Niacin and Trigonelline against Cancer Cells

<<snip>>
The present study indicates for the first time the anti-invasive
activities of niacin and trigonelline against cancer cells
<<snip>>

Anti-Invasive Activity of Niacin and Trigonelline against Cancer Cells

Nobuhiro Hirakawa, Rieko Okauchi, Yutaka Miura, and Kazumi Yagasaki

Department of Applied Biological Science, Tokyo Noko University,
Saiwai-cho 3-5-8, Fuchu, Tokyo 183-8509, Japan

The effects of niacin, namely, nicotinic acid and nicotinamide, and
trigonelline on the proliferation and invasion of cancer cells were
studied using a rat ascites hepatoma cell line of AH109A in culture.
Niacin and trigonelline inhibited the invasion of hepatoma cells at
concentrations of 2.5-40 µM without affecting proliferation.
Hepatoma cells previously cultured with a reactive oxygen species
(ROS)-generating system showed increased invasive activity. Niacin and
trigonelline suppressed this ROS-potentiated invasive capacity through
simultaneous treatment of AH109A cells with the ROS-generating system.
The present study indicates for the first time the anti-invasive
activities of niacin and trigonelline against cancer cells.


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