John wrote:
> Cheers!
>
> http://www.nytimes.com/2008/06/04/he...hp&oref=slogin
>
> John C.
"The company Sirtris, meanwhile, has been testing resveratrol and other
drugs that activate sirtuin. These drugs are small molecules, more
stable than resveratrol, and can be given in smaller doses. In April,
Sirtris reported that its formulation of resveratrol, called SRT501,
reduced glucose levels in diabetic patients."
SRT501 was given to type 2 diabetics in doses of 2.5 and 5 grams. This
is much more than the supplements typically sold. The clinical trial of
resveratrol on subjects with metabolic syndrome also is using doses of 5
grams. Sirtris is also conducting a clinical trial with T2DMs using a
combination of SRT501 and
metformin. Their first SRT501 trial in T2DMs
was done in India. The high purity resveratrol (99%) is not extracted
from grapes. Mega doses of lower purity extracts from polygonum
cuspidatum that contain resveratrol can produce diarrhea.
The next statement is interesting in that some of these so called mimic
are about 1,000 times more effective in activating SIRT1. Their chemical
structure is not that similar to resveratrol.
"The company plans to start clinical trials of its resveratrol mimic
soon. Sirtris’s value to GlaxoSmithKline is presumably that its
sirtuin-activating drugs could be used to treat a spectrum of
degenerative diseases, like cancer and Alzheimer’s, if the underlying
theory is correct."
Some other links on resveratrol:
1.
http://www.diabetesincontrol.com/res...ryarticle=5641
2.
http://tinyurl.com/66qaox
3. Sirtuins: Novel targets for metabolic disease -
http://tinyurl.com/64yjph; PMID: 18393104
4. A scholar.google search for resveratrol+"advanced glycation end
products" resulted in 246 finds -
http://tinyurl.com/5aotjd
5. phase+II+enzymes+resveratrol: 3,170 finds -
http://tinyurl.com/2s95w5
6. phase+II+enzymes+resveratrol+"insulin resistance": 218 finds -
http://tinyurl.com/2xj2py
Frank
New article on Resveratrol 
Linear Mode
