IP6 and cancer

Inositol hexaphosphate represses telomerase activity and translocates
TERT from the nucleus in mouse and human prostate cancer cells via the
deactivation of Akt and PKCalpha.
Jagadeesh S, Banerjee PP
Biochem Biophys Res Commun. 2006 Nov 3; 349(4): 1361-7

Inositol hexaphosphate (IP6) has anti-proliferative effects on a
variety of cancer cells, including prostate cancer. However, the
molecular mechanism of anti-proliferative effects of IP6 is not
entirely understood. Since the activation of telomerase is crucial for
cells to gain immortality and proliferation ability, we examined the
role of IP6 in the regulation of telomerase activity in prostate cancer
cells. Here, we show that IP6 represses telomerase activity in mouse
and human prostate cancer cells dose-dependently. In addition, IP6
prevents the translocation of TERT to the nucleus. Since
phosphorylation of TERT by Akt and/or PKCalpha is necessary for nuclear
translocation, we examined phosphorylation of Akt and PKCalpha after
IP6 treatments. Our results show that IP6 inhibits phosphorylation of
Akt and PKCalpha. These results show for the first time that IP6
represses telomerase activity in prostate cancer cells by
posttranslational modification of TERT via the deactivation of Akt and
PKCalpha.


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Terms Related · Graph Tag · Scopus · Cites
10.1016/j.bbrc.2006.09.002


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