Lecithin therapy in controlling inflammatory cytokines

Effects of polyenylphosphatidylcholine on cytokines, nitrite/nitrate
levels, antioxidant activity and lipid peroxidation in rats with
sepsis.
Demirbilek S, Ersoy MO, Demirbilek S, Karaman A, Akin M, Bayraktar M,
Bayraktar N
Intensive Care Med. 2004 Oct ; 30(10): 1974-8

OBJECTIVES: To determine the effect of pretreatment with
polyenylphosphatidylcholine (lecithin, PPC) on plasma levels of tumor
necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-10, total
nitrite/nitrate (NOx), and tissue levels of superoxide dismutase (SOD)
and malondialdehyde (MDA) in septic rats. DESIGN: Prospective,
randomized, controlled animal study. SETTING: University laboratory.
SUBJECTS: Forty-five Spraque-Dawley rats were divided into three
groups: group C, sham-operated; group S, sepsis; and group P, sepsis
pretreated with PPC. INTERVENTIONS: Rats were made septic by cecal
ligation and puncture (CLP). Group P rats were treated with PPC (100
mg/day orally) for 10 days before sepsis. Twenty-four hours later CLP,
plasma concentrations of TNF-alpha, IL-6 and IL-10 and plasma levels of
NOx were measured. SOD and MDA were determined in liver, lung and heart
homogenates. MEASUREMENTS AND MAIN RESULTS: All rats in group P
survived during the 24-h observation time after CLP, whereas survival
rate in group S was 66.7% (10/15; P<0.05). PPC significantly reduced
plasma levels of TNF-alpha (P=0.006), IL-6 (P=0.007), IL-10 (P=0.016),
NOx (P<0.001), and tissue levels of MDA (P<0.001) in group P with
respect to in group S. Tissue levels of SOD significantly increased in
group P when compared with group S (P<0.001). CONCLUSIONS: These
results show that PPC pretreatment exerts cumulative effects in
decreasing the levels of cytokines, NOx, and tissue MDA concentrations,
with a concomitant increase in survival in septic rats. Lecithin
therapy may be a useful adjuvant therapy in controlling of the
excessive production of the inflammatory cytokines in patients with
severe sepsis. DESCRIPTOR: SIRS/sepsis, experimental studies.


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