Leukemia and Oxidative Stress

Malondialdehyde and protein carbonyl as biomarkers for oxidative
stress and disease progression in patients with chronic myeloid
leukemia.
In Vivo. 2008 Jul-Aug;22(4):525-8.
Ahmad R, Tripathi AK, Tripathi P, Singh S, Singh R, Singh RK.
Department of Biochemistry, C.S.M. Medical University, Lucknow, India.

BACKGROUND:
Oxidative stress, a pervasive condition of an increased amount of free
radicals, is now recognized to be prominent feature of various
diseases and their progression. However, evidence for this association
has often been lacking because of a lack of specific biomarkers and
methods available to evaluate oxidative stress status in humans with
disease conditions. Emphasis is now being placed on biomarkers of
oxidative stress, which can be objectively measured and evaluated as
indicators of normal biological and pathogenic processes. The aim of
this study was to investigate the plasma levels of malondialdehyde
(MDA) and protein carbonyl (PC) as biomarkers for oxidative stress and
disease progression in patients with chronic myeloid leukemia (CML).
MATERIALS AND METHODS:
The study included 20 CML patients and 10 age-and sex-matched healthy
control volunteers. The mean age of CML patients was 37.11+/-11.36
years and that of controls was 31.07+/-7.60 years.
RESULTS:
There was a significant increase (p<0.05) in plasma MDA and PC levels
in CML patients as compared to healthy volunteers. Our results also
showed that plasma MDA and PC levels were significantly higher
(p<0.001) in both chronic phase (CML-CP) and accelerated phase (CML-
AP) as compared to healthy volunteers. During the follow-up of 12
months, two patients of CML-CP progressed to the accelerated phase.
The mean plasma levels of MDA and PC in patients with CML-CP who
progressed to CML-AP were found to be higher than in patients with CML-
CP who did not progress to the accelerated phase.
CONCLUSION:
Plasma MDA and PC appears to reflect the oxidative stress status and
disease progression in CML and can be used as biomarkers for oxidative
stress and disease progression.

PMID: 18712183


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Does oxidative stress cause the progression of leukemia or is oxidative
stress a result of the disease itself?

"ironjustice" <teamtanner@hotmail.com> wrote in message
news:098acde0-06c4-4743-b972-c282db287762@79g2000hsk.googlegroups.com...
> Malondialdehyde and protein carbonyl as biomarkers for oxidative
> stress and disease progression in patients with chronic myeloid
> leukemia.
> In Vivo. 2008 Jul-Aug;22(4):525-8.
> Ahmad R, Tripathi AK, Tripathi P, Singh S, Singh R, Singh RK.
> Department of Biochemistry, C.S.M. Medical University, Lucknow, India.
>
> BACKGROUND:
> Oxidative stress, a pervasive condition of an increased amount of free
> radicals, is now recognized to be prominent feature of various
> diseases and their progression. However, evidence for this association
> has often been lacking because of a lack of specific biomarkers and
> methods available to evaluate oxidative stress status in humans with
> disease conditions. Emphasis is now being placed on biomarkers of
> oxidative stress, which can be objectively measured and evaluated as
> indicators of normal biological and pathogenic processes. The aim of
> this study was to investigate the plasma levels of malondialdehyde
> (MDA) and protein carbonyl (PC) as biomarkers for oxidative stress and
> disease progression in patients with chronic myeloid leukemia (CML).
> MATERIALS AND METHODS:
> The study included 20 CML patients and 10 age-and sex-matched healthy
> control volunteers. The mean age of CML patients was 37.11+/-11.36
> years and that of controls was 31.07+/-7.60 years.
> RESULTS:
> There was a significant increase (p<0.05) in plasma MDA and PC levels
> in CML patients as compared to healthy volunteers. Our results also
> showed that plasma MDA and PC levels were significantly higher
> (p<0.001) in both chronic phase (CML-CP) and accelerated phase (CML-
> AP) as compared to healthy volunteers. During the follow-up of 12
> months, two patients of CML-CP progressed to the accelerated phase.
> The mean plasma levels of MDA and PC in patients with CML-CP who
> progressed to CML-AP were found to be higher than in patients with CML-
> CP who did not progress to the accelerated phase.
> CONCLUSION:
> Plasma MDA and PC appears to reflect the oxidative stress status and
> disease progression in CML and can be used as biomarkers for oxidative
> stress and disease progression.
>
> PMID: 18712183
>
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://tinyurl.com/634q5a
>
>
> Man Is A Herbivore!
> http://tinyurl.com/4rq595
>
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
>

> Malondialdehyde and protein carbonyl as biomarkers for oxidative
> stress and disease progression in patients with chronic myeloid
> leukemia.

Risk of leukaemia among pesticide manufacturing workers: a review and
meta-analysis of cohort studies.
PURPOSE: The purpose of this paper is to review available cohort
studies and to estimate quantitatively the association between
occupational exposure in plants manufacturing pesticides and
leukaemia. ... Exposure to pesticides may be a significant risk factor
for specifically developing myeloid leukaemia and there is a need for
additional large well-conducted studies with clear definition of
exposure and of leukaemia type(s). PMID: 18028905

> Malondialdehyde and protein carbonyl as biomarkers for oxidative
> stress and disease progression in patients with chronic myeloid
> leukemia.

Below abstract indicates invlovement of Aryl Hydrocarbon Meditated
Pathways in myeloblastic leukemia.

The t(1;12)(q21;p13) translocation of human acute myeloblastic
leukemia results in a TEL-ARNT fusion.
The TEL/ETV6 gene is located at 12p13 and encodes a member of the ETS
family of transcription factors. Translocated ETS leukemia (TEL) is
frequently involved in chromosomal translocations in human
malignancies, usually resulting in the expression of fusion proteins
between the amino-terminal part of TEL and either unrelated
transcription factors or protein tyrosine kinases. We have
characterized a t(1;12)(q21;p13) translocation in an acute
myeloblastic leukemia (AML-M2). At the protein level, the
untranslocated TEL copy and, as a result of the t(1;12) translocation,
a fusion protein between TEL and essentially all of aryl hydrocarbon
receptor nuclear translocator (ARNT) are expressed. The involvement of
ARNT in human leukemogenesis has not been previously described. The
ARNT protein belongs to a subfamily of the "basic region helix-loop-
helix" (bHLH) protein that shares an additional region of similarity
called the PAS (Per, ARNT, SIM) domain. ARNT is the central partner of
several heterodimeric transcription factors, including those
containing the aryl hydrocarbon (dioxin) receptor (AhR) and the
hypoxia-inducible factor 1alpha (HIF1alpha). Our results show that the
TEL-ARNT fusion protein is the crucial product of the translocation
and suggest that interference with the activity of AhR or HIF1alpha
can contribute to leukemogenesis. PMID: 10829078

On Aug 25, 4:11*pm, jay <jaym1...@hotmail.com> wrote: Malondialdehyde
and protein carbonyl as biomarkers for oxidative stress and disease
progression <<

The thread is oxidative stress ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/634q5a


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Aug 25, 4:15*pm, jay <jaym1...@hotmail.com> wrote: Malondialdehyde
and protein carbonyl as biomarkers for oxidative stress and disease
progression <<

The thread is oxidative stress ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/634q5a


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Aug 25, 2:20*pm, "kaptan" <nospam.thanks> wrote:
Does oxidative stress cause the progression of leukemia or is
oxidative
stress a result of the disease itself? <<

It doesn't look like this study addressed that at all ..

This article says that **elevated** malondialdehydes and protein
carbonyls can be used as markers for "things going south" ..

CONCLUSION:
Plasma MDA and PC appears to reflect the oxidative stress status and
disease progression in CML and can be used as biomarkers for
oxidative
stress and disease progression.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/634q5a


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




>
> "ironjustice" <teamtan...@hotmail.com> wrote in message
>
> news:098acde0-06c4-4743-b972-c282db287762@79g2000hsk.googlegroups.com...
>
>
>
> > Malondialdehyde and protein carbonyl as biomarkers for oxidative
> > stress and disease progression in patients with chronic myeloid
> > leukemia.
> > In Vivo. 2008 Jul-Aug;22(4):525-8.
> > Ahmad R, Tripathi AK, Tripathi P, Singh S, Singh R, Singh RK.
> > Department of Biochemistry, C.S.M. Medical University, Lucknow, India.
>
> > BACKGROUND:
> > Oxidative stress, a pervasive condition of an increased amount of free
> > radicals, is now recognized to be prominent feature of various
> > diseases and their progression. However, evidence for this association
> > has often been lacking because of a lack of specific biomarkers and
> > methods available to evaluate oxidative stress status in humans with
> > disease conditions. Emphasis is now being placed on biomarkers of
> > oxidative stress, which can be objectively measured and evaluated as
> > indicators of normal biological and pathogenic processes. The aim of
> > this study was to investigate the plasma levels of malondialdehyde
> > (MDA) and protein carbonyl (PC) as biomarkers for oxidative stress and
> > disease progression in patients with chronic myeloid leukemia (CML).
> > MATERIALS AND METHODS:
> > The study included 20 CML patients and 10 age-and sex-matched healthy
> > control volunteers. The mean age of CML patients was 37.11+/-11.36
> > years and that of controls was 31.07+/-7.60 years.
> > RESULTS:
> > There was a significant increase (p<0.05) in plasma MDA and PC levels
> > in CML patients as compared to healthy volunteers. Our results also
> > showed that plasma MDA and PC levels were significantly higher
> > (p<0.001) in both chronic phase (CML-CP) and accelerated phase (CML-
> > AP) as compared to healthy volunteers. During the follow-up of 12
> > months, two patients of CML-CP progressed to the accelerated phase.
> > The mean plasma levels of MDA and PC in patients with CML-CP who
> > progressed to CML-AP were found to be higher than in patients with CML-
> > CP who did not progress to the accelerated phase.
> > CONCLUSION:
> > Plasma MDA and PC appears to reflect the oxidative stress status and
> > disease progression in CML and can be used as biomarkers for oxidative
> > stress and disease progression.
>
> > PMID: 18712183
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!
> >http://tinyurl.com/634q5a
>
> > Man Is A Herbivore!
> >http://tinyurl.com/4rq595
>
> > DEAD PEOPLE WALKING
> >http://tinyurl.com/zk9fk- Hide quoted text -
>
> - Show quoted text -