Going Intermittent

I have decided to go on to intermittent HDT after 14 months on Eligard (6
months) then Luperon (8 months). My latest PSA (today) is another
undetectable (< 0.05).

I KNOW that the jury is out on the continuous versus intermittent question
so this is, if not an educated guess, then at least an informed gamble. I
shall have quarterly PSA tests and am prepared to go back on therapy if it
rises alarmingly.

Good health to you all.

JP

On May 7, 11:38�am, "Joe Price" <joepr...@shaw.ca> wrote:
> I have decided to go on to intermittent HDT after 14 months on Eligard (6
> months) then Luperon (8 months). �My latest PSA (today) is another
> undetectable (< 0.05).
>
> I KNOW that the jury is out on the continuous versus intermittent question
> so this is, if not an educated guess, then at least an informed gamble. �I
> shall have quarterly PSA tests and am prepared to go back on therapy if it
> rises alarmingly.
>
> Good health to you all.
>
> JP

Good for you. I'm only on one month of Lupron and wanting to go on
intermittent already! But, I won't consider such a short time until
my psa gets down lower.....one month of lupron lowered it from 1.37
to .89. So we'll see what a couple more months will do.
I should add I haven't experienced any side effects yet and am
exercising like a maniac to ward off muscle loss.

On May 7, Joe Price wrote:

> I have decided to go on to intermittent HDT after 14 months on Eligard (6
> months) then Luperon [sic: Lupron] (8 months). My latest PSA (today) is another
> undetectable (< 0.05).
>
> I KNOW that the jury is out on the continuous versus intermittent question
> so this is, if not an educated guess, then at least an informed gamble. I
> shall have quarterly PSA tests and am prepared to go back on therapy if it
> rises alarmingly.

I recommend a test for serum testosterone (T). This will produce
evidence whether the ADT is succeeding. On ADT, the T should be at
castrate level, < 20 ng/dL. See,
http://www.prostate-cancer.org/educa...ToBiology.html

Strum and other knowledgeable med oncs recommend at least one full year
of UD (=/< 0.05 ng/mL) PSAs while on ADT before moving to an off-phase.

When to restart is a vexed question. Some say 2.0 ng/mL above nadir.
Others have other criteria.

See an article on the topic at
http://www.prostate-cancer.org/educa...trum_IADT.html

Also see this September 2007 abstract: Scholz M, et al., "Prostate
cancer-specific survival and clinical progression-free survival in men
with prostate cancer treated intermittently with testosterone
inactivating pharmaceuticals." Urology. 2007 Sep;70(3):506-10.

Abstract: www.pubmed.gov Search on Pub Med ID 17905106

Pub Med is a service of the US National Library of Medicine.

Regards,

Steve J

"Joe Price" <joeprice@shaw.ca> wrote in message
news:N1kUj.119645$rd2.103091@pd7urf3no...

>I have decided to go on to intermittent HDT after 14 months on Eligard (6
>months) then Luperon (8 months). My latest PSA (today) is another
>undetectable (< 0.05).

That's great news, Joe. On both counts. I wish I had the hangy down things
to try IADT.

On Wed, 07 May 2008 15:38:21 GMT, "Joe Price" <joeprice@shaw.ca>
wrote:

>I have decided to go on to intermittent HDT after 14 months on Eligard (6
>months) then Luperon (8 months). My latest PSA (today) is another
>undetectable (< 0.05).
>
>I KNOW that the jury is out on the continuous versus intermittent question
>so this is, if not an educated guess, then at least an informed gamble. I
>shall have quarterly PSA tests and am prepared to go back on therapy if it
>rises alarmingly.
>
>Good health to you all.
>
>JP
>
>
I have decided to take the same path,
original PSA 176.0 11/05, Gleason 4+3, first Zoladex 17/01/06
and last Zoladex 17/01/08
History
nov05 psa 176 casodex
jan1706 zoladex
jan2306 psa 4.0
apr1706 psa 0.8
jul1706 psa 0.4
oct1706 psa 0.3
jan1707 psa 0.2
apr1707 psa 0.2
jul1707 psa 0.1
oct1707 psa 0.1
jan1708 psa 0.1
jan2508 MRI
jan2908 bone scan
Apr3008 psa 0.1

Good Luck Colin

<Chris.McBorner@barnetuk.com> wrote in message
news:j5ua24tisd5cr0b532lhcoaga791j0calc@4ax.com...
> On Wed, 07 May 2008 15:38:21 GMT, "Joe Price" <joeprice@shaw.ca>
> wrote:
>
>>I have decided to go on to intermittent HDT after 14 months on Eligard (6
>>months) then Luperon (8 months). My latest PSA (today) is another
>>undetectable (< 0.05).

Always good to see someone go from 176 to zero and stay there.


--
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA <.1 <.1 <.1 .27 .37 .75 PSAD 0.19 years
EBRT 05-07/2002 @ 47
PSA .34 .22 .15 .21 .32 PSAD .056 years
Lupron 07/03 (1 mo) 8/03 and every 4 months there after
PSA .07 .05 .06 .09 .08 .132 .145 PSAD 1.4 years
Casodex added daily 07/06
PSA <0.04, <0.05, <0.04, <0.04, <0.1 2/12/08
Non Illegitimi Carborundum