"Jim Chinnis" <jchinnis@SPAMalum.mit.edu> wrote in message
news:3sg6b3pt8vlg8umlpih5ge9et71v4pmb3g@4ax.com...
> "GysdeJongh" <jongh711@planet.nl> wrote in part:
> Very, very interesting. Does the hypothalamus respond with inhibited
> firing
> to glucose or to insulin? I assume the former, but I'm a novice in this
> area.
Hi Jim Chinnis,
To both these and a zillion other signals.....
The human body a a very perfect survival machine.It is geared to getting
enough food and reproduction.Most of the signals are unconscious and we only
find out if there is something wrong
I seem to remember that you are a statistician than regard it as a
multivariate optimization problem which , as ussual , ended up in a local
maximum.So we are all different in that we are all different walking local
maximum solutions of the survival problem that evolution found
Cholecytostokin is a signal which terminates an ongoing meal signalling :
"Hey stop now we have eaten enough" The CCK signal is provoked most strongly
by proteins , also by _some_ fats and just a little bit by
carbohydrates.Unfortunately CCK is not evoked at all in T2D.So.....they are
far better of with (branced) amino acids and good fats because , for them
the vicious circle : inject insulin , eat carbs , get more hugry because of
the insulin and the carbs , eat more carbs will get them in even more
problems
There are very nice articles on this.Look for "The Brain-Gut axis"
Here is an exceprt from the article and a nice colourfull review
The brain plays a central role in the regulation of food intake and energy
balance (1). Hypothalamic- and brain stem nuclei perceive and integrate
circulating metabolic (glucose, lipids) and hormonal (e.g. leptin, insulin,
and various gut peptides) cues reflecting available fuel sources. Indeed, an
oral glucose load acutely mitigates hypothalamic neuronal activity in
healthy humans (2). Efferent neuroendocrine ensembles subsequently
orchestrate food intake and fuel metabolism so as to maintain energy
homeostasis (1;3). Energy imbalance and anomalous fuel flux are metabolic
hallmarks of obesity and type 2 diabetes mellitus. In view of the critical
role of the brain in the control of metabolism alluded to above,
inappropriate hypothalamic processing of signals indicating disruption of
energy homeostasis could contribute to such metabolic anomalies. We
hypothesized that hypothalamic neuronal activity in response to glucose
ingestion would be altered in patients with DM2, reflecting aberrant
perception of current metabolic status
Free review :
J Clin Invest. 2007 Jan;117(1):24-32.
The role of gut hormones in glucose homeostasis.
Drucker DJ.
The gastrointestinal tract has a crucial role in the control of energy
homeostasis through its role in the digestion, absorption, and assimilation
of ingested nutrients. Furthermore, signals from the gastrointestinal tract
are important regulators of gut motility and satiety, both of which have
implications for the long-term control of body weight. Among the specialized
cell types in the gastrointestinal mucosa, enteroendocrine cells have
important roles in regulating energy intake and glucose homeostasis through
their actions on peripheral target organs, including the endocrine pancreas.
This article reviews the biological actions of gut hormones regulating
glucose homeostasis, with an emphasis on mechanisms of action and the
emerging therapeutic roles of gut hormones for the treatment of type 2
diabetes mellitus.
PMID: 17200703
hth
Gys
Low carb is better because then the brain does knows that you have eaten something 
Linear Mode
