Diabetes Res Clin Pract. 2007 Oct 31;
Long-term effects of a diet loosely restricting carbohydrates on HbA1c
levels, BMI and tapering of sulfonylureas in type 2 diabetes: A 2-year
follow-up study.
The aim was to assess the long-term effect of a loose restriction of
carbohydrate intake (carbohydrate-reduced diet: CARD) compared to a
conventional diet (CD) in type 2 diabetes. One hundred and thirty-three type
2 diabetic outpatients followed the CD (n=57, 1734+/-410kcal,
carbohydrate

rotein:fat ratio=57:16:26) or CARD (n=76, 1773+/-441kcal,
carbohydrate

rotein:fat ratio=45:18:33) according to their own will, and
were followed up for 2 years. Glycemic control, body mass index (BMI), serum
cholesterols and dose of antidiabetic drugs were assessed at baseline and
after 1 and 2 years. At baseline, hemoglobin A1c (HbA1c) and BMI levels were
7.1+/-1.0% and 24.2+/-2.9, respectively, in the CD group, and 7.4+/-1.1% and
25.1+/-3.4 in the CARD group, showing no significant differences. During the
2-year follow-up period, HbA1c levels were significantly improved in the
CARD group (CD: 7.5+/-1.3%, CARD: 6.7+/-0.6%, P<0.001), and BMI decreased
more significantly in the CARD group . The doses of sulfonylureas clearly
tapered, and serum cholesterol profiles improved significantly with the
CARD. Our results warrant a long-term and large-scale randomized study of
the diet for type 2 diabetes.
PMID: 17980451
Gys