"Steve Jordan" <mycroftscj1@cox.net> wrote in message
news:Cebdj.31537$1C4.23494@newsfe10.phx...
> On December 28, Alan wrote:
>
>> I found this on another newsgroup.
>>
>> Apparently, hormone therapy can seriously magnify the effects of
>> aspirin, causing liver problems.
>
> The "hormone therapy" D'Amico referred to in his letter was flutamide
> (Eulexin). How widely used is that med?
Good point.
What we need to know is whether it's a drug interaction that
causes the problem, in which case people on flutamide can
switch to something else, or whether it's the drug effect that
affects the aspirin response. If it's the effect of the drug, then
other drugs with similar effects, perhaps like
Casodex, might
also be involved. Or it could be worse than that.
> It's details like this that often change the meaning of a
> popular-press
> article.
>
> And why not stop the aspirin rather than the med? And if the aspirin
> is
> clinically required, is there some other med that can be substituted?
Yes. I should have been sharp enough to raise these points
myself.
I had elevated liver enzymes while on
Lupron and my doctors
decided not to continue the Lupron. I'm wondering now if I was
taking aspirin during that period (I use it often, though not every
day), and if that was the real cause of the liver problem. At the
time, no one thought about aspirin.
The standard advice is "talk to your doctor", but they probably
don't know a lot either. I would think that everyone getting hormone
therapy should have liver enzyme levels checked along with other
standard blood tests from time to time and, if they are elevated,
think about everything that could be involved. Aspirin and
tylenol
can both cause liver problems. Maybe
ibuprofen can. There might
be something other than the ADT that can be stopped and the levels
checked again before abandoning ADT.
>
> D'Amico raises more questions than he answers.
>
> Welcome to the world of PCa.
>
> Regards,
>
> Steve J 
Aspirin and hormone therapy 
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