Chemopreventive Chemotherapeutic Curcumin

Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a
biologically active iron chelator.
Jiao Y, Wilkinson J, Di X, Wang W, Hatcher H, Kock ND, D'Agostino R,
Knovich MA, Torti FM, Torti SV
Blood 2008 Sep 24.

Curcumin is a natural product currently in human clinical trials for a
variety of neoplastic, preneoplastic and inflammatory conditions.
We previously observed that in cultured cells, curcumin exhibits
properties of an iron chelator.
To test whether the chelator activity of curcumin is sufficient to
induce iron deficiency in vivo, mice were placed on diets containing
graded concentrations of both iron and curcumin for 26 weeks.
Mice receiving the lowest level of dietary iron exhibited borderline
iron deficiency, with reductions in spleen and liver iron, but little
effect on hemoglobin, hematocrit, transferrin saturation or plasma
iron.
Against this backdrop of subclinical iron deficiency, curcumin exerted
profound effects on systemic iron, inducing a dose-dependent decline
in hematocrit, hemoglobin, serum iron and transferrin saturation, the
appearance of microcytic anisocytotic red blood cells, and decreases
in spleen and liver iron content. Curcumin repressed synthesis of
hepcidin, a peptide that plays a central role in regulation of
systemic iron balance.
These results demonstrate that curcumin has the potential to affect
systemic iron metabolism, particularly in a settling of subclinical
iron deficiency.
This may affect the use of curcumin in patients with marginal iron
stores or those exhibiting the anemia of cancer and chronic disease.

Blood [Blood]
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