Bloodletting And Diabetes

"These results justify iron depletion"

http://care.diabetesjournals.org/cgi...tract/31/3/e18

Diabetes Care. 2008 Jan;31(1):3-8. Epub 2007 Oct 24. Links
Bloodletting ameliorates insulin sensitivity and secretion in parallel
to reducing liver iron in carriers of HFE gene mutations.
Equitani F, Fernandez-Real JM, Menichella G, Koch M, Calvani M, Nobili
V, Mingrone G, Manco M.
Transfusion Medicine, SanFilippo Neri Hospital, Rome, Italy.

OBJECTIVE:
To clarify the pathogenesis of diabetes associated with mutations of
the hemochromatosis (HFE) gene, 17 carriers, 9 normal glucose tolerant
(NGT) and 8 diabetic, were evaluated in an interventional trial.
RESEARCH DESIGN AND METHODS:
At enrollment and after a 2-year bloodletting period, euglycemic-
hyperinsulinemic clamp, oral glucose tolerance test (OGTT), liver
histology (nonalcoholic fatty liver disease activity score [NAS]), and
liver iron content (LIC) were assessed.
RESULTS:
NGT subjects had significantly higher baseline insulin sensitivity (P
<or= 0.001), secretion, and insulinogenic index (calculated from the
OGTT) (P <or= 0.0001 for both) and lower LIC (P = 0.004) and NAS (P =
0.02) than diabetic patients. Baseline LIC correlated negatively with
insulin secretion (NGT r(0) = -0.676, P <or= 0.0001; diabetes r(0) =
-0.589, P = 0.02) and insulin sensitivity (M value) (NGT r(0) =
-0.597, P = 0.009; diabetes r(0) = -0.535, P = 0.03) and positively
with NAS (diabetes r(0) = 0.649, P = 0.007) and triglycerides (NGT
r(0) = 0.563, P = 0.015). At month 24, circulating iron was reduced by
179 +/- 26% in NGT and 284 +/- 54% in diabetic subjects. Insulin
secretion (NGT 20 +/- 4%; diabetes 33 +/- 7%) and insulin sensitivity
(NGT 25 +/- 5%; diabetes 18 +/- 3%) increased. LIC decreased in both
groups (NGT 126 +/- 42%; diabetes 61 +/- 13%), and NAS ameliorated
(NGT 65.1 +/- 6.5 vs. 38.1 +/- 6.83; P <or= 0.0001; diabetes 2.1 +/-
10.7 vs. 69.9 +/- 10; P <or= 0.0001).
CONCLUSIONS:
Iron depletion ameliorates insulin secretion and sensitivity in NGT
and diabetic carriers of HFE gene mutations. This amelioration occurs
in parallel with decreased LIC and improved NAS. These results justify
glucose tolerance testing and prophylactic iron depletion in
asymptomatic carriers as well.

PMID: 17959863 [PubMed - indexed for MEDLINE]


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On May 9, 11:37*pm, the Ferrous Fuckwit <clutching@straws> netkooked:

<snip of off-topic and plagiarized information>

That's how you spend your Friday nights, Fuckwit?
Trolling the internet? Pretending you aren't a
crackpot? You're sad. Seeing as you have so much
free time on your hands, you are now expected to
reveal your qualifications to give medical advice.

--Bill Thompson

Actually, it can't be seen as plagiarized when there is fully citing
of source material.

And it can be seen as on-topic for the diabetes group. And for the
nutrition and pathology groups. Maybe the lupus group, and with
a stretch, maybe the fibromyalgia group.

In spite of his one-person parade, there is some value to what he
says, for some of the readers. If a person doesn't deal well with the
iron, there can indeed be problems that are not typically attributed
to iron overload. Used to happen more when iron skillets were more
common, with metal spatulas instead of plastic.

Also, it should be considered if a person has had at least 13 blood
transfusions, not necessarily within a narrow time frame. Several
years, even, especially for men, pre and postmenopausal women.

But the part that is so annoying about him is the presentation of
iron overload as the single most relevant factor from diabetes to
end organ failure in lupus. Certainly not apologizing for him, he
is a pest at times, but sometimes he presents something of value,
even if you have to pick through a lot of shit for the piece of corn.

On May 10, 11:50 pm, "wrtho...@ix.netcom.com" <wrthomp...@gmail.com>
wrote:
> On May 9, 11:37 pm, the Ferrous Fuckwit <clutching@straws> netkooked:
>
> <snip of off-topic and plagiarized information>
>
> That's how you spend your Friday nights, Fuckwit?
> Trolling the internet? Pretending you aren't a
> crackpot? You're sad. Seeing as you have so much
> free time on your hands, you are now expected to
> reveal your qualifications to give medical advice.
>
> --Bill Thompson

wrthomps@ix.netcom.com wrote:
> On May 9, 11:37 pm, the Ferrous Fuckwit <clutching@straws> netkooked:
>
> <snip of off-topic and plagiarized information>
>
> That's how you spend your Friday nights, Fuckwit?
> Trolling the internet? Pretending you aren't a
> crackpot? You're sad. Seeing as you have so much
> free time on your hands, you are now expected to
> reveal your qualifications to give medical advice.
>
> --Bill Thompson

Crawl back down the drain where you came from :-(

"Michael B" wrote:

> Actually, it can't be seen as plagiarized when there is fully citing
> of source material.

Rusty is posting copyrighted material without the permission of
the copyright owner. He could be taken into court and successfully
prosecuted, although I doubt that anyone would bother with such
a pipsqueak as him.

> And it can be seen as on-topic for the diabetes group. And for the
> nutrition and pathology groups. Maybe the lupus group, and with
> a stretch, maybe the fibromyalgia group.

If Rusty had something on-topic for alt.support.lupus, it
didn't show up. And if there are ever any kernels of corn
in his posts, nobody should have to sift through his Mount
Bandinis of fertilizer to find them. The bulk of his posts
don't say anything helpful to anyone, which is just more
evidence that he is not qualified to give medical advice.

Don't worry, I intend to give it a rest for a while. I don't
like to bother people (not that TeamTroller is "people").

--Bill Thompson

"Michael B" <baughfam@bellsouth.net> wrote in message
news:f3dc750e-f644-47cb-8e8b-05ce5a1068c5@59g2000hsb.googlegroups.com...
> Actually, it can't be seen as plagiarized when there is fully citing
> of source material.
>
> And it can be seen as on-topic for the diabetes group. And for the
> nutrition and pathology groups.

Pathology groups? No - not really.


> In spite of his one-person parade, there is some value to what he
> says, for some of the readers. If a person doesn't deal well with the
> iron, there can indeed be problems that are not typically attributed
> to iron overload. Used to happen more when iron skillets were more
> common, with metal spatulas instead of plastic.
>
> Also, it should be considered if a person has had at least 13 blood
> transfusions, not necessarily within a narrow time frame. Several
> years, even, especially for men, pre and postmenopausal women.

Read what he's posted carefully. You'll find that there are well known side
effects of massive iron overloads, like in the example of multiple blood
transfusions. There are also well know problems of iron metabolism. All of
which are quite rare in the great scheme of things.
However the Ferrous Fool utterly misunderstands what's going on, and
furthermore rejects all attempts at enlightening him. Instead he prefers to
continue his religous crusade by posting any mention of iron onto any
seemingly random newsgroup.
I suspect someone close to him died of one of these rare conditions and it's
unhinged him somewhat.

> But the part that is so annoying about him is the presentation of
> iron overload as the single most relevant factor from diabetes to
> end organ failure in lupus. Certainly not apologizing for him, he
> is a pest at times, but sometimes he presents something of value,
> even if you have to pick through a lot of shit for the piece of corn.

The only "bits of corn" I've ever found are those things which are factually
true but posted out of context.

On May 11, 8:33*pm, "William R. Thompson" <wrtho...@ix.netcom.com>
wrote:Rusty is posting copyrighted material <<

People send me .. stuff .. and I .. forward .. stuff ..

Like the stuff below .. and seeing you ain't a woman .. stfu ..

"Those with lupus were more prone to such traditional risk factors for
heart disease as hypertension and diabetes and were five to eight
times more likely to develop CHD than women in the general population"

TUESDAY, Nov. 4 (HealthDayNews) -- Women with lupus have more risk
factors for heart disease than women without the autoimmune disorder,
says a study by researchers at the University of Toronto Lupus Clinic.

In addition to traditional risk factors for heart disease, women with
lupus have several novel metabolic risk factors that may be linked to
the inflammation caused by lupus, the researchers say. Their report
appears in the November issue of Arthritis and Rheumatism.

The study, which included 250 women with lupus and 250 healthy women
in a control group, found those with lupus were more prone to such
traditional risk factors for heart disease as hypertension and
diabetes. Lupus patients were also more sedentary.

The two groups were matched for age. Despite that, the women with
lupus were more likely to be menopausal -- 38 percent compared to 19
percent of the control group. Women with lupus experienced menopause,
on average, five years earlier than women in the control group.

The lupus patients also had much higher levels of triglycerides, low-
density lipoprotein (LDL) cholesterol and homocysteine. These are all
factors related to lipid metabolism and characteristic of inflammatory
disorders such as lupus. These probably contribute to the loss of
protection from coronary heart disease (CHD) in women with lupus.

"Many of the factors identified are potentially amenable to screening
and intervention. Further studies to understand the additional
contribution of the inflammatory process to CHD risk in lupus are
needed, as are studies to accurately predict the future risk of CHD in
this high-risk population," lead researcher Dr. Ian N. Bruce says in a
prepared statement.

Several previous studies confirmed that women with lupus are five to
eight times more likely to develop CHD than women in the general
population. That risk is especially pronounced among women younger
than 55.

Lupus is an autoimmune disorder that's marked by progressive damage to
the kidneys, heart and brain.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> "Michael B" *wrote:
> > Actually, it can't be seen as plagiarized when there is fully citing
> > of source material.
>
> Rusty is posting copyrighted material without the permission of
> the copyright owner. *He could be taken into court and successfully
> prosecuted, although I doubt that anyone would bother with such
> a pipsqueak as him.
>
> > And it can be seen as on-topic for the diabetes group. And for the
> > nutrition and pathology groups. Maybe the lupus group, and with
> > a stretch, maybe the fibromyalgia group.
>
> If Rusty had something on-topic for alt.support.lupus, it
> didn't show up. *And if there are ever any kernels of corn
> in his posts, nobody should have to sift through his Mount
> Bandinis of fertilizer to find them. The bulk of his posts
> don't say anything helpful to anyone, which is just more
> evidence that he is not qualified to give medical advice.
>
> Don't worry, I intend to give it a rest for a while. *I don't
> like to bother people (not that TeamTroller is "people").
>
> --Bill Thompson

So he admits to passing on bad information he doesn't understand.


"ironjustice" <teamtanner@hotmail.com> wrote in message
news:c83af1f4-f6ab-4236-8d3e-3551c3aa2394@m44g2000hsc.googlegroups.com...
On May 11, 8:33 pm, "William R. Thompson" <wrtho...@ix.netcom.com>
wrote:Rusty is posting copyrighted material <<

People send me .. stuff .. and I .. forward .. stuff ..

Like the stuff below .. and seeing you ain't a woman .. stfu ..

"Those with lupus were more prone to such traditional risk factors for
heart disease as hypertension and diabetes and were five to eight
times more likely to develop CHD than women in the general population"

TUESDAY, Nov. 4 (HealthDayNews) -- Women with lupus have more risk
factors for heart disease than women without the autoimmune disorder,
says a study by researchers at the University of Toronto Lupus Clinic.

In addition to traditional risk factors for heart disease, women with
lupus have several novel metabolic risk factors that may be linked to
the inflammation caused by lupus, the researchers say. Their report
appears in the November issue of Arthritis and Rheumatism.

The study, which included 250 women with lupus and 250 healthy women
in a control group, found those with lupus were more prone to such
traditional risk factors for heart disease as hypertension and
diabetes. Lupus patients were also more sedentary.

The two groups were matched for age. Despite that, the women with
lupus were more likely to be menopausal -- 38 percent compared to 19
percent of the control group. Women with lupus experienced menopause,
on average, five years earlier than women in the control group.

The lupus patients also had much higher levels of triglycerides, low-
density lipoprotein (LDL) cholesterol and homocysteine. These are all
factors related to lipid metabolism and characteristic of inflammatory
disorders such as lupus. These probably contribute to the loss of
protection from coronary heart disease (CHD) in women with lupus.

"Many of the factors identified are potentially amenable to screening
and intervention. Further studies to understand the additional
contribution of the inflammatory process to CHD risk in lupus are
needed, as are studies to accurately predict the future risk of CHD in
this high-risk population," lead researcher Dr. Ian N. Bruce says in a
prepared statement.

Several previous studies confirmed that women with lupus are five to
eight times more likely to develop CHD than women in the general
population. That risk is especially pronounced among women younger
than 55.

Lupus is an autoimmune disorder that's marked by progressive damage to
the kidneys, heart and brain.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> "Michael B" wrote:
> > Actually, it can't be seen as plagiarized when there is fully citing
> > of source material.
>
> Rusty is posting copyrighted material without the permission of
> the copyright owner. He could be taken into court and successfully
> prosecuted, although I doubt that anyone would bother with such
> a pipsqueak as him.
>
> > And it can be seen as on-topic for the diabetes group. And for the
> > nutrition and pathology groups. Maybe the lupus group, and with
> > a stretch, maybe the fibromyalgia group.
>
> If Rusty had something on-topic for alt.support.lupus, it
> didn't show up. And if there are ever any kernels of corn
> in his posts, nobody should have to sift through his Mount
> Bandinis of fertilizer to find them. The bulk of his posts
> don't say anything helpful to anyone, which is just more
> evidence that he is not qualified to give medical advice.
>
> Don't worry, I intend to give it a rest for a while. I don't
> like to bother people (not that TeamTroller is "people").
>
> --Bill Thompson

On May 12, 1:16*am, "Manky Badger" <you.m...@be.joking>
wrote:Pathology groups? No - not really. <<

I .. rest .. my .. case ..

http://library.med.utah.edu/WebPath/webpath.html

Pathology covers .. disease .. **process** ..

What disease you figure doesn't HAVE a .. process ..

Eh ..

Tell me ..

Tell everyone ..

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk





> "Michael B" <baugh...@bellsouth.net> wrote in message
>
> news:f3dc750e-f644-47cb-8e8b-05ce5a1068c5@59g2000hsb.googlegroups.com...
>
> > Actually, it can't be seen as plagiarized when there is fully citing
> > of source material.
>
> > And it can be seen as on-topic for the diabetes group. And for the
> > nutrition and pathology groups.
>
> Pathology groups? No - not really.
>
> > In spite of his one-person parade, there is some value to what he
> > says, for some of the readers. If a person doesn't deal well with the
> > iron, there can indeed be problems that are not typically attributed
> > to iron overload. Used to happen more when iron skillets were more
> > common, with metal spatulas instead of plastic.
>
> > Also, it should be considered if a person has had at least 13 blood
> > transfusions, not necessarily within a narrow time frame. Several
> > years, even, especially for men, pre and postmenopausal women.
>
> Read what he's posted carefully. You'll find that there are well known side
> effects of massive iron overloads, like in the example of multiple blood
> transfusions. There are also well know problems of iron metabolism. All of
> which are quite rare in the great scheme of things.
> However the Ferrous Fool utterly misunderstands what's going on, and
> furthermore rejects all attempts at enlightening him. Instead he prefers to
> continue his religous crusade by posting any mention of iron onto any
> seemingly random newsgroup.
> I suspect someone close to him died of one of these rare conditions and it's
> unhinged him somewhat.
>
> > But the part that is so annoying about him is the presentation of
> > iron overload as the single most relevant factor from diabetes to
> > end organ failure in lupus. *Certainly not apologizing for him, he
> > is a pest at times, but sometimes he presents something of value,
> > even if you have to pick through a lot of shit for the piece of corn.
>
> The only "bits of corn" I've ever found are those things which are factually
> true but posted out of context.

On May 12, 9:54*am, "Cheeky Bastard" <InvalidEm...@aol.com> wrote:
So he admits to passing on bad information he doesn't understand. <<

I admit to passing on information which invokes .. thought.

Whether you are ABLE .. to .. think .. is a different question ..

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


>
> "ironjustice" <teamtan...@hotmail.com> wrote in message
>
> news:c83af1f4-f6ab-4236-8d3e-3551c3aa2394@m44g2000hsc.googlegroups.com...
> On May 11, 8:33 pm, "William R. *Thompson" <wrtho...@ix.netcom.com>
> wrote:Rusty is posting copyrighted material <<
>
> People send me .. stuff .. and I .. forward .. stuff ..
>
> Like the stuff below .. and seeing you ain't a woman .. stfu ..
>
> "Those with lupus were more prone to such traditional risk factors for
> heart disease as hypertension and diabetes and were five to eight
> times more likely to develop CHD than women in the general population"
>
> TUESDAY, Nov. 4 (HealthDayNews) -- Women with lupus have more risk
> factors for heart disease than women without the autoimmune disorder,
> says a study by researchers at the University of Toronto Lupus Clinic.
>
> In addition to traditional risk factors for heart disease, women with
> lupus have several novel metabolic risk factors that may be linked to
> the inflammation caused by lupus, the researchers say. Their report
> appears in the November issue of Arthritis and Rheumatism.
>
> The study, which included 250 women with lupus and 250 healthy women
> in a control group, found those with lupus were more prone to such
> traditional risk factors for heart disease as hypertension and
> diabetes. Lupus patients were also more sedentary.
>
> The two groups were matched for age. Despite that, the women with
> lupus were more likely to be menopausal -- 38 percent compared to 19
> percent of the control group. Women with lupus experienced menopause,
> on average, five years earlier than women in the control group.
>
> The lupus patients also had much higher levels of triglycerides, low-
> density lipoprotein (LDL) cholesterol and homocysteine. These are all
> factors related to lipid metabolism and characteristic of inflammatory
> disorders such as lupus. These probably contribute to the loss of
> protection from coronary heart disease (CHD) in women with lupus.
>
> "Many of the factors identified are potentially amenable to screening
> and intervention. Further studies to understand the additional
> contribution of the inflammatory process to CHD risk in lupus are
> needed, as are studies to accurately predict the future risk of CHD in
> this high-risk population," lead researcher Dr. Ian N. Bruce says in a
> prepared statement.
>
> Several previous studies confirmed that women with lupus are five to
> eight times more likely to develop CHD than women in the general
> population. That risk is especially pronounced among women younger
> than 55.
>
> Lupus is an autoimmune disorder that's marked by progressive damage to
> the kidneys, heart and brain.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > "Michael B" wrote:
> > > Actually, it can't be seen as plagiarized when there is fully citing
> > > of source material.
>
> > Rusty is posting copyrighted material without the permission of
> > the copyright owner. He could be taken into court and successfully
> > prosecuted, although I doubt that anyone would bother with such
> > a pipsqueak as him.
>
> > > And it can be seen as on-topic for the diabetes group. And for the
> > > nutrition and pathology groups. Maybe the lupus group, and with
> > > a stretch, maybe the fibromyalgia group.
>
> > If Rusty had something on-topic for alt.support.lupus, it
> > didn't show up. And if there are ever any kernels of corn
> > in his posts, nobody should have to sift through his Mount
> > Bandinis of fertilizer to find them. The bulk of his posts
> > don't say anything helpful to anyone, which is just more
> > evidence that he is not qualified to give medical advice.
>
> > Don't worry, I intend to give it a rest for a while. I don't
> > like to bother people (not that TeamTroller is "people").
>
> > --Bill Thompson- Hide quoted text -
>
> - Show quoted text -

"ironjustice" <teamtanner@hotmail.com> wrote in message
news:a64ce5e2-7b8c-424b-beef-e6815097b454@k13g2000hse.googlegroups.com...
On May 12, 1:16 am, "Manky Badger" <you.m...@be.joking>
wrote:Pathology groups? No - not really. <<

I .. rest .. my .. case ..

http://library.med.utah.edu/WebPath/webpath.html

Pathology covers .. disease .. **process** ..

What disease you figure doesn't HAVE a .. process ..

Eh ..

Tell me ..

Tell everyone ..
-------------------------------------------------------------------

The regular contributors to sci.med.pathology (with one exception) are
educated to postgraduate level.
That one exception is not, and he has no understanding of the articles he
randomly posts and contributes nothing to the group.

Therefore the constant stream of ferrous tommyfoolery is irrelevent to the
group.

On May 12, 3:16*am, "Manky Badger" <you.m...@be.joking> wrote:
> "Michael B" <baugh...@bellsouth.net> wrote in message
>
> news:f3dc750e-f644-47cb-8e8b-05ce5a1068c5@59g2000hsb.googlegroups.com...
>
> > Actually, it can't be seen as plagiarized when there is fully citing
> > of source material.
>
> > And it can be seen as on-topic for the diabetes group. And for the
> > nutrition and pathology groups.
>
> Pathology groups? No - not really.
>
> > In spite of his one-person parade, there is some value to what he
> > says, for some of the readers. If a person doesn't deal well with the
> > iron, there can indeed be problems that are not typically attributed
> > to iron overload. Used to happen more when iron skillets were more
> > common, with metal spatulas instead of plastic.
>
> > Also, it should be considered if a person has had at least 13 blood
> > transfusions, not necessarily within a narrow time frame. Several
> > years, even, especially for men, pre and postmenopausal women.
>
> Read what he's posted carefully. You'll find that there are well known side
> effects of massive iron overloads, like in the example of multiple blood
> transfusions. There are also well know problems of iron metabolism. All of
> which are quite rare in the great scheme of things.
> However the Ferrous Fool utterly misunderstands what's going on, and
> furthermore rejects all attempts at enlightening him. Instead he prefers to
> continue his religous crusade by posting any mention of iron onto any
> seemingly random newsgroup.
> I suspect someone close to him died of one of these rare conditions and it's
> unhinged him somewhat.
>
> > But the part that is so annoying about him is the presentation of
> > iron overload as the single most relevant factor from diabetes to
> > end organ failure in lupus. *Certainly not apologizing for him, he
> > is a pest at times, but sometimes he presents something of value,
> > even if you have to pick through a lot of shit for the piece of corn.
>
> The only "bits of corn" I've ever found are those things which are factually
> true but posted out of context.

Manky,

RE: I suspect someone close to him died of one of these rare
conditions and it's
unhinged him somewhat.

Quite honestly, I've often thought that perhaps he's the one that has
an iron condition. Perhaps that's why he has such interest.....

In any event, there has been some articles that I've enjoyed, others I
haven't. I'm positive and certain, that he can say the same about
me......

It's like watching tv or listening to music, if you don't want to
watch or hear, change the channel. In this case, don't read.....

Take care and be well out there! Debra

I've snipped all follow-up groups except a.s.d

My last check-up my doctor mentioned that my iron was up and said 'we
fix that by bloodletting.'
I used my best Marty Feldmen voice and asked "should I gather the
leeches?' He said "That's one of the options" very straight faced.
Is that really true? Has anyone here had bloodletting via leech
before? Just curious.

Sean

"Sean" <spk_gbv@msn.com> wrote in message
news:fded5951-5d96-4894-bf0a-6a3159f36f09@b9g2000prh.googlegroups.com...
> I've snipped all follow-up groups except a.s.d
>
> My last check-up my doctor mentioned that my iron was up and said 'we
> fix that by bloodletting.'
> I used my best Marty Feldmen voice and asked "should I gather the
> leeches?' He said "That's one of the options" very straight faced.
> Is that really true? Has anyone here had bloodletting via leech
> before? Just curious.
>

I don't know about bloodletting use, but medical leeches are making a
comeback. (so are maggots) Try Google for more info on the subject.
bj

So, has anyone asked him why he's hung up on iron in particular? I'll ask:
Tom, why are you obsessed with iron over any other health issue? Nanny
"dar" <darhody@gmail.com> wrote in message
news:ca9513fe-57b8-4a6c-8915-96739e80b4e6@y21g2000hsf.googlegroups.com...
On May 12, 3:16 am, "Manky Badger" <you.m...@be.joking> wrote:
> "Michael B" <baugh...@bellsouth.net> wrote in message
>
> news:f3dc750e-f644-47cb-8e8b-05ce5a1068c5@59g2000hsb.googlegroups.com...
>
> > Actually, it can't be seen as plagiarized when there is fully citing
> > of source material.
>
> > And it can be seen as on-topic for the diabetes group. And for the
> > nutrition and pathology groups.
>
> Pathology groups? No - not really.
>
> > In spite of his one-person parade, there is some value to what he
> > says, for some of the readers. If a person doesn't deal well with the
> > iron, there can indeed be problems that are not typically attributed
> > to iron overload. Used to happen more when iron skillets were more
> > common, with metal spatulas instead of plastic.
>
> > Also, it should be considered if a person has had at least 13 blood
> > transfusions, not necessarily within a narrow time frame. Several
> > years, even, especially for men, pre and postmenopausal women.
>
> Read what he's posted carefully. You'll find that there are well known
> side
> effects of massive iron overloads, like in the example of multiple blood
> transfusions. There are also well know problems of iron metabolism. All of
> which are quite rare in the great scheme of things.
> However the Ferrous Fool utterly misunderstands what's going on, and
> furthermore rejects all attempts at enlightening him. Instead he prefers
> to
> continue his religous crusade by posting any mention of iron onto any
> seemingly random newsgroup.
> I suspect someone close to him died of one of these rare conditions and
> it's
> unhinged him somewhat.
>
> > But the part that is so annoying about him is the presentation of
> > iron overload as the single most relevant factor from diabetes to
> > end organ failure in lupus. Certainly not apologizing for him, he
> > is a pest at times, but sometimes he presents something of value,
> > even if you have to pick through a lot of shit for the piece of corn.
>
> The only "bits of corn" I've ever found are those things which are
> factually
> true but posted out of context.

Manky,

RE: I suspect someone close to him died of one of these rare
conditions and it's
unhinged him somewhat.

Quite honestly, I've often thought that perhaps he's the one that has
an iron condition. Perhaps that's why he has such interest.....

In any event, there has been some articles that I've enjoyed, others I
haven't. I'm positive and certain, that he can say the same about
me......

It's like watching tv or listening to music, if you don't want to
watch or hear, change the channel. In this case, don't read.....

Take care and be well out there! Debra

On May 13, 10:04*pm, "nanny" <gloria...@woh.rr.com> wrote:
So, has anyone asked him why he's hung up on iron in particular? *<<

Hard work.

On May 13, 10:04 pm, "nanny" <gloria...@woh.rr.com> wrote:I'll ask:
Tom, why are you obsessed with iron over any other health issue? <<

Years ago Linus Pauling and his work with what he believed to be very
high levels of oxidative stress/ rust / free radicals / reactive
oxygen species / lack of antioxidants.

His work was and is still accepted as very good work.

Linus Pauling was a double Nobel prize winner.

Years later I was flipping through a People magazine at my
physiotherapists office and ran across a mans' hypothesis.
His hypothesis is "the iron from meat builds progressively in the body
leading to high levels of rust / oxidative stress."

That clicked in my mind as an explanation for the high level of
oxidative stress and this clue led me into the last few years of work.

Here we are today fifteen years later and iron reduction therapy /
phlebotomy has JUST been proposed FOR literally everyone.

Just like I've been proposing.

Evidently it seems I'm right.

Using .."how do you feel" ..as a marker.

"These results justify iron depletion"

http://care.diabetesjournals.org/cgi...tract/31/3/e18


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk





Nanny"dar" <darh...@gmail.com> wrote in message
>
> news:ca9513fe-57b8-4a6c-8915-96739e80b4e6@y21g2000hsf.googlegroups.com...
> On May 12, 3:16 am, "Manky Badger" <you.m...@be.joking> wrote:
>
>
>
>
>
> > "Michael B" <baugh...@bellsouth.net> wrote in message
>
> >news:f3dc750e-f644-47cb-8e8b-05ce5a1068c5@59g2000hsb.googlegroups.com...
>
> > > Actually, it can't be seen as plagiarized when there is fully citing
> > > of source material.
>
> > > And it can be seen as on-topic for the diabetes group. And for the
> > > nutrition and pathology groups.
>
> > Pathology groups? No - not really.
>
> > > In spite of his one-person parade, there is some value to what he
> > > says, for some of the readers. If a person doesn't deal well with the
> > > iron, there can indeed be problems that are not typically attributed
> > > to iron overload. Used to happen more when iron skillets were more
> > > common, with metal spatulas instead of plastic.
>
> > > Also, it should be considered if a person has had at least 13 blood
> > > transfusions, not necessarily within a narrow time frame. Several
> > > years, even, especially for men, pre and postmenopausal women.
>
> > Read what he's posted carefully. You'll find that there are well known
> > side
> > effects of massive iron overloads, like in the example of multiple blood
> > transfusions. There are also well know problems of iron metabolism. All of
> > which are quite rare in the great scheme of things.
> > However the Ferrous Fool utterly misunderstands what's going on, and
> > furthermore rejects all attempts at enlightening him. Instead he prefers
> > to
> > continue his religous crusade by posting any mention of iron onto any
> > seemingly random newsgroup.
> > I suspect someone close to him died of one of these rare conditions and
> > it's
> > unhinged him somewhat.
>
> > > But the part that is so annoying about him is the presentation of
> > > iron overload as the single most relevant factor from diabetes to
> > > end organ failure in lupus. Certainly not apologizing for him, he
> > > is a pest at times, but sometimes he presents something of value,
> > > even if you have to pick through a lot of shit for the piece of corn.
>
> > The only "bits of corn" I've ever found are those things which are
> > factually
> > true but posted out of context.
>
> Manky,
>
> RE: *I suspect someone close to him died of one of these rare
> conditions and it's
> unhinged him somewhat.
>
> Quite honestly, I've often thought that perhaps he's the one that has
> an iron condition. *Perhaps that's why he has such interest.....
>
> In any event, there has been some articles that I've enjoyed, others I
> haven't. *I'm positive and certain, that he can say the same about
> me......
>
> It's like watching tv or listening to music, if you don't want to
> watch or hear, change the channel. *In this case, don't read.....
>
> Take care and be well out there! *Debra- Hide quoted text -
>
> - Show quoted text -

On May 12, 1:42*pm, "Manky Badger" <you.m...@be.joking> wrote:The
regular contributors to sci.med.pathology (with one exception) are
educated to postgraduate level. <<

Now you got somesplainin to do there ..lucy ..

You mean these guys ..yourself included .. are educated to such a
degree.. and searching the group for the iron posting one finds
nothing but me.

Now with iron being found to be such a problem .. IE: everyone with
long term diabetes and the NIH clinical trial .. means .. ?

Either the pathology interested people ON your list are collectively
not interested in posting to a list of your caliber ..or .. ? .. they
just missed it .. missed the boat .. missed the obvious .. dismissed
the obvious .. killed women men children fetuses and it seems try to
kill my ..fkg ..dog.

The only real justice to this whole deal is the appointment of a ..
vet .. to oversee you guys ..

Heh .. heh ..

How's THAT .. feel .. there .. educated .. pathology ..interested ..
guy ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


> "ironjustice" <teamtan...@hotmail.com> wrote in message
>
> news:a64ce5e2-7b8c-424b-beef-e6815097b454@k13g2000hse.googlegroups.com...
> On May 12, 1:16 am, "Manky Badger" <you.m...@be.joking>
> wrote:Pathology groups? No - not really. <<
>
> I .. rest .. my .. case ..
>
> http://library.med.utah.edu/WebPath/webpath.html
>
> Pathology covers .. disease .. **process** ..
>
> What disease you figure doesn't HAVE a .. process ..
>
> Eh ..
>
> Tell me ..
>
> Tell everyone ..
> -------------------------------------------------------------------
>
> The regular contributors to sci.med.pathology (with one exception) are
> educated to postgraduate level.
> That one exception is not, and he has no understanding of the articles he
> randomly posts and contributes nothing to the group.
>
> Therefore the constant stream of ferrous tommyfoolery is irrelevent to the
> group.

<ironjustice@aol.com> wrote in message
news:9bc3405f-d4cb-486a-b65f-ea3c42703b50@b64g2000hsa.googlegroups.com...
On May 12, 1:42 pm, "Manky Badger" <you.m...@be.joking> wrote:The
regular contributors to sci.med.pathology (with one exception) are
educated to postgraduate level. <<

Now you got somesplainin to do there ..lucy ..

You mean these guys ..yourself included .. are educated to such a
degree.. and searching the group for the iron posting one finds
nothing but me.

Now with iron being found to be such a problem .. IE: everyone with
long term diabetes and the NIH clinical trial .. means .. ?

Either the pathology interested people ON your list are collectively
not interested in posting to a list of your caliber ..or .. ? .. they
just missed it .. missed the boat .. missed the obvious .. dismissed
the obvious .. killed women men children fetuses and it seems try to
kill my ..fkg ..dog.
-----------------------------------------------------------------------------------------------------


Tommy, I'm sorry to put this so bluntly, but with all your posts you flatter
yourself that you have something to contribute to the sci.med.pathology
newsgroup (and all the others).

You are wrong.
You do not.

If you think you do have something to contribute, review the years of
postings that you've put up contradictory gibberish, particularly to how you
conduct yourself in discussion.

On May 15, 9:58*am, "Manky Badger" <you.m...@be.joking> wrote:If you
think you do have something to contribute <<

Read my lips ..

If I post to the sci.med.pathology list .. YOU .. just stfu ..

Your stupidity is astounding ..

Simple in your face .. evidence .. IE: .. no discussion WHATSOFKGEVER
about increased death due to epo .. increased death in the world IE:
malaria death in children .. increased death in cancer .. increased
death in diabetes .. increased death in Sickle .. Thalassemia and
aplastic anemia related diseases ..increased death in Hepatitis..

And on the pathology list .. ?..fkall to say about ANY of the
above ..

Well .. evidently .. you are a bunch of braindeadfkgmorons ..

Simple logic ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




> <ironjust...@aol.com> wrote in message
>
> news:9bc3405f-d4cb-486a-b65f-ea3c42703b50@b64g2000hsa.googlegroups.com...
> On May 12, 1:42 pm, "Manky Badger" <you.m...@be.joking> wrote:The
> regular contributors to sci.med.pathology (with one exception) are
> *educated to postgraduate level. <<
>
> Now you got somesplainin to do there ..lucy ..
>
> You mean these guys ..yourself included .. are educated to such a
> degree.. and searching the group for the iron posting one finds
> nothing but me.
>
> Now with iron being found to be such a problem .. IE: everyone with
> long term diabetes and the NIH clinical trial .. means .. ?
>
> Either the pathology interested people ON your list are collectively
> not interested in posting to a list of your caliber ..or .. ? .. they
> just missed it .. missed the boat .. missed the obvious .. dismissed
> the obvious .. killed women men children fetuses and it seems try to
> kill my ..fkg ..dog.
> ---------------------------------------------------------------------------*--------------------------
>
> Tommy, I'm sorry to put this so bluntly, but with all your posts you flatter
> yourself that you have something to contribute to the sci.med.pathology
> newsgroup (and all the others).
>
> You are wrong.
> You do not.
>
> If you think you do have something to contribute, review the years of
> postings that you've put up contradictory gibberish, particularly to how you
> conduct yourself in discussion.

"ironjustice" <teamtanner@hotmail.com> wrote in message
news:7be5f2ae-8d78-474c-91f6-c9c4a8774ae5@m73g2000hsh.googlegroups.com...
On May 15, 9:58 am, "Manky Badger" <you.m...@be.joking> wrote:

>>If youthink you do have something to contribute <<

Read my lips ..

If I post to the sci.med.pathology list .. YOU .. just stfu ..
------------------------------------------------------------------------------------------

As I said, Tommy. Just look at how you "conduct a discussion".
You bend over backwards to make yourself a figure of ridicule, and then seem
amazed that people treat you as one.

On May 14, 10:27*pm, "ironjust...@aol.com" <ironjust...@aol.com>
wrote:Linus Pauling and his work with what he believed to be very
high levels of oxidative stress/ rust / free radicals / reactive
oxygen species / lack of antioxidants. <<

This would be a human model of increased oxidation in the body.

American Journal of Clinical Nutrition, Vol. 81, No. 1, 95-103,
January 2005
© 2005 American Society for Clinical Nutrition

--------------------------------------------------------------------------------

ORIGINAL RESEARCH COMMUNICATION

-Tocopherol disappearance is faster in cigarette smokers and is
inversely related to their ascorbic acid status1,2,3
Richard S Bruno, Rajasekhar Ramakrishnan, Thomas J Montine, Tammy M
Bray and Maret G Traber
1 From the Department of Human Nutrition, The Ohio State University,
Columbus, OH (RSB); the Linus Pauling Institute, Oregon State
University, Corvallis, OR (RSB, TMB, and MGT); the College of
Physicians and Surgeons, Columbia University, New York (RR); the
Department of Pathology, University of Washington, Seattle (TJM)

2 Supported by grants to MGT (NIH DK59576) and TJM (AG05144 and
AG16835). The Natural Source Vitamin E Association provided partial
support for the purchase of the LC-MS and provided the deuterium-
labeled -tocopheryl acetate supplements. Tocopherol standards
including d0- (unlabeled), d6-RRR, and d3-all-rac--tocopheryl acetates
and unlabeled d0--tocopherol were gifts from James Clark (Cognis
Nutrition and Health, LaGrange, IL); all-rac--5,7,8-(CD3)3-tocopheryl
acetate (d9-all-rac--tocopheryl acetate) was provided by Carolyn Good
(General Mills) and was synthesized by Isotec Inc (Miamisburg, OH).

3 Address reprint requests to MG Traber, 561A Weniger Hall, Linus
Pauling Institute, Oregon State University, Corvallis, OR 97331. E-
mail: maret.traber@oregonstate.edu.

Background: Cigarette smokers have enhanced oxidative stress from
cigarette smoke exposure and from their increased inflammatory
responses.

Objective: The objective of this study was to determine whether
cigarette smoking increases plasma -tocopherol disappearance in
otherwise healthy humans.

Design: Smokers and nonsmokers (n = 10/group) were supplemented with
deuterium-labeled -tocopheryl acetates (75 mg each of d3-RRR--
tocopheryl acetate and d6-all-rac--tocopherols acetate) for 6 evenings
(days –6 to –1). Plasma -tocopherols, ascorbic acid, uric acid, and F2-
isoprostanes were measured in blood samples collected on days –6
through 17. The urinary -tocopherol metabolite, -carboxy-ethyl-hydroxy-
chroman (-CEHC), was measured on days –6, 0, and 17 in 24-h urine
samples.

Results: F2-isoprostanes were, on average, 40% higher in smokers than
in nonsmokers. On day 0, plasma labeled and unlabeled -tocopherol
concentrations were not significantly different between groups.
Smoking resulted in faster fractional disappearance of plasma -
tocopherol (0.215 ± 0.011 compared with 0.191 ± 0.009 pools/d; P <
0.05). Fractional disappearance rates of -tocopherol correlated with
plasma ascorbic acid concentrations in smokers (P = 0.021) but not in
nonsmokers despite plasma ascorbic acid concentrations that were not
significantly different between groups. By day 17, cigarette smoking
resulted in lower plasma -tocopherol concentrations and urinary
excretion of labeled and unlabeled -CEHC (P < 0.05).

Conclusions: Cigarette smoking increased -tocopherol disappearance.
Greater rates of -tocopherol disappearance in smokers appear to be
related to increased oxidative stress accompanied by lower plasma
ascorbic acid concentrations. Thus, smokers have an increased
requirement for both -tocopherol and ascorbic acid.


Key Words: Oxidative stress • vitamin E • vitamin C • cigarette smoke
• antioxidants • dietary requirements


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




> On May 13, 10:04*pm, "nanny" <gloria...@woh.rr.com> wrote:
> *So, has anyone asked him why he's hung up on iron in particular? *<<
>
> Hard work.
>
> On May 13, 10:04 pm, "nanny" <gloria...@woh.rr.com> wrote:I'll ask:
> Tom, why are you obsessed with iron over any other health issue? <<
>
> Years ago Linus Pauling and his work with what he believed to be very
> high levels of oxidative stress/ rust / free radicals / reactive
> oxygen species / lack of antioxidants.
>
> His work was and is still accepted as very good work.
>
> Linus Pauling was a double Nobel prize winner.
>
> Years later I was flipping through a People magazine at my
> physiotherapists office and ran across a mans' hypothesis.
> His hypothesis is "the iron from meat builds progressively in the body
> leading to high levels of rust / oxidative stress."
>
> That clicked in my mind as an explanation for the high level of
> oxidative stress and this clue led me into the last few years of work.
>
> Here we are today fifteen years later and iron reduction therapy /
> phlebotomy has JUST been proposed FOR literally everyone.
>
> Just like I've been proposing.
>
> Evidently it seems I'm right.
>
> Using .."how do you feel" ..as a marker.
>
> "These results justify iron depletion"
>
> http://care.diabetesjournals.org/cgi...tract/31/3/e18
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> Nanny"dar" <darh...@gmail.com> wrote in message
>
> >news:ca9513fe-57b8-4a6c-8915-96739e80b4e6@y21g2000hsf.googlegroups.com...
> > On May 12, 3:16 am, "Manky Badger" <you.m...@be.joking> wrote:
>
> > > "Michael B" <baugh...@bellsouth.net> wrote in message
>
> > >news:f3dc750e-f644-47cb-8e8b-05ce5a1068c5@59g2000hsb.googlegroups.com....
>
> > > > Actually, it can't be seen as plagiarized when there is fully citing
> > > > of source material.
>
> > > > And it can be seen as on-topic for the diabetes group. And for the
> > > > nutrition and pathology groups.
>
> > > Pathology groups? No - not really.
>
> > > > In spite of his one-person parade, there is some value to what he
> > > > says, for some of the readers. If a person doesn't deal well with the
> > > > iron, there can indeed be problems that are not typically attributed
> > > > to iron overload. Used to happen more when iron skillets were more
> > > > common, with metal spatulas instead of plastic.
>
> > > > Also, it should be considered if a person has had at least 13 blood
> > > > transfusions, not necessarily within a narrow time frame. Several
> > > > years, even, especially for men, pre and postmenopausal women.
>
> > > Read what he's posted carefully. You'll find that there are well known
> > > side
> > > effects of massive iron overloads, like in the example of multiple blood
> > > transfusions. There are also well know problems of iron metabolism. All of
> > > which are quite rare in the great scheme of things.
> > > However the Ferrous Fool utterly misunderstands what's going on, and
> > > furthermore rejects all attempts at enlightening him. Instead he prefers
> > > to
> > > continue his religous crusade by posting any mention of iron onto any
> > > seemingly random newsgroup.
> > > I suspect someone close to him died of one of these rare conditions and
> > > it's
> > > unhinged him somewhat.
>
> > > > But the part that is so annoying about him is the presentation of
> > > > iron overload as the single most relevant factor from diabetes to
> > > > end organ failure in lupus. Certainly not apologizing for him, he
> > > > is a pest at times, but sometimes he presents something of value,
> > > > even if you have to pick through a lot of shit for the piece of corn..
>
> > > The only "bits of corn" I've ever found are those things which are
> > > factually
> > > true but posted out of context.
>
> > Manky,
>
> > RE: *I suspect someone close to him died of one of these rare
> > conditions and it's
> > unhinged him somewhat.
>
> > Quite honestly, I've often thought that perhaps he's the one that has
> > an iron condition. *Perhaps that's why he has such interest.....
>
> > In any event, there has been some articles that I've enjoyed, others I
> > haven't. *I'm positive and certain, that he can say the same about
> > me......
>
> > It's like watching tv or listening to music, if you don't want to
> > watch or hear, change the channel. *In this case, don't read.....
>
> > Take care and be well out there! *Debra- Hide quoted text -
>
> > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -

"ironjustice" <teamtanner@hotmail.com> wrote in message
news:7be5f2ae-8d78-474c-91f6-c9c4a8774ae5@m73g2000hsh.googlegroups.com...
On May 15, 9:58 am, "Manky Badger" <you.m...@be.joking> wrote:If you
think you do have something to contribute <<

Read my lips ..

If I post to the sci.med.pathology list .. YOU .. just stfu ..

Your stupidity is astounding ..

Simple in your face .. evidence .. IE: .. no discussion WHATSOFKGEVER
about increased death due to epo .. increased death in the world IE:
malaria death in children .. increased death in cancer .. increased
death in diabetes .. increased death in Sickle .. Thalassemia and
aplastic anemia related diseases ..increased death in Hepatitis..

And on the pathology list .. ?..fkall to say about ANY of the
above ..

Well .. evidently .. you are a bunch of braindeadfkgmorons ..

Simple logic ..


Who loves ya.
Tom


.................................................. .................................................. .................................................. .......................
Another fine example of Rusty posting so much he makes himself ill.
If everyone was as sick as he thinks they are you would not see them
posting on the internet.

CB

On May 15, 1:39*pm, "Cheeky Bastard" <InvalidEm...@aol.com> wrote:If
everyone was as sick as he thinks they are you would not see them
posting on the internet. <<

If people weren't as sick as I .. know .. they ARE .. I wouldn't be
here ..

I've said before if people were 'merely inconvenienced' BY disease I
wouldn't be here.

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


> "ironjustice" <teamtan...@hotmail.com> wrote in message
>
> news:7be5f2ae-8d78-474c-91f6-c9c4a8774ae5@m73g2000hsh.googlegroups.com...
> On May 15, 9:58 am, "Manky Badger" <you.m...@be.joking> wrote:If you
> think you do have something to contribute <<
>
> Read my lips ..
>
> If I post to the sci.med.pathology list .. YOU .. just stfu ..
>
> Your stupidity is astounding ..
>
> Simple in your face .. evidence .. IE: .. no discussion WHATSOFKGEVER
> about increased death due to epo .. increased death in the world IE:
> malaria death in children .. increased death in cancer .. increased
> death indiabetes.. increased death in Sickle .. Thalassemia and
> aplastic anemia related diseases ..increased death in Hepatitis..
>
> And on the pathology list .. ?..fkall to say about ANY of the
> above ..
>
> Well .. evidently .. you are a bunch of braindeadfkgmorons ..
>
> Simple logic ..
>
> Who loves ya.
> Tom
>
> .................................................. ..........................*....................... .................................................. ...*......................
> Another fine example of Rusty posting so much he makes himself ill.
> *If everyone was as sick as he thinks they are you would not see them
> posting on the internet.
>
> CB

On May 15, 6:39*pm, ironjustice <teamtan...@hotmail.com> wrote:
bloodletting <<

"Restriction of iron may have positive effects on health in general
and aging in particular"

Galaris D, Mantzaris M, Amorgianiotis C
Oxidative stress and aging: the potential role of iron. [Journal
Article]
Hormones (Athens) 2008 Apr-Jun; 7(2):114-22.


According to the free radical theory of aging proposed by Denham
Harman more than 50 years ago, oxidatively modified cellular
components accumulate continuously in the cells during the organism's
lifespan leading to progressive decline of cellular functions. Since
then, it has been shown that proteins, lipids, nucleic acids and
other
cell components undergo reversible and/or irreversible oxidative
modifications during aging. Moreover, oxidized cell components can
undergo further oxidative modifications leading to formation of
products that cell degradation systems are incapable of removing.
Accumulation of such non-degradable aggregates further inhibits the
functionality of degradation systems, thus aggravating the effects
and
leading to a vicious cycle. In this presentation, we propose that the
availability of intracellular iron in its redox active form (labile
iron) represents the main catalyst that mediates extensive oxidative
modifications of cellular components and ultimately leads to their
accumulation and consequent cellular dysfunction. It is tempting to
speculate that regulated restriction of labile iron may have positive
effects on