LoBAG Diet Research

Hi All

This also relates to the current threads on reduced carb
diets.

This review appeared recently in Nutrition and Metabolism,
the original paper was discussed a couple of years ago here:

http://www.nutritionandmetabolism.com/content/3/1/16
Control of blood glucose in type 2 diabetes without weight
loss by modification of diet composition
A snippet:
"Based on the above principles, we have designed a diet in
which the carbohydrate was decreased from 55% to 20%. The
protein was increased from 15% to 30%. The fat was increased
from 30% to 50%, keeping the saturated fat constant at ~11%.
We refer to this as a LoBAG20, diet with the subscript of 20
added because the diet contains 20% total carbohydrate.
Eight men with untreated type 2 diabetes were studied using
a randomized crossover design [32]. Subjects were on each
diet for 5 weeks with a washout period in between. The diets
were isocaloric; subjects remained weight stable. All food
was provided.

The postprandial glucose concentrations were markedly
attenuated following 5 weeks on the LoBAG20 diet (Figure 8).
In addition, the fasting glucose concentration was
significantly decreased as well. The net area response,
using the fasting concentration as baseline was
significantly decreased (by 65%) on the LoBAG20 diet.
Similarly, the total area response, using zero as baseline,
was decreased by 45%.

The fasting serum insulin concentrations were similar, but
the excursions after meals were significantly greater when
ingesting the standard diet, i.e. before the LoBAG20 diet
(Figure 9). The net insulin area response, using the fasting
insulin concentration as baseline, was decreased by 40%. The
total insulin area response, using zero as baseline, was
decreased by 25% following 5 weeks on the LoBAG20 diet. Both
insulin area decreases were statistically significant"

Gannon's research was initially supported by the ADA - but
their comments on her work were less than enthusiastic, as
we also discussed in a past thread:
http://www.diabetes.org/diabetes-res...otein-diet.jsp

In the full text a further study using 30% carb content
(LoBAG30) was mentioned. I found it here, but cannot access
the full text:
http://tinyurl.com/ydhkn6 or
http://ajpendo.physiology.org/cgi/co...urcetype=HWCIT

If anyone has access, I'd be interested in seeing the
method, results and conclusion please.
Cheers, Alan, T2, Australia.
d&e, metformin 1000mg, ezetrol 10mg
Everything in Moderation - Except Laughter.
--
http://loraldiabetes.blogspot.com/
http://loraltravel.blogspot.com/
latest: The Vatican

Alan S wrote:
> Hi All
>
> This also relates to the current threads on reduced carb
> diets.
>
> This review appeared recently in Nutrition and Metabolism,
> the original paper was discussed a couple of years ago here:
>
> http://www.nutritionandmetabolism.com/content/3/1/16
> Control of blood glucose in type 2 diabetes without weight
> loss by modification of diet composition

Metabolic effect of a LoBAG30 diet in men with type 2 diabetes -
http://ajpendo.physiology.org/cgi/co...act/291/4/E786
"Overall, the lack of negative effects, the improved glucose control,
and the positive nitrogen balance suggest such a diet will be beneficial
for older subjects with type 2 diabetes. Nevertheless, the long-term
effects and general applicability of the diet remain to be determined."

A Gannon and Nuttall search - http://tinyurl.com/y5x9yw

Frank

On Thu, 09 Nov 2006 21:24:04 -0500, Jefferson
<xyz@adelphia.netng> wrote:

>Alan S wrote:
>> Hi All
>>
>> This also relates to the current threads on reduced carb
>> diets.
>>
>> This review appeared recently in Nutrition and Metabolism,
>> the original paper was discussed a couple of years ago here:
>>
>> http://www.nutritionandmetabolism.com/content/3/1/16
>> Control of blood glucose in type 2 diabetes without weight
>> loss by modification of diet composition
>
>Metabolic effect of a LoBAG30 diet in men with type 2 diabetes -
>http://ajpendo.physiology.org/cgi/co...act/291/4/E786
>"Overall, the lack of negative effects, the improved glucose control,
>and the positive nitrogen balance suggest such a diet will be beneficial
>for older subjects with type 2 diabetes. Nevertheless, the long-term
>effects and general applicability of the diet remain to be determined."
>
>A Gannon and Nuttall search - http://tinyurl.com/y5x9yw
>
>Frank

Thanks Frank; my problem is getting something more detailed
than the abstract.

Cheers, Alan, T2, Australia.
d&e, metformin 1000mg, ezetrol 10mg
Everything in Moderation - Except Laughter.
--
http://loraldiabetes.blogspot.com/
http://loraltravel.blogspot.com/
latest: The Vatican

On Thu, 09 Nov 2006 21:24:04 -0500, Jefferson
<xyz@adelphia.netng> wrote:

>Alan S wrote:
>> Hi All
>>
>> This also relates to the current threads on reduced carb
>> diets.
>>
>> This review appeared recently in Nutrition and Metabolism,
>> the original paper was discussed a couple of years ago here:
>>
>> http://www.nutritionandmetabolism.com/content/3/1/16
>> Control of blood glucose in type 2 diabetes without weight
>> loss by modification of diet composition
>
>Metabolic effect of a LoBAG30 diet in men with type 2 diabetes -
>http://ajpendo.physiology.org/cgi/co...act/291/4/E786
>"Overall, the lack of negative effects, the improved glucose control,
>and the positive nitrogen balance suggest such a diet will be beneficial
>for older subjects with type 2 diabetes. Nevertheless, the long-term
>effects and general applicability of the diet remain to be determined."
>
>A Gannon and Nuttall search - http://tinyurl.com/y5x9yw
>
>Frank

Frank, or whoever just sent me an email - thanks. It
disappeared somehow in being transferred from mailwasher to
outlook express. Would you re-send please.

I caught a glimpse of "LoBAG" which is why I'm guessing the
source is related to here.

Sorry 'bout that.

Cheers, Alan, T2, Australia.
d&e, metformin 1000mg, ezetrol 10mg
Everything in Moderation - Except Laughter.
--
http://loraldiabetes.blogspot.com/
http://loraltravel.blogspot.com/
latest: The Vatican

Alan S wrote:

> On Thu, 09 Nov 2006 21:24:04 -0500, Jefferson
> <xyz@adelphia.netng> wrote:
>
>
>>Alan S wrote:
>>
>>>Hi All
>>>
>>>This also relates to the current threads on reduced carb
>>>diets.
>>>
>>>This review appeared recently in Nutrition and Metabolism,
>>>the original paper was discussed a couple of years ago here:
>>>
>>>http://www.nutritionandmetabolism.com/content/3/1/16
>>>Control of blood glucose in type 2 diabetes without weight
>>>loss by modification of diet composition
>>
>>Metabolic effect of a LoBAG30 diet in men with type 2 diabetes -
>>http://ajpendo.physiology.org/cgi/co...act/291/4/E786
>>"Overall, the lack of negative effects, the improved glucose control,
>>and the positive nitrogen balance suggest such a diet will be beneficial
>>for older subjects with type 2 diabetes. Nevertheless, the long-term
>>effects and general applicability of the diet remain to be determined."
>>
>>A Gannon and Nuttall search - http://tinyurl.com/y5x9yw
>>
>>Frank
>
>
> Thanks Frank; my problem is getting something more detailed
> than the abstract.
>
The reason I sent the search results was that there were other articles
by different authors such as Effect of whey on blood glucose and insulin
responses to composite breakfast and lunch meals in type 2 diabetic
subjects - http://www.ajcn.org/cgi/content/full/82/1/69 - that can
somewhat bridge the gap until the full article is available on the
LoBAG30 diet by Gannon and Nutt. I did some other searches today that
are related to the impact of proteins on glucose control, i.e.,
DPP-IV+inhibition+amino+acid - http://tinyurl.com/yg9vsr and
DPP-IV+inhibition+LEUCINE - http://tinyurl.com/y9glo9.

Frank

On Fri, 10 Nov 2006 13:39:48 -0500, Jefferson
<xyz@adelphia.netng> wrote:

>Alan S wrote:
>
>> On Thu, 09 Nov 2006 21:24:04 -0500, Jefferson
>> <xyz@adelphia.netng> wrote:
>>
>>
>>>Alan S wrote:
>>>
>>>>Hi All
>>>>
>>>>This also relates to the current threads on reduced carb
>>>>diets.
>>>>
>>>>This review appeared recently in Nutrition and Metabolism,
>>>>the original paper was discussed a couple of years ago here:
>>>>
>>>>http://www.nutritionandmetabolism.com/content/3/1/16
>>>>Control of blood glucose in type 2 diabetes without weight
>>>>loss by modification of diet composition
>>>
>>>Metabolic effect of a LoBAG30 diet in men with type 2 diabetes -
>>>http://ajpendo.physiology.org/cgi/co...act/291/4/E786
>>>"Overall, the lack of negative effects, the improved glucose control,
>>>and the positive nitrogen balance suggest such a diet will be beneficial
>>>for older subjects with type 2 diabetes. Nevertheless, the long-term
>>>effects and general applicability of the diet remain to be determined."
>>>
>>>A Gannon and Nuttall search - http://tinyurl.com/y5x9yw
>>>
>>>Frank
>>
>>
>> Thanks Frank; my problem is getting something more detailed
>> than the abstract.
>>
>The reason I sent the search results was that there were other articles
>by different authors such as Effect of whey on blood glucose and insulin
>responses to composite breakfast and lunch meals in type 2 diabetic
>subjects - http://www.ajcn.org/cgi/content/full/82/1/69 - that can
>somewhat bridge the gap until the full article is available on the
>LoBAG30 diet by Gannon and Nutt. I did some other searches today that
>are related to the impact of proteins on glucose control, i.e.,
>DPP-IV+inhibition+amino+acid - http://tinyurl.com/yg9vsr and
>DPP-IV+inhibition+LEUCINE - http://tinyurl.com/y9glo9.
>
>Frank
>
Thanks Frank.

So much to read, so little time...:-)

Cheers, Alan, T2, Australia.
d&e, metformin 1000mg, ezetrol 10mg
Everything in Moderation - Except Laughter.
--
http://loraldiabetes.blogspot.com/
http://loraltravel.blogspot.com/
latest: The Vatican

Alan S wrote:
(snipped)
> So much to read, so little time...:-)

Go to reference #18 of the following article to open up the full which I
cite further down:
Hyperinsulinaemia, hyperaminoacidaemia and post-exercise muscle
anabolism: the search for the optimal recovery drink
http://bjsm.bmj.com/cgi/content/full/40/11/900

Co-Ingestion of a Protein Hydrolysate with or without Additional Leucine
Effectively Reduces Postprandial Blood Glucose Excursions in Type 2
Diabetic Men (Note: This a round-about way to get the full article -
http://jn.nutrition.org/cgi/content/full/136/5/1294)

"The greater insulin response after protein or protein/leucine
co-ingestion reduced the glucose response. The differences in glucose
responses between the Cho and Cho+Pro or Cho+Pro+Leu trials were of
similar magnitude in both groups. However, expressed relatively, the
reductions in the glucose response were 15 ± 5 and 12 ± 3% in the Type 2
diabetes group, and 92 ± 2 and 97 ± 3% in the control group,
respectively, compared with the Cho trial. These data extend previous
findings (15,16), and show that protein/leucine co-ingestion represents
an effective strategy for reducing postprandial blood glucose excursions
after the ingestion of a single bolus of carbohydrate, resembling the
amount of carbohydrate in a low-fat meal. Consequently, our data imply
that such nutritional interventions can be applied to improve
postprandial blood glucose homeostasis in patients with Type 2 diabetes.
We speculated that co-ingestion of protein/leucine with every main meal
could improve blood glucose homeostasis over more prolonged periods.
However, because daily food intake generally includes 3 main meals with
various between-meal snacks, more studies are warranted to establish the
potential of protein/amino acid co-ingestion as a strategy to improve
blood glucose homeostasis under daily, free-living conditions."

"Abbreviations used: AUC, area under the curve above baseline; BW, body
weight; Cho, carbohydrate trial; Cho+Pro, carbohydrate+protein trial;
Cho+Pro+Leu, carbohydrate+protein+leucine trial; EAA, essential amino
acid; EAA-Leu, essential amino acid minus leucine; En%, energy percent;
HbA1c, glycosylated hemoglobin; OGIS, oral glucose sensitivity; OGTT,
oral glucose tolerance test."

In this set of 3 trials, a person of 70 kilograms (154 pounds) ingested
280 mL of a drink composed of 49 grams of carbohydrates, 21 grams of
protein hydrolate, and 7 grams of leucine amino acid. This sounds like
a lot, but it would be a drink of 250 mL or nearly 8 ounces.

AMINO ACID COMPOSITION OF FRESH AND COOKED BEEF CUTS -
http://www.jbc.org/cgi/reprint/193/1/23.pdf (See table I)

Some other amino acid references (I didn't try to be very selective):
http://biology.clc.uc.edu/courses/bio104/compprot.htm
http://www.eas.com/nutrition/articles.asp?cmsId=411
http://www.csmngt.com/amino_acids.htm
Frank