STUDY: Invasive Carcinomas after Silicone Breast Implants

From Health Lover, Ilena Rosenthal

www.BreastImplantAwareness.org/
http://ilenarose.blogspot.com

World J Surg Oncol. 2008 Mar 14;6:33.

http://www.ncbi.nlm.nih.gov/pubmed/1...t=AbstractPlus
Invasive micropapillary carcinomas arising 42 years after
augmentation mammoplasty: a case report and literature review.
Tanaka Y, Morishima I, Kikuchi K.

Department of Breast and Thyroid Surgery Tsukuba Medical Center
Hospital, 1-3-1, Amakubo, Tsukuba-city, Ibaraki, 305-0005, Japan.
choshi_sai_yuu@k6.dion.ne.jp

BACKGROUND: There has been no definitive consensus regarding the
causal relationships between foreign bodies in the breast and
carcinogenesis. This report describes the first case of invasive
micropapillary carcinomas after augmentation mammoplasty. Multiple
tumors located in immediate contact with the siliconomas suggested a
causal link between the siliconomas and carcinomas. CASE PRESENTATION:
This report presents the case of a 64-year-old female who underwent
liquid silicone injections for augmentation mammoplasty 42 years
previously. Eight years before admission, siliconomas of the left
breast were removed due to pain and discomfort. The patient visited
the hospital for further treatment of newly diagnosed carcinoma of the
left breast. Images showed multiple tumors located in various areas of
the left breast. The pathological findings of the left breast showed
each tumor to be solitary and not continuous with the others. The
tumors were diagnosed to be invasive micropapillary carcinomas, and
they all came into immediate contact with the residual siliconomas.
The siliconomas were therefore suspected to have played a causative
role in the development of the breast cancer. CONCLUSION: This rare
case of multiple invasive micropapillary carcinomas following
augmentation mammoplasty provides evidence that siliconomas may lead
to carcinomas. Although a causal relationship was not established
unequivocally, we review evidence that suggest silicone gel may cause
cell damage responsible for carcinoma development.

PMID: 18341700 [PubMed - indexed for MEDLINE]