Emergency Department, 'La Sapienza' University, Rome,
Italy
3 Headache Centre, Department of Internal Medicine, University of
Florence, Florence, Italy
4 Department of Laboratory Services, Section of Toxicology and
Clinical Pharmacology, Headache Centre, University of Modena and
Reggio Emilia, Modena, Italy
5 Headache Centre, Neurologic Clinic I, University of Bari, Bari,
Italy
6 Medical Department, Solvay Pharma S.p.A., Grugliasco, Torino, Italy
7 Regional Referral Headache Centre, Department of Medical Sciences,
II School of Medicine, 'La Sapienza' University, Rome, Italy
8 University Centre for Adaptive Disorders and Headache (UCADH), IRCCS
'C. Mondino' Institute of Neurology Foundation, Pavia, Italy;
Department of Neurology and Otolaryngology, 'La Sapienza' University,
Rome, Italy
9 Headache Centre, Neurologic Clinic II, University of Torino, Torino,
Italy
10 Headache Centre, Neurologic Clinic, Department of Medical and
Surgical Specialties and Public Health, University of Perugia,
Perugia, Italy
11 Headache Centre, University of Chieti, Chieti, Italy
12 Headache Centre, Department of Neurosciences, University of Padova,
Padova, Italy
Correspondence to: Carla Uslenghi, Solvay Pharma S.p.A., Via della
Libertà, 30 - 10095 Grugliasco, Torino, Italy Tel.: + 39 011 40279343
Fax: + 39 02 70057821 Email: carla.uslenghi@solvay.com,

This study is registered in the Italian website for the registration
of clinical trials (http://oss-sper-clin.sanita.it/).

Disclosures Irene Grazioli and Carla Uslenghi are employees of Solvay
Pharma S.p.A.

Received April 2007; Accepted April 2007.

Acknowledgements

The authors wish to acknowledge other investigators from Italy who
participated in this study:

Grazia Sances (University Centre for Adaptive Disorders and Headache,
IRCCS 'C. Mondino' Institute of Neurology Foundation, Pavia, Italy);

Gianluca Bruti (Pain Centre, Emergency Department, 'La Sapienza'
University, Rome);

Francesco De Cesaris (Headache Centre, Department of Internal
Medicine, University of Florence);

Maria Pia Prudenzano (Headache Centre, Neurologic Clinic I, University
of Bari);

Sergio De Filippis, Gabriella Coloprisco (Regional Referral Headache
Centre, Department of Medical Sciences, II School of Medicine, 'La
Sapienza' University, Rome);

Lidia Savi (Headache Centre, Neurologic Clinic II, University of
Torino);

Cristiana Rossi, Andrea Alberti, Francesca Coppola, Antonio Baldi
(Headache Centre, Neurologic Clinic, Department of Medical and
Surgical Specialties and Public Health, University of Perugia);

Graziella Di Meo (Headache Centre, University of Chieti);

Ferdinando Maggioni, Filippo Dainese (Headache Centre, Department of
Neurosciences, University of Padova);

Paolo Liberini (Department of Neurology, Spedali Civili, Brescia);

Giorgio Bono (Department of Neurology, Ospedale di Circolo e
Fondazione Macchi, Varese);

Filippo Brighina, Antonina Aloisio (Institute of Neuropsychiatry,
University of Palermo);

Giovanni Regesta, Marco Fonzari (Department of Neurology, San Martino
Hospital, Genova).

4:
Sarchielli P, Mancini ML, Floridi A, Coppola F, Rossi C, Nardi K,
Acciarresi M, Pini LA, Calabresi P.
Abstract
Increased levels of neurotrophins are not specific for chronic
migraine: evidence from primary fibromyalgia syndrome.
J Pain. 2007 Sep;8(9):737-45. Epub 2007 Jul 5.
PMID: 17611164 [PubMed - in process]

5:
Mattioni A, Paciaroni M, Sarchielli P, Murasecco D, Pelliccioli GP,
Calabresi P.
No Abstract
Multiple cranial nerve palsies in a patient with internal carotid
artery dissection.
Eur Neurol. 2007;58(2):125-7. Epub 2007 Jun 13. No abstract available.
PMID: 17570922 [PubMed - indexed for MEDLINE]

6:
Mainardi F, Lisotto C, Palestini C, Sarchielli P, Maggioni F, Zanchin
G.
Abstract
Headache attributed to airplane travel ("airplane headache"): first
italian case.
J Headache Pain. 2007 Jun;8(3):196-9. Epub 2007 Jun 11.
PMID: 17563837 [PubMed - in process]

7:
Sarchielli P, Zaffaroni M, Floridi A, Greco L, Candeliere A, Mattioni
A, Tenaglia S, Di Filippo M, Calabresi P.
Abstract
Production of brain-derived neurotrophic factor by mononuclear cells
of patients with multiple sclerosis treated with glatiramer acetate,
interferon-beta 1a, and high doses of immunoglobulins.
Mult Scler. 2007 Apr;13(3):313-31. Epub 2007 Jan 29.
PMID: 17439900 [PubMed - indexed for MEDLINE]

8:
Sarchielli P, Pedini M, Coppola F, Rossi C, Baldi A, Corbelli I,
Mancini ML, Calabresi P.
Abstract
Application of the ICHD-II criteria to the diagnosis of primary
chronic headaches via a computerized structured record.
Headache. 2007 Jan;47(1):38-44.
PMID: 17355492 [PubMed - indexed for MEDLINE]

9:
Calabresi P, Galletti F, Rossi C, Sarchielli P, Cupini LM.
Abstract
Antiepileptic drugs in migraine: from clinical aspects to cellular
mechanisms.
Trends Pharmacol Sci. 2007 Apr;28(4):188-95. Epub 2007 Mar 6. Review.
PMID: 17337068 [PubMed - indexed for MEDLINE]

10:
Mancini ML, Stracci F, Tambasco N, Sarchielli P, Rossi A, Calabresi
P.
Abstract
Prevalence of essential tremor in the territory of Lake Trasimeno,
Italy: results of a population-based study.
Mov Disord. 2007 Mar 15;22(4):540-5.
PMID: 17260338 [PubMed - indexed for MEDLINE]

11:
Sarchielli P, Pini LA, Coppola F, Rossi C, Baldi A, Mancini ML,
Calabresi P.
Abstract
Endocannabinoids in chronic migraine: CSF findings suggest a system
failure.
Neuropsychopharmacology. 2007 Jun;32(6):1384-90. Epub 2006 Nov 22.
Erratum in: Neuropsychopharmacology. 2007 Jun;32(6):1432.
PMID: 17119542 [PubMed - indexed for MEDLINE]

12:
Tenaglia S, Paciaroni M, Hamam M, Sarchielli P, Pelliccioli GP,
Calabresi P.
No Abstract
Giant basilar apex aneurysm presenting as bilateral thalamic
compression with neuropsychological disorders.
Eur Neurol. 2006;56(1):57-8. Epub 2006 Aug 17. No abstract available.
PMID: 16921245 [PubMed - indexed for MEDLINE]

13:
Sarchielli P, Floridi A, Mancini ML, Rossi C, Coppola F, Baldi A, Pini
LA, Calabresi P.
Abstract
NF-kappaB activity and iNOS expression in monocytes from internal
jugular blood of migraine without aura patients during attacks.
Cephalalgia. 2006 Sep;26(9):1071-9.
PMID: 16919057 [PubMed - indexed for MEDLINE]

14:
Sarchielli P.
No Abstract
Trigger factors of migraine and tension-type headache.
J Headache Pain. 2006 Sep;7(4):172-3. No abstract available.
PMID: 16897623 [PubMed - indexed for MEDLINE]

15:
Sarchielli P, Mancini ML, Calabresi P.
Abstract
Practical considerations for the treatment of elderly patients with
migraine.
Drugs Aging. 2006;23(6):461-89. Review.
PMID: 16872231 [PubMed - indexed for MEDLINE]

16:
Sarchielli P, Alberti A, Candeliere A, Floridi A, Capocchi G,
Calabresi P.
Abstract
Glial cell line-derived neurotrophic factor and somatostatin levels in
cerebrospinal fluid of patients affected by chronic migraine and
fibromyalgia.
Cephalalgia. 2006 Apr;26(4):409-15.
PMID: 16556241 [PubMed - indexed for MEDLINE]

17:
Sarchielli P, Alberti A, Baldi A, Coppola F, Rossi C, Pierguidi L,
Floridi A, Calabresi P.
Abstract
Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin
expression in the internal jugular blood of migraine patients without
aura assessed ictally.
Headache. 2006 Feb;46(2):200-7.
PMID: 16492228 [PubMed - indexed for MEDLINE]

18:
Sarchielli P, Pini LA, Zanchin G, Alberti A, Maggioni F, Rossi C,
Floridi A, Calabresi P.
Abstract
Clinical-biochemical correlates of migraine attacks in rizatriptan
responders and non-responders.
Cephalalgia. 2006 Mar;26(3):257-65.
PMID: 16472331 [PubMed - indexed for MEDLINE]

19:
Pini LA, Guidetti G, Brovia D, Pontremoli P, Sarchielli P.
Abstract
Topo-kinesthetic memory in chronic headaches. A new test for chronic
patients: preliminary report.
J Headache Pain. 2005 Dec;6(6):448-54. Epub 2005 Nov 10.
PMID: 16388339 [PubMed - indexed for MEDLINE]

20:
Sarchielli P, Pedini M, Alberti A, Rossi C, Baldi A, Corbelli I,
Calabresi P.
Abstract
Application of ICHD 2nd edition criteria for primary headaches with
the aid of a computerised, structured medical record for the
specialist.
J Headache Pain. 2005 Sep;6(4):205-10.
PMID: 16362665 [PubMed - indexed for MEDLINE]
////////////////////////////////////////////////////////////


http://groups.yahoo.com/group/aspartameNM/message/1464
13 mainstream research studies in 24 months showing aspartame
toxicity, also 3 relevant studies on methanol and formaldehyde: Murray
2007.08.17

http://groups.yahoo.com/group/aspartameNM/message/1475
19,000 people, the 4% of users of aspartame who drink average 5 cans
daily, have more problems in NIH AARP study of 474,000 people: Murray
2007.09.21
http://RMForAll.blogspot.com September 21, 2007

http://groups.yahoo.com/group/aspartameNM/message/1141
Nurses Health Study can quickly reveal the extent of aspartame
(methanol, formaldehyde, formic acid) toxicity: Murray 2004.11.21

The Nurses Health Study is a bonanza of information about the health
of
probably hundreds of nurses who use 6 or more cans daily
of diet soft drinks -- they have also stored blood and tissue samples
from their immense pool of subjects, over 100,000 for decades.

http://groups.yahoo.com/group/aspartameNM/message/1473
this first page of a long review appreciates details in Unhee Lim
study:
bias, omissions, incuriosity = opportunity, aspartame safety
evaluation,
Magnuson BA, Burdock GA, Williams GM, 7 more, 2007 Sept, Ajinomoto
funded 98 pages html [$ 32 781888262_content.pdf]: Murray 2007.09.17


http://groups.yahoo.com/group/aspartameNM/message/1467
4 cases of aspartame-induced thrombocytopenia [ very low platelets in
blood ], HJ Roberts MD, Letter in Southern Medical Journal 2007 May:
100(5); 543: Murray 2007.08.25

http://groups.yahoo.com/group/aspartameNM/message/1468
Formaldehyde induced urticarial vasculitis in male medical student,
age 40, Michael Pellizzari, Gillian Marshman, Flinders U.,
Australasian J. Dermatol. 2007 Aug: Murray 2007.08.29

http://groups.yahoo.com/group/aspartameNM/message/1469
highly toxic formaldehyde, the cause of alcohol hangovers, is made by
the body from 100 mg doses of methanol from dark wines and liquors,
dimethyl dicarbonate, and aspartame: Murray 2007.08.31

http://groups.yahoo.com/group/aspartameNM/message/1470
new details on how formaldehyde and formic acid from methanol are
neurotoxic: Chun Lai Nie, Rong Giao He, et al, PLoS ONE 2(7): e629
2007.07.18 Chinese Academy of Sciences, Beijing: Murray 20097.09.01
////////////////////////////////////////////////////////////


http://groups.yahoo.com/group/aspartameNM/message/1457
aspartame bans, tis more an avalanche than a trend...: Rich Murray
2007.08.17

[ see also:
http://groups.yahoo.com/group/aspartameNM/message/1458
ASDA, Wal-Mart's UK supermarket chain, bans artificial colors, trans
fats, MSG and aspartame, Marguerite Kelly, The Washington Post: Murray
2007.08.03 ]

So far, USA print and broadcast media are deaf, blind, and dumb,
regarding recent major bans of aspartame and MSG in the UK and EU.

The EU Parliament voted July 12 to ban artificial sweeteners
in newly born and infant foods.

On May 15 four huge UK supermarket chains announced bans
of aspartame and MSG, food dyes, and many additives
to protect kids from ADHD --
Sainsbury, Tesco, Marks & Spencer, and ASDA, a unit of WalMart.

May 31: Coca-Cola and the much larger Cargill Inc.,
after years of secret development, with 24 patents,
will soon sell rebiana (stevia) in drinks and food
in the many nations where it is approved as a sweetener --
for decades a major sweetener in Japan, China, Korea, Taiwan,
Thailand, Malasia, Saint Kitts, Nevis,
Brazil, Peru, Paraguay, Uruguay, and Israel,
and an approved supplement in USA, Australia, and Canada,
according to Wikipedia.

http://groups.yahoo.com/group/aspartameNM/message/1395
Aspartame Controversy, in Wikipedia democratic
encyclopedia, 72 references (including AspartameNM # 864
and 1173 by Murray, brief fair summary of much more research:
Murray 2007.01.01

http://groups.yahoo.com/group/aspartameNM/message/1453
Souring on fake sugar (aspartame), Jennifer Couzin,
Science 2007.07.06: 4 page letter to FDA from 12 eminent
USA toxicologists re two Ramazzini Foundation
cancer studies 2007.06.25: Murray 2007.07.18

http://groups.yahoo.com/group/aspartameNMmessage/1451
Artificial sweeteners (aspartame, sucralose) and coloring
agents will be banned from use in newly-born and baby foods,
the European Parliament decided: Latvia ban in schools 2006:
Murray 2007.07.12

http://groups.yahoo.com/group/aspartameNMmessage/1437
stevia to be approved and cyclamates limited by
Food Standards Australia New Zealand:
JMC Geuns critiques of two recent stevia studies by Nunes:
Murray 2007.05.29

http://groups.yahoo.com/group/aspartameNM/message/1427
more from The Independent, UK, Martin Hickman, re ASDA
(unit of Wal-Mart Stores) and Marks & Spencer ban of
aspartame, MSG, artificial chemical additives and dyes
to prevent ADHD in kids: urray 2007.05.16
http://news.independent.co.uk/uk/hea...cle2548747.ece

http://groups.yahoo.com/group/aspartameNM/message/1426
ASDA (unit of Wal-Mart Stores WMT.N) and Marks & Spencer
will join Tesco and also Sainsbury to ban and limit
aspartame, MSG, artificial flavors dyes preservatives additives,
trans fats, salt "nasties" to protect kids from ADHD:
leading UK media: Murray 2007.05.15

http://groups.yahoo.com/group/aspartameNM/message/1438
Coca-Cola and Cargill Inc., after years of development,
with 24 patents, will soon sell rebiana (stevia)
in drinks and foods: Murray 2007.05.31

www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed search PubMed
////////////////////////////////////////////////////////////