STUDY: Lymphoma post breast implants

Note from Ilena Rosenthal: We have had several women in our
international support group be diagnosed with lymphoma ... and a few
have had the lymphomas, exactly where their implants were ... such as
this one.

http://ilena-rosenthal.blogspot.com
www.BreastImplantAwareness.org

Virchows Arch. 2006 Nov;449(5):561-4. Epub 2006 Sep 16. Links
Anaplastic large-cell non-Hodgkin's lymphoma of the breast in
periprosthetic localisation 32 years after treatment for primary
breast cancer--a case report.Fritzsche FR, Pahl S, Petersen I,
Burkhardt M, Dankof A, Dietel M, Kristiansen G.
Institute of Pathology, Charité Universitätsmedizin Berlin,
Schumannstr. 20/21, 10117 Berlin, Germany.

Primary, as well as secondary, lymphomas of the breast are rare
diseases and might, in some cases, be misdiagnosed as breast cancer on
routine hematoxylin/eosin stainings. We report a case of an anaplastic
large cell lymphoma in a 72-year-old woman with a history of breast
cancer treated with breast-ablative surgery and a subsequent silicon
implant 32 years ago. Clinically, she presented with an ulceration of
the skin, which had developed within a few months. On conventional
histology, the tumor cells were mimicking poorly differentiated
invasive ductal carcinoma with a prominent leukocytic infiltrate. The
immunoprofile of the tumor showed negativity for cytokeratins
and led to the diagnosis of a CD30-positive anaplastic large cell
lymphoma.

Ilena Rose wrote:

> Note from Ilena Rosenthal: We have had several women in our
> international support group be diagnosed with lymphoma ... and a few
> have had the lymphomas, exactly where their implants were ... such as
> this one.
>
> Virchows Arch. 2006 Nov;449(5):561-4. Epub 2006 Sep 16. Links
> Anaplastic large-cell non-Hodgkin's lymphoma of the breast in
> periprosthetic localisation 32 years after treatment for primary
> breast cancer--a case report.Fritzsche FR, Pahl S, Petersen I,
> Burkhardt M, Dankof A, Dietel M, Kristiansen G.
> Institute of Pathology, Charité Universitätsmedizin Berlin,
> Schumannstr. 20/21, 10117 Berlin, Germany.
>
> Primary, as well as secondary, lymphomas of the breast are rare
> diseases and might, in some cases, be misdiagnosed as breast cancer on
> routine hematoxylin/eosin stainings. We report a case of an anaplastic
> large cell lymphoma in a 72-year-old woman with a history of breast
> cancer treated with breast-ablative surgery and a subsequent silicon
> implant 32 years ago. Clinically, she presented with an ulceration of
> the skin, which had developed within a few months. On conventional
> histology, the tumor cells were mimicking poorly differentiated
> invasive ductal carcinoma with a prominent leukocytic infiltrate. The
> immunoprofile of the tumor showed negativity for cytokeratins
> and led to the diagnosis of a CD30-positive anaplastic large cell
> lymphoma.

Casual; not causal
Peter Moran can probably explain this to you if you don't understand it.
J