Methotrexate inhibits erythropoiesis / chemical bloodletting .. ?

<<snip>>
consequence of a **powerful inhibitory effect** of high-dose
methotrexate on erythropoiesis {red blood cell production]
<<snip>>

1: Klin Wochenschr. 1986 May 15;64(10):475-80. Links
The influence of high-dose methotrexate therapy on serum iron.Schalhorn
A, Wilmanns W, Koczorek GE.
After 43 cycles of high-dose methotrexate (MTX), the behavior of serum
iron was determined. In virtually all cases, typical changes were
demonstrated: 8-12 h after termination of treatment there was a sharp
increase in serum iron. After 48-60 h, maximum values of 295% (median)
of the pretreatment levels were found. Only when the serum MTX had
dropped to 6.6 X 10(-8) M, after 62 h (median), did the serum iron
level begin to drop; 72 h after termination of treatment the serum iron
level had returned to the pretreatment level in only one, and after 108
h, only in 50% of the patients. The marked and persistent rise in serum
iron must be considered a consequence of a powerful inhibitory effect
of high-dose methotrexate on erythropoiesis. A possible explanation for
the particular sensitivity of erythropoiesis to MTX may be the marked
storage of MTX, and in particular MTX polyglutamates, in mature
erythrocytes and their progenitor cells.

PMID: 3459938 [PubMed - indexed for MEDLINE]

-----------------------------------------------------------------------------

It seems this .. effect of methotrexate is well known .. it
**decreases** red blood cell production therefore .. making it ..
chemical bloodletting / reduction of red blood cell production ..

<<snip>>
methotrexate shifts iron from being utilized in hemoglobin synthesis to
liver stores
<<snip>>

Titre du document / Document title
Effect of methotrexate and folinic acid on accumulation of iron in mice
Auteur(s) / Author(s)
IQBAL M. P. ; MEHBOOBALI N. ; SULTANA F. ; KHAN F. B. ; SURREY I. A. ;
KAKEPOTO G. N. ;
Résumé / Abstract
A mouse-model was used to investigate the effect of methotrexate (MTX)
and folinic acid on accumulation of iron in young growing mice. Four
equal groups of Balb/c young male mice were treated (subcutaneously)
with either MTX, or folinic acid, or MTX plus folinic acid, or
physiological saline on every second day. After 3 weeks of treatment,
liver, spleen, kidney, small intestine, brain, skeletal muscle and
heart were removed and analyzed for iron contents using a
spectrophotometric method. When the mean values of iron in liver of
four groups were compared using one way ANOVA followed by Tukey's HSD
test, the group receiving MTX alone was found to have significantly (p
= 0.004) more accumulation of iron in liver. The group receiving MTX
plus folinic acid had iron accumulation in the liver similar to the
placebo group. However, the mean values of iron in brain, kidney, small
intestine, skeletal muscle, heart and spleen in all the groups, were
not found to be statistically different. The data indicate that MTX
shifts iron from being utilized in hemoglobin synthesis to liver
stores. Folinic acid administration 8 h post-MTX, however, prevents
this shift of iron to liver. Decreased levels of iron in plasma in mice
treated with MTX alone suggest decreased availability of iron to other
tissues for their normal growth and development.
Revue / Journal Title
Medical hypotheses (Med. hypotheses) ISSN 0306-9877
Source / Source
2003, vol. 61, no4, pp. 444-445 [2 page(s) (article)]
Langue / Language
Anglais

Editeur / Publisher
Elsevier, Kidlington, ROYAUME-UNI (1975) (Revue)



Localisation / Location
INIST-CNRS, Cote INIST : 18253, 35400011268084.0060


Copyright 2006 INIST-CNRS. All rights reserved

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ou sur tout support que ce soit, ne pourra être faite sans l'accord
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or by any means, without the prior written permission of INIST-CNRS.

Nº notice refdoc (ud4) : 15221864


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