EGFR protects cancer cells from starvation via a kinase-independentmechanism

http://www.acor.org/news/whatsnew.html?item_id=6735

EGFR protects cancer cells from starvation via a kinase-independent
mechanism

Published: May 05, 2008


Excerpt

“Our results suggest that EGFR, independent of its kinase activity,
maintains the basal intracellular glucose level and thereby prevents
cancer cells from succumbing to autophagic death. It is possible that this
function of the EGFR may even increase the survival capacity of cancer
cells in the presence of chemotherapeutic agents,” offers study author Dr.
Mien-Chie Hung. The researchers suggest that inhibition of both
EGFR-mediated SGLT1 stabilization and EGFR kinase activity may be
necessary for eradication of epithelial tumors.


Source: Cancer Cell