Anti-inflammatory Antitumor Activity

Miraculous .. stuff.

This would be my .. freeee .. bisphosphonate .. aaaa gain.

Remember .. ? .. the one that is **better** than those .. expensive
**unaffordable** .. other bisphosphonates .. like etidronate .. ?

http://tinyurl.com/2wuhuk

The influence of phytic acid on TNF-alpha and its receptors genes'
expression in colon cancer Caco-2 cells.
Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E,
Kierot J, Weglarz L
Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9.

Inositol hexaphosphate (IP6, phytic acid) is a naturally occurring
carbohydrate abundantly present in high-fiber diets and it is also
contained in almost all mammalian cells.
It plays an important role in signal transduction, cell proliferation
and differentiation. Some natural substances have been shown to elicit
an impact on the expression of TNF-alpha and its receptors in cancer
cells.
TNF-alpha represents cytokine very often deregulated at the level of
both gene expression and signal transmission through TNF-alpha
receptors (TNFRI and TNFRII).
The aim of the present study was to analyze the IP6 influence on the
transcription of genes coding for TNF-alpha and its receptors in human
colon cancer cells line Caco-2.
Real-time QRT-PCR based on TaqMan methodology was applied to analyze
quantitatively the transcript levels of these genes.
Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2
cells stimulation for 1, 6, 12 and 24 h.
The results showed that IP6 modulated the expression of the listed
genes at transcription level in a dose and time dependent manner.
The enhanced TNFRI and decreased TNF-alpha and TNFRII transcription in
Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive
evidence for anti-inflammatory and antitumor activity of IP6.

Acta poloniae pharmaceutica [Acta Pol Pharm]
--------------------------------------------------------------------------------
The last study found there was not enough evidence to say one
bisphosphonate was better than another.
This study found .. phyate IS .. **better**.


"No evidence currently available to definitely confirm that
one bisphosphonate is better than another"


"Phytate found to be the most effective"


Phytate inhibits bovine pericardium calcification in vitro
Cardiovascular Pathology, Volume 17, Issue 3, May-June 2008, Pages
139-145
F¨¦lix Grases, Pilar Sanchis, Antonia Costa-Bauz¨¢, Oriol Bonnin,
Bernat
Isern, Joan Perell¨®, Rafael M. Prieto


Objective
The present study examined the inhibitory effects of pyrophosphate,
etidronate, and phytate on bovine pericardium calcification in vitro.
Methods
Bovine pericardium was glutaraldehyde fixed and then placed in a flow
chamber in the presence of a synthetic physiological fluid alone
(control) or the fluid plus various concentrations of pyrophosphate,
etidronate, or phytate. Following a 96-h incubation, fragments were
removed and assayed for calcification by measuring calcium and
phosphorus levels.


Results
The data indicated that both pyrophosphate and etidronate at 1 mg/l
(5.75 and 4.95 ¦ÌM, respectively) inhibited bovine pericardium
calcification, whereas neither agent had an effect at 0.5 mg/l (2.87
and 2.47 ¦ÌM, respectively). Phytate was the most potent inhibitor of
calcification, and the effects of this agent were apparent at levels
as low as 0.25 mg/l (0.39 ¦ÌM).


Conclusions
While pyrophosphate, etidronate, and phytate were all able to inhibit
bovine pericardium calcification in vitro, phytate was found to be
the
most effective.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Jul 13, 5:32 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
> Miraculous .. stuff.
>
> This would be my .. freeee .. bisphosphonate .. aaaa gain.
>
> Remember .. ? .. the one that is **better** than those .. expensive
> **unaffordable** .. other bisphosphonates .. like etidronate .. ?
>
> http://tinyurl.com/2wuhuk
>
> The influence of phytic acid on TNF-alpha and its receptors genes'
> expression in colon cancer Caco-2 cells.
> Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E,
> Kierot J, Weglarz L
> Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9.
>
> Inositol hexaphosphate (IP6, phytic acid) is a naturally occurring
> carbohydrate abundantly present in high-fiber diets and it is also
> contained in almost all mammalian cells.
> It plays an important role in signal transduction, cell proliferation
> and differentiation. Some natural substances have been shown to elicit
> an impact on the expression of TNF-alpha and its receptors in cancer
> cells.
> TNF-alpha represents cytokine very often deregulated at the level of
> both gene expression and signal transmission through TNF-alpha
> receptors (TNFRI and TNFRII).
> The aim of the present study was to analyze the IP6 influence on the
> transcription of genes coding for TNF-alpha and its receptors in human
> colon cancer cells line Caco-2.
> Real-time QRT-PCR based on TaqMan methodology was applied to analyze
> quantitatively the transcript levels of these genes.
> Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2
> cells stimulation for 1, 6, 12 and 24 h.
> The results showed that IP6 modulated the expression of the listed
> genes at transcription level in a dose and time dependent manner.
> The enhanced TNFRI and decreased TNF-alpha and TNFRII transcription in
> Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive
> evidence for anti-inflammatory and antitumor activity of IP6.
>
> Acta poloniae pharmaceutica [Acta Pol Pharm]
> ---------------------------------------------------------------------------------
> The last study found there was not enough evidence to say one
> bisphosphonate was better than another.
> This study found .. phyate IS .. **better**.
>
> "No evidence currently available to definitely confirm that
> one bisphosphonate is better than another"
>
> "Phytate found to be the most effective"
>
> Phytate inhibits bovine pericardium calcification in vitro
> Cardiovascular Pathology, Volume 17, Issue 3, May-June 2008, Pages
> 139-145
> F¨¦lix Grases, Pilar Sanchis, Antonia Costa-Bauz¨¢, Oriol Bonnin,
> Bernat
> Isern, Joan Perell¨®, Rafael M. Prieto
>
> Objective
> The present study examined the inhibitory effects of pyrophosphate,
> etidronate, and phytate on bovine pericardium calcification in vitro.
> Methods
> Bovine pericardium was glutaraldehyde fixed and then placed in a flow
> chamber in the presence of a synthetic physiological fluid alone
> (control) or the fluid plus various concentrations of pyrophosphate,
> etidronate, or phytate. Following a 96-h incubation, fragments were
> removed and assayed for calcification by measuring calcium and
> phosphorus levels.
>
> Results
> The data indicated that both pyrophosphate and etidronate at 1 mg/l
> (5.75 and 4.95 ¦ÌM, respectively) inhibited bovine pericardium
> calcification, whereas neither agent had an effect at 0.5 mg/l (2.87
> and 2.47 ¦ÌM, respectively). Phytate was the most potent inhibitor of
> calcification, and the effects of this agent were apparent at levels
> as low as 0.25 mg/l (0.39 ¦ÌM).
>
> Conclusions
> While pyrophosphate, etidronate, and phytate were all able to inhibit
> bovine pericardium calcification in vitro, phytate was found to be
> the
> most effective.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

Sorry - is this relevant to MS? I have learned while writing my eBook
"Multiple Sclerosis - a Quick Start Guide for the Newly Diagnosed,
their Families and Carers" that antiinflamattory drugs do have
potential as "rescue therapies" but there are risks as well,. It
doesn't sound like this is targeted to help control MS symptoms. Or am
I missing something?
Guy

On Jul 14, 10:30 am, Guy <guy.thomp...@guyt.co.uk> wrote:It
doesn't sound like this is targeted to help control MS symptoms <<

"There is no inflammation in those with multiple sclerosis."

Is that what you are saying .. ?

"Immune-mediated inflammation"

Colour Doppler imaging evaluation of blood flow parameters in the
ophthalmic artery in acute and chronic phases of optic neuritis in
multiple sclerosis.
Hrad¨ªlek P, Stourac P, Bar M, Zapletalov¨¢ O, Skoloud¨ªk D
Acta Ophthalmol 2008 Jun 19.

Purpose:
Optic neuritis (ON) is a common manifestation of multiple sclerosis
(MS). It is caused by the immune-mediated inflammation of the optic
nerve. Some vascular factors that may influence blood flow in the
ophthalmic artery (OA) have also been suggested as factors in the
pathogenesis of ON. The purpose of our study was to evaluate blood
flow velocities and resistance (RI) and pulsatile (PI) indices in the
OA in both orbits in patients in the acute and chronic phases of
unilateral ON and to compare these with equivalent findings in healthy
control subjects.
Methods:
Orbital colour Doppler imaging (CDI) was performed in 40 consecutive
MS patients during acute unilateral ON prior to corticosteroid
treatment. Optic neuritis was diagnosed on the basis of clinical
presentation and facultative assessment of visual evoked potentials
(VEPs). The peak systolic (PSV) and end-diastolic (EDV) velocities and
RI and PI were measured in the OA in both eyes. We compared results
from affected and unaffected orbits using the paired t-test. The same
measurements were performed in 114 MS patients with a history of acute
unilateral ON that occurred > 1 year prior to ultrasound examination.
We also measured the same parameters in the middle cerebral arteries
(MCAs) on both sides in all subjects in both groups. The same
measurements were obtained in healthy controls.
Results:
The PSV (p < 0.0001), RI (p < 0.0001) and PI (p < 0.0001) in the OA in
the eye affected with acute ON were significantly higher than in the
unaffected eye. There was no difference in EDV in the OA between
affected and unaffected eyes (p > 0.05) in the group with acute ON. We
did not observe any significant differences between eyes in either
blood flow velocities or the RI or PI (p > 0.05) in the group in the
chronic phase of ON or in the control group. All the parameters in the
MCAs on both sides were normal in both the acute and chronic groups,
as well as in the control group.
Conclusions: Pathophysiological changes during acute unilateral ON
influence orbital haemodynamics, as is indicated by increased PSV, RI
and PI in the OA in eyes affected with ON. However, these changes do
not persist over longer periods.

Acta ophthalmologica [Acta Ophthalmol]
--------------------------------------------------------------------------------

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> On Jul 13, 5:32 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
>
>
>
>
>
> > Miraculous .. stuff.
>
> > This would be my .. freeee .. bisphosphonate .. aaaa gain.
>
> > Remember .. ? .. the one that is **better** than those .. expensive
> > **unaffordable** .. other bisphosphonates .. like etidronate .. ?
>
> >http://tinyurl.com/2wuhuk
>
> > The influence of phytic acid on TNF-alpha and its receptors genes'
> > expression in colon cancer Caco-2 cells.
> > Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E,
> > Kierot J, Weglarz L
> > Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9.
>
> > Inositol hexaphosphate (IP6, phytic acid) is a naturally occurring
> > carbohydrate abundantly present in high-fiber diets and it is also
> > contained in almost all mammalian cells.
> > It plays an important role in signal transduction, cell proliferation
> > and differentiation. Some natural substances have been shown to elicit
> > an impact on the expression of TNF-alpha and its receptors in cancer
> > cells.
> > TNF-alpha represents cytokine very often deregulated at the level of
> > both gene expression and signal transmission through TNF-alpha
> > receptors (TNFRI and TNFRII).
> > The aim of the present study was to analyze the IP6 influence on the
> > transcription of genes coding for TNF-alpha and its receptors in human
> > colon cancer cells line Caco-2.
> > Real-time QRT-PCR based on TaqMan methodology was applied to analyze
> > quantitatively the transcript levels of these genes.
> > Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2
> > cells stimulation for 1, 6, 12 and 24 h.
> > The results showed that IP6 modulated the expression of the listed
> > genes at transcription level in a dose and time dependent manner.
> > The enhanced TNFRI and decreased TNF-alpha and TNFRII transcription in
> > Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive
> > evidence for anti-inflammatory and antitumor activity of IP6.
>
> > Acta poloniae pharmaceutica [Acta Pol Pharm]
> > ----------------------------------------------------------------------------------
> > The last study found there was not enough evidence to say one
> > bisphosphonate was better than another.
> > This study found .. phyate IS .. **better**.
>
> > "No evidence currently available to definitely confirm that
> > one bisphosphonate is better than another"
>
> > "Phytate found to be the most effective"
>
> > Phytate inhibits bovine pericardium calcification in vitro
> > Cardiovascular Pathology, Volume 17, Issue 3, May-June 2008, Pages
> > 139-145
> > F¨¦lix Grases, Pilar Sanchis, Antonia Costa-Bauz¨¢, Oriol Bonnin,
> > Bernat
> > Isern, Joan Perell¨®, Rafael M. Prieto
>
> > Objective
> > The present study examined the inhibitory effects of pyrophosphate,
> > etidronate, and phytate on bovine pericardium calcification in vitro.
> > Methods
> > Bovine pericardium was glutaraldehyde fixed and then placed in a flow
> > chamber in the presence of a synthetic physiological fluid alone
> > (control) or the fluid plus various concentrations of pyrophosphate,
> > etidronate, or phytate. Following a 96-h incubation, fragments were
> > removed and assayed for calcification by measuring calcium and
> > phosphorus levels.
>
> > Results
> > The data indicated that both pyrophosphate and etidronate at 1 mg/l
> > (5.75 and 4.95 ¦ÌM, respectively) inhibited bovine pericardium
> > calcification, whereas neither agent had an effect at 0.5 mg/l (2.87
> > and 2.47 ¦ÌM, respectively). Phytate was the most potent inhibitor of
> > calcification, and the effects of this agent were apparent at levels
> > as low as 0.25 mg/l (0.39 ¦ÌM).
>
> > Conclusions
> > While pyrophosphate, etidronate, and phytate were all able to inhibit
> > bovine pericardium calcification in vitro, phytate was found to be
> > the
> > most effective.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!http://tinyurl.com/4rq595
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> Sorry - is this relevant to MS? I have learned while writing my eBook
> "Multiple Sclerosis - a Quick Start Guide for the Newly Diagnosed,
> their Families and Carers" that antiinflamattory drugs do have
> potential as "rescue therapies" but there are risks as well,. It
> doesn't sound like this is targeted to help control MS symptoms. Or am
> I missing something?
> Guy- Hide quoted text -
>
> - Show quoted text -

Nothing ironjustice a.k.a. Tin Pot Tommy says that makes any sense. Ignore
him and maybe the little troll will go back under his (rusty) bridge... We
can only hope!
Shelley

"Guy" <guy.thompson@guyt.co.uk> wrote in message
news:ad1c28d7-6467-49ed-b2c4-0dfeaa30989e@2g2000hsn.googlegroups.com...
On Jul 13, 5:32 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
> Miraculous .. stuff.
>
> This would be my .. freeee .. bisphosphonate .. aaaa gain.
>
> Remember .. ? .. the one that is **better** than those .. expensive
> **unaffordable** .. other bisphosphonates .. like etidronate .. ?
>
> http://tinyurl.com/2wuhuk
>
> The influence of phytic acid on TNF-alpha and its receptors genes'
> expression in colon cancer Caco-2 cells.
> Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E,
> Kierot J, Weglarz L
> Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9.
>
> Inositol hexaphosphate (IP6, phytic acid) is a naturally occurring
> carbohydrate abundantly present in high-fiber diets and it is also
> contained in almost all mammalian cells.
> It plays an important role in signal transduction, cell proliferation
> and differentiation. Some natural substances have been shown to elicit
> an impact on the expression of TNF-alpha and its receptors in cancer
> cells.
> TNF-alpha represents cytokine very often deregulated at the level of
> both gene expression and signal transmission through TNF-alpha
> receptors (TNFRI and TNFRII).
> The aim of the present study was to analyze the IP6 influence on the
> transcription of genes coding for TNF-alpha and its receptors in human
> colon cancer cells line Caco-2.
> Real-time QRT-PCR based on TaqMan methodology was applied to analyze
> quantitatively the transcript levels of these genes.
> Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2
> cells stimulation for 1, 6, 12 and 24 h.
> The results showed that IP6 modulated the expression of the listed
> genes at transcription level in a dose and time dependent manner.
> The enhanced TNFRI and decreased TNF-alpha and TNFRII transcription in
> Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive
> evidence for anti-inflammatory and antitumor activity of IP6.
>
> Acta poloniae pharmaceutica [Acta Pol Pharm]
> ---------------------------------------------------------------------------------
> The last study found there was not enough evidence to say one
> bisphosphonate was better than another.
> This study found .. phyate IS .. **better**.
>
> "No evidence currently available to definitely confirm that
> one bisphosphonate is better than another"
>
> "Phytate found to be the most effective"
>
> Phytate inhibits bovine pericardium calcification in vitro
> Cardiovascular Pathology, Volume 17, Issue 3, May-June 2008, Pages
> 139-145
> F¨¦lix Grases, Pilar Sanchis, Antonia Costa-Bauz¨¢, Oriol Bonnin,
> Bernat
> Isern, Joan Perell¨®, Rafael M. Prieto
>
> Objective
> The present study examined the inhibitory effects of pyrophosphate,
> etidronate, and phytate on bovine pericardium calcification in vitro.
> Methods
> Bovine pericardium was glutaraldehyde fixed and then placed in a flow
> chamber in the presence of a synthetic physiological fluid alone
> (control) or the fluid plus various concentrations of pyrophosphate,
> etidronate, or phytate. Following a 96-h incubation, fragments were
> removed and assayed for calcification by measuring calcium and
> phosphorus levels.
>
> Results
> The data indicated that both pyrophosphate and etidronate at 1 mg/l
> (5.75 and 4.95 ¦ÌM, respectively) inhibited bovine pericardium
> calcification, whereas neither agent had an effect at 0.5 mg/l (2.87
> and 2.47 ¦ÌM, respectively). Phytate was the most potent inhibitor of
> calcification, and the effects of this agent were apparent at levels
> as low as 0.25 mg/l (0.39 ¦ÌM).
>
> Conclusions
> While pyrophosphate, etidronate, and phytate were all able to inhibit
> bovine pericardium calcification in vitro, phytate was found to be
> the
> most effective.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

Sorry - is this relevant to MS? I have learned while writing my eBook
"Multiple Sclerosis - a Quick Start Guide for the Newly Diagnosed,
their Families and Carers" that antiinflamattory drugs do have
potential as "rescue therapies" but there are risks as well,. It
doesn't sound like this is targeted to help control MS symptoms. Or am
I missing something?
Guy

Anti-inflammatory ? Tom's head in a bucket of ice water to help reduce the
SWELLING.

On Jul 14, 12:07*pm, "Shelley" <no...@nohow.com> wrote:
Nothing ironjustice a.k.a. Tin Pot Tommy says that makes any sense.
*Ignore
him and maybe the little troll will go back under his (rusty)
bridge... We
can only hope! * <<

There IS .. inflammation IN .. multiple sclerosis ..

NO MATTER what .. these .. people TRY to tell you ..

You must have realized by now .. if you ARE writing an E-book ..
inflammation IS .. involved ..

Sooo .. evidentally .. at the very LEAST .. **you** are privy to the
FACT .. abuse OF .. me .. **specifically** comes .. BEFORE .. 'that
little kid over there'.

These people will tell you NOT to explore .. avenues .. KNOWING full
well those avenues ARE the ones you so desperately .. seek .. JUST in
order to .. abuse .. **me** ..

Leave .. quickly ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> Shelley
>
> "Guy" <guy.thomp...@guyt.co.uk> wrote in message
>
> news:ad1c28d7-6467-49ed-b2c4-0dfeaa30989e@2g2000hsn.googlegroups.com...
> On Jul 13, 5:32 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
>
>
>
>
>
> > Miraculous .. stuff.
>
> > This would be my .. freeee .. bisphosphonate .. aaaa gain.
>
> > Remember .. ? .. the one that is **better** than those .. expensive
> > **unaffordable** .. other bisphosphonates .. like etidronate .. ?
>
> >http://tinyurl.com/2wuhuk
>
> > The influence of phytic acid on TNF-alpha and its receptors genes'
> > expression in colon cancer Caco-2 cells.
> > Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E,
> > Kierot J, Weglarz L
> > Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9.
>
> > Inositol hexaphosphate (IP6, phytic acid) is a naturally occurring
> > carbohydrate abundantly present in high-fiber diets and it is also
> > contained in almost all mammalian cells.
> > It plays an important role in signal transduction, cell proliferation
> > and differentiation. Some natural substances have been shown to elicit
> > an impact on the expression of TNF-alpha and its receptors in cancer
> > cells.
> > TNF-alpha represents cytokine very often deregulated at the level of
> > both gene expression and signal transmission through TNF-alpha
> > receptors (TNFRI and TNFRII).
> > The aim of the present study was to analyze the IP6 influence on the
> > transcription of genes coding for TNF-alpha and its receptors in human
> > colon cancer cells line Caco-2.
> > Real-time QRT-PCR based on TaqMan methodology was applied to analyze
> > quantitatively the transcript levels of these genes.
> > Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2
> > cells stimulation for 1, 6, 12 and 24 h.
> > The results showed that IP6 modulated the expression of the listed
> > genes at transcription level in a dose and time dependent manner.
> > The enhanced TNFRI and decreased TNF-alpha and TNFRII transcription in
> > Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive
> > evidence for anti-inflammatory and antitumor activity of IP6.
>
> > Acta poloniae pharmaceutica [Acta Pol Pharm]
> > ---------------------------------------------------------------------------*------
> > The last study found there was not enough evidence to say one
> > bisphosphonate was better than another.
> > This study found .. phyate IS .. **better**.
>
> > "No evidence currently available to definitely confirm that
> > one bisphosphonate is better than another"
>
> > "Phytate found to be the most effective"
>
> > Phytate inhibits bovine pericardium calcification in vitro
> > Cardiovascular Pathology, Volume 17, Issue 3, May-June 2008, Pages
> > 139-145
> > F¨¦lix Grases, Pilar Sanchis, Antonia Costa-Bauz¨¢, Oriol Bonnin,
> > Bernat
> > Isern, Joan Perell¨®, Rafael M. Prieto
>
> > Objective
> > The present study examined the inhibitory effects of pyrophosphate,
> > etidronate, and phytate on bovine pericardium calcification in vitro.
> > Methods
> > Bovine pericardium was glutaraldehyde fixed and then placed in a flow
> > chamber in the presence of a synthetic physiological fluid alone
> > (control) or the fluid plus various concentrations of pyrophosphate,
> > etidronate, or phytate. Following a 96-h incubation, fragments were
> > removed and assayed for calcification by measuring calcium and
> > phosphorus levels.
>
> > Results
> > The data indicated that both pyrophosphate and etidronate at 1 mg/l
> > (5.75 and 4.95 ¦ÌM, respectively) inhibited bovine pericardium
> > calcification, whereas neither agent had an effect at 0.5 mg/l (2.87
> > and 2.47 ¦ÌM, respectively). Phytate was the most potent inhibitor of
> > calcification, and the effects of this agent were apparent at levels
> > as low as 0.25 mg/l (0.39 ¦ÌM).
>
> > Conclusions
> > While pyrophosphate, etidronate, and phytate were all able to inhibit
> > bovine pericardium calcification in vitro, phytate was found to be
> > the
> > most effective.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!http://tinyurl.com/4rq595
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> Sorry - is this relevant to MS? I have learned while writing my eBook
> "Multiple Sclerosis - a Quick Start Guide for the Newly Diagnosed,
> their Families and Carers" that antiinflamattory drugs do have
> potential as "rescue therapies" but there are risks as well,. It
> doesn't sound like this is targeted to help control MS symptoms. Or am
> I missing something?
> Guy- Hide quoted text -
>
> - Show quoted text -

On Jul 14, 7:49*pm, "Cheeky Bastard" <InvalidEm...@aol.com> wrote:
testosterone depleted retarded fatboy <<

This just .. drips .. of .. support ..

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Jul 14, 10:30 am, Guy <guy.thomp...@guyt.co.uk> wrote:anti-
inflammatory <<

http://www.medicineatmichigan.org/ma...gs/default.asp

"All autoimmune diseases -- such as rheumatoid arthritis, psoriasis,
lupus or multiple sclerosis -- are diseases in which the inflammatory
response is unregulated, excessive and out of control. So
understanding the inflammatory system from A to Z will have huge
applications in any number of diseases or clinical situations."


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> On Jul 13, 5:32 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
>
>
>
>
>
> > Miraculous .. stuff.
>
> > This would be my .. freeee .. bisphosphonate .. aaaa gain.
>
> > Remember .. ? .. the one that is **better** than those .. expensive
> > **unaffordable** .. other bisphosphonates .. like etidronate .. ?
>
> >http://tinyurl.com/2wuhuk
>
> > The influence of phytic acid on TNF-alpha and its receptors genes'
> > expression in colon cancer Caco-2 cells.
> > Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E,
> > Kierot J, Weglarz L
> > Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9.
>
> > Inositol hexaphosphate (IP6, phytic acid) is a naturally occurring
> > carbohydrate abundantly present in high-fiber diets and it is also
> > contained in almost all mammalian cells.
> > It plays an important role in signal transduction, cell proliferation
> > and differentiation. Some natural substances have been shown to elicit
> > an impact on the expression of TNF-alpha and its receptors in cancer
> > cells.
> > TNF-alpha represents cytokine very often deregulated at the level of
> > both gene expression and signal transmission through TNF-alpha
> > receptors (TNFRI and TNFRII).
> > The aim of the present study was to analyze the IP6 influence on the
> > transcription of genes coding for TNF-alpha and its receptors in human
> > colon cancer cells line Caco-2.
> > Real-time QRT-PCR based on TaqMan methodology was applied to analyze
> > quantitatively the transcript levels of these genes.
> > Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2
> > cells stimulation for 1, 6, 12 and 24 h.
> > The results showed that IP6 modulated the expression of the listed
> > genes at transcription level in a dose and time dependent manner.
> > The enhanced TNFRI and decreased TNF-alpha and TNFRII transcription in
> > Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive
> > evidence for anti-inflammatory and antitumor activity of IP6.
>
> > Acta poloniae pharmaceutica [Acta Pol Pharm]
> > ----------------------------------------------------------------------------------
> > The last study found there was not enough evidence to say one
> > bisphosphonate was better than another.
> > This study found .. phyate IS .. **better**.
>
> > "No evidence currently available to definitely confirm that
> > one bisphosphonate is better than another"
>
> > "Phytate found to be the most effective"
>
> > Phytate inhibits bovine pericardium calcification in vitro
> > Cardiovascular Pathology, Volume 17, Issue 3, May-June 2008, Pages
> > 139-145
> > F¨¦lix Grases, Pilar Sanchis, Antonia Costa-Bauz¨¢, Oriol Bonnin,
> > Bernat
> > Isern, Joan Perell¨®, Rafael M. Prieto
>
> > Objective
> > The present study examined the inhibitory effects of pyrophosphate,
> > etidronate, and phytate on bovine pericardium calcification in vitro.
> > Methods
> > Bovine pericardium was glutaraldehyde fixed and then placed in a flow
> > chamber in the presence of a synthetic physiological fluid alone
> > (control) or the fluid plus various concentrations of pyrophosphate,
> > etidronate, or phytate. Following a 96-h incubation, fragments were
> > removed and assayed for calcification by measuring calcium and
> > phosphorus levels.
>
> > Results
> > The data indicated that both pyrophosphate and etidronate at 1 mg/l
> > (5.75 and 4.95 ¦ÌM, respectively) inhibited bovine pericardium
> > calcification, whereas neither agent had an effect at 0.5 mg/l (2.87
> > and 2.47 ¦ÌM, respectively). Phytate was the most potent inhibitor of
> > calcification, and the effects of this agent were apparent at levels
> > as low as 0.25 mg/l (0.39 ¦ÌM).
>
> > Conclusions
> > While pyrophosphate, etidronate, and phytate were all able to inhibit
> > bovine pericardium calcification in vitro, phytate was found to be
> > the
> > most effective.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!http://tinyurl.com/4rq595
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> Sorry - is this relevant to MS? I have learned while writing my eBook
> "Multiple Sclerosis - a Quick Start Guide for the Newly Diagnosed,
> their Families and Carers" that antiinflamattory drugs do have
> potential as "rescue therapies" but there are risks as well,. It
> doesn't sound like this is targeted to help control MS symptoms. Or am
> I missing something?
> Guy- Hide quoted text -
>
> - Show quoted text -

On Jul 14, 8:41 pm, "ironjust...@aol.com" <ironjust...@aol.com>
wrote:anti-
inflammatory <<

http://www.medicineatmichigan.org/ma...gs/default.asp

"The mainstays of treatment are still corticosteroids, aspirin and non-
steroidal anti-inflammatory drugs (NSAIDs) like ibruprofen."

The articles below though .. show .. iron to BE .. "coincidentally" ..
closely involved.

Aspirin / iron chelating
Ibuprofen / iron chelating
Corticosteroid / improves siderosis

Ibuprofen prevents oxidant lung injury and in vitro lipid peroxidation
by chelating iron.
http://www.pubmedcentral.nih.gov/art...i?artid=296904

Iron chelation as a possible mechanism for aspirin-induced
malondialdehyde production by mouse liver microsomes and mitochondria.
http://www.pubmedcentral.nih.gov/art...i?artid=442488

Superficial hemosiderosis of the central nervous system improved by
corticosteroids
http://tinyurl.com/5dbjoa

"Pharmaceutical companies introduced a new type of anti-inflammatory
drug their cost per patient ranges from $12,000 to $20,000 each year.
There's still no new powerful, reasonably priced drug that can be used
across the board for these inflammatory diseases."

I would say there is .. the phytic acid mentioned in the article ..

VERY inexpensive.


Indian J Exp Biol. 2004 Feb;42(2):179-85. Related Articles, Links

Antiinflammatory and antiulcer activities of phytic acid in rats.


Sudheer Kumar M, Sridhar Reddy B, Kiran Babu S, Bhilegaonkar PM,
Shirwaikar A,
Unnikrishnan MK.


Department of Pharmacology, College of Pharmaceutical Sciences,
Manipal 576
119, India.


Maximum antiinflammatory activity of phytic acid (PA) was seen at an
oral dose
of 150 mg/kg in the carrageenan induced rat paw edema model. Although
PA showed
ability to prevent denaturation of proteins, it showed less
antiinflammatory
activity than ibuprofen. Ability of PA to bring down thermal
denaturation of
proteins might be a contributing factor in the mechanism of action
against
inflammation. PA, at all the doses tested, showed significant
protection from
ulcers induced by ibuprofen, ethanol and cold stress, with a maximum
activity
at 150 mg/kg. There was a significant increase in gastric tissue
malondialdehyde levels in ethanol treated rats but these levels
decreased
following PA pretreatment. Moreover, pretreatment with PA
significantly
inhibited various effects of ethanol on gastric mucosa, such as,
reduction in
the concentration of nonprotein sulfhydryl groups, necrosis,
erosions,
congestion and hemorrhage. These results suggested that gastro-
protective
effect of PA could be mediated by its antioxidant activity and
cytoprotection
of gastric mucosa.


PMID: 15282951 [PubMed - in process]


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk





> On Jul 14, 10:30 am, Guy <guy.thomp...@guyt.co.uk> wrote:anti-
> inflammatory <<
>
> http://www.medicineatmichigan.org/ma...gs/default.asp
>
> "All autoimmune diseases -- such as rheumatoid arthritis, psoriasis,
> lupus or multiple sclerosis -- are diseases in which the inflammatory
> response is unregulated, excessive and out of control. So
> understanding the inflammatory system from A to Z will have huge
> applications in any number of diseases or clinical situations."
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > On Jul 13, 5:32 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
>
> > > Miraculous .. stuff.
>
> > > This would be my .. freeee .. bisphosphonate .. aaaa gain.
>
> > > Remember .. ? .. the one that is **better** than those .. expensive
> > > **unaffordable** .. other bisphosphonates .. like etidronate .. ?
>
> > >http://tinyurl.com/2wuhuk
>
> > > The influence of phytic acid on TNF-alpha and its receptors genes'
> > > expression in colon cancer Caco-2 cells.
> > > Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E,
> > > Kierot J, Weglarz L
> > > Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9.
>
> > > Inositol hexaphosphate (IP6, phytic acid) is a naturally occurring
> > > carbohydrate abundantly present in high-fiber diets and it is also
> > > contained in almost all mammalian cells.
> > > It plays an important role in signal transduction, cell proliferation
> > > and differentiation. Some natural substances have been shown to elicit
> > > an impact on the expression of TNF-alpha and its receptors in cancer
> > > cells.
> > > TNF-alpha represents cytokine very often deregulated at the level of
> > > both gene expression and signal transmission through TNF-alpha
> > > receptors (TNFRI and TNFRII).
> > > The aim of the present study was to analyze the IP6 influence on the
> > > transcription of genes coding for TNF-alpha and its receptors in human
> > > colon cancer cells line Caco-2.
> > > Real-time QRT-PCR based on TaqMan methodology was applied to analyze
> > > quantitatively the transcript levels of these genes.
> > > Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2
> > > cells stimulation for 1, 6, 12 and 24 h.
> > > The results showed that IP6 modulated the expression of the listed
> > > genes at transcription level in a dose and time dependent manner.
> > > The enhanced TNFRI and decreased TNF-alpha and TNFRII transcription in
> > > Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive
> > > evidence for anti-inflammatory and antitumor activity of IP6.
>
> > > Acta poloniae pharmaceutica [Acta Pol Pharm]
> > > -----------------------------------------------------------------------------------
> > > The last study found there was not enough evidence to say one
> > > bisphosphonate was better than another.
> > > This study found .. phyate IS .. **better**.
>
> > > "No evidence currently available to definitely confirm that
> > > one bisphosphonate is better than another"
>
> > > "Phytate found to be the most effective"
>
> > > Phytate inhibits bovine pericardium calcification in vitro
> > > Cardiovascular Pathology, Volume 17, Issue 3, May-June 2008, Pages
> > > 139-145
> > > F¨¦lix Grases, Pilar Sanchis, Antonia Costa-Bauz¨¢, Oriol Bonnin,
> > > Bernat
> > > Isern, Joan Perell¨®, Rafael M. Prieto
>
> > > Objective
> > > The present study examined the inhibitory effects of pyrophosphate,
> > > etidronate, and phytate on bovine pericardium calcification in vitro.
> > > Methods
> > > Bovine pericardium was glutaraldehyde fixed and then placed in a flow
> > > chamber in the presence of a synthetic physiological fluid alone
> > > (control) or the fluid plus various concentrations of pyrophosphate,
> > > etidronate, or phytate. Following a 96-h incubation, fragments were
> > > removed and assayed for calcification by measuring calcium and
> > > phosphorus levels.
>
> > > Results
> > > The data indicated that both pyrophosphate and etidronate at 1 mg/l
> > > (5.75 and 4.95 ¦ÌM, respectively) inhibited bovine pericardium
> > > calcification, whereas neither agent had an effect at 0.5 mg/l (2.87
> > > and 2.47 ¦ÌM, respectively). Phytate was the most potent inhibitor of
> > > calcification, and the effects of this agent were apparent at levels
> > > as low as 0.25 mg/l (0.39 ¦ÌM).
>
> > > Conclusions
> > > While pyrophosphate, etidronate, and phytate were all able to inhibit
> > > bovine pericardium calcification in vitro, phytate was found to be
> > > the
> > > most effective.
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > > Man Is A Herbivore!http://tinyurl.com/4rq595
>
> > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> > Sorry - is this relevant to MS? I have learned while writing my eBook
> > "Multiple Sclerosis - a Quick Start Guide for the Newly Diagnosed,
> > their Families and Carers" that antiinflamattory drugs do have
> > potential as "rescue therapies" but there are risks as well,. It
> > doesn't sound like this is targeted to help control MS symptoms. Or am
> > I missing something?
> > Guy- Hide quoted text -
>
> > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -

<guy.thomp...@guyt.co.uk> wrote:

(snip of Ferrous Hilton's maunderings)

> Sorry - is this relevant to MS? I have learned while writing my eBook
> "Multiple Sclerosis - a Quick Start Guide for the Newly Diagnosed,
> their Families and Carers" that antiinflamattory drugs do have
> potential as "rescue therapies" but there are risks as well,. It
> doesn't sound like this is targeted to help control MS symptoms. Or am
> I missing something?

No, it's Rusty who's missing something--his marbles.

Tom Hennessy (alias Ironjustice; better known as Rusty,
Ironman and the Ferrous Fuckwit) is a persistent troll who
floods assorted newsgroups with off-topic posts. He isn't
honest enough to give a clear, straight answer, but it seems
he wants people to eliminate all iron from their bodies. He's
made a number of bizarre statements which have everyone
convinced that he's nuts. The only thing crazier than
Rusty is taking his advice.

--Bill Thompson

On Jul 15, 4:27*am, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
> On Jul 14, 12:07*pm, "Shelley" <no...@nohow.com> wrote:
> *Nothing ironjustice a.k.a. Tin Pot Tommy says that makes any sense.
> *Ignore
> *him and maybe the little troll will go back under his (rusty)
> bridge... We
> *can only hope! * <<
>
> There IS .. inflammation IN .. multiple sclerosis ..
>
> NO MATTER what .. these .. people TRY to tell you ..
>
> You must have realized by now .. if you ARE writing an E-book ..
> inflammation IS .. involved ..
>
> Sooo .. evidentally .. at the very LEAST .. **you** are privy to the
> FACT .. abuse OF .. me .. **specifically** comes .. BEFORE .. 'that
> little kid over there'.
>
> These people will tell you NOT to explore .. avenues .. KNOWING full
> well those avenues ARE the ones you so desperately .. seek .. JUST in
> order to .. abuse .. **me** ..
>
> Leave .. quickly ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > Shelley
>
> > "Guy" <guy.thomp...@guyt.co.uk> wrote in message
>
> >news:ad1c28d7-6467-49ed-b2c4-0dfeaa30989e@2g2000hsn.googlegroups.com...
> > On Jul 13, 5:32 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
>
> > > Miraculous .. stuff.
>
> > > This would be my .. freeee .. bisphosphonate .. aaaa gain.
>
> > > Remember .. ? .. the one that is **better** than those .. expensive
> > > **unaffordable** .. other bisphosphonates .. like etidronate .. ?
>
> > >http://tinyurl.com/2wuhuk
>
> > > The influence of phytic acid on TNF-alpha and its receptors genes'
> > > expression in colon cancer Caco-2 cells.
> > > Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E,
> > > Kierot J, Weglarz L
> > > Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9.
>
> > > Inositol hexaphosphate (IP6, phytic acid) is a naturally occurring
> > > carbohydrate abundantly present in high-fiber diets and it is also
> > > contained in almost all mammalian cells.
> > > It plays an important role in signal transduction, cell proliferation
> > > and differentiation. Some natural substances have been shown to elicit
> > > an impact on the expression of TNF-alpha and its receptors in cancer
> > > cells.
> > > TNF-alpha represents cytokine very often deregulated at the level of
> > > both gene expression and signal transmission through TNF-alpha
> > > receptors (TNFRI and TNFRII).
> > > The aim of the present study was to analyze the IP6 influence on the
> > > transcription of genes coding for TNF-alpha and its receptors in human
> > > colon cancer cells line Caco-2.
> > > Real-time QRT-PCR based on TaqMan methodology was applied to analyze
> > > quantitatively the transcript levels of these genes.
> > > Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2
> > > cells stimulation for 1, 6, 12 and 24 h.
> > > The results showed that IP6 modulated the expression of the listed
> > > genes at transcription level in a dose and time dependent manner.
> > > The enhanced TNFRI and decreased TNF-alpha and TNFRII transcription in
> > > Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive
> > > evidence for anti-inflammatory and antitumor activity of IP6.
>
> > > Acta poloniae pharmaceutica [Acta Pol Pharm]
> > > ---------------------------------------------------------------------------**------
> > > The last study found there was not enough evidence to say one
> > > bisphosphonate was better than another.
> > > This study found .. phyate IS .. **better**.
>
> > > "No evidence currently available to definitely confirm that
> > > one bisphosphonate is better than another"
>
> > > "Phytate found to be the most effective"
>
> > > Phytate inhibits bovine pericardium calcification in vitro
> > > Cardiovascular Pathology, Volume 17, Issue 3, May-June 2008, Pages
> > > 139-145
> > > F¨¦lix Grases, Pilar Sanchis, Antonia Costa-Bauz¨¢, Oriol Bonnin,
> > > Bernat
> > > Isern, Joan Perell¨®, Rafael M. Prieto
>
> > > Objective
> > > The present study examined the inhibitory effects of pyrophosphate,
> > > etidronate, and phytate on bovine pericardium calcification in vitro.
> > > Methods
> > > Bovine pericardium was glutaraldehyde fixed and then placed in a flow
> > > chamber in the presence of a synthetic physiological fluid alone
> > > (control) or the fluid plus various concentrations of pyrophosphate,
> > > etidronate, or phytate. Following a 96-h incubation, fragments were
> > > removed and assayed for calcification by measuring calcium and
> > > phosphorus levels.
>
> > > Results
> > > The data indicated that both pyrophosphate and etidronate at 1 mg/l
> > > (5.75 and 4.95 ¦ÌM, respectively) inhibited bovine pericardium
> > > calcification, whereas neither agent had an effect at 0.5 mg/l (2.87
> > > and 2.47 ¦ÌM, respectively). Phytate was the most potent inhibitor of
> > > calcification, and the effects of this agent were apparent at levels
> > > as low as 0.25 mg/l (0.39 ¦ÌM).
>
> > > Conclusions
> > > While pyrophosphate, etidronate, and phytate were all able to inhibit
> > > bovine pericardium calcification in vitro, phytate was found to be
> > > the
> > > most effective.
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > > Man Is A Herbivore!http://tinyurl.com/4rq595
>
> > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> > Sorry - is this relevant to MS? I have learned while writing my eBook
> > "Multiple Sclerosis - a Quick Start Guide for the Newly Diagnosed,
> > their Families and Carers" that antiinflamattory drugs do have
> > potential as "rescue therapies" but there are risks as well,. It
> > doesn't sound like this is targeted to help control MS symptoms. Or am
> > I missing something?
> > Guy- Hide quoted text -
>
> > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -

Of course I know Inflammation is involved in triggering MS atacks,
otherwise those of us who have MS lesions would often not have too
much to worry about. But there are lots of inflammatios all over the
body, and people are trying various anti-inflammatory drugs to see if
they work to manage MS ("second hand medicines" I call them in my book
- not to say they are bad, but they need to be tested to see if they
do help and don't have unexpected side effects). My question was only
about whether there is anything new and specific to MS in this
announcement.
Guy

On Jul 15, 4:44*am, Guy <guy.thomp...@guyt.co.uk> wrote:My question
was only
about whether there is anything new and specific to MS in this
announcement. <<

It would give credence to the previous studies.
They recommend alpha-linolenic acid in those with multiple sclerosis.

These fatty acids ALL come from the parent fatty acid .. alpha-
linolenic acid found in plants.

http://tinyurl.com/2ky887

Conclusions
Based on the review above, the following strategies may be considered:
1. Increase intake of fats that are rich in omega- 3 fatty acids,
which include EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid),
and ALA (alpha-linolenic acid).


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk







> On Jul 15, 4:27*am, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
>
>
>
>
>
> > On Jul 14, 12:07*pm, "Shelley" <no...@nohow.com> wrote:
> > *Nothing ironjustice a.k.a. Tin Pot Tommy says that makes any sense.
> > *Ignore
> > *him and maybe the little troll will go back under his (rusty)
> > bridge... We
> > *can only hope! * <<
>
> > There IS .. inflammation IN .. multiple sclerosis ..
>
> > NO MATTER what .. these .. people TRY to tell you ..
>
> > You must have realized by now .. if you ARE writing an E-book ..
> > inflammation IS .. involved ..
>
> > Sooo .. evidentally .. at the very LEAST .. **you** are privy to the
> > FACT .. abuse OF .. me .. **specifically** comes .. BEFORE .. 'that
> > little kid over there'.
>
> > These people will tell you NOT to explore .. avenues .. KNOWING full
> > well those avenues ARE the ones you so desperately .. seek .. JUST in
> > order to .. abuse .. **me** ..
>
> > Leave .. quickly ..
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!http://tinyurl.com/4rq595
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> > > Shelley
>
> > > "Guy" <guy.thomp...@guyt.co.uk> wrote in message
>
> > >news:ad1c28d7-6467-49ed-b2c4-0dfeaa30989e@2g2000hsn.googlegroups.com....
> > > On Jul 13, 5:32 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
>
> > > > Miraculous .. stuff.
>
> > > > This would be my .. freeee .. bisphosphonate .. aaaa gain.
>
> > > > Remember .. ? .. the one that is **better** than those .. expensive
> > > > **unaffordable** .. other bisphosphonates .. likeetidronate.. ?
>
> > > >http://tinyurl.com/2wuhuk
>
> > > > The influence ofphyticacid on TNF-alpha and its receptors genes'
> > > > expression in colon cancer Caco-2 cells.
> > > > Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E,
> > > > Kierot J, Weglarz L
> > > > Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9.
>
> > > > Inositol hexaphosphate (IP6,phyticacid) is a naturally occurring
> > > > carbohydrate abundantly present in high-fiber diets and it is also
> > > > contained in almost all mammalian cells.
> > > > It plays an important role in signal transduction, cell proliferation
> > > > and differentiation. Some natural substances have been shown to elicit
> > > > an impact on the expression of TNF-alpha and its receptors in cancer
> > > > cells.
> > > > TNF-alpha represents cytokine very often deregulated at the level of
> > > > both gene expression and signal transmission through TNF-alpha
> > > > receptors (TNFRI and TNFRII).
> > > > The aim of the present study was to analyze the IP6 influence on the
> > > > transcription of genes coding for TNF-alpha and its receptors in human
> > > > colon cancer cells line Caco-2.
> > > > Real-time QRT-PCR based on TaqMan methodology was applied to analyze
> > > > quantitatively the transcript levels of these genes.
> > > > Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2
> > > > cells stimulation for 1, 6, 12 and 24 h.
> > > > The results showed that IP6 modulated the expression of the listed
> > > > genes at transcription level in a dose and time dependent manner.
> > > > The enhanced TNFRI and decreased TNF-alpha and TNFRII transcriptionin
> > > > Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive
> > > > evidence for anti-inflammatory and antitumor activity of IP6.
>
> > > > Acta poloniae pharmaceutica [Acta Pol Pharm]
> > > > ---------------------------------------------------------------------------***------
> > > > The last study found there was not enough evidence to say one
> > > > bisphosphonate was better than another.
> > > > This study found .. phyate IS .. **better**.
>
> > > > "No evidence currently available to definitely confirm that
> > > > one bisphosphonate is better than another"
>
> > > > "Phytate found to be the most effective"
>
> > > > Phytate inhibits bovine pericardium calcification in vitro
> > > > Cardiovascular Pathology, Volume 17, Issue 3, May-June 2008, Pages
> > > > 139-145
> > > > F¨¦lix Grases, Pilar Sanchis, Antonia Costa-Bauz¨¢, Oriol Bonnin,
> > > > Bernat
> > > > Isern, Joan Perell¨®, Rafael M. Prieto
>
> > > > Objective
> > > > The present study examined the inhibitory effects of pyrophosphate,
> > > >etidronate, and phytate on bovine pericardium calcification in vitro..
> > > > Methods
> > > > Bovine pericardium was glutaraldehyde fixed and then placed in a flow
> > > > chamber in the presence of a synthetic physiological fluid alone
> > > > (control) or the fluid plus various concentrations of pyrophosphate,
> > > >etidronate, or phytate. Following a 96-h incubation, fragments were
> > > > removed and assayed for calcification by measuring calcium and
> > > > phosphorus levels.
>
> > > > Results
> > > > The data indicated that both pyrophosphate andetidronateat 1 mg/l
> > > > (5.75 and 4.95 ¦ÌM, respectively) inhibited bovine pericardium
> > > > calcification, whereas neither agent had an effect at 0.5 mg/l (2.87
> > > > and 2.47 ¦ÌM, respectively). Phytate was the most potent inhibitor of
> > > > calcification, and the effects of this agent were apparent at levels
> > > > as low as 0.25 mg/l (0.39 ¦ÌM).
>
> > > > Conclusions
> > > > While pyrophosphate,etidronate, and phytate were all able to inhibit
> > > > bovine pericardium calcification in vitro, phytate was found to be
> > > > the
> > > > most effective.
>
> > > > Who loves ya.
> > > > Tom
>
> > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > > > Man Is A Herbivore!http://tinyurl.com/4rq595
>
> > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> > > Sorry - is this relevant to MS? I have learned while writing my eBook
> > > "Multiple Sclerosis - a Quick Start Guide for the Newly Diagnosed,
> > > their Families and Carers" that antiinflamattory drugs do have
> > > potential as "rescue therapies" but there are risks as well,. It
> > > doesn't sound like this is targeted to help control MS symptoms. Or am
> > > I missing something?
> > > Guy- Hide quoted text -
>
> > > - Show quoted text -- Hide quoted text -
>
> > - Show quoted text -
>
> Of course I know Inflammation is involved in triggering MS atacks,
> otherwise those of us who have MS lesions would often not have too
> much to worry about. But there are lots of inflammatios all over the
> body, and people are trying various anti-inflammatory drugs to see if
> they work to manage MS ("second hand medicines" I call them in my book
> - not to say they are bad, but they need to be tested to see if they
> do help and don't have unexpected side effects). My question was only
> about whether there is anything new and specific to MS in this
> announcement.
> Guy- Hide quoted text -
>
> - Show quoted text -

It can't be called abuse when you like being whipped. Otherwise you would
not post in groups were many don't agree with you and more importantly WON'T
agree with you.

CB
<ironjustice@aol.com> wrote in message
news:4ca66d21-2ced-4186-b79e-3b58e25b015c@56g2000hsm.googlegroups.com...
On Jul 14, 12:07 pm, "Shelley" <no...@nohow.com> wrote:
Nothing ironjustice a.k.a. Tin Pot Tommy says that makes any sense.
Ignore
him and maybe the little troll will go back under his (rusty)
bridge... We
can only hope! <<

There IS .. inflammation IN .. multiple sclerosis ..

NO MATTER what .. these .. people TRY to tell you ..

You must have realized by now .. if you ARE writing an E-book ..
inflammation IS .. involved ..

Sooo .. evidentally .. at the very LEAST .. **you** are privy to the
FACT .. abuse OF .. me .. **specifically** comes .. BEFORE .. 'that
little kid over there'.

These people will tell you NOT to explore .. avenues .. KNOWING full
well those avenues ARE the ones you so desperately .. seek .. JUST in
order to .. abuse .. **me** ..

Leave .. quickly ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> Shelley
>
> "Guy" <guy.thomp...@guyt.co.uk> wrote in message
>
> news:ad1c28d7-6467-49ed-b2c4-0dfeaa30989e@2g2000hsn.googlegroups.com...
> On Jul 13, 5:32 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
>
>
>
>
>
> > Miraculous .. stuff.
>
> > This would be my .. freeee .. bisphosphonate .. aaaa gain.
>
> > Remember .. ? .. the one that is **better** than those .. expensive
> > **unaffordable** .. other bisphosphonates .. like etidronate .. ?
>
> >http://tinyurl.com/2wuhuk
>
> > The influence of phytic acid on TNF-alpha and its receptors genes'
> > expression in colon cancer Caco-2 cells.
> > Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E,
> > Kierot J, Weglarz L
> > Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9.
>
> > Inositol hexaphosphate (IP6, phytic acid) is a naturally occurring
> > carbohydrate abundantly present in high-fiber diets and it is also
> > contained in almost all mammalian cells.
> > It plays an important role in signal transduction, cell proliferation
> > and differentiation. Some natural substances have been shown to elicit
> > an impact on the expression of TNF-alpha and its receptors in cancer
> > cells.
> > TNF-alpha represents cytokine very often deregulated at the level of
> > both gene expression and signal transmission through TNF-alpha
> > receptors (TNFRI and TNFRII).
> > The aim of the present study was to analyze the IP6 influence on the
> > transcription of genes coding for TNF-alpha and its receptors in human
> > colon cancer cells line Caco-2.
> > Real-time QRT-PCR based on TaqMan methodology was applied to analyze
> > quantitatively the transcript levels of these genes.
> > Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2
> > cells stimulation for 1, 6, 12 and 24 h.
> > The results showed that IP6 modulated the expression of the listed
> > genes at transcription level in a dose and time dependent manner.
> > The enhanced TNFRI and decreased TNF-alpha and TNFRII transcription in
> > Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive
> > evidence for anti-inflammatory and antitumor activity of IP6.
>
> > Acta poloniae pharmaceutica [Acta Pol Pharm]
> > ---------------------------------------------------------------------------*------
> > The last study found there was not enough evidence to say one
> > bisphosphonate was better than another.
> > This study found .. phyate IS .. **better**.
>
> > "No evidence currently available to definitely confirm that
> > one bisphosphonate is better than another"
>
> > "Phytate found to be the most effective"
>
> > Phytate inhibits bovine pericardium calcification in vitro
> > Cardiovascular Pathology, Volume 17, Issue 3, May-June 2008, Pages
> > 139-145
> > F¨¦lix Grases, Pilar Sanchis, Antonia Costa-Bauz¨¢, Oriol Bonnin,
> > Bernat
> > Isern, Joan Perell¨®, Rafael M. Prieto
>
> > Objective
> > The present study examined the inhibitory effects of pyrophosphate,
> > etidronate, and phytate on bovine pericardium calcification in vitro.
> > Methods
> > Bovine pericardium was glutaraldehyde fixed and then placed in a flow
> > chamber in the presence of a synthetic physiological fluid alone
> > (control) or the fluid plus various concentrations of pyrophosphate,
> > etidronate, or phytate. Following a 96-h incubation, fragments were
> > removed and assayed for calcification by measuring calcium and
> > phosphorus levels.
>
> > Results
> > The data indicated that both pyrophosphate and etidronate at 1 mg/l
> > (5.75 and 4.95 ¦ÌM, respectively) inhibited bovine pericardium
> > calcification, whereas neither agent had an effect at 0.5 mg/l (2.87
> > and 2.47 ¦ÌM, respectively). Phytate was the most potent inhibitor of
> > calcification, and the effects of this agent were apparent at levels
> > as low as 0.25 mg/l (0.39 ¦ÌM).
>
> > Conclusions
> > While pyrophosphate, etidronate, and phytate were all able to inhibit
> > bovine pericardium calcification in vitro, phytate was found to be
> > the
> > most effective.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!http://tinyurl.com/4rq595
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> Sorry - is this relevant to MS? I have learned while writing my eBook
> "Multiple Sclerosis - a Quick Start Guide for the Newly Diagnosed,
> their Families and Carers" that antiinflamattory drugs do have
> potential as "rescue therapies" but there are risks as well,. It
> doesn't sound like this is targeted to help control MS symptoms. Or am
> I missing something?
> Guy- Hide quoted text -
>
> - Show quoted text -

<ironjustice@aol.com> wrote in message
news:a11e0fbc-088b-4b64-83d0-3fa1b2da5bef@56g2000hsm.googlegroups.com...
On Jul 14, 7:49 pm, "Cheeky Bastard" <InvalidEm...@aol.com> wrote:
<<

>This just .. drips .. of .. support ..

Yes Tommy sticking your head in a bucket of ice water will help you. There's
your support.

Besides you don't come to Usenet looking for support, you just plagiarize
and post to make yourself feel wanted or needed.

Who loves ya Tommy? Who? Who? Tell us.

CB

Guy, are you new to usenet? HE IS A TROLL. He's not here to contribute,
only to cause trouble. You can't have a meaningful dialogue with him and
share ideas, scientific or otherwise. He is a disturbed idiot. And I'm
only encouraging him by writing about him, as well as crossposting, which I
hate, so I'll sign off.

Best of luck with your e-book!

Shelley


"Guy" <guy.thompson@guyt.co.uk> wrote in message
news:afd78826-0f32-44c0-9a9b-4fc2680b5339@p25g2000hsf.googlegroups.com...
On Jul 15, 4:27 am, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
> On Jul 14, 12:07 pm, "Shelley" <no...@nohow.com> wrote:
> Nothing ironjustice a.k.a. Tin Pot Tommy says that makes any sense.
> Ignore
> him and maybe the little troll will go back under his (rusty)
> bridge... We
> can only hope! <<
>
> There IS .. inflammation IN .. multiple sclerosis ..
>
> NO MATTER what .. these .. p