High Intake of Heme Iron Boosts Cardiovascular Risk in Diabetics
By David Douglas
NEW YORK (Reuters Health) Jan 09 - A diet rich in heme iron and in red
meat may have adverse cardiovascular consequences in women with type 2
diabetes, Massachusetts-based researchers report in the January issue
of Diabetes Care.
It might be advisable that "patients with type 2 diabetes may limit
consumption of heme iron and red meat," lead investigator Dr. Lu Qi
told Reuters Health.
Dr. Qi of Harvard School of Public Health, Boston and colleagues note
that diabetes-related metabolic abnormalities may aggravate the
adverse effects of excess iron stores on cardiovascular health.
However, they say, little is known about whether iron consumption may
also affect coronary heart disease risk.
To investigate further, the researchers prospectively followed 6,161
women taking part in the Nurses' Health Study who reported a diagnosis
of type 2 diabetes. During 54,455 person-years of follow-up from 1980
through 2000, the team documented 550 incident cases of coronary heart
disease.
After adjustment for age and body mass index, high intakes of both
heme iron and red meat were associated with a significantly increased
risk of fatal coronary heart disease, coronary revascularization, and
total coronary heart disease.
Specifically, total coronary heart disease risk was 50% greater in
women with the highest intake of heme iron compared with those with
the lowest intake. Diet-associated risks were greater in
postmenopausal than in premenopausal women.
The researchers acknowledge that the findings don't prove that high
heme iron intake causes an increased risk of coronary heart disease in
diabetic patients, but cutting back on consumption might be prudent.
Diabetes Care 2007;30:101-106.
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