"Normal" levels of iron

Iron and copper toxicity in diseases of aging, particularly
atherosclerosis and Alzheimer's disease.
Brewer GJ
Exp Biol Med (Maywood). 2007 Feb ; 232(2): 323-35

In this review, we point out that natural selection does not act to
lessen human diseases after the reproductive and caregiving period and
that normal levels of iron and copper that may be healthy during the
reproductive years appear to be contributing to diseases of aging and
possibly the aging process itself. It is clear that oxidant damage
contributes to many of the diseases of aging, such as atherosclerosis,
Alzheimer's disease, Parkinson's diseases, diabetes, diseases of
inflammation, diseases of fibrosis, diseases of autoimmunity, and so
on. It is equally clear that both iron and copper can contribute to
excess production of damaging reactive oxygen species through Fenton
chemistry. Here, we examine the evidence that "normal" levels of iron
and copper contribute to various diseases of aging.

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Tom


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