Poor usage of Human Genome Organisation (HUGO) standard genenomenclature hampers efficient retrieval of cancer marker data.

Poor usage of HUGO standard gene nomenclature in cancer marker
studies.
by Marc Lacroix
InTextoResearch, Baelen (Wallonia), Belgium
in International Journal of Biological Markers (2008) 23, 123-126


Since 1989, the Human Genome Organisation (HUGO) attempts to ensure
that for each gene there is one name and one symbol. The resulting
standard nomenclature is, however, poorly applied in clinical studies,
which impairs the efficient retrieval of information. This lack of
support is reflected in the present survey of 303 articles (from 106
journals) reporting on disseminated tumour cell detection.

Types of cancer examined: breast, liver, lung, melanoma, ovary,
prostate, bladder, cervical, colorectal, esophagus, gastric, head &
neck, pancreas, kidney, thyroid.

Markers (official symbol, official name):

ANKRD30A (Ankyrin repeat domain 30A), more frequently used aliases:
B726; B726P; NY-BR-1;

CEACAM5 (Carcinoembryonic antigen-related cell adhesion molecule 5),
more frequently used aliases: carcinoembryonic antigen; CEA;

DCT (Dopachrome tautomerase), more frequently used aliases: tyrosinase-
related protein-2; TRP-2;

EGFR (Epidermal growth factor receptor), more frequently used alias:
EGF-R;

FOLH1 (Folate hydrolase 1), more frequently used aliases: prostate-
specific membrane antigen; PSM; PSMA;

GUCY2C (Guanylate cyclase 2C ), more frequently used aliases: guanylyl
cyclase C; guanylylcyclase C; GCC;

KLK3 (Kallikrein-related peptidase 3), more frequently used aliases:
prostate specific antigen; prostate-specific antigen; PSA;

KRT7 (Keratin 7), more frequently used aliases: cytokeratin 7; CK7;
CK-7;

KRT19 (Keratin 19), more frequently used aliases: cytokeratin 19;
cytokeratin-19; CK19; CK-19;

KRT20 (Keratin 20), more frequently used aliases: cytokeratin 20;
cytokeratin-20; CK20; CK-20; CK 20;

MLANA (Melan-A), more frequently used aliases: melanoma antigen
recognized by T cells 1; MART1, MART-1;

MUC1 (Mucin 1), more frequently used aliases: mucin type I;
polymorphic epithelial mucin; EMA; MUC-1; MUC 1;

MUCL1 (Mucin-like 1), more frequently used aliases: small mucin-like
protein; small breast epithelial mucin; BS106; SBEM;

OR51E2 (Olfactory receptor, family 51, subfamily E, member 2), more
frequently used aliases: prostate-specific G protein coupled receptor;
prostate-specific gene with homology to G protein receptor; PSGR;
STAG1/PMEPA1;

PLUNC (Palate, lung and nasal epithelium carcinoma associated ), more
frequently used aliases: lung-specific X-protein; lunx;

SCGB2A1 (Secretoglobin family 2A, member 1), more frequently used
aliases: mammaglobin B; mammaglobin-B; mammaglobin 2; mamB; MGB2;

SCGB2A2 (Secretoglobin family 2A, member 2), more frequently used
aliases: mammaglobin; mammaglobin A; mammaglobin 1; MAM; mam; hMAM;
hMAM-A; MG; MGB1; MMG;

SERPINB3 (Serine (or cysteine) proteinase inhibitor, clade B
(ovalbumin), member 3), more frequently used aliases: squamous cell
carcinoma antigen 1; SCCA1; SCC;

SERPINB4 (Serine (or cysteine) proteinase inhibitor, clade B
(ovalbumin), member 4), more frequently used aliases: squamous cell
carcinoma antigen 2; SCCA2;

SERPINB5 (Serine (or cysteine) proteinase inhibitor, clade B
(ovalbumin), member 5), more frequently used aliases: maspin; MAS;

SILV (Silver homolog), more frequently used aliases: Gp100; GP-100;

TACSTD1 (Tumor-associated calcium signal transducer 1), more
frequently used aliases: epithelial glycoprotein 2; epithelial
glycoprotein 40; EGP40; EGP2; KS1/4; GA733-2;

TERT (Telomerase reverse transcriptase), more frequently used aliases:
hTERT; h-TERT;

TFF1 (Trefoil factor 1), more frequently used alias: PS2;

UCHL1 (Ubiquitin carboxyl-terminal esterase L1), more frequently used
aliases: ubiquitin thiolesterase; PGP 9.5