Food Flavonoids and Cancer Recurrence

Flavonoids to be used to treat iron excess.

http://tinyurl.com/6o4skg
-----------
Consumption of a Flavonol-Rich Diet May Reduce the Risk of Advanced
Adenoma Recurrence
COLORECTAL ADENOMA, ADVANCED ADENOMA RECURRENCE, CANCER - Diet,
Flavonols, Flavonoids, Isoflavonoids, Kaempferol, Genistein,
Formononetin, Beans, Onions, Apples, Tea
"Dietary flavonoids and colorectal adenoma recurrence in the polyp
prevention trial," Bobe G, Lanza E, et al, Cancer Epidemiol Biomarkers
Prev, 2008; 17(6): 1344-53. (Address: Laboratory of Cancer Prevention,
National Cancer Institute-Frederick, Room 110, Building 576,
Frederick, MD 21702-1201, USA. E-mail: gb246f@nih.gov ).
Summary:
In a 4-year, randomized, dietary intervention study involving 1,905
subjects with at least one histologically confirmed colorectal adenoma
identified within 6 months prior to baseline, results indicate that
consumption of a flavonol-rich diet may decrease the risk of advanced
adenoma recurrence.
The subjects were randomized to low-fat (<= 20% of energy), high-fiber
(18g/100 kcal), high-fruit (>= 5 servings per day), and high-vegetable
(>= 5 servings per day) diets. Intake of flavonoids was assessed using
a food frequency questionnaire. Using multivariate logistic regression
models adjusted for potential confounders, total flavonoid intake was
not associated with any or advanced adenoma recurrence.
However, high intake of flavonols - consumption of beans, onions,
apples, and tea - was associated with a reduced risk of advanced
adenoma recurrence, where the highest quartile of flavonol intake was
associated with a 76% reduced risk of advanced adenoma recurrence,
compared with the lowest quartile of intake. Similarly, highest
quartiles for intakes of isoflavonoids, kaempferol, genistein and
formononetin were associated with 54%, 56%, 62%, and 51% reduced risks
of advanced adenoma recurrence, respectively, compared with the
corresponding lowest quartiles of intake.
Thus, the authors of this study conclude, "Our data suggest that a
flavonol-rich diet may decrease the risk of advanced adenoma
recurrence."
-------------------------

Med Hypotheses 1998 Aug;51(2):129-32

The case for iron repletion as a promoter in testicular cancer.

Crawford RD

Department of Chemistry and Biochemistry, Loyola Marymount University,
Los Angeles, CA 90045-8225, USA.
The incidence of testicular cancer has increased considerably in this
century.
Current hypotheses (most specifically, those concerning
environmental estrogens) show inconsistencies with this increase,
either in terms of time course or individual exposure to proposed
promoters. This new hypothesis, which attributes the increased
incidence in testicular cancer to our current more iron-replete
dietary status, is devoid of these inconsistencies. Evidence to
support this hypothesis includes the following: (a) the iron-related
mechanism of drugs used in the treatment of testicular cancer, (b)
dietary associations with disease frequency, (c) the similarity of
time course between historic increases in testicular cancer incidence
and dietary iron availability, and (d) potential genetic associations
with hemochromatosis. The link between incidence of the cancer and
cyptorchidism is also addressed. The article concludes with potential
experimental approaches to test the hypothesis.
PMID: 9881819, UI: 99096146
---------------
J Gastroenterol Hepatol 2001 May;16(5):491-4

Iron and hepatocellular carcinoma.

Deugnier Y, Turlin B

*Clinique des Maladies du Foie,Laboratoire d'Anatomie Pathologie B
and*,Institut National de la Sante et de la Recherche Medicale, Unite
522, Hopital Pontchaillou, Rennes, France.

The high prevalence of hepatocellular carcinoma (HCC) in genetic
hemochromatosis (GH) and the association between increased body iron
stores and occurrence of HCC in subjects with iron overload unrelated
to GH, and the experimental evidence of a co-carcinogenic role of iron
strongly support that iron is involved in the development of HCC.

PMID: 11350542, UI: 21248950
___

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Tom


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On Jul 6, 3:20*pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
Flavonoids to be used to treat iron excess. http://tinyurl.com/6o4skg
<<

"Activity could be ascribed to flavonoids iron-chelating
effectiveness"

Antioxidant and iron-chelating activities of the flavonoids catechin,
quercetin and diosmetin on iron-loaded rat hepatocyte cultures

Isabelle Morela, , Gérard Lescoat†, Pascale Cogrela, Odile Sergenta,
Nicole Pasdeloup†, Pierre Brissot†, Pierre Cillarda and Josiane
Cillarda

a Laboratoire de Biologie Cellulaire et Végétale, UFR des Sciences
Pharmaceutiques, 2 av., du Pr. Léon Bernard, France

† INSERM U.49, Unité de Recherches Hépatologiques, Hôpital
Pontchaillou, Rennes, France


Received 8 May 1992; accepted 12 October 1992. ; Available online 15
November 2002.




References and further reading may be available for this article. To
view references and further reading you must purchase this article.


Abstract
The cytoprotective effect of three flavonoids, catechin, quercetin and
diosmetin, was investigated on iron-loaded hepatocyte cultures,
considering two parameters: the prevention of iron-increased lipid
peroxidation and the inhibition of intracellular enzyme release. These
two criteria of cytoprotection allowed the calculation of mean
inhibitory concentrations ( 50) which revealed that the effectiveness
of these flavonoids could be classified as follows: catechin >
quercetin > diosmetin. These 50 values have been related to
structural characteristics of the flavonoids tested. Moreover, the
investigation of the capacity of these flavonoids to remove iron from
iron-loaded hepatocytes revealed a good relationship between this iron-
chelating ability and the cytoprotective effect. The cytoprotective
activity of catechin, quercetin and diosmetin could thus be ascribed
to their widely known antiradical property but also to their iron-
chelating effectiveness. These findings increase further the prospects
for the development and clinical application of these potent
antioxidants.

Abbreviations: Fe-NTA, ferric iron nitrilotriacetate; NTA,
nitrilotriacetic acid; MDA, malondialdehyde; LDH, lactate
dehydrogenase; DMSO, dimethyl sulfoxide

Article Outline
• References


Biochemical Pharmacology
Volume 45, Issue 1, 7 January 1993, Pages 13-19
doi:10.1016/0006-2952(93)90371-3
Copyright © 1993 Published by Elsevier Science Inc.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> -----------
> Consumption of a Flavonol-Rich Diet May Reduce the Risk of Advanced
> Adenoma Recurrence
> COLORECTAL ADENOMA, ADVANCED ADENOMA RECURRENCE, CANCER - Diet,
> Flavonols, Flavonoids, Isoflavonoids, Kaempferol, Genistein,
> Formononetin, Beans, Onions, Apples, Tea
> "Dietary flavonoids and colorectal adenoma recurrence in the polyp
> prevention trial," Bobe G, Lanza E, et al, Cancer Epidemiol Biomarkers
> Prev, 2008; 17(6): 1344-53. (Address: Laboratory of Cancer Prevention,
> National Cancer Institute-Frederick, Room 110, Building 576,
> Frederick, MD 21702-1201, USA. E-mail: gb2...@nih.gov ).
> Summary:
> In a 4-year, randomized, dietary intervention study involving 1,905
> subjects with at least one histologically confirmed colorectal adenoma
> identified within 6 months prior to baseline, results indicate that
> consumption of a flavonol-rich diet may decrease the risk of advanced
> adenoma recurrence.
> The subjects were randomized to low-fat (<= 20% of energy), high-fiber
> (18g/100 kcal), high-fruit (>= 5 servings per day), and high-vegetable
> (>= 5 servings per day) diets. Intake of flavonoids was assessed using
> a food frequency questionnaire. Using multivariate logistic regression
> models adjusted for potential confounders, total flavonoid intake was
> not associated with any or advanced adenoma recurrence.
> However, high intake of flavonols - consumption of beans, onions,
> apples, and tea - was associated with a reduced risk of advanced
> adenoma recurrence, where the highest quartile of flavonol intake was
> associated with a 76% reduced risk of advanced adenoma recurrence,
> compared with the lowest quartile of intake. Similarly, highest
> quartiles for intakes of isoflavonoids, kaempferol, genistein and
> formononetin were associated with 54%, 56%, 62%, and 51% reduced risks
> of advanced adenoma recurrence, respectively, compared with the
> corresponding lowest quartiles of intake.
> Thus, the authors of this study conclude, "Our data suggest that a
> flavonol-rich diet may decrease the risk of advanced adenoma
> recurrence."
> -------------------------
>
> Med Hypotheses 1998 Aug;51(2):129-32
>
> The case for iron repletion as a promoter in testicular cancer.
>
> Crawford RD
>
> Department of Chemistry and Biochemistry, Loyola Marymount University,
> Los Angeles, CA 90045-8225, USA.
> The incidence of testicular cancer has increased considerably in this
> century.
> Current hypotheses (most specifically, those concerning
> environmental estrogens) show inconsistencies with this increase,
> either in terms of time course or individual exposure to proposed
> promoters. This new hypothesis, which attributes the increased
> incidence in testicular cancer to our current more iron-replete
> dietary status, is devoid of these inconsistencies. Evidence to
> support this hypothesis includes the following: (a) the iron-related
> mechanism of drugs used in the treatment of testicular cancer, (b)
> dietary associations with disease frequency, (c) the similarity of
> time course between historic increases in testicular cancer incidence
> and dietary iron availability, and (d) potential genetic associations
> with hemochromatosis. The link between incidence of the cancer and
> cyptorchidism is also addressed. The article concludes with potential
> experimental approaches to test the hypothesis.
> PMID: 9881819, UI: 99096146
> ---------------
> J Gastroenterol Hepatol 2001 May;16(5):491-4
>
> Iron and hepatocellular carcinoma.
>
> Deugnier Y, Turlin B
>
> *Clinique des Maladies du Foie,Laboratoire d'Anatomie Pathologie B
> and*,Institut National de la Sante et de la Recherche Medicale, Unite
> 522, Hopital Pontchaillou, Rennes, France.
>
> The high prevalence of hepatocellular carcinoma (HCC) in genetic
> hemochromatosis (GH) and the association between increased body iron
> stores and occurrence of HCC in subjects with iron overload unrelated
> to GH, and the experimental evidence of a co-carcinogenic role of iron
> strongly support that iron is involved in the development of HCC.
>
> PMID: 11350542, UI: 21248950
> * * *___
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

On Jul 6, 3:30*pm, "ironjust...@aol.com" <ironjust...@aol.com>
wrote:iron-chelating flavonoids catechin, quercetin and diosmetin <<

This is a commercial site but gives a pretty good idea.

http://www.catechinskincare.com/NewF...ecatechins.php

What Are Catechins?


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




> On Jul 6, 3:20*pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
> *Flavonoids to be used to treat iron excess.http://tinyurl.com/6o4skg
> <<
>
> "Activity could be ascribed to flavonoids iron-chelating
> effectiveness"
>
> Antioxidant and iron-chelating activities of the flavonoids catechin,
> quercetin and diosmetin on iron-loaded rat hepatocyte cultures
>
> Isabelle Morela, , Gérard Lescoat†, Pascale Cogrela, Odile Sergenta,
> Nicole Pasdeloup†, Pierre Brissot†, Pierre Cillarda and Josiane
> Cillarda
>
> a Laboratoire de Biologie Cellulaire et Végétale, UFR des Sciences
> Pharmaceutiques, 2 av., du Pr. Léon Bernard, France
>
> † INSERM U.49, Unité de Recherches Hépatologiques, Hôpital
> Pontchaillou, Rennes, France
>
> Received 8 May 1992; *accepted 12 October 1992. ; Available online 15
> November 2002.
>
> References and further reading may be available for this article. To
> view references and further reading you must purchase this article.
>
> Abstract
> The cytoprotective effect of three flavonoids, catechin, quercetin and
> diosmetin, was investigated on iron-loaded hepatocyte cultures,
> considering two parameters: the prevention of iron-increased lipid
> peroxidation and the inhibition of intracellular enzyme release. These
> two criteria of cytoprotection allowed the calculation of mean
> inhibitory concentrations ( 50) which revealed that the effectiveness
> of these flavonoids could be classified as follows: catechin >
> quercetin > diosmetin. These *50 values have been related to
> structural characteristics of the flavonoids tested. Moreover, the
> investigation of the capacity of these flavonoids to remove iron from
> iron-loaded hepatocytes revealed a good relationship between this iron-
> chelating ability and the cytoprotective effect. The cytoprotective
> activity of catechin, quercetin and diosmetin could thus be ascribed
> to their widely known antiradical property but also to their iron-
> chelating effectiveness. These findings increase further the prospects
> for the development and clinical application of these potent
> antioxidants.
>
> Abbreviations: Fe-NTA, ferric iron nitrilotriacetate; NTA,
> nitrilotriacetic acid; MDA, malondialdehyde; LDH, lactate
> dehydrogenase; DMSO, dimethyl sulfoxide
>
> Article Outline
> • References
>
> Biochemical Pharmacology
> Volume 45, Issue 1, 7 January 1993, Pages 13-19
> doi:10.1016/0006-2952(93)90371-3
> Copyright © 1993 Published by Elsevier Science Inc.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > -----------
> > Consumption of a Flavonol-Rich Diet May Reduce the Risk of Advanced
> > Adenoma Recurrence
> > COLORECTAL ADENOMA, ADVANCED ADENOMA RECURRENCE, CANCER - Diet,
> > Flavonols, Flavonoids, Isoflavonoids, Kaempferol, Genistein,
> > Formononetin, Beans, Onions, Apples, Tea
> > "Dietary flavonoids and colorectal adenoma recurrence in the polyp
> > prevention trial," Bobe G, Lanza E, et al, Cancer Epidemiol Biomarkers
> > Prev, 2008; 17(6): 1344-53. (Address: Laboratory of Cancer Prevention,
> > National Cancer Institute-Frederick, Room 110, Building 576,
> > Frederick, MD 21702-1201, USA. E-mail: gb2...@nih.gov ).
> > Summary:
> > In a 4-year, randomized, dietary intervention study involving 1,905
> > subjects with at least one histologically confirmed colorectal adenoma
> > identified within 6 months prior to baseline, results indicate that
> > consumption of a flavonol-rich diet may decrease the risk of advanced
> > adenoma recurrence.
> > The subjects were randomized to low-fat (<= 20% of energy), high-fiber
> > (18g/100 kcal), high-fruit (>= 5 servings per day), and high-vegetable
> > (>= 5 servings per day) diets. Intake of flavonoids was assessed using
> > a food frequency questionnaire. Using multivariate logistic regression
> > models adjusted for potential confounders, total flavonoid intake was
> > not associated with any or advanced adenoma recurrence.
> > However, high intake of flavonols - consumption of beans, onions,
> > apples, and tea - was associated with a reduced risk of advanced
> > adenoma recurrence, where the highest quartile of flavonol intake was
> > associated with a 76% reduced risk of advanced adenoma recurrence,
> > compared with the lowest quartile of intake. Similarly, highest
> > quartiles for intakes of isoflavonoids, kaempferol, genistein and
> > formononetin were associated with 54%, 56%, 62%, and 51% reduced risks
> > of advanced adenoma recurrence, respectively, compared with the
> > corresponding lowest quartiles of intake.
> > Thus, the authors of this study conclude, "Our data suggest that a
> > flavonol-rich diet may decrease the risk of advanced adenoma
> > recurrence."
> > -------------------------
>
> > Med Hypotheses 1998 Aug;51(2):129-32
>
> > The case for iron repletion as a promoter in testicular cancer.
>
> > Crawford RD
>
> > Department of Chemistry and Biochemistry, Loyola Marymount University,
> > Los Angeles, CA 90045-8225, USA.
> > The incidence of testicular cancer has increased considerably in this
> > century.
> > Current hypotheses (most specifically, those concerning
> > environmental estrogens) show inconsistencies with this increase,
> > either in terms of time course or individual exposure to proposed
> > promoters. This new hypothesis, which attributes the increased
> > incidence in testicular cancer to our current more iron-replete
> > dietary status, is devoid of these inconsistencies. Evidence to
> > support this hypothesis includes the following: (a) the iron-related
> > mechanism of drugs used in the treatment of testicular cancer, (b)
> > dietary associations with disease frequency, (c) the similarity of
> > time course between historic increases in testicular cancer incidence
> > and dietary iron availability, and (d) potential genetic associations
> > with hemochromatosis. The link between incidence of the cancer and
> > cyptorchidism is also addressed. The article concludes with potential
> > experimental approaches to test the hypothesis.
> > PMID: 9881819, UI: 99096146
> > ---------------
> > J Gastroenterol Hepatol 2001 May;16(5):491-4
>
> > Iron and hepatocellular carcinoma.
>
> > Deugnier Y, Turlin B
>
> > *Clinique des Maladies du Foie,Laboratoire d'Anatomie Pathologie B
> > and*,Institut National de la Sante et de la Recherche Medicale, Unite
> > 522, Hopital Pontchaillou, Rennes, France.
>
> > The high prevalence of hepatocellular carcinoma (HCC) in genetic
> > hemochromatosis (GH) and the association between increased body iron
> > stores and occurrence of HCC in subjects with iron overload unrelated
> > to GH, and the experimental evidence of a co-carcinogenic role of iron
> > strongly support that iron is involved in the development of HCC.
>
> > PMID: 11350542, UI: 21248950
> > * * *___
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!http://tinyurl.com/4rq595
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -
>
> - Show quoted text -