Iron withholding: a defense against disease.
J Alzheimers Dis 2008 May; 13(4):451-63.
Weinberg ED, Miklossy J
Excessive and misplaced iron promotes an array of neurodegenerative
and endocrine diseases as well as cardiomyopathy, arthropathy,
neoplasia and infection.
Vertebrates maintain an iron withholding defense system designed to
prevent accumulation of redox-active (free) iron in sensitive sites
and to sequester the metal in innocuous packages.
Numerous genetic, behavioral and environmental factors counteract the
defense system.
Our increasing awareness of the pathologic roles of iron, as well as
of the methods for prevention of iron loading coupled with intensified
research and development of tissue specific iron chelator drugs, can
be expected to yield marked improvements in human health.
Journal of Alzheimer's disease : JAD [J Alzheimers Dis]
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