Oxidative stress / periodontitis

<<snip>>
oxidative stress plays a major role in the development of periodontitis
<<snip>>

Medical Journal of The Islamic Republic of Iran
National Research Centre of Medical Sciences of I.R. IRAN
ISSN: 1016-1430
Vol. 19, No. 2, 2005, pp. 141-145
Bioline Code: mr05008
Full paper language: English
Document available free of charge

Medical Journal of The Islamic Republic of Iran, Vol. 19, No. 2, 2005,
pp. 141-145
ADVANCED GLYCATION END PRODUCTS AND THIOBARBITURIC ACID REACTIVE
SUBSTANCE IN GINGIVAL TISSUES OF DIABETIC AND NON-DIABETIC PATIENTS
WITH CHRONIC PERIODONTITIS
B. HOOSHMAND, M.T. GOODARZI, F. OURAI, M.R. SAFARI, AND S. AMIRI
Abstract


Background: Production of advanced glycation end products (AGEs) is
directly linked to the level and duration of hyperglycemia in diabetic
patients. Oxidative stress plays a major role in the pathogenesis of
diabetes mellitus. Free radicals are formed in diabetes by glucose
oxidation, nonenzymatic glycation of proteins and subsequent oxidative
degradation of glycated proteins. Thiobarbituric acid reactive
substance (TBARs) is a factor evidence in the presence of oxidative
stress as a potential mechanism underlying periodontal disease
associated with diabetes.
Methods: 11 subjects (mean age 38.9 years, 6M, 5F) with chronic
periodontitis associated with diabetes (5 Type I, 6 Type II) and 16
subjects (mean age 36.7 years, 7M, 6F) with chronic periodontitis as a
matched control group participated in this study. Clinical attachment
loss and bleeding on probing were determined in all subjects during
clinical examination. FBS and HbA1c were measured in all subjects.
Sections of gingival tissue of all patients were removed during
periodontal surgery.AGEs and TBARS were measured in all removed
gingival tissues. The statistical analysis was carried out using
T-test, Mann-Whitney U-test and Spearman correlation coefficient.
Results: FBS in diabetic and non-diabetic patients was 155.0 ± 82.0
and 87.4±10.6 mg/dL respectively and the difference between the two
groups was statistically significant (p= 0.03 ). There was also a
significant difference in HbA1c between the two studied groups (5±0.04
and 9.1±1.03%) in diabetic and non-diabetic subjects respectively, (p=
0.000). A higher level of TBARs was observed in diabetic patients
compared to non-diabetics (1.13±0.3 vs 0.05±0.01 mole/lit ; p=
0.001). Clinical attachment loss also was higher in diabetic patients
(p= 0.008).
Conclusion: From the results of this study it can be concluded that
oxidative stress plays a major role in the development of periodontitis
in diabetic patients.
Keywords
Diabetes, Periodontitis, Advanced glycation end products (AGE),
Thiobarbituric acid reactive substance (TBARS).


© Copyright 2005 -Medical Journal of the Islamic Republic of Iran


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