Lecithin In Diabetes

[ironjustice]

Told ya .. soooooo ..

Lecithin component may reduce fatty liver, improve insulin sensitivity
May 25, 2011
A natural product called DLPC (dilauroyl phosphatidylcholine)
increases sensitivity to insulin and reduces fatty liver in mice,
leading Baylor College of Medicine (www.bcm.edu) researchers to
believe it may provide a treatment for prediabetic patients. DLPC is
an unusual phospholipid and a trace component of the dietary
supplement lecithin. Dr. David D. Moore (www.bcm.edu/mcb/index.cfm?
pmid=7696), professor of molecular and cellular biology at BCM, and
his colleagues at first thought that DLPC would provide a useful tool
in studying the function of a receptor protein – liver receptor
homolog -1 or LRH-1 – that regulates the production of bile acids in
the liver.

Studies in mice soon showed that DLPC could stimulate LRH-1 activity.
In addition to a small increase in bile acid levels, DLPC improved
regulation of glucose and fat within the liver. A report on this work
appears in the current issue of the journal Nature (www.nature.com).
Moore is collaborating with Dr. Lawrence Chan (http://www.bcm.edu/
medicine/diabetes-endocrinology/?pmid=1189), director of the Diabetes
and Endocrine Research Center (http://www.bcm.edu/diabetescenter/) at
BCM, on a pilot study to find out how well DLPC works in patients with
prediabetes.

"We know it works well in mice," said Moore. The link of LRH-1 to bile
acids may contribute to its effect on glucose levels and fat because
small, non-toxic increases in bile acid levels can improve metabolic
disorders.

Dr. Jae Man Lee, then a graduate student in Moore's laboratory, first
proposed screening compounds to see which activated LRH-1. He found
that DLPC, a structurally unusual phosphatidylcholine (a form of
phospholipid that is important in the formation of cell membranes)
enhanced LRH-1 activity in cells.

In mice, DLPC induced the production of bile acid enzymes and lowered
fat in the liver. It also increased levels of bile acids and regulated
glucose or sugar circulating in the blood. In two kinds of mice that
had resistance to insulin, DLPC also decreased fatty liver and lowered
glucose levels in the blood. However, DLPC had no effect in mice that
had no LRH-1 in the liver.

The effect on the insulin resistant mice was striking.

"Their overall body weight was not changed," said Moore. "But they had
improved sensitivity to insulin (which helps keep glucose levels in
check) and less fatty livers. We are interested in why it gets rid of
the fat in the liver."

DLPC decreased the levels of proteins associated with formation of
fatty acids and triglycerides, including a key regulator called
SREBP-1c that encourages the deposition of fat in tissues.

"DLPC is a natural product," said Moore. "Lecithin is a mixture of
many compounds but DLPC is one of them."

The ongoing clinical study, which involves people who are overweight
but not diabetic, employs an approved form of DLPC that is used in
liposomes, little globules of fat that take drugs into the body. An
initial glucose tolerance test to determine how sensitive the people
are to insulin at the start of the study is followed by another after
the subjects take DLPC or a placebo for two months. Neither the
patients in study nor the physicians know who is getting DLPC and who
is getting the placebo.

The study is still enrolling subjects, and there are no results yet.

Source: Baylor College of Medicine

------------

Just a reminder ..

"It was the choline that kept the dogs alive"


Peripheral administration of CDP-choline and its cholinergic
metabolites increases serum insulin: muscarinic and nicotinic
acetylcholine receptors are both involved in their actions.
Ilcol YO, Cansev M, Yilmaz MS, Hamurtekin E, Ulus IH.
Neurosci Lett. 2008 Jan 24;431(1):71-6. Epub 2007 Dec 4.
Department of Biochemistry, Uludag University Medical School,
Bursa 16059, Turkey. ye...@uludag.edu.tr


Abstract
The present study was designed to test the effects of CDP-choline
and its metabolites on serum insulin concentrations in rats and
to investigate the involvements of cholinergic and adrenergic
receptors in the effect.
Intraperitoneal (i.p.) administration of CDP-choline (200-600
micromol/kg) increased serum insulin in a dose- and time-related
manner.
Equivalent doses (200-600 micromol/kg; i.p.) of phosphocholine
or choline also increased serum insulin dose-dependently.
Serum-free choline concentrations increased several-fold
following i.p. administration of CDP-choline, phosphocholine or
choline itself.
In contrast, equivalent doses of cytidine monophosphate and
cytidine failed to alter serum insulin concentrations.
The increases in serum insulin induced by i.p. 600 micromol/kg
of CDP-choline, phosphocholine or choline were abolished by
pretreatment with the ganglionic nicotinic acetylcholine receptor
antagonist hexamethonium (15 mg/kg; i.p.), or by the muscarinic
receptor antagonist atropine methylnitrate (2 mg/kg; i.p.).
Pretreatment with prazosin (0.5 mg/kg; i.p.), an alpha
(1)-adrenoceptor antagonist, or yohimbine (5 mg/kg, i.p.),
an alpha(2)-adrenoceptor antagonist, enhanced slightly the
increases in serum insulin in response to 600 micromol/kg of
CDP-choline, phosphocholine and choline.
Serum insulin also increased following central administration
of choline; the effect was blocked by intracerebroventricularly
injected atropine, mecamylamine or hemicholinium-3 (HC-3).
It is concluded that CDP-choline or its cholinergic metabolites
phosphocholine and choline increases circulating insulin
concentrations by increasing muscarinic and nicotinic cholinergic
neurotransmission in the insulin secreting beta-cells.


PMID: 18162319


----------


Choline increases serum insulin in rat when injected
intraperitoneally and augments basal and stimulated
aceylcholine release from the rat minced pancreas in vitro.
Ilcol YO, Gurun MS, Taga Y, Ulus IH.
Eur J Biochem. 2003 Mar;270(5):991-9.
Department of Biochemistry, Uludag University Medical School,
16059 Gorukle Kampusu, Bursa, Turkey. ye...@uludag.edu.tr


Abstract
Intraperitoneal injection of choline (30-90 mg.kg-1)
produced a dose-dependent increase in serum insulin,
glucose and choline levels in rats.
The increase in serum insulin induced by choline
(90 mg.kg-1) was blocked by pretreatment with the
muscarinic acetylcholine receptor antagonists,
atropine (2 mg.kg-1), pirenzepine (2 mg.kg-1) and
4-diphenylacetoxy-N-methylpiperidine (2 mg.kg-1)
or the ganglionic nicotinic receptor antagonist,
hexamethonium (15 mg.kg-1).
The effect of choline on serum insulin and glucose
was enhanced by oral glucose administration (3 g.kg-1).
Choline administration was associated with a
significant (P < 0.001) increase in the acetylcholine
content of pancreatic tissue.
Choline (10-130 microm) increased basal and stimulated
acetylcholine release but failed to evoke insulin
release from the minced pancreas at considerably higher
concentrations (0.1-10 mm).
Hemicholium-3, a choline uptake inhibitor, attenuated
the increase in acetylcholine release induced by
choline augmentation.
Choline (1-32 mm) inhibited [3H]quinuclidinyl benzilate
binding to the muscarinic receptors in the pancreatic
homogenates.
These data show that choline, a precursor of the
neurotransmitter acetylcholine, increases serum insulin
by indirectly stimulating peripheral acetylcholine
receptors through the enhancement of acetylcholine
synthesis and release.


PMID: 12603332
----------


Lecithin is recommended as a BETTER method of choline supplementation
due to its ability to produce a 5 times increase of choline and a
retention time of 3 times as many hours.


Lecithin consumption raises serum-free-choline levels.
Lancet 1977 Jul 9;2(8028):68-9
Wurtman RJ, Hirsch MJ, Growdon JH.


Consumption of choline by rats sequentially increases
serum-choline, brain-choline, and brain-acetylcholine
concentrations.
In man consumption of choline increases in levels in the
serum and cerebrospinal fluid; its administration is an
effective way of treating tardive dyskinesia.
We found that oral lecithin is considerably more effective in
raising human serum-choline levels than an equivalent quantity
of choline chloride.
30 minutes after ingestion of choline chloride (2-3 g free base),
serum- choline levels rose by 86% and returned to normal values
within 4 hours; 1 hour after lecithin ingestion, these levels rose
by 265% and remained significantly raised for 12 hours.
Lecithin may therefore be the method of choice for accelerating
acetylcholine synthesis by increasing the availability of choline,
its precursor in the blood.


----------------


http://www.sciencenews.org/articles/...5/timeline.asp


A new vitamin that is essential for liver function and that may play
an important role in controlling diabetes was described at the
meeting of the American and Canadian Medical Associations by one of
its
discoverers, Dr. C.H. Best of Toronto, codiscoverer of insulin, the
life-saving remedy for diabetes.
The new vitamin has a real name, choline, instead of a letter, as do
most other members of the vitamin family. It is found in many foods,
but the best sources are meat, egg yolk, and yeast.


Dr. M. Hershey and Miss M.E. Huntsman, of the University of Toronto,
were responsible for many of the fundamental observations that led up
to the discovery of the significance of choline, Dr. Best stated.


Lack of this vitamin causes the serious condition of fatty liver, Dr.
Best said. When the liver becomes fatty, it fails to make sugar or
handle bile or do many of the things it should do, he explained.


The vitamin was discovered in the course of insulin investigations.
Dogs that had no pancreas, the insulin-secreting organ, failed to
live for more than a few months, even when given insulin injections.
When they were fed minced pancreas, in addition to the insulin, they
lived for years.


However, chemical studies of the pancreas showed that in addition to
producing insulin and a digestive ferment, this organ contained
choline, and that it was the choline in the diet of minced pancreas
that kept the dogs alive after they had lost their own pancreases.


-------------------------------------------


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

[montygraham]

Who told whom? The key question is, what is the underlying cause?
Unless you were born around 1900, there is no way you could have been
the first to recognize the "benefits" of this substance, for example:

http://www.springerlink.com/content/t80678710703h523/

However, you do seem to be quite resistant to recognizing the
underlying cause, which the evidence as a whole clearly suggests is
oxidative stress/lipid peroxidation.

[mrbrklyn]

On May 26, 6:06*pm, montygraham <monty1...@lycos.com> wrote:
> Who told whom? *The key question is, what is the underlying cause?
> Unless you were born around 1900, there is no way you could have been
> the first to recognize the "benefits" of this substance, for example:
>
> http://www.springerlink.com/content/t80678710703h523/
>
> However, you do seem to be quite resistant to recognizing the
> underlying cause, which the evidence as a whole clearly suggests is
> oxidative stress/lipid peroxidation.

Thus speakith Monty the troll

Did you read my recent post here, "Using basic logic to understand
"HIV/AIDS."" ?

They have abandoned logic, even at the most basic level. We are
beyond
the Emperor's New Clothes now. In this case, the "Emperor" has no
kingdom, aside from the asylum and his fellow inmates, whom he calls
his "subjects." Like all periods of fanaticism, this one will come to
an end at some point, and historians like myself will write about it
in
very similar terms as they do now the witchcraft fears of the
sixteenth
and seventeenth centuries in Europe. Being heavily "invested" in a
notion is quite similar to insanity, and many of us realize this in
politics these days, but when it comes to what is considered
"science,"
it is much easier to convince the public that "white is black" and
"black is white." Thus, it will take longer for the deadly
"HIV=AIDS=DEATH" house of cards to crumble than it does for
incompetent, ideological-minded politicians to be voted out of office.

If you have yet to do so, I explain what the best explanation for
"HIV/AIDS" is on my web site:

http://groups.msn.com/TheScientificDebateForum-/

I quote the "virus hunters" directly, and I also cite numerous studies
from the scientific literature.

[Ellen K.]

Nobody here is talking about HIV/AIDS.

"mrbrklyn" <[email protected]> wrote in message
news:[email protected]...
On May 26, 6:06 pm, montygraham <monty1...@lycos.com> wrote:
> Who told whom? The key question is, what is the underlying cause?
> Unless you were born around 1900, there is no way you could have been
> the first to recognize the "benefits" of this substance, for example:
>
> http://www.springerlink.com/content/t80678710703h523/
>
> However, you do seem to be quite resistant to recognizing the
> underlying cause, which the evidence as a whole clearly suggests is
> oxidative stress/lipid peroxidation.

Thus speakith Monty the troll

Did you read my recent post here, "Using basic logic to understand
"HIV/AIDS."" ?

They have abandoned logic, even at the most basic level. We are
beyond
the Emperor's New Clothes now. In this case, the "Emperor" has no
kingdom, aside from the asylum and his fellow inmates, whom he calls
his "subjects." Like all periods of fanaticism, this one will come to
an end at some point, and historians like myself will write about it
in
very similar terms as they do now the witchcraft fears of the
sixteenth
and seventeenth centuries in Europe. Being heavily "invested" in a
notion is quite similar to insanity, and many of us realize this in
politics these days, but when it comes to what is considered
"science,"
it is much easier to convince the public that "white is black" and
"black is white." Thus, it will take longer for the deadly
"HIV=AIDS=DEATH" house of cards to crumble than it does for
incompetent, ideological-minded politicians to be voted out of office.

If you have yet to do so, I explain what the best explanation for
"HIV/AIDS" is on my web site:

http://groups.msn.com/TheScientificDebateForum-/

I quote the "virus hunters" directly, and I also cite numerous studies
from the scientific literature.

[Ala]

"mrbrklyn" <[email protected]> wrote in message
news:[email protected]...

>Thus speakith Monty the troll

>Did you read my recent post here, "Using basic logic to understand
>"HIV/AIDS."" ?

>They have abandoned logic, even at the most basic level. We are
>beyond
>the Emperor's New Clothes now. In this case, the "Emperor" has no
>kingdom, aside from the asylum and his fellow inmates, whom he calls
>his "subjects." Like all periods of fanaticism, this one will come to
>an end at some point, and historians like myself will write about it
>in
>very similar terms as they do now the witchcraft fears of the
>sixteenth
>and seventeenth centuries in Europe. Being heavily "invested" in a
>notion is quite similar to insanity, and many of us realize this in
>politics these days, but when it comes to what is considered
>"science,"
>it is much easier to convince the public that "white is black" and
>"black is white." Thus, it will take longer for the deadly
>"HIV=AIDS=DEATH" house of cards to crumble than it does for
i>ncompetent, ideological-minded politicians to be voted out of office.

>If you have yet to do so, I explain what the best explanation for
>"HIV/AIDS" is on my web site:


Thank you for enlightening me.

[mrbrklyn]

On May 26, 6:06*pm, montygraham <monty1...@lycos.com> wrote:
> Who told whom? *The key question is, what is the underlying cause?
> Unless you were born around 1900, there is no way you could have been
> the first to recognize the "benefits" of this substance, for example:
>
> http://www.springerlink.com/content/t80678710703h523/
>
> However, you do seem to be quite resistant to recognizing the
> underlying cause, which the evidence as a whole clearly suggests is
> oxidative stress/lipid peroxidation.


thus speakith Monty the troll



Did you read my recent post here, "Using basic logic to understand
"HIV/AIDS."" ?

They have abandoned logic, even at the most basic level. We are
beyond
the Emperor's New Clothes now. In this case, the "Emperor" has no
kingdom, aside from the asylum and his fellow inmates, whom he calls
his "subjects." Like all periods of fanaticism, this one will come to
an end at some point, and historians like myself will write about it
in
very similar terms as they do now the witchcraft fears of the
sixteenth
and seventeenth centuries in Europe. Being heavily "invested" in a
notion is quite similar to insanity, and many of us realize this in
politics these days, but when it comes to what is considered
"science,"
it is much easier to convince the public that "white is black" and
"black is white." Thus, it will take longer for the deadly
"HIV=AIDS=DEATH" house of cards to crumble than it does for
incompetent, ideological-minded politicians to be voted out of office.

If you have yet to do so, I explain what the best explanation for
"HIV/AIDS" is on my web site:

http://groups.msn.com/TheScientificDebateForum-/

[mrbrklyn]

On May 26, 10:48*pm, "Ellen K." <firstinitiallastn...@dslextreme.com>
wrote:
> Nobody here is talking about HIV/AIDS.
>
> "mrbrklyn" <ceo.brook...@gmail.com> wrote in message
>
> news:[email protected]...
> On May 26, 6:06 pm, montygraham <monty1...@lycos.com> wrote:
>
> > Who told whom? The key question is, what is the underlying cause?
> > Unless you were born around 1900, there is no way you could have been
> > the first to recognize the "benefits" of this substance, for example:
>
> >http://www.springerlink.com/content/t80678710703h523/
>
> > However, you do seem to be quite resistant to recognizing the
> > underlying cause, which the evidence as a whole clearly suggests is
> > oxidative stress/lipid peroxidation.
>
> Thus speakith Monty the troll
>
> Did you read my recent post here, "Using basic logic to understand
> "HIV/AIDS."" ?
>
> They have abandoned logic, even at the most basic level. *We are
> beyond
> the Emperor's New Clothes now. *In this case, the "Emperor" has no
> kingdom, aside from the asylum and his fellow inmates, whom he calls
> his "subjects." *Like all periods of fanaticism, this one will come to
> an end at some point, and historians like myself will write about it
> in
> very similar terms as they do now the witchcraft fears of the
> sixteenth
> and seventeenth centuries in Europe. *Being heavily "invested" in a
> notion is quite similar to insanity, and many of us realize this in
> politics these days, but when it comes to what is considered
> "science,"
> it is much easier to convince the public that "white is black" and
> "black is white." *Thus, it will take longer for the deadly
> "HIV=AIDS=DEATH" house of cards to crumble than it does for
> incompetent, ideological-minded politicians to be voted out of office.
>
> If you have yet to do so, I explain what the best explanation for
> "HIV/AIDS" is on my web site:
>
> http://groups.msn.com/TheScientificDebateForum-/
>
> I quote the "virus hunters" directly, and I also cite numerous studies
> from the scientific literature.

quack quack

Warning::: Monty1945 is a certified nut case pretending to have
medical credentials. He posts across the Internet, trolling for
victims and recommends a diet high saturated fat content for a
healthy lifestyle, and as a cure for disease. He denies the
existence of AID's. In addition, "Dr Monty" by admission in usenet,
uses his body for experimental purposes, the results, being as
they are, a completely dysfunctional brain pattern, probably
secondary to the stoke he has acquired by following his own medical
advice. He's also been know to have two way conversations with his
AM/FM radio and to hound professional athletes.

Anything he posts needs to be viewed as the rantings of a brain
damaged adult limited to 24/7 skill nursing care.

[Ellen K.]

"mrbrklyn" <[email protected]> wrote in message
news:[email protected]..
On May 26, 10:48 pm, "Ellen K." <firstinitiallastn...@dslextreme.com>
wrote:
> Nobody here is talking about HIV/AIDS.
>
> "mrbrklyn" <ceo.brook...@gmail.com> wrote in message
>
> news:[email protected]...
> On May 26, 6:06 pm, montygraham <monty1...@lycos.com> wrote:
>
> > Who told whom? The key question is, what is the underlying cause?
> > Unless you were born around 1900, there is no way you could have been
> > the first to recognize the "benefits" of this substance, for example:
>
> >http://www.springerlink.com/content/t80678710703h523/
>
> > However, you do seem to be quite resistant to recognizing the
> > underlying cause, which the evidence as a whole clearly suggests is
> > oxidative stress/lipid peroxidation.
>
> Thus speakith Monty the troll
>
> Did you read my recent post here, "Using basic logic to understand
> "HIV/AIDS."" ?
>
> They have abandoned logic, even at the most basic level. We are
> beyond
> the Emperor's New Clothes now. In this case, the "Emperor" has no
> kingdom, aside from the asylum and his fellow inmates, whom he calls
> his "subjects." Like all periods of fanaticism, this one will come to
> an end at some point, and historians like myself will write about it
> in
> very similar terms as they do now the witchcraft fears of the
> sixteenth
> and seventeenth centuries in Europe. Being heavily "invested" in a
> notion is quite similar to insanity, and many of us realize this in
> politics these days, but when it comes to what is considered
> "science,"
> it is much easier to convince the public that "white is black" and
> "black is white." Thus, it will take longer for the deadly
> "HIV=AIDS=DEATH" house of cards to crumble than it does for
> incompetent, ideological-minded politicians to be voted out of office.
>
> If you have yet to do so, I explain what the best explanation for
> "HIV/AIDS" is on my web site:
>
> http://groups.msn.com/TheScientificDebateForum-/
>
> I quote the "virus hunters" directly, and I also cite numerous studies
> from the scientific literature.

quack quack

Warning::: Monty1945 is a certified nut case pretending to have
medical credentials. He posts across the Internet, trolling for
victims and recommends a diet high saturated fat content for a
healthy lifestyle, and as a cure for disease. He denies the
existence of AID's. In addition, "Dr Monty" by admission in usenet,
uses his body for experimental purposes, the results, being as
they are, a completely dysfunctional brain pattern, probably
secondary to the stoke he has acquired by following his own medical
advice. He's also been know to have two way conversations with his
AM/FM radio and to hound professional athletes.

Anything he posts needs to be viewed as the rantings of a brain
damaged adult limited to 24/7 skill nursing care.

==============================

You guys can discuss whatever you like in the group where your message
originated, but this is a DIABETES discussion and nobody here is interested.

[Susan]

x-no-archive: yes

On 5/31/2011 3:08 AM, Ellen K. wrote:

> You guys can discuss whatever you like in the group where your message
> originated, but this is a DIABETES discussion and nobody here is
> interested.

EXACTLY why you're supposed to delete those cross posts before replying.
Otherwise, you invite more of the same crud.

:-)

See above.

Susan