The Great Promise Of Iron Depletion

Summary
Expert Opinion on Therapeutic Patents
November 2006, Vol. 16, No. 11, Pages 1533-1556
(doi:10.1517/13543776.16.11.1533)

Iron chelators as therapeutic iron depletion agents
Noah Birch�1, Xiang Wang�1 & Hyun-Soon Chong�1
1Chemistry Division, Biological, Chemical and Physical Sciences
Department,Illinois Institute of Technology, Chicago, IL 60616, USA.
Chong@iit.edu
† Author for correspondence

The great promise of iron depletion as a therapeutic strategy for
various diseases, including iron overload, cancers, Alzheimer’s
disease, Parkinson’s disease, tuberculosis, HIV, and fungal and
malaria infection, has stimulated research on the development of iron
chelators as iron depletion agents. In November 2005, the FDA approved
deferasirox (ICL670A; Exjade®), the first once-daily oral drug for
treatment of chronic iron overload. So far, five iron chelators,
deferoxamine, deferiprone, deferasirox, dexrazorane and ciclopirox,
have been approved for use in iron overload, anticancer or antifungal
therapy. Triapine® is in Phase I and II clinical trials for the
treatment of various metastatic and solid cancers. A desferrithiocin
analogue, deferitrin, is presently in a Phase I trial for the
treatment of iron overload diseases. Among the iron chelators being
evaluated in preclinical settings are the analogues of deferiprone,
pyridoxal isonicotinoyl hydrazone, desferrithiocin, deferoxamine,
thiosemicarbazone, tachpyridine, N,N'-bis(2-
hydroxybenzyl)ethylenediamine-N,N'-diacetic acid and hydroxyquinoline.
This review describes the comparative properties of iron chelators in
clinical use and evaluates the patent status of the novel synthetic
iron chelators in preclinical settings.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Mar 2, 10:02*am, ironjustice <teamtan...@hotmail.com> wrote:
> Summary
> Expert Opinion on Therapeutic Patents
> November 2006, Vol. 16, No. 11, Pages 1533-1556
> (doi:10.1517/13543776.16.11.1533)
>
> Iron chelators as therapeutic iron depletion agents
> Noah Birch 1, Xiang Wang 1 & Hyun-Soon Chong 1
> 1Chemistry Division, Biological, Chemical and Physical Sciences
> Department,Illinois Institute of Technology, Chicago, IL 60616, USA.
> Ch...@iit.edu
> † Author for correspondence
>
> The great promise of iron depletion as a therapeutic strategy for
> various diseases, including iron overload, cancers, Alzheimer’s
> disease, Parkinson’s disease, tuberculosis, HIV, and fungal and
> malaria infection, has stimulated research on the development of iron
> chelators as iron depletion agents. In November 2005, the FDA approved
> deferasirox (ICL670A; Exjade®), the first once-daily oral drug for
> treatment of chronic iron overload. So far, five iron chelators,
> deferoxamine, deferiprone, deferasirox, dexrazorane and ciclopirox,
> have been approved for use in iron overload, anticancer or antifungal
> therapy. Triapine® is in Phase I and II clinical trials for the
> treatment of various metastatic and solid cancers. A desferrithiocin
> analogue, deferitrin, is presently in a Phase I trial for the
> treatment of iron overload diseases. Among the iron chelators being
> evaluated in preclinical settings are the analogues of deferiprone,
> pyridoxal isonicotinoyl hydrazone, desferrithiocin, deferoxamine,
> thiosemicarbazone, tachpyridine, N,N'-bis(2-
> hydroxybenzyl)ethylenediamine-N,N'-diacetic acid and hydroxyquinoline.
> This review describes the comparative properties of iron chelators in
> clinical use and evaluates the patent status of the novel synthetic
> iron chelators in preclinical settings.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

Very intersting, but...

It seems to me that this is the usual medical quackery.
Spend millions defining a symptom.
Spend more millions developing a drug to treat the symptom.
Gain Billions using the new drug to treat the symptom.

Very profitable, but...what is the cause? Why not just eliminate the
cause of the symptom?

DrCee
You cannot secure nor restore health with pus or poisons.

On 2 Mar, 19:24, drcee...@insightbb.com wrote:
> On Mar 2, 10:02 am, ironjustice <teamtan...@hotmail.com> wrote:
>
>
>
> > Summary
> > Expert Opinion on Therapeutic Patents
> > November 2006, Vol. 16, No. 11, Pages 1533-1556
> > (doi:10.1517/13543776.16.11.1533)
>
> > Iron chelators as therapeutic iron depletion agents
> > Noah Birch 1, Xiang Wang 1 & Hyun-Soon Chong 1
> > 1Chemistry Division, Biological, Chemical and Physical Sciences
> > Department,Illinois Institute of Technology, Chicago, IL 60616, USA.
> > Ch...@iit.edu
> > † Author for correspondence
>
> > The great promise of iron depletion as a therapeutic strategy for
> > various diseases, including iron overload, cancers, Alzheimer’s
> > disease, Parkinson’s disease, tuberculosis, HIV, and fungal and
> > malaria infection, has stimulated research on the development of iron
> > chelators as iron depletion agents. In November 2005, the FDA approved
> > deferasirox (ICL670A; Exjade®), the first once-daily oral drug for
> > treatment of chronic iron overload. So far, five iron chelators,
> > deferoxamine, deferiprone, deferasirox, dexrazorane and ciclopirox,
> > have been approved for use in iron overload, anticancer or antifungal
> > therapy. Triapine® is in Phase I and II clinical trials for the
> > treatment of various metastatic and solid cancers. A desferrithiocin
> > analogue, deferitrin, is presently in a Phase I trial for the
> > treatment of iron overload diseases. Among the iron chelators being
> > evaluated in preclinical settings are the analogues of deferiprone,
> > pyridoxal isonicotinoyl hydrazone, desferrithiocin, deferoxamine,
> > thiosemicarbazone, tachpyridine, N,N'-bis(2-
> > hydroxybenzyl)ethylenediamine-N,N'-diacetic acid and hydroxyquinoline.
> > This review describes the comparative properties of iron chelators in
> > clinical use and evaluates the patent status of the novel synthetic
> > iron chelators in preclinical settings.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> > Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> Very intersting, but...
>
> It seems to me that this is the usual medical quackery.
> Spend millions defining a symptom.
> Spend more millions developing a drug to treat the symptom.
> Gain Billions using the new drug to treat the symptom.
>
> Very profitable, but...what is the cause? Why not just eliminate the
> cause of the symptom?
>
> DrCee
> You cannot secure nor restore health with pus or poisons.

Agreed, seems like its being done the long way!

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