In mice, fat stored under skin but not liver means no diabetes

Fat stored in the liver increases insulin resistance.

I think we learn along with the scientists, the details of this disease.

http://www.newscientist.com/article.ns?id=dn12530

The "world's fattest mice", genetically engineered to overproduce a
key hormone, weigh five times as much as normal mice do – but
bizarrely do not develop diabetes, reveals a new study. The findings
shed light on how current diabetes medications work and point to new
drug targets to treat the disease, say the study's researchers.

....

When Scherer and his team examined the distribution of body fat within
the mice, they found that the obese rodents with an abundance of
adiponectin had a great deal of fat stored under the skin, but very
little fat within organs such as the liver.

This unusual allocation of fat might explain why the animals remained
in good health – extra fat in the liver can make the organ less
sensitive to insulin, thereby leading to diabetes.

....

The new findings might lead to new ways of treating diabetes in the
future, says Scherer. He notes that many drugs currently used to treat
diabetes lead to an increase in adiponectin levels in patients.

Scherer says that giving adiponectin itself would not work well since
the protein gets broken down very quickly in the body. But he adds
that scientists might want to look for compounds that can act directly
on the adiponectin signalling pathway to migrate fat out of the liver
of obese patients.

Journal reference: Journal of Clinical Investigation (DOI:
10.1172/JCI31021)