prostate cancer vaccine

After Prostate removal at 45 and radiation at 46 my PSA is on the rise again
at 50. 0.05-0.5-1.5-1.89 all 3 months apart.Now Robert Wood Johnson Cancer
center in New Jersey wants to put me in a cancer vaccine trial that is in
the 3rd phase.I not sure what it is called yet. Has any body here tried one
with success? The release form is enough to scare you to death.

"cured?" <onmysideagain@hotmail.com> wrote in message
news:u9udnZ9qEbnmgQnbnZ2dnUVZ_hWdnZ2d@comcast.com. ..
> After Prostate removal at 45 and radiation at 46 my PSA is on the rise
> again at 50. 0.05-0.5-1.5-1.89 all 3 months apart.Now Robert Wood Johnson
> Cancer center in New Jersey wants to put me in a cancer vaccine trial that
> is in the 3rd phase.I not sure what it is called yet. Has any body here
> tried one with success? The release form is enough to scare you to death.
Is it Provenge?

They had been at 3rd Phase then put it to the FDA for approval. The FDA
sent them back for more testing. I'd be surprised if they're up and running
already, but they could be.




--
PSA 16 10/17/2000 @ 46
Biopsy 11/01/2000 G7 (3+4), T2c
RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
PSA <.1 <.1 <.1 .27 .37 .75 PSAD 0.19 years
EBRT 05-07/2002 @ 47
PSA .34 .22 .15 .21 .32 PSAD .056 years
Lupron 07/03 (1 mo) 8/03 and every 4 months there after
PSA .07 .05 .06 .09 .08 .132 .145 PSAD 1.4 years
Casodex added daily 07/06
PSA <0.04, <0.05, <0.04 (06/12/2007)
Non Illegitimi Carborundum

You might find this link useful if you don't like the odds. You may just
flip once you see this interview on google video about the polotics of
cancer. It seems they have a cure but they cannot patent a naturally
occuring product so is not worth money to them. Anyway, here's the link.
Paul.
http://video.google.com/videoplay?do...07988644640556



"cured?" <onmysideagain@hotmail.com> wrote in message
news:u9udnZ9qEbnmgQnbnZ2dnUVZ_hWdnZ2d@comcast.com. ..
> After Prostate removal at 45 and radiation at 46 my PSA is on the rise
again
> at 50. 0.05-0.5-1.5-1.89 all 3 months apart.Now Robert Wood Johnson Cancer
> center in New Jersey wants to put me in a cancer vaccine trial that is in
> the 3rd phase.I not sure what it is called yet. Has any body here tried
one
> with success? The release form is enough to scare you to death.
>
>

Oops, I forgot the book on YK2 and how it was the end of the earth. Pardon
me.....

Gourd Dancer
"Paul" <pmathotyourpants@westnet.com.au> wrote in message
news:13988ja4uklf5a5@corp.supernews.com...
> You might find this link useful if you don't like the odds. You may just
> flip once you see this interview on google video about the polotics of
> cancer. It seems they have a cure but they cannot patent a naturally
> occuring product so is not worth money to them. Anyway, here's the link.
> Paul.
> http://video.google.com/videoplay?do...07988644640556
>
>
>
> "cured?" <onmysideagain@hotmail.com> wrote in message
> news:u9udnZ9qEbnmgQnbnZ2dnUVZ_hWdnZ2d@comcast.com. ..
>> After Prostate removal at 45 and radiation at 46 my PSA is on the rise
> again
>> at 50. 0.05-0.5-1.5-1.89 all 3 months apart.Now Robert Wood Johnson
>> Cancer
>> center in New Jersey wants to put me in a cancer vaccine trial that is in
>> the 3rd phase.I not sure what it is called yet. Has any body here tried
> one
>> with success? The release form is enough to scare you to death.
>>
>>
>
>

Oh great!. This writer has written about the Federal Reserve, John Birch
Society, United Nations, and Cancer. His slant is a "great multi-government
conspiratory"and how is affects the common man. Pure snake oil.

Gourd Dancer
"Paul" <pmathotyourpants@westnet.com.au> wrote in message
news:13988ja4uklf5a5@corp.supernews.com...
> You might find this link useful if you don't like the odds. You may just
> flip once you see this interview on google video about the polotics of
> cancer. It seems they have a cure but they cannot patent a naturally
> occuring product so is not worth money to them. Anyway, here's the link.
> Paul.
> http://video.google.com/videoplay?do...07988644640556
>
>
>
> "cured?" <onmysideagain@hotmail.com> wrote in message
> news:u9udnZ9qEbnmgQnbnZ2dnUVZ_hWdnZ2d@comcast.com. ..
>> After Prostate removal at 45 and radiation at 46 my PSA is on the rise
> again
>> at 50. 0.05-0.5-1.5-1.89 all 3 months apart.Now Robert Wood Johnson
>> Cancer
>> center in New Jersey wants to put me in a cancer vaccine trial that is in
>> the 3rd phase.I not sure what it is called yet. Has any body here tried
> one
>> with success? The release form is enough to scare you to death.
>>
>>
>
>

On Tue, 10 Jul 2007 20:00:06 -0400, cured? wrote:

> After Prostate removal at 45 and radiation at 46 my PSA is on the rise again
> at 50. 0.05-0.5-1.5-1.89 all 3 months apart.Now Robert Wood Johnson Cancer
> center in New Jersey wants to put me in a cancer vaccine trial that is in
> the 3rd phase.I not sure what it is called yet. Has any body here tried one
> with success? The release form is enough to scare you to death.

If it's Provenge, even those who question its efficacy admit that
it's safe. Only transient flu-like symptoms have been reported.

Provenge was up for approval and was told more data is needed.
There is an ongoing Phase 3 test.

A search (prostate cancer [ALL-FIELDS] AND "robert wood"
[ALL-FIELDS] AND vaccine [ALL-FIELDS]) only came up with a PII
trial at robert wood johnson, and I don't see Provenge there:

http://clinicaltrials.gov/ct/show/NCT00108732?order=1

p.

"Paul B" <pb_publicR.e.m.o.v.e@operamail.com> wrote in message
news:1hvfswuu7sc06.dlg@pbpublic.invalid...
> On Tue, 10 Jul 2007 20:00:06 -0400, cured? wrote:
>
>> After Prostate removal at 45 and radiation at 46 my PSA is on the rise again
>> at 50. 0.05-0.5-1.5-1.89 all 3 months apart.Now Robert Wood Johnson Cancer
>> center in New Jersey wants to put me in a cancer vaccine trial that is in
>> the 3rd phase.I not sure what it is called yet. Has any body here tried one
>> with success? The release form is enough to scare you to death.
>
> If it's Provenge, even those who question its efficacy admit that
> it's safe. Only transient flu-like symptoms have been reported.
>
> Provenge was up for approval and was told more data is needed.
> There is an ongoing Phase 3 test.
>
> A search (prostate cancer [ALL-FIELDS] AND "robert wood"
> [ALL-FIELDS] AND vaccine [ALL-FIELDS]) only came up with a PII
> trial at robert wood johnson, and I don't see Provenge there:
>
> http://clinicaltrials.gov/ct/show/NCT00108732?order=1
>
> p.

cured?,

I'm sorry that you're going through this.

I looked at the clinicaltrials.gov document that Paul B found. My
reading of the document is that the trials folks will put you on
the new combination vaccine therapy and monitor your progress
closely. If the disease gets worse, they'll put you on hormone
therapy too.

In other words, you won't be giving up the standard treatment to
get the new one. You'll get the new treatment and, if it's not
working, they'll use the standard treatment too.

Confirm that with the doctors. I may have read it wrong. Ask them
if you will get hormone therapy if the vaccines don't stop PSA rise.
Ask them when HT will be applied. Ask them if there is a placebo
group and a chance you won't actually get a vaccine (which is no
worse than not entering the trial if they still put you on HT.) Also
ask them if there were any side effects in the Phase I trial, and
how bad they were.

My inclination would be to do this - for several reasons. A big
one is that you'll be getting a shot at a very advanced treatment
that, if it does work, is more likely to work now than after your
cancer is far along.

A second reason is that, in a clinical trial, you get treated by
genuine experts, not low bidder health insurance doctors who
may or may not really know what they're doing.

A third reason is that you'll be contributing to the future of PCa
treatment for all of us, and for your sons and grandsons. We
need clinical trial volunteers to advance medical science.

Best of luck to you.

Alan

On Jul 10, 5:00 pm, "cured?" <onmysideag...@hotmail.com> wrote:
> After Prostate removal at 45 and radiation at 46 my PSA is on the rise again
> at 50. 0.05-0.5-1.5-1.89 all 3 months apart.Now Robert Wood Johnson Cancer
> center in New Jersey wants to put me in a cancer vaccine trial that is in
> the 3rd phase.I not sure what it is called yet. Has any body here tried one
> with success? The release form is enough to scare you to death.

I searched for vaccine clinical trials, for a Phase III trial in New
Jersey at RWJ Cancer Center. Both the GVAX and Provenge are for a more
advanced cancer than yours. There is a Phase II now recruiting by the
name:

Phase II Study of Vaccine Therapy Comprising Vaccinia-PSA-TRICOM
Vaccine and Fowlpox-PSA-TRICOM Vaccine Combined With Sargramostim (GM-
CSF) in Patients With Prostate-Specific Antigen Progression After
Local Therapy for Early Prostate Cancer

This seems to be the trial that Alan commented on. Like he said, you
need to be aware and agree that if the vaccine is not capable of
reversing cancer progression you will be treated with a 30 day course
of Casodex and then Zoladex This is androgen deprivation. This will be
done while still treating you with the vaccine. The outline:

Outline

This is a multicenter study.

Patients receive vaccinia-PSA-TRICOM vaccine subcutaneously (SC) on
day 1 and sargramostim (GM-CSF) SC on days 1-4 during weeks 1-4.
Beginning in week 5, patients receive fowlpox-PSA-TRICOM vaccine SC on
day 1 and GM-CSF SC on days 1-4. Treatment with fowlpox-PSA-TRICOM
vaccine and GM-CSF repeats every 4 weeks for 3 courses (weeks 5-16).
Beginning in week 17, patients receive fowlpox-PSA-TRICOM vaccine and
GM-CSF as above every 12 weeks in the absence of clinical or
biochemical disease progression or unacceptable toxicity.

Patients with biochemical or clinical disease progression receive
androgen ablation therapy comprising oral bicalutamide once daily for
1 month and goserelin SC once every 4 weeks in addition to fowlpox-PSA-
TRICOM vaccine and GM-CSF. Treatment continues in the absence of
further clinical or biochemical disease progression.

After completion of study treatment, patients are followed every 3
months for 2 years, every 6 months for 3 years, and then annually for
10 years.

The protocol ids are:
ECOG-E9802
NCT00108732

Alan gave you good advice. Talk to your doctor. Verify with him what
we interpret the protocol to be.

Wish you the best outcome,

RalphV
www.pcainaz.org/phpbb