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Steroids and psa test (XP)
  1. #1
    Zipadeedoodaa Guest

    Default Steroids and psa test (XP)

    I am currently on 20mg.Prednisolone for my asthma (short term) and during
    last week I had a follow up psa test (six monthly) which showed a higher
    figure than expected.

    I had a radical prostatectomy 11 years ago and in recent years I've shown a
    low level of psa. i.e 0.6.

    Last week it showed over 1.0 and I cannot see my urologist for two weeks.

    Is there any evidence of prednisolone affecting blood test results?

    Many thanks,

    zipadeedodaa




  2. #2
    I.P. Freely Guest

    Default Re: Steroids and psa test (XP)

    Zipadeedoodaa wrote:
    > I am currently on 20mg.Prednisolone for my asthma (short term) and during
    > last week I had a follow up psa test (six monthly) which showed a higher
    > figure than expected.
    >
    > I had a radical prostatectomy 11 years ago and in recent years I've shown a
    > low level of psa. i.e 0.6.
    >
    > Last week it showed over 1.0 and I cannot see my urologist for two weeks.
    >
    > Is there any evidence of prednisolone affecting blood test results?


    Google sez prednisone (converted by healthy livers into pednisolone)
    lowers PSA by about 33%.

    I.P.

  3. #3
    Steve Kramer Guest

    Default Re: Steroids and psa test (XP)


    "Zipadeedoodaa" <[email protected]> wrote in message
    news:45fc0174$0$8734$[email protected]..
    >I am currently on 20mg.Prednisolone for my asthma (short term) and during
    > last week I had a follow up psa test (six monthly) which showed a higher
    > figure than expected.
    >
    > I had a radical prostatectomy 11 years ago and in recent years I've shown
    > a
    > low level of psa. i.e 0.6.
    >
    > Last week it showed over 1.0 and I cannot see my urologist for two weeks.
    >
    > Is there any evidence of prednisolone affecting blood test results?


    I have not neard of prednisolone affecting PSAs one way or t'other. You
    might want to Google if and see if PSAs are mentioned.

    However, your urologist will not be able to tell you anything, likely, in
    two weeks either. To diagnose biological failure, you will need three rises
    in PSA. So, maybe you'll know in six months, but not now.

    I would not worry about it at all at this point. A lab can make a mistake
    of 4/10ths of a nanogram (one millionth of a gram).



    --
    PSA 16 10/17/2000 @ 46
    Biopsy 11/01/2000 G7 (3+4), T2c
    RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
    PSA <.1 <.1 <.1 .27 .37 .75
    EBRT 05-07/2002 @ 47
    PSA .34 .22 .15 .21 .32
    Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
    2/06, 6/06
    PSA .07 .05 .06 .09 .08 .132 .145
    Casodex added daily 07/06
    PSA <0.04, <0.05
    Non Illegitimi Carborundum



  4. #4
    ron Guest

    Default Re: Steroids and psa test (XP)

    On Mar 17, 3:45 pm, "Steve Kramer" <skra...@cinci.rr.com>
    wrote...snip...
    > However, your urologist will not be able to tell you anything, likely, in
    > two weeks either. To diagnose biological failure, you will need three rises
    > in PSA. So, maybe you'll know in six months, but not now.


    Hi Steve...My recollection is that "3 rises" is a part of the ASTRO
    definition of biochemical failure (DOF) and typically applied to seeds
    or RT monotherapies. Surgeons (and rad oncs using seeds + XBRT) often
    use other definitions of biochemical failure. Some, like Walsh, use
    PSA>0.2, some use PSA>0.4, still others use PSA>0.2 and one confirming
    PSA. In any case, many docs don't need 3 rises to call a post-
    surgical (or seeds + RT) failure...Best wishes and good health, ron


  5. #5
    Steve Kramer Guest

    Default Re: Steroids and psa test (XP)


    "ron" <[email protected]> wrote in message
    news:[email protected] oups.com...
    > On Mar 17, 3:45 pm, "Steve Kramer" <skra...@cinci.rr.com>
    > wrote...snip...
    >> However, your urologist will not be able to tell you anything, likely, in
    >> two weeks either. To diagnose biological failure, you will need three
    >> rises
    >> in PSA. So, maybe you'll know in six months, but not now.

    >
    > Hi Steve...My recollection is that "3 rises" is a part of the ASTRO
    > definition of biochemical failure (DOF) and typically applied to seeds
    > or RT monotherapies. Surgeons (and rad oncs using seeds + XBRT) often
    > use other definitions of biochemical failure. Some, like Walsh, use
    > PSA>0.2, some use PSA>0.4, still others use PSA>0.2 and one confirming
    > PSA. In any case, many docs don't need 3 rises to call a post-
    > surgical (or seeds + RT) failure...Best wishes and good health, ron


    That is an interesting distinction that I do not recall seeing or reading.
    I do not understand what difference it would make as to which method was
    initially used to eliminate the primary source. However, flying in the face
    of such logic is the fact that surgery patients expect undetectable readings
    and radiation patients expect a very low nadir. So, you may be right.

    Regardless, your postulate is correct, then he is already past the largest
    of the standards. But, he advised that he was at that level for some time.

    I myself acted at 0.3 or over even though once it was only the 2nd rise.

    I guess my salient point to this rambling is that I concur with the latter
    part of your post.




    --
    PSA 16 10/17/2000 @ 46
    Biopsy 11/01/2000 G7 (3+4), T2c
    RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins
    PSA <.1 <.1 <.1 .27 .37 .75
    EBRT 05-07/2002 @ 47
    PSA .34 .22 .15 .21 .32
    Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05, 5/05, 10/05,
    2/06, 6/06
    PSA .07 .05 .06 .09 .08 .132 .145
    Casodex added daily 07/06
    PSA <0.04, <0.05
    Non Illegitimi Carborundum



  6. #6
    MAS Guest

    Default Re: Steroids and psa test (XP)

    Steroids have PCa killing properties therefore lowering PSA. During chemo, I
    was on 30 mg a day for six months.

    Gourd Dancer

    "Zipadeedoodaa" <[email protected]> wrote in message
    news:45fc0174$0$8734$[email protected]..
    >I am currently on 20mg.Prednisolone for my asthma (short term) and during
    > last week I had a follow up psa test (six monthly) which showed a higher
    > figure than expected.
    >
    > I had a radical prostatectomy 11 years ago and in recent years I've shown
    > a
    > low level of psa. i.e 0.6.
    >
    > Last week it showed over 1.0 and I cannot see my urologist for two weeks.
    >
    > Is there any evidence of prednisolone affecting blood test results?
    >
    > Many thanks,
    >
    > zipadeedodaa
    >
    >
    >




  7. #7
    Eduardo Bronstein Guest

    Default Re: Steroids and psa test (XP)


    "Zipadeedoodaa" <[email protected]> escribió en el mensaje
    news:45fc0174$0$8734$[email protected]..
    |I am currently on 20mg.Prednisolone for my asthma (short term) and during
    | last week I had a follow up psa test (six monthly) which showed a higher
    | figure than expected.
    |
    | I had a radical prostatectomy 11 years ago and in recent years I've shown
    a
    | low level of psa. i.e 0.6.
    |
    | Last week it showed over 1.0 and I cannot see my urologist for two weeks.
    |
    | Is there any evidence of prednisolone affecting blood test results?
    |

    Prednisone monotherapy is well tolerated and is associated with a clinically
    relevant response rate in patients with asymptomatic HRPC. Prolonged time to
    progression and thus avoidance of more toxic chemotherapy is possible in
    some patients.

    Looks at this site. I hope it is useful.

    http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

    Regards.



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