Interesting article on salmon

Salmon Slashes Prostate Risk in Swedish Study

All men benefit, and the majority enjoy a remarkable 72 percent cut in
risk thanks to genetics
by Craig Weatherby

The Swedes queried 1,500 men diagnosed with prostate cancer about their
diets, and compared the answers with a healthy control group.
The results indicate that men who eat salmon more than once a week are
43 percent less likely to develop prostate cancer, in comparison with
men who never eat salmon.
However, not all the salmon-eating men benefited from the fish equally.
Blood tests showed that 60 percent of the salmon-eating men benefited
dramatically from eating fatty fish regularly, probably because they
had a particular variant of the gene that controls activation of the
pro-inflammatory COX-2 enzyme.
Prostate cancer growth is spurred by inflammation, and the risk among
the salmon eaters with this variation of the COX-2 gene was a whopping
72 percent lower than for the men who never ate fatty fish.
It's likely that the omega-3s ingested by the men with this genetic
variation caused the COX-2 enzyme to create more anti-inflammatory
prostaglandins than in the other men.

Prostaglandins are ephemeral, hormone-like substances, some of which
are anti-inflammatory, others of which are pro-inflammatory. Dietary
omega-3s from fish induce creation of anti-inflammatory prostaglandins
via their influence on the genes that control the COX-2 enzyme.

Interestingly, the yellow pigment in turmeric (curcumin) also exerts
anti-inflammatory, COX-2-mediated effects, which is why it slows
prostate cancer growth in cell studies.
Lead author Maria Hedelin, Ph.D. opined that it makes sense to eat
fatty fish, even though 40 percent of men lack the "protective" variant
of the gene.
As she said, "This study shows that there is an interaction between
dietary factors and our genes, but it's always hard to say what role
the genes play. Omega-3 fatty acids can still be good for men who don't
carry this gene variant in completely different ways."

Sources
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consumption of fatty fish with prostate cancer risk is modified by
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