"Decreasing nigral iron levels "
Neurorescue Effect of Rosmarinic Acid on 6-Hydroxydopamine-Lesioned
Nigral Dopamine Neurons in Rat Model of Parkinson's Disease.
J Mol Neurosci. 2011 Dec 29.
Wang J, Xu H, Jiang H, Du X, Sun P, Xie J.
Department of Neurosurgery, the Affiliated Hospital of Medical
College, Qingdao University, Qingdao, 266003, China.
Rosmarinic acid (RA) is a naturally occurring polyphenolic compound.
It has been reported that RA possessed antioxidant and anti-
Our previous study showed that RA could protect MES23.5 dopaminergic
cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in
The purpose of this study was to explore the neuroreparative
(neurorescue) effect of RA on 6-OHDA-lesioned rat model of
disease (PD) in vivo.
In this study, the rats were given RA orally after intrastriatal 6-
Results showed that the dopamine content in the striatum decreased
the numbers of tyrosine hydroxylase-immunoreactive neurons reduced
after 6-OHDA treatment.
RA treatment after 6-OHDA administration could restore these changes.
Further studies demonstrated that 6-OHDA treatment increased the
staining positive cells, which were markedly decreased by RA
Moreover, RA suppressed the increased ratio of Bax/Bcl-2 at gene
induced by 6-OHDA.
This indicates that the neurorescue effects of RA against 6-ODHA-
induced degeneration of the nigrostriatal dopaminergic system were
achieved by decreasing nigral iron levels and regulating the ratio of
Bcl-2/Bax gene expression.
From Wikipedia, the free encyclopedia
Rosmarinic acid is a natural phenol antioxidant carboxylic acid found
in many Lamiaceae herbs used commonly as culinary herbs such as lemon
balm, rosemary, oregano, sage, thyme and peppermint.
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