Metformin biological 1/2 Life

I found 2 values; 6.2 Hr - Plasma, 17.6 Hr - Blood.

Which would be the effective half-life?

I go see my Dr. next week and want to ask for multiple doses during the day,
or an extended release. Don't have an Endocrinologist yet.

On Aug 1, 3:05?pm, "Stumpy" <perilm...@spamnet.con> wrote:
> I found 2 values; 6.2 Hr - Plasma, 17.6 Hr - Blood.
>
> Which would be the effective half-life?
>
> I go see my Dr. next week and want to ask for multiple doses during the day,
> or an extended release. Don't have an Endocrinologist yet.

Stumpy: Very smart question. If you can tolerate Regular metformin
rather than extended release you are better off so far as effective
blood levels. Extended release is a compromise due to GI side effects
in some patients and also made more money as a patent extension for
the drug company. Extended release is not absorbed so well and comes
out the other end partially "dry" in many patients. The package insert
indicates partial absorption. Many patients do not tolerate Regular
metformin so I am told. Some of this side effect might be due to
insistent intake of too many carbs which is contraindiacted in
diabetes anyway. I take metformin R 2x/day with no problems. (2000mg
daily). If I eat too many carbs some GI problems occur on occasion.

Larry

>> I found 2 values; 6.2 Hr - Plasma, 17.6 Hr - Blood.
>>
>> Which would be the effective half-life?
>>
>> I go see my Dr. next week and want to ask for multiple doses during the
>> day,
>> or an extended release. Don't have an Endocrinologist yet.
>
> Stumpy: Very smart question. If you can tolerate Regular metformin
> rather than extended release you are better off so far as effective
> blood levels. Extended release is a compromise due to GI side effects
> in some patients and also made more money as a patent extension for
> the drug company. Extended release is not absorbed so well and comes
> out the other end partially "dry" in many patients. The package insert
> indicates partial absorption. Many patients do not tolerate Regular
> metformin so I am told. Some of this side effect might be due to
> insistent intake of too many carbs which is contraindiacted in
> diabetes anyway. I take metformin R 2x/day with no problems. (2000mg
> daily). If I eat too many carbs some GI problems occur on occasion.
>
> Larry
>

The first 2 weeks of 850mg/day caused problems. It's better now. Will ask
for 500mg/2X. If the extended release is still under patent then my
insurance won't cover it anyway.

On Wed, 1 Aug 2007 15:05:16 -0700, "Stumpy" <perilmung@spamnet.con>
wrote:

>I found 2 values; 6.2 Hr - Plasma, 17.6 Hr - Blood.
>
>Which would be the effective half-life?
>
>I go see my Dr. next week and want to ask for multiple doses during the day,
>or an extended release. Don't have an Endocrinologist yet.
>

Interesting question. I got a gastric reaction within an hour of
taking the first dose; but it took about 3 weeks for a consistent
affect on the bg. I felt more awake within a couple of days of
stopping it.

From that data, I'd say the plasma one. I took 500mg in the morning
and again at night.

Nicky.
T2 dx 05/04 + underactive thyroid
D&E, 100ug thyroxine
Last A1c 5.6% BMI 25

I get a reflux reaction when ever the metformin tabs touch my mouth/throat.


"Nicky" <ukc802466929@btconnect.com> a écrit ...
> "Stumpy" <perilmung@spamnet.con> wrote:
>
>>I found 2 values; 6.2 Hr - Plasma, 17.6 Hr - Blood.
>>
>>Which would be the effective half-life?
>>
>>I go see my Dr. next week and want to ask for multiple doses during the
>>day,
>>or an extended release. Don't have an Endocrinologist yet.
>>
>
> Interesting question. I got a gastric reaction within an hour of
> taking the first dose; but it took about 3 weeks for a consistent
> affect on the bg. I felt more awake within a couple of days of
> stopping it.
>
> From that data, I'd say the plasma one. I took 500mg in the morning
> and again at night.
>
> Nicky.
> T2 dx 05/04 + underactive thyroid
> D&E, 100ug thyroxine
> Last A1c 5.6% BMI 25

On Fri, 3 Aug 2007 05:24:18 +0200, " Frank t2" <a@b.c> wrote:

>I get a reflux reaction when ever the metformin tabs touch my mouth/throat.

Hmmm. If you're not trying to win the prize for the fastest reaction -
could you wrap them in something? I know they're the size of a horse
pill... but for some reason a bit of salami came to mind. Might be too
much cat-sitting a cat who needs 2 thyroxine pills a day, and hates
the whole concept... there's probably a more appropriate method : )
Can't use fats, or you'll mess with the absorption.

Nicky.
T2 dx 05/04 + underactive thyroid
D&E, 100ug thyroxine
Last A1c 5.6% BMI 25

Stumpy <perilmung@spamnet.con> wrote:
: >> I found 2 values; 6.2 Hr - Plasma, 17.6 Hr - Blood.
: >>
: >> Which would be the effective half-life?
: >>
: >> I go see my Dr. next week and want to ask for multiple doses during the
: >> day,
: >> or an extended release. Don't have an Endocrinologist yet.
: >
: > Stumpy: Very smart question. If you can tolerate Regular metformin
: > rather than extended release you are better off so far as effective
: > blood levels. Extended release is a compromise due to GI side effects
: > in some patients and also made more money as a patent extension for
: > the drug company. Extended release is not absorbed so well and comes
: > out the other end partially "dry" in many patients. The package insert
: > indicates partial absorption. Many patients do not tolerate Regular
: > metformin so I am told. Some of this side effect might be due to
: > insistent intake of too many carbs which is contraindiacted in
: > diabetes anyway. I take metformin R 2x/day with no problems. (2000mg
: > daily). If I eat too many carbs some GI problems occur on occasion.
: >
: > Larry
: >

: The first 2 weeks of 850mg/day caused problems. It's better now. Will ask
: for 500mg/2X. If the extended release is still under patent then my
: insurance won't cover it anyway.

Its not. I get mine a Kmart for $15 for a 3 months supply, that's 360
pills! They offer thi price fo rmany generics without any insurance. I
us it because it is ess than the copay for my Medicare D
plan and keeps me out of the donut hole longer.

Wendy

Chocolate ? <eg>

Seriously, I can still take them and have done for abt 10 years now.


"Nicky" <ukc802466929@btconnect.com> a écrit ...
> On Fri, 3 Aug 2007 05:24:18 +0200, " Frank t2" <a@b.c> wrote:
>
>>I get a reflux reaction whenever the metformin tabs touch my mouth/throat.
>
> Hmmm. If you're not trying to win the prize for the fastest reaction -
> could you wrap them in something? I know they're the size of a horse
> pill... but for some reason a bit of salami came to mind. Might be too
> much cat-sitting a cat who needs 2 thyroxine pills a day, and hates
> the whole concept... there's probably a more appropriate method : )
> Can't use fats, or you'll mess with the absorption.
>
> Nicky.
> T2 dx 05/04 + underactive thyroid
> D&E, 100ug thyroxine
> Last A1c 5.6% BMI 25

On Fri, 3 Aug 2007 23:52:59 +0200, " Frank t2" <a@b.c> wrote:

>
>Chocolate ? <eg>

Chocolate coated metformin would probably have a market : )

Nicky.
T2 dx 05/04 + underactive thyroid
D&E, 100ug thyroxine
Last A1c 5.6% BMI 25

lol ... mmmmmmm !

Strange that pharmaceuticals never considered flavours in their medecines
....
How hard can it be ? .. same pricing (to be eligible for health plans), but
such an edge on the competition !

Imagine ... 85% chocolate coated metformin !


"Nicky" <ukc802466929@btconnect.com> a écrit ...
> " Frank t2" <a@b.c> wrote:
>
>>
>>Chocolate ? <eg>
>
> Chocolate coated metformin would probably have a market : )
>
> Nicky.
> T2 dx 05/04 + underactive thyroid
> D&E, 100ug thyroxine
> Last A1c 5.6% BMI 25

On 4-Aug-2007, " Frank t2" <a@b.c> wrote:

> Strange that pharmaceuticals never considered flavours in their medecines

Oh, but they sometimes do consider and use flavors, especially children's
meds... Just look at the liquids like amoxycillen, liquid tylenol, benadryl,
etc.

Then many of the chewables are flavored, as well....

Will, T2

----== Posted via Newsfeeds.Com - Unlimited-Unrestricted-Secure Usenet News==----
http://www.newsfeeds.com The #1 Newsgroup Service in the World! 120,000+ Newsgroups
----= East and West-Coast Server Farms - Total Privacy via Encryption =----