Is Your Deodorant a Potential Cause of Breast Cancer?

Thanks again Dave ... I just found this.

Excerpt: “Aluminium is a metalloestrogen, it is genotoxic, is bound
by DNA and has been shown to be carcinogenic. It is also a pro-oxidant
and this unusual property might provide a mechanistic basis for any
putative carcinogenicity. The confirmed presence of aluminium in
breast tissue biopsies highlights its potential as a possible factor
in the aetiology of breast cancer”.



http://ilenarose.blgospot.com
Health Lover

http://ilena-rosenthal.blogspot.com

http://www.sciencedaily.com/releases...0831210302.htm

Aluminum In Breast Tissue: A Possible Factor In The Cause Of Breast
Cancer
Science Daily — A new study has identified a regionally-specific
distribution of aluminium in breast tissue which may have implications
for the cause of breast cancer.


--------------------------------------------------------------------------------
Scientists have found that the aluminium content of breast tissue and
breast tissue fat was significantly higher in the outer regions of the
breast, in close proximity to the area where there would be the
highest density of antiperspirant.

Recent research has linked breast cancer with the use of
aluminium-based, underarm antiperspirants. The known, but unaccounted
for, higher incidence of tumours in the upper outer quadrant of the
breast seemed to support such a contention. However, the
identification of a mechanism of antiperspirant-induced breast cancer
has remained elusive.

A team, led by Dr Chris Exley of the Birchall Centre for Inorganic
Chemistry and Materials at Keele University in the UK, measured the
aluminium content of breast tissue from 17 breast cancer patients
recruited from Wythenshaw Hospital, Manchester, UK. Whether
differences in the distribution of aluminium in the breast are related
to the known higher incidence of tumours in the outer upper quadrant
of the breast remains to be ascertained.

The major constituent of antiperspirant is aluminium salts which have
long been associated with cancer, as well as other human disease. The
daily application of aluminium-based antiperspirants should result in
the presence of aluminium in the tissue of the underarm and
surrounding areas, though there is almost no data on aluminium in
breast tissue.

Breast cancer is the most common malignancy in women and is the
leading cause of death among women aged 35-54. The cause of breast
cancer is unknown and is likely to be a combination of generic and
environmental factors.

Each of the patients in the study had undergone a mastectomy and
biopsies from four different regions of the breast on a transect from
the outer (axilla and lateral) to the inner (middle and medial) breast
were collected.

Tests showed that while there were significant differences in the
concentrations of aluminium between individuals they did show “a
statistically higher concentration of aluminium in the outer as
compared with the inner region of the breast”.

The report, published in the Journal of Inorganic Biochemistry, goes
on: “We have confirmed the presence of aluminium in breast tissue and
its possible regional distribution within the breast. Higher content
of aluminium in the outer breast might be explained by this region’s
closer proximity to the underarm where the highest density of
application of antiperspirant could be assumed. There is evidence that
skin is permeable to aluminium when applied as antiperspirant.

“However, we have no direct evidence that the aluminium measured in
these breast biopsies originated from antiperspirant. An alternative
explanation might be that tumourous tissue acts as a ‘sink’ for
systemic aluminium”.

But it goes on to say that “aluminium in breast tissue might
contribute” to breast cancer.

“Aluminium is a metalloestrogen, it is genotoxic, is bound by DNA and
has been shown to be carcinogenic. It is also a pro-oxidant and this
unusual property might provide a mechanistic basis for any putative
carcinogenicity. The confirmed presence of aluminium in breast tissue
biopsies highlights its potential as a possible factor in the
aetiology of breast cancer”.

http://ilenarose.blgospot.com
Health Lover

http://ilena-rosenthal.blogspot.com


http://www.google.com/search?q=upper...e7&rlz=1I7GGLJ

Good question Mary.

I did a quick google search and found a variety of estimates from
various studies. I saw 41%, 60% and a variety of other guesses.

I believe this is one of the unfortunate scientific situations where
industry interests have corrupted some of the science linking aluminum
and breast cancer, having prematurely dismissed it because of the
raminfications for industry if the public became aware.

Regarding the specific comment ... I think there is no way to know the
exact incidences and positions of various cancers ... even more so in
the past.

Breast cancer science is still in its infancy, and we are just coming
out of the dark ages where industry junk science rules on certain
politically charged issues such as environmental and chemical poisons.

Who knows the exact types and positions years ago scientifically
speaking, of breast and lymphatic cancers before the rise of packaged
deodorants and antipersperants with aluminum?

I saw the rapid cover-up and trivialization and downright lies in a
recent discussion about aluminum adjuvant in every Gardasil jab by a
crowd vehement to conclude that it was benign.

I believe there is much to be discovered in this potential connection
.... without the chemical and aluminum industry and their PR teams
influencing the science.

Here was one study that caught my eye.


http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
Lymphatic axillary metastasis in cancer of the breast]The average size
of the tumor was 4.9 cm, 21 patients (42%) had evidence of ganglionar
axilar metastasis, 64% were located in the upper-outer quadrant, ...
http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract



>
> ... . There has been a known, but
> unexplained, increased incidence of tumors in the upper outer quadrant
> of the breast ...


Since when?

Mary

>
> Good question Mary.

I asked since when? because of the claim: " ... . There has been a known,
but
unexplained, increased incidence of tumors in the upper outer quadrant of
the breast ... "
>

>
> I did a quick google search and found a variety of estimates from
> various studies. I saw 41%, 60% and a variety of other guesses.

41% and 60% of what?
>
> I believe this is one of the unfortunate scientific situations where
> industry interests have corrupted some of the science linking aluminum
> and breast cancer, having prematurely dismissed it because of the
> raminfications for industry if the public became aware.
>
> Regarding the specific comment ... I think there is no way to know the
> exact incidences and positions of various cancers ... even more so in
> the past.

Quite. So why was it said? It trivialises the rest of the claim.

Mary

http://ilenarose.blgospot.com
Health Lover

http://ilena-rosenthal.blogspot.com

http://www.ncbi.nlm.nih.gov/sites/en...RVAbstractPlus
An earlier age of breast cancer diagnosis related to more frequent use
of antiperspirants/deodorants and underarm shaving

An earlier age of breast cancer diagnosis related to more frequent use
of antiperspirants/deodorants and underarm shaving.McGrath KG.
Department of Medicine, Saint Joseph Hospital-Resurrection Health
Care, Mail Box 285, 2900 N Lake Shore Drive, Chicago, Il 60657, USA.

Breast cancer incidence suggests a lifestyle cause. A lifestyle factor
used near the breast is the application of antiperspirants/deodorants
accompanied by axillary shaving. A previous study did not support a
link with breast cancer. If these habits have a role in breast cancer
development, women using antiperspirants/deodorants and shaving their
underarms frequently would be expected to have an earlier age of
diagnosis than those doing so less often. An earlier age of diagnosis
would also be expected in those starting to use deodorants and shaving
at an earlier age. This is the first study to investigate the
intensity of underarm exposure in a cohort of breast cancer survivors.
Four hundred and thirty-seven females diagnosed with breast cancer
were surveyed. Once grouped by their frequency of underarm hygiene
habits, the mean age of diagnosis was the primary end point. Secondary
end points included the overall frequency of these habits, and
potential usage group confounding variables were evaluated. All
statistical tests were two-sided. Frequency and earlier onset of
antiperspirant/deodorant usage with underarm shaving were associated
with an earlier age of breast cancer diagnosis. Combined habits are
likely for this earlier age of diagnosis. In conclusion, underarm
shaving with antiperspirant/deodorant use may play a role in breast
cancer. It is not clear which of these components are involved.
Reviewed literature insinuates absorption of aluminium salts
facilitated by dermal barrier disruption. Case-controlled
investigations are needed before alternative underarm hygiene habits
are suggested.

PMID: 14639125 [PubMed - indexed for MEDLINE]

http://ilenarose.blgospot.com
Health Lover

http://ilena-rosenthal.blogspot.com

J Inorg Biochem. 2005 Sep;99(9):1912-9. Links
Aluminium, antiperspirants and breast cancer.Darbre PD.
Division of Cell and Molecular Biology, School of Animal and Microbial
Sciences, The University of Reading, P.O. Box 228, Whiteknights,
Reading, RG6 6AJ, UK

Aluminium salts are used as the active antiperspirant agent in
underarm cosmetics, but the effects of widespread, long term and
increasing use remain unknown, especially in relation to the breast,
which is a local area of application. Clinical studies showing a
disproportionately high incidence of breast cancer in the upper outer
quadrant of the breast together with reports of genomic instability in
outer quadrants of the breast provide supporting evidence for a role
for locally applied cosmetic chemicals in the development of breast
cancer. Aluminium is known to have a genotoxic profile, capable of
causing both DNA alterations and epigenetic effects, and this would be
consistent with a potential role in breast cancer if such effects
occurred in breast cells. Oestrogen is a well established influence in
breast cancer and its action, dependent on intracellular receptors
which function as ligand-activated zinc finger transcription factors,
suggests one possible point of interference from aluminium. Results
reported here demonstrate that aluminium in the form of aluminium
chloride or aluminium chlorhydrate can interfere with the function of
oestrogen receptors of MCF7 human breast cancer cells both in terms of
ligand binding and in terms of oestrogen-regulated reporter gene
expression. This adds aluminium to the increasing list of metals
capable of interfering with oestrogen action and termed
metalloestrogens. Further studies are now needed to identify the
molecular basis of this action, the longer term effects of aluminium
exposure and whether aluminium can cause aberrations to other
signalling pathways in breast cells. Given the wide exposure of the
human population to antiperspirants, it will be important to establish
dermal absorption in the local area of the breast and whether long
term low level absorption could play a role in the increasing
incidence of breast cancer.

PMID: 16045991 [PubMed - indexed for MEDLINE]

http://ilenarose.blgospot.com
Health Lover

http://ilena-rosenthal.blogspot.comJ Appl Toxicol. 2003
Sep-Oct;23(5):285-8

http://www.ncbi.nlm.nih.gov/sites/en...RVAbstractPlus
J Appl Toxicol. 2003 Mar-Apr;23(2):89-95.
Parabens, oestrogenicity, underarm cosmetics and breast cancer: a
perspective on a hypothesis.Harvey PW.
A recent review by Darbre (2003) published in this journal (J. Appi.
Toxicol. 23: 89-95) has attracted public and scientific interest that
requires perspective, particularly on the use of esters of
p-hydroxybenzoic acid (parabens) as preservatives in underarm
cosmetics. Although parabens are generally regarded as safe, recent
reports suggest that they are oestrogenic in a variety of in vitro
(including MCF7 and ZR-75-1 human breast cancer cell lines) and in
vivo tests for oestrogenicity (uterotrophic assays in both rat and
mouse).

There are also recent reports of adverse reproductive and
developmental outcomes in rodent toxicity studies.

Of interest is the lack of activity by the oral route but clear
activity by the subcutaneous and topical routes, which is of some
relevance to the use of underarm cosmetics. There would seem to be a
case now to supplement these emerging toxicity data with longer term
regulatory standard tests examining other oestrogenic endpoints and at
least to consider these findings in more up-to-date risk assessments
specific for cosmetic use.

Further, there are few data on the use of underarm cosmetics and the
risk of breast cancer, and although one recent retrospective
interview-based study found no association there is a need for more
thorough investigation taking into account the type of chemicals used.

Darbre has forwarded a hypothesis and called for further work to
establish whether or not the use of underarm cosmetics (particularly
containing oestrogenic formulants) contributes to the rising incidence
of breast cancer.

It would seem prudent to conduct this work because the current
database is sparse and the effects of long-term low-level exposures to
weakly oestrogenic chemicals on human health, particularly their
application to the underarm and the risks of breast cancer, are
unknown. The role of oestrogens in breast cancer, however, is
undisputed.

http://ilenarose.blgospot.com
Health Lover

http://ilena-rosenthal.blogspot.com

Wrong Myrl ... you are an exposed liar for quack Barrett.
www.BreastImplantAwareness.org

J Inorg Biochem. 2005 Sep;99(9):1912-9. Links
Aluminium, antiperspirants and breast cancer.Darbre PD.
Division of Cell and Molecular Biology, School of Animal and Microbial
Sciences, The University of Reading, P.O. Box 228, Whiteknights,
Reading, RG6 6AJ, UK

Aluminium salts are used as the active antiperspirant agent in
underarm cosmetics, but the effects of widespread, long term and
increasing use remain unknown, especially in relation to the breast,
which is a local area of application. Clinical studies showing a
disproportionately high incidence of breast cancer in the upper outer
quadrant of the breast together with reports of genomic instability in
outer quadrants of the breast provide supporting evidence for a role
for locally applied cosmetic chemicals in the development of breast
cancer. Aluminium is known to have a genotoxic profile, capable of
causing both DNA alterations and epigenetic effects, and this would be
consistent with a potential role in breast cancer if such effects
occurred in breast cells. Oestrogen is a well established influence in
breast cancer and its action, dependent on intracellular receptors
which function as ligand-activated zinc finger transcription factors,
suggests one possible point of interference from aluminium. Results
reported here demonstrate that aluminium in the form of aluminium
chloride or aluminium chlorhydrate can interfere with the function of
oestrogen receptors of MCF7 human breast cancer cells both in terms of
ligand binding and in terms of oestrogen-regulated reporter gene
expression. This adds aluminium to the increasing list of metals
capable of interfering with oestrogen action and termed
metalloestrogens. Further studies are now needed to identify the
molecular basis of this action, the longer term effects of aluminium
exposure and whether aluminium can cause aberrations to other
signalling pathways in breast cells. Given the wide exposure of the
human population to antiperspirants, it will be important to establish
dermal absorption in the local area of the breast and whether long
term low level absorption could play a role in the increasing
incidence of breast cancer.

PMID: 16045991 [PubMed - indexed for MEDLINE]

This question opens up a can of worms for me. It just occured to me
after reading it that "for some reason" I have stopped using any and all
deodorants since my bc diagnosis several years ago. All I can remember
is that I was told it is only safe to you the baby powder with the
cornstarch and make sure it is not one with any fragrance in it. So for
years I have doused myself daily with this stuff and frankly like it
better than any of the messy deodorants.

Frankly, I don't remember "why" I was told to discontinue deodorants but
my theory in this area is to be safe than sorry. Besides it is always
a "White Christmas" in my home after I use so much of that baby powder!
<g

Bea

'NO FORWARDS OR SPAM, PLEASE"

On Sep 10, 9:59 am, pm9...@webtv.net (Bea Oo) wrote:
> This question opens up a can of worms for me. It just occured to me
> after reading it that "for some reason" I have stopped using any and all
> deodorants since my bc diagnosis several years ago. All I can remember
> is that I was told it is only safe to you the baby powder with the
> cornstarch and make sure it is not one with any fragrance in it. So for
> years I have doused myself daily with this stuff and frankly like it
> better than any of the messy deodorants.
>
> Frankly, I don't remember "why" I was told to discontinue deodorants but
> my theory in this area is to be safe than sorry. Besides it is always
> a "White Christmas" in my home after I use so much of that baby powder!
> <g
>
> Bea
>
> 'NO FORWARDS OR SPAM, PLEASE"

Thwe studies posted show no evidence, read it carefully "may",
"could"," more investigation needed", "animal studies"

I can find many articles stating there may or could be life in outer
space and more investigation is needed, but that does not mean there
is life in outer space.

Illena needs to take a course in research to understand what she is
saying.....go for a MPH so you know what you are talking about.