Iron and Alcohol / Liver Cancer

http://content.karger.com/ProdukteDB....asp?Doi=95072

<<snip>>
evidence that the potential of ethanol and iron to induce oxidative
stress is an important pathomechanism underlying development of
Hepatocellular Carcinoma
<<snip>>


Alcohol, Tobacco and Cancer

Alcohol and Iron as Cofactors in Hepatocellular Carcinoma

Petersen D

Cho CH, Purohit V (eds): Alcohol, Tobacco and Cancer. Basel, Karger,
2006, pp 175-188 (DOI: 10.1159/000095072)

Article (PDF 96 KB) Free Preview


Abstract:
Oxidative stress is recognized as a central mechanism in the initiation
and promotion stages of carcinogenesis. The combined pro-oxidant
potential of ethanol and iron ranges from additive to synergistic with
respect to initiating hepatocellular oxidative stress through
antioxidant depletion. Disorders such as hemochromatosis and alcoholic
liver disease are associated with significant oxidative stress and the
hepatic accumulation of iron, both of which are predisposing factors
for development of hepatocellular carcinoma (HCC). Sustained oxidative
stress and redox imbalance associated with exposure to alcohol and iron
results in DNA damage and the activation of cellular transcription
factors which, in turn, initiate or contribute to neoplastic
progression of the liver. Evidence is now emerging that activation of
the transcription factor nuclear factor-B in hepatic macrophage plays a
significant role in initiation and propagation of early malignant
clones that eventually lead to the development of HCC. Consequently,
there is persuasive evidence that the potential of ethanol and iron to
induce oxidative stress is an important pathomechanism underlying
development of HCC. This review summarizes recently published studies,
which describe the cellular events and mechanisms potentially involved
in initiation and progression of HCC in individuals experiencing
oxidative stress as a consequence of hepatic iron accumulation and
chronic alcohol ingestion.



© 2006 S. Karger AG, Basel


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