Once-Weekly Extenatide Lowers HbA1c More Than Daily OralAntidiabetics or Insulin Glargine

[Kurt]

http://www.diabetes.org/news-researc...de-lowers.html

(excerpt)

Patients in both studies who took exenatide also lost significantly
more weight than patients receiving the other drugs‚ and there were no
cases of major hypoglycemia with any drugs used in these studies. The
results of both studies were published June 26 in The Lancet.

[Julie Bove]

"Kurt" <[email protected]> wrote in message
news:[email protected]...
http://www.diabetes.org/news-researc...de-lowers.html

(excerpt)

Patients in both studies who took exenatide also lost significantly
more weight than patients receiving the other drugs‚ and there were no
cases of major hypoglycemia with any drugs used in these studies. The
results of both studies were published June 26 in The Lancet.

---

I read it but don't know what it is. Is it a pill? A shot?

[Kurt]

On Jun 29, 8:46Â*pm, "Julie Bove" <julieb...@verizon.net> wrote:
> "Kurt" <kurtwheeling1...@hotmail.com> wrote in message
>
> news:[email protected]...http://www.diabetes.org/news-researc...the-news/once-...
>
> (excerpt)
>
> Patients in both studies who took exenatide also lost significantly
> more weight than patients receiving the other drugs and there were no
> cases of major hypoglycemia with any drugs used in these studies. The
> results of both studies were published June 26 in The Lancet.
>
> ---
>
> I read it but don't know what it is. Â*Is it a pill? Â*A shot?

http://www.endotext.org/obesity/obes...obesity15b.htm

Extenatide
Extenatide is a new injectable treatment for T2DM that mimics the
actions of the pancreatic incretin hormone glucagon-like-peptide-1,
and thereby enhances insulin secretion. In addition to its glucose
lowering benefit, extenatide has demonstrated weight loss efficacy in
trials with diabetics. DeFranzo el al (44) investigated the effect of
exenatide on glycemic control in 336 obese patients with diabetes with
a mean BMI of 34 and who had failed to achieve adequate glycemic
control on metformin. Patients were randomized into 3 groups to either
receive exenatide (5 ï�*g or 10 ï�*g twice daily) or placebo inaddition
to metformin. There was no dietary intervention offered during this
trial. At week 30 hemoglobin A1c (Hb A1c) change from baseline for the
twice-daily 5 and 10 ï�*g extenatide groups were -0.40 and -0.78%,
respectively. Placebo group revealed a change in baseline Hb A1c of +
0.08% (P<0.002).

In addition to a significant reduction iin Hb A1c measurement,
extenatide treated patients

demonstrated a dose-dependent decline in weight of -2.8 kg in the 10
ï�*g and -1.6 kg in the 5 ï�*g group. Extenatide is generally well-
tolerated and did not increase the incidence of hypoglycemia.

[Julie Bove]

"Kurt" <[email protected]> wrote in message
news:[email protected]...
On Jun 29, 8:46 pm, "Julie Bove" <julieb...@verizon.net> wrote:
> "Kurt" <kurtwheeling1...@hotmail.com> wrote in message
>
> news:[email protected]...http://www.diabetes.org/news-researc...the-news/once-...
>
> (excerpt)
>
> Patients in both studies who took exenatide also lost significantly
> more weight than patients receiving the other drugs and there were no
> cases of major hypoglycemia with any drugs used in these studies. The
> results of both studies were published June 26 in The Lancet.
>
> ---
>
> I read it but don't know what it is. Is it a pill? A shot?

http://www.endotext.org/obesity/obes...obesity15b.htm

Extenatide
Extenatide is a new injectable treatment for T2DM that mimics the
actions of the pancreatic incretin hormone glucagon-like-peptide-1,
and thereby enhances insulin secretion. In addition to its glucose
lowering benefit, extenatide has demonstrated weight loss efficacy in
trials with diabetics. DeFranzo el al (44) investigated the effect of
exenatide on glycemic control in 336 obese patients with diabetes with
a mean BMI of 34 and who had failed to achieve adequate glycemic
control on metformin. Patients were randomized into 3 groups to either
receive exenatide (5 ?g or 10 ?g twice daily) or placebo in addition
to metformin. There was no dietary intervention offered during this
trial. At week 30 hemoglobin A1c (Hb A1c) change from baseline for the
twice-daily 5 and 10 ?g extenatide groups were -0.40 and -0.78%,
respectively. Placebo group revealed a change in baseline Hb A1c of +
0.08% (P<0.002).

In addition to a significant reduction iin Hb A1c measurement,
extenatide treated patients

demonstrated a dose-dependent decline in weight of -2.8 kg in the 10
?g and -1.6 kg in the 5 ?g group. Extenatide is generally well-
tolerated and did not increase the incidence of hypoglycemia.

===

Thanks!

[Trinkwasser]

On Tue, 29 Jun 2010 20:46:38 -0700, "Julie Bove"
<[email protected]> wrote:


>I read it but don't know what it is. Is it a pill? A shot?
>
Byetta.

The long acting version may come out under a different name.

[Peppermint Patootie]

In article <i0eemr$kqg$[email protected]>,
"Julie Bove" <[email protected]> wrote:

> "Kurt" <[email protected]> wrote in message
> news:[email protected]...
> http://www.diabetes.org/news-researc...once-weekly-ex
> tenatide-lowers.html
>
> (excerpt)
>
> Patients in both studies who took exenatide also lost significantly
> more weight than patients receiving the other drugs‚ and there were no
> cases of major hypoglycemia with any drugs used in these studies. The
> results of both studies were published June 26 in The Lancet.
>
> ---
>
> I read it but don't know what it is. Is it a pill? A shot?

It's Byetta, but I think it has a different name when it's the once a
week one.

PP, T2: diet, exercise, Byetta
--
"What you fail to understand is that criticising established authority by means
of argument and evidence is a crucial aspect of how science works."
- Chris Malcolm

[Julie Bove]

"Trinkwasser" <[email protected]> wrote in message
news:[email protected]..
> On Tue, 29 Jun 2010 20:46:38 -0700, "Julie Bove"
> <[email protected]> wrote:
>
>
>>I read it but don't know what it is. Is it a pill? A shot?
>>
> Byetta.
>
> The long acting version may come out under a different name.

It's not Byetta. That was mentioned and it said that it works better.

[Julie Bove]

"Peppermint Patootie" <[email protected]> wrote in message
news[email protected]..
> In article <i0eemr$kqg$[email protected]>,
> "Julie Bove" <[email protected]> wrote:
>
>> "Kurt" <[email protected]> wrote in message
>> news:[email protected]...
>> http://www.diabetes.org/news-researc...once-weekly-ex
>> tenatide-lowers.html
>>
>> (excerpt)
>>
>> Patients in both studies who took exenatide also lost significantly
>> more weight than patients receiving the other drugs, and there were no
>> cases of major hypoglycemia with any drugs used in these studies. The
>> results of both studies were published June 26 in The Lancet.
>>
>> ---
>>
>> I read it but don't know what it is. Is it a pill? A shot?
>
> It's Byetta, but I think it has a different name when it's the once a
> week one.

Hmmm... Can't see how that would help then.

[W. Baker]

Julie Bove <[email protected]> wrote:

: "Kurt" <[email protected]> wrote in message
: news:[email protected]...
: On Jun 29, 8:46 pm, "Julie Bove" <julieb...@verizon.net> wrote:
: > "Kurt" <kurtwheeling1...@hotmail.com> wrote in message
: >
: > news:[email protected]...http://www.diabetes.org/news-researc...the-news/once-...
: >
: > (excerpt)
: >
: > Patients in both studies who took exenatide also lost significantly
: > more weight than patients receiving the other drugs and there were no
: > cases of major hypoglycemia with any drugs used in these studies. The
: > results of both studies were published June 26 in The Lancet.
: >
: > ---
: >
: > I read it but don't know what it is. Is it a pill? A shot?

: http://www.endotext.org/obesity/obes...obesity15b.htm

: Extenatide
: Extenatide is a new injectable treatment for T2DM that mimics the
: actions of the pancreatic incretin hormone glucagon-like-peptide-1,
: and thereby enhances insulin secretion. In addition to its glucose
: lowering benefit, extenatide has demonstrated weight loss efficacy in
: trials with diabetics. DeFranzo el al (44) investigated the effect of
: exenatide on glycemic control in 336 obese patients with diabetes with
: a mean BMI of 34 and who had failed to achieve adequate glycemic
: control on metformin. Patients were randomized into 3 groups to either
: receive exenatide (5 ?g or 10 ?g twice daily) or placebo in addition
: to metformin. There was no dietary intervention offered during this
: trial. At week 30 hemoglobin A1c (Hb A1c) change from baseline for the
: twice-daily 5 and 10 ?g extenatide groups were -0.40 and -0.78%,
: respectively. Placebo group revealed a change in baseline Hb A1c of +
: 0.08% (P<0.002).

: In addition to a significant reduction iin Hb A1c measurement,
: extenatide treated patients

: demonstrated a dose-dependent decline in weight of -2.8 kg in the 10
: ?g and -1.6 kg in the 5 ?g group. Extenatide is generally well-
: tolerated and did not increase the incidence of hypoglycemia.

: ===

: Thanks!

Byetta is the daily extenatide. You have heard of that.

Wendy

[W. Baker]

Julie Bove <[email protected]> wrote:

: "Trinkwasser" <[email protected]> wrote in message
: news:[email protected]..
: > On Tue, 29 Jun 2010 20:46:38 -0700, "Julie Bove"
: > <[email protected]> wrote:
: >
: >
: >>I read it but don't know what it is. Is it a pill? A shot?
: >>
: > Byetta.
: >
: > The long acting version may come out under a different name.

: It's not Byetta. That was mentioned and it said that it works better.

It is a new formulation of the SAME drug that needs to be taken on ly once
a week instead of 2 times a day.

Wendy

[Julie Bove]

"W. Baker" <[email protected]> wrote in message
news:i0g7nd$ctg$[email protected]..
> Julie Bove <[email protected]> wrote:
>
> : "Kurt" <[email protected]> wrote in message
> :
> news:[email protected]...
> : On Jun 29, 8:46 pm, "Julie Bove" <julieb...@verizon.net> wrote:
> : > "Kurt" <kurtwheeling1...@hotmail.com> wrote in message
> : >
> : >
> news:[email protected]...http://www.diabetes.org/news-researc...the-news/once-...
> : >
> : > (excerpt)
> : >
> : > Patients in both studies who took exenatide also lost significantly
> : > more weight than patients receiving the other drugs and there were no
> : > cases of major hypoglycemia with any drugs used in these studies. The
> : > results of both studies were published June 26 in The Lancet.
> : >
> : > ---
> : >
> : > I read it but don't know what it is. Is it a pill? A shot?
>
> : http://www.endotext.org/obesity/obes...obesity15b.htm
>
> : Extenatide
> : Extenatide is a new injectable treatment for T2DM that mimics the
> : actions of the pancreatic incretin hormone glucagon-like-peptide-1,
> : and thereby enhances insulin secretion. In addition to its glucose
> : lowering benefit, extenatide has demonstrated weight loss efficacy in
> : trials with diabetics. DeFranzo el al (44) investigated the effect of
> : exenatide on glycemic control in 336 obese patients with diabetes with
> : a mean BMI of 34 and who had failed to achieve adequate glycemic
> : control on metformin. Patients were randomized into 3 groups to either
> : receive exenatide (5 ?g or 10 ?g twice daily) or placebo in addition
> : to metformin. There was no dietary intervention offered during this
> : trial. At week 30 hemoglobin A1c (Hb A1c) change from baseline for the
> : twice-daily 5 and 10 ?g extenatide groups were -0.40 and -0.78%,
> : respectively. Placebo group revealed a change in baseline Hb A1c of +
> : 0.08% (P<0.002).
>
> : In addition to a significant reduction iin Hb A1c measurement,
> : extenatide treated patients
>
> : demonstrated a dose-dependent decline in weight of -2.8 kg in the 10
> : ?g and -1.6 kg in the 5 ?g group. Extenatide is generally well-
> : tolerated and did not increase the incidence of hypoglycemia.
>
> : ===
>
> : Thanks!
>
> Byetta is the daily extenatide. You have heard of that.

Yes. But what they said was confusing because it said it worked better than
Byetta.

[Julie Bove]

"W. Baker" <[email protected]> wrote in message
news:i0g7p5$ctg$[email protected]..
> Julie Bove <[email protected]> wrote:
>
> : "Trinkwasser" <[email protected]> wrote in message
> : news:[email protected]..
> : > On Tue, 29 Jun 2010 20:46:38 -0700, "Julie Bove"
> : > <[email protected]> wrote:
> : >
> : >
> : >>I read it but don't know what it is. Is it a pill? A shot?
> : >>
> : > Byetta.
> : >
> : > The long acting version may come out under a different name.
>
> : It's not Byetta. That was mentioned and it said that it works better.
>
> It is a new formulation of the SAME drug that needs to be taken on ly once
> a week instead of 2 times a day.

Then it's of no interest to me.

[W. Baker]

Julie Bove <[email protected]> wrote:

: "W. Baker" <[email protected]> wrote in message
: news:i0g7nd$ctg$[email protected]..
: > Julie Bove <[email protected]> wrote:
: >
: > : "Kurt" <[email protected]> wrote in message
: > :
: > news:[email protected]...
: > : On Jun 29, 8:46 pm, "Julie Bove" <julieb...@verizon.net> wrote:
: > : > "Kurt" <kurtwheeling1...@hotmail.com> wrote in message
: > : >
: > : >
: > news:[email protected]...http://www.diabetes.org/news-researc...the-news/once-...
: > : >
: > : > (excerpt)
: > : >
: > : > Patients in both studies who took exenatide also lost significantly
: > : > more weight than patients receiving the other drugs and there were no
: > : > cases of major hypoglycemia with any drugs used in these studies. The
: > : > results of both studies were published June 26 in The Lancet.
: > : >
: > : > ---
: > : >
: > : > I read it but don't know what it is. Is it a pill? A shot?
: >
: > : http://www.endotext.org/obesity/obes...obesity15b.htm
: >
: > : Extenatide
: > : Extenatide is a new injectable treatment for T2DM that mimics the
: > : actions of the pancreatic incretin hormone glucagon-like-peptide-1,
: > : and thereby enhances insulin secretion. In addition to its glucose
: > : lowering benefit, extenatide has demonstrated weight loss efficacy in
: > : trials with diabetics. DeFranzo el al (44) investigated the effect of
: > : exenatide on glycemic control in 336 obese patients with diabetes with
: > : a mean BMI of 34 and who had failed to achieve adequate glycemic
: > : control on metformin. Patients were randomized into 3 groups to either
: > : receive exenatide (5 ?g or 10 ?g twice daily) or placebo in addition
: > : to metformin. There was no dietary intervention offered during this
: > : trial. At week 30 hemoglobin A1c (Hb A1c) change from baseline for the
: > : twice-daily 5 and 10 ?g extenatide groups were -0.40 and -0.78%,
: > : respectively. Placebo group revealed a change in baseline Hb A1c of +
: > : 0.08% (P<0.002).
: >
: > : In addition to a significant reduction iin Hb A1c measurement,
: > : extenatide treated patients
: >
: > : demonstrated a dose-dependent decline in weight of -2.8 kg in the 10
: > : ?g and -1.6 kg in the 5 ?g group. Extenatide is generally well-
: > : tolerated and did not increase the incidence of hypoglycemia.
: >
: > : ===
: >
: > : Thanks!
: >
: > Byetta is the daily extenatide. You have heard of that.

: Yes. But what they said was confusing because it said it worked better
than : Byetta.

It may well, perhaps because like extended release pills,
the med is better spread over time. byetta is he brand name of
Extendatide injected twice a day,, which is the generic name for lizard
spit:-)

Wendy

[GysdeJongh]

"Julie Bove" <[email protected]> wrote in message
news:i0g3l0$k3k$[email protected]..

>>>I read it but don't know what it is. Is it a pill? A shot?

Injections
Several times per day : exenatide or Byetta
Once per day : Liraglitude or Victoza
Once a week : long acting exenatide or Byduron