Iron acts as a tumour initiator

Human & Experimental Toxicology, Vol. 24, No. 8, 409-413 (2005)
DOI: 10.1191/0960327105ht544oa
© 2005 SAGE Publications

Evidence that iron overload plus croton oil induce skin tumours in mice

H Rezazadeh
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz
University of Medical Sciences, Tabriz-51664, Iran;
rezafar81@hotmail.com

A R Nayebi

A Garjani

A Sheikhulislami

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz
University of Medical Sciences, Tabriz, Iran

H Babaei

Drug Applied Research Center, Tabriz University of Medical Sciences,
Tabriz, Iran

Iron overload is known to occur due to different factors including
genetic disorders. It has been shown that iron overload predisposes
humans to an increased risk of cancer. However, the mechanism by which
iron overload enhances chemically induced carcinogenesis is not known.
In this report, for the first time it is shown that iron overload acts
as a tumour initiator. Female albino Swiss mice were given iron dextran
1 mg/mouse per day intramuscularly for 15 days and croton oil 0.5 mg in
200 mL acetone/mouse topically twice a week for 30 weeks. During this
period, the animals were observed for tumour incidence. There were
significantly higher yields of tumours in those animals receiving both
iron and croton oil. However, the group of animals treated only with
acetone, iron, croton oil and 7,12-dimethylben-z(a)anthracene (DMBA)
alone did not develop any tumours during 30 weeks of observation.
Further, croton oil-mediated induction in cutaneous lipid peroxidation
(LPO) level was higher in the iron-overload group. The results of this
study suggest that oxidative stress generated by iron overload is
responsible for croton oil mediated skin carcinogenesis.


Key Words: croton oil · iron overload · skin tumorigenesis

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