More med makes higher BG's?

Can too much Glipizide cause daytime highs, perhaps by some liver dump
mechanisim?

At 2.5 Glipizide per day, my elderly T2 friend feels good but the morning
figures and the A1c are a little higher than the doctors like (c. 150).
When he goes up to 5.0 mg per day, after a few days he gets mid-afternoon
highs (200-300) that make him feel ill and impair his functioning.

Does it make sense that the higher dosage could cause the higher BG's, or
is this just coincidence?


-----
Skinny

"skinny" <no@none.com> wrote in message
news:1h8pyaea588zz.12xj323uxs2zu.dlg@40tude.net...
> Can too much Glipizide cause daytime highs, perhaps by some liver dump
> mechanisim?
>
> At 2.5 Glipizide per day, my elderly T2 friend feels good but the morning
> figures and the A1c are a little higher than the doctors like (c. 150).
> When he goes up to 5.0 mg per day, after a few days he gets mid-afternoon
> highs (200-300) that make him feel ill and impair his functioning.
>
> Does it make sense that the higher dosage could cause the higher BG's, or
> is this just coincidence?

It's possible he is going too low and then having a liver dump. What kind
of diet is he eating? Perhaps on those meds he needs to eat more carbs?

Julie Bove wrote:
> "skinny" <no@none.com> wrote in message
> news:1h8pyaea588zz.12xj323uxs2zu.dlg@40tude.net...
>> Can too much Glipizide cause daytime highs, perhaps by some liver dump
>> mechanisim?
>>
>> At 2.5 Glipizide per day, my elderly T2 friend feels good but the morning
>> figures and the A1c are a little higher than the doctors like (c. 150).
>> When he goes up to 5.0 mg per day, after a few days he gets mid-afternoon
>> highs (200-300) that make him feel ill and impair his functioning.
>>
>> Does it make sense that the higher dosage could cause the higher BG's, or
>> is this just coincidence?
>
> It's possible he is going too low and then having a liver dump. What kind
> of diet is he eating? Perhaps on those meds he needs to eat more carbs?

IMO, he'd be better off lowering the meds. More insulin to lower bg
beyond what is needed to control bg is not a good thing.

--
http://www.ornery-geeks.org/consulting/

skinny wrote:
> Can too much Glipizide cause daytime highs, perhaps by some liver dump
> mechanisim?
>
> At 2.5 Glipizide per day, my elderly T2 friend feels good but the morning
> figures and the A1c are a little higher than the doctors like (c. 150).
> When he goes up to 5.0 mg per day, after a few days he gets mid-afternoon
> highs (200-300) that make him feel ill and impair his functioning.
>
> Does it make sense that the higher dosage could cause the higher BG's, or
> is this just coincidence?
>
>
> -----
> Skinny

Glipizide can be a hunger inducer and source of weight gain because it
pushes the pancreas to produce more endogenous insulin which stimulates
appetite.

Having taken the drug for years (before electing to start insulin
injections early) I always suspected that Glipizide dosing was inexact
relative to its effect. One is given a fixed dose by his doctor, but add
exercise and you get an unexpected low, something that often happened to me.

On the other hand, eat a little too much due to the hunger that is
stimulated by the drug and you get a high reading. Add to that the
typical rising level of blood sugar from awaking to the late morning for
many Type II's and you find that a static dose of Glipizide leaves you
with an afternoon high. Try covering that with more drug and you're
likely to get a low.

I used to shave Glipizide pills to better adjust my dosage to
conditions, and had some success with it.