Potent Mind-altering Antioxidant

Cannabis may limit damage from strokes and Alzheimer's
Independent, The (London), Jul 6, 1998 by Steve Connor Science
Editor
CANNABIS COULD protect brain cells against the effects of a stroke and
may help to slow the mental deterioration associated with neurological
disorders such as Alzheimer's and Parkinson's diseases.

Scientists have found that a component of marijuana acts as a powerful
antioxidant in the brain which can prevent cells being damaged when a
blood vessel in the head becomes blocked during a stroke.

Experiments revealed that cannabidiol, which is a harmless constituent
of marijuana and does not produce a "high", is a more powerful
antioxidant than vitamins C and D, which are known to neutralise the
highly damaging free radicals released during a stroke.
Dr Aidan Hampson, a British-born researcher at the United States
National Institute of Mental Health, near Washington DC, said the
discovery could eventually lead to a treatment for stroke based on the
cannabis plant.

"We have reason to believe we are on to a good thing here. Cannabidiol
was given to humans in large doses in other clinical trials with no
significant adverse effects," Dr Hampson said. "We could synthesise it
and administer it to patients as a pill, in an inhaler or even as a
suppository, although that would not be as popular. It is non-
psychoactive which makes it particularly useful."

The research, which is published in the Proceedings of the National
Academy of Science, also found that the mind-altering ingredient of
cannabis - tetrahyrocannabinol (THC) - also behaved as a potent
antioxidant which protected brain cells against the sort of oxygen
starvation caused by a stroke.

The US National Academy of Sciences, which publishes the proceedings,
said: "These findings suggest that cannabidiol may be a promising
treatment for stroke and other neurological disorders including
Parkinson's and Alzheimer's diseases, (which are) also thought to
involve oxidative damage."

Dr Hampson said that when a blood vessel in the brain becomes blocked
a complex set of reactions takes place that culminates in the power
houses of the cell, called mitochondria, pumping out free radicals.

When he exposed the nerve cells of laboratory animals to cannabidiol
he found it significantly reduced the damage resulting from the
release of free radicals. The dose levels were similar to those known
to be safe in humans.

"These are the very first results and I would be surprised if we get
through all the stages of drug trials for humans in less than five or
six years," Dr Hampson said.

However, the research findings do not explain whether people who smoke
cannabis are less likely to suffer ill effects following a stroke. "We
don't know whether smoking produces these levels of cannabidiol," he
said.

Copyright 1998 Newspaper Publishing PLC
Provided by ProQuest Information and Learning Company. All rights
Reserved.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Mar 11, 10:45 am, ironjustice <teamtan...@hotmail.com>
wrote:cannabidiol <<

Published online on August 1, 2000, 10.1073/pnas.160105897
PNAS | August 15, 2000 | vol. 97 | no. 17 | 9561-9566
Immunology
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-
arthritic therapeutic in murine collagen-induced arthritis
A. M. Malfait*,, R. Gallily,, P. F. Sumariwalla*, A. S. Malik*, E.
Andreakos*, R. Mechoulam, and M. Feldmann*,§
* Kennedy Institute of Rheumatology, 1 Aspenlea Road, Hammersmith,
London W6 8LH, United Kingdom; and Hebrew University, Hadassah
Medical School, P.O.B. 12272, Jerusalem 91120, Israel

Edited by Anthony Cerami, The Kenneth S. Warren Laboratories,
Tarrytown, NY, and approved June 2, 2000 (received for review March
10, 2000)
Abstract
The therapeutic potential of cannabidiol (CBD), the major
nonpsychoactive component of cannabis, was explored in murine collagen-
induced arthritis (CIA). CIA was elicited by immunizing DBA/1 mice
with type II collagen (CII) in complete Freund's adjuvant.
The CII used was either bovine or murine, resulting in classical acute
CIA or in chronic relapsing CIA, respectively. CBD was administered
after onset of clinical symptoms, and in both models of arthritis the
treatment effectively blocked progression of arthritis. CBD was
equally effective when administered i.p. or orally.
The dose dependency showed a bell-shaped curve, with an optimal effect
at 5 mg/kg per day i.p. or 25 mg/kg per day orally.
Clinical improvement was associated with protection of the joints
against severe damage.
Ex vivo, draining lymph node cells from CBD-treated mice showed a
diminished CII-specific proliferation and IFN- production, as well as
a decreased release of tumor necrosis factor by knee synovial cells.
In vitro effects of CBD included a dose-dependent suppression of
lymphocyte proliferation, both mitogen-stimulated and antigen-
specific, and the blockade of the Zymosan-triggered reactive oxygen
burst by peritoneal granulocytes.
It also was found that CBD administration was capable of blocking the
lipopolysaccharide-induced rise in serum tumor necrosis factor in C57/
BL mice.
Taken together, these data show that CBD, through its combined
immunosuppressive and anti-inflammatory actions, has a potent anti-
arthritic effect in CIA.

Cannabidiol (CBD) is one of the major components of Cannabis sativa,
marijuana (1). Marijuana contains approximately 80 constituents,
termed cannabinoids (2, 3).
CBD is not psychoactive, unlike the other major component of cannabis,
9-tetrahydrocannabinol (9THC) (4, 5).
A vast literature documents the immune modulating effects of
cannabinoids, in vivo and in vitro, mainly of 9THC and synthetic
analogues such as CP55,940 (reviewed in ref. 6).
A nonexhaustive list of in vitro effects includes inhibition of the
proliferative responses of T lymphocytes (7), inhibition of cytotoxic
T cell activity (8), suppression of macrophage function and antigen
presentation (9, 10), and inhibition of NO production by macrophages
(11).
Reports on the in vitro effects of CBD on immune cells are scarce and
include the modulation of tumor necrosis factor (TNF), IL-1, and IFN-
by human peripheral blood mononuclear cells (12, 13) and the
suppression of chemokine production by a human B cell line (14).
These potentially anti-inflammatory properties of CBD, together with
the lack of psychotropic effect and low toxicity (15), prompted us to
test the potential of CBD as a therapeutic agent in collagen-induced
arthritis (CIA).

CIA, a murine model for rheumatoid arthritis (RA), is elicited by
immunizing DBA/1 mice with type II collagen (CII) in complete Freund's
adjuvant (16).
The immune response to CII involves both humoral and cellular
mechanisms (17, 18), and the cellular response is T helper 1-mediated
(19). CIA is characterized by rapid onset of clinical joint
inflammation, resulting in destruction of joint tissues and cartilage/
bone erosions.
Suppression of the inflammatory process by blocking TNF with mAbs has
proven an effective treatment of CIA (20, 21), and these findings led
to the successful use of TNF blockade in multiple phase I, II, and III
clinical trials with RA patients (reviewed in ref. 22), thus
validating the predictive value of CIA as a model for RA.
In the present study, we report that CBD has a beneficial therapeutic
action on established CIA, and we explore its mode of action.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> Cannabis may limit damage from strokes and Alzheimer's
> Independent, The (London), Jul 6, 1998 by Steve Connor Science
> Editor
> CANNABIS COULD protect brain cells against the effects of a stroke and
> may help to slow the mental deterioration associated with neurological
> disorders such as Alzheimer's and Parkinson's diseases.
>
> Scientists have found that a component of marijuana acts as a powerful
> antioxidant in the brain which can prevent cells being damaged when a
> blood vessel in the head becomes blocked during a stroke.
>
> Experiments revealed that cannabidiol, which is a harmless constituent
> of marijuana and does not produce a "high", is a more powerful
> antioxidant than vitamins C and D, which are known to neutralise the
> highly damaging free radicals released during a stroke.
> Dr Aidan Hampson, a British-born researcher at the United States
> National Institute of Mental Health, near Washington DC, said the
> discovery could eventually lead to a treatment for stroke based on the
> cannabis plant.
>
> "We have reason to believe we are on to a good thing here. Cannabidiol
> was given to humans in large doses in other clinical trials with no
> significant adverse effects," Dr Hampson said. "We could synthesise it
> and administer it to patients as a pill, in an inhaler or even as a
> suppository, although that would not be as popular. It is non-
> psychoactive which makes it particularly useful."
>
> The research, which is published in the Proceedings of the National
> Academy of Science, also found that the mind-altering ingredient of
> cannabis - tetrahyrocannabinol (THC) - also behaved as a potent
> antioxidant which protected brain cells against the sort of oxygen
> starvation caused by a stroke.
>
> The US National Academy of Sciences, which publishes the proceedings,
> said: "These findings suggest that cannabidiol may be a promising
> treatment for stroke and other neurological disorders including
> Parkinson's and Alzheimer's diseases, (which are) also thought to
> involve oxidative damage."
>
> Dr Hampson said that when a blood vessel in the brain becomes blocked
> a complex set of reactions takes place that culminates in the power
> houses of the cell, called mitochondria, pumping out free radicals.
>
> When he exposed the nerve cells of laboratory animals to cannabidiol
> he found it significantly reduced the damage resulting from the
> release of free radicals. The dose levels were similar to those known
> to be safe in humans.
>
> "These are the very first results and I would be surprised if we get
> through all the stages of drug trials for humans in less than five or
> six years," Dr Hampson said.
>
> However, the research findings do not explain whether people who smoke
> cannabis are less likely to suffer ill effects following a stroke. "We
> don't know whether smoking produces these levels of cannabidiol," he
> said.
>
> Copyright 1998 Newspaper Publishing PLC
> Provided by ProQuest Information and Learning Company. All rights
> Reserved.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

On Mar 11, 11:16 am, ironjustice <teamtan...@hotmail.com>
wrote:cannabidiol has a beneficial therapeutic
action on established CIA, and we explore its mode of action <<

I assume everyone can speak .. German .. ?


Article
Interaction of Trivalent Iron with Some Cannabinoids and their
related
compounds
Dr. Z. Mobarak 1 *, Dr. H. Aly 2, Dr. D. Bieniek 3
1The National Center of Social and Criminological Research, Awkaf
City, Gezira P.O., Cairo, A.R. Egypt
2Atomic Energy Establishment, Cairo, A.R. Egypt
3Institute for Ecological Chemistry, 8042 Neuherberg/FRG


*Correspondence to Z. Mobarak, The National Center of Social and
Criminological Research, Awkaf City, Gezira P.O., Cairo, A.R. Egypt


Abstract


Translated Abstract
Wechselwirkung zwischen Eisen(III)-Ionen und einigen Cannabinoiden
und
verwandten Verbindungen
Die Reaktion zwischen Orcinol, Olivetol oder Cannabidiol und
dreiwertigem Eisen wurde spektroskopisch untersucht. Zwischen
Eisen(III)-Ionen und Orcinol bzw. Olivetol bilden sich in Methanol
1:3
Komplexe (Dissoziationskonstanten 1,5 × 10-5 bzw. 2,5 × 10-7). Keine
Wechselwirkung konnte unter analogen Bedingungen zwischen Fe3+-ionen
und Cannabidiol beobachtet werden.


---------------------------------------------------------------------------*-----
Received: 7 March 1979
Digital Object Identifier (DOI)


10.1002/prac.19803220303 About DOI


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Not to rain on your parade but who know's what will kill ya nowadays just
a thought, keep up the good work 'Ironjustice'


Antioxidant Supplements Actually Raise Risk of Cancer
thedermblog.com - "It has been drilled into the public by countless
magazines, product ads, and television commercials. Vitamin C, pomegranate,
resveratrol, coffeeberry: Eat them! Apply them to your face! Add them to
your cereal! Surely soaking up bad free radicals must protect you against
cancer, no?"More. (Health)

184 Comments ShareBury supernova17 made popular 6 hr 20 min ago
http://digg.com/health/Antioxidant_S...Risk_of_Cancer

-------------------------------------------------------------------------------------------------

"ironjustice" <ironjustice@aol.com> wrote in message
news:a1c33e7c-a752-4dfb-b237-be1b5fbb32a3@d4g2000prg.googlegroups.com...
> Cannabis may limit damage from strokes and Alzheimer's
> Independent, The (London), Jul 6, 1998 by Steve Connor Science
> Editor
> CANNABIS COULD protect brain cells against the effects of a stroke and
> may help to slow the mental deterioration associated with neurological
> disorders such as Alzheimer's and Parkinson's diseases.
>
> Scientists have found that a component of marijuana acts as a powerful
> antioxidant in the brain which can prevent cells being damaged when a
> blood vessel in the head becomes blocked during a stroke.
>
> Experiments revealed that cannabidiol, which is a harmless constituent
> of marijuana and does not produce a "high", is a more powerful
> antioxidant than vitamins C and D, which are known to neutralise the
> highly damaging free radicals released during a stroke.
> Dr Aidan Hampson, a British-born researcher at the United States
> National Institute of Mental Health, near Washington DC, said the
> discovery could eventually lead to a treatment for stroke based on the
> cannabis plant.
>
> "We have reason to believe we are on to a good thing here. Cannabidiol
> was given to humans in large doses in other clinical trials with no
> significant adverse effects," Dr Hampson said. "We could synthesise it
> and administer it to patients as a pill, in an inhaler or even as a
> suppository, although that would not be as popular. It is non-
> psychoactive which makes it particularly useful."
>
> The research, which is published in the Proceedings of the National
> Academy of Science, also found that the mind-altering ingredient of
> cannabis - tetrahyrocannabinol (THC) - also behaved as a potent
> antioxidant which protected brain cells against the sort of oxygen
> starvation caused by a stroke.
>
> The US National Academy of Sciences, which publishes the proceedings,
> said: "These findings suggest that cannabidiol may be a promising
> treatment for stroke and other neurological disorders including
> Parkinson's and Alzheimer's diseases, (which are) also thought to
> involve oxidative damage."
>
> Dr Hampson said that when a blood vessel in the brain becomes blocked
> a complex set of reactions takes place that culminates in the power
> houses of the cell, called mitochondria, pumping out free radicals.
>
> When he exposed the nerve cells of laboratory animals to cannabidiol
> he found it significantly reduced the damage resulting from the
> release of free radicals. The dose levels were similar to those known
> to be safe in humans.
>
> "These are the very first results and I would be surprised if we get
> through all the stages of drug trials for humans in less than five or
> six years," Dr Hampson said.
>
> However, the research findings do not explain whether people who smoke
> cannabis are less likely to suffer ill effects following a stroke. "We
> don't know whether smoking produces these levels of cannabidiol," he
> said.
>
> Copyright 1998 Newspaper Publishing PLC
> Provided by ProQuest Information and Learning Company. All rights
> Reserved.
>
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://jesuswasavegetarian.7h.com
>
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
>
>
>
>

On Mar 11, 4:37 pm, "Joe_Z" <Jo...@nana.net> wrote:
> Not to rain on your parade but who know's what will kill ya nowadays just
> a thought, keep up the good work 'Ironjustice'

We've had 10,000 years experience with weed, and not
one attributable death.

On Mar 11, 5:00 pm, Father Haskell
> We've had 10,000 years experience with weed, and not
> one attributable death.

As in Mary-Jane Magdalene

On Mar 11, 6:20 pm, J666 <jeaa...@gmail.com> wrote:
> On Mar 11, 5:00 pm, Father Haskell
> > We've had 10,000 years experience with weed, and not
> > one attributable death.
>
> As in Mary-Jane Magdalene

Or Dawn "Mary Ann" Wells.

"Father Haskell" <fatherhaskell@yahoo.com> wrote in message
news:2f436058-3918-48c9-a7c1-46dcfca7679f@u10g2000prn.googlegroups.com...
> On Mar 11, 4:37 pm, "Joe_Z" <Jo...@nana.net> wrote:
>> Not to rain on your parade but who know's what will kill ya nowadays
>> just
>> a thought, keep up the good work 'Ironjustice'
>
> We've had 10,000 years experience with weed, and not
> one attributable death.

Well then this buds for you... mark another 10,ooo please...

On Tue, 11 Mar 2008 20:37:55 GMT, "Joe_Z" <Joe_Z@nana.net> wrote:

>Not to rain on your parade but who know's what will kill ya nowadays just
>a thought, keep up the good work 'Ironjustice'
>
>

please do not encourage the mentally ill to stay ill.

On Mar 11, 11:17 am, ironjustice <teamtan...@hotmail.com> wrote:
cannabidiol <<

Jeez ..

Dronabinol / cannabidiol [Sativex; Bayer, GW Pharmaceuticals] has been
approved by Health Canada for adults with moderate to severe cancer
pain
Source: Inpharma, Volume 1, Number 1600, 2007-08-11 , pp. 23-23(1)

Publisher: Adis International
---------------------------
http://tinyurl.com/366gow

Cannabinoids: Their Role in Pain and Palliation
Author: McCarberg, Bill H.1

Source: Journal of Pain & Palliative Care Pharmacotherapy, Volume 21,
Number 3, 24 August 2007 , pp. 19-28(10)

Publisher: Haworth Press
Abstract:

Controversy is associated with the issue of cannabis and cannabinoids
in clinical care in the United States.
Recent research has demonstrated the underlying mechanisms of
cannabinoid analgesia via endocannabinoids, an endogenous system of
retrograde neuromodulatory messengers that work in tandem with
endogenous opioids.
Additional receptor and non-receptor mechanisms of cannabinoid drugs
have pertinent activity, including anti-carcinogenesis and
neuroprotection, that may be of key importance in aging and terminal
patient populations.
The results of clinical trials with synthetic and plant-based
cannabinoids suggest that the role of formulation and delivery system
is critical in optimizing the risk-benefit profile of cannabinoid
products.
Synergy between opioids and cannabinoids may produce opioid-sparing
effects, as well as extend the duration of analgesia and reduce opioid
tolerance and dependence.
This article reviews the mechanism of action of cannabinoids, examines
marketed agents and those in clinical trials, and addresses their role
in treatment of chronic pain, cancer, neurodegenerative diseases, and
HIV/ AIDS.
The ability of cannabinoid medicines to treat pain, associated sleep
disorders, appetite loss, muscle spasm and a wide variety of other
symptoms suggests that such agents may in the future play an important
role in palliative care. doi:10.1300/J354v21n03_04
Keywords: Cannabis; cannabinoids; pain; analgesia; THC; cannabidiol;
palliative care

Document Type: Research article

DOI: 10.1300/J354v21n03_04

Affiliations: 1: Founder and Director, Department of Family Medicine,
Pain Management Program, Kaiser Permanente, Escondido, CA, 92025,
Email: Bill.H.Mccarberg@kp.org

---------------------------
Dronabinol/cannabidiol is effective for the treatment of neuropathic
pain
Source: Inpharma, Volume 1, Number 1614, 2007-11-17 , pp. 20-20(1)

Publisher: Adis International
---------------------------

Health Canada has issued a Qualifying Notice for the approval of
dronabinol/cannabidiol
Source: Inpharma, Volume 1, Number 1594, 2007-06-30 , pp. 23-23(1)

Publisher: Adis International
---------------------------

Will Medicinal Cannabinoids Prove to be Useful Clinically?
Author: Smith, Paul F.1

Source: Current Drug Therapy, Volume 2, Number 2, May 2007 , pp.
143-150(8)

Publisher: Bentham Science Publishers


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http://jesuswasavegetarian.7h.com


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http://tinyurl.com/a3cc3


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http://tinyurl.com/zk9fk




< previous article | next article > | view search results



Key: - Free Content - New Content - Subscribed Content -
Free Trial Content


Abstract:

In some parts of the world, medicinal cannabinoids have already been
used to treat nausea and vomiting associated with chemotherapy and
wasting in diseases such as AIDS and terminal cancer. However, over
the last several years, currently used cannabinoids, such as
dronabinol, as well as newly developed cannabis-based medicines such
as Sativex(R) (narrow ratio combination of Ä9-tetrahydrocannabinol and
cannabidiol), have been investigated for the treatment of spasticity,
chronic pain, disruption of sleep and urinary dysfunction associated
with multiple sclerosis and other neurological disorders. Although
some clinical trials have yielded positive results, others have not
and there has been controversy regarding the use of subjective rating
scales to measure pain and spasticity. Adverse side effects have been
generally mild and transient; however, researchers and clinicians are
still concerned about the prospect of long-term adverse side effects.
This review will summarise and critically evaluate the currently
available clinical trial data.



Keywords: Cannabinoids; cannabis; multiple sclerosis; pain;
spasticity

Document Type: Research article

Affiliations: 1: Dept. of Pharmacology and Toxicology, School of
Medical Sciences, University of Otago, Dunedin, New Zealand.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk





> On Mar 11, 10:45 am, ironjustice <teamtan...@hotmail.com>
> wrote:cannabidiol <<
>
> Published online on August 1, 2000, 10.1073/pnas.160105897
> PNAS | August 15, 2000 | vol. 97 | no. 17 | 9561-9566
> Immunology
> The nonpsychoactive cannabis constituent cannabidiol is an oral anti-
> arthritic therapeutic in murine collagen-induced arthritis
> A. M. Malfait*,, R. Gallily,, P. F. Sumariwalla*, A. S. Malik*, E.
> Andreakos*, R. Mechoulam, and M. Feldmann*,§
> * Kennedy Institute of Rheumatology, 1 Aspenlea Road, Hammersmith,
> London W6 8LH, United Kingdom; and Hebrew University, Hadassah
> Medical School, P.O.B. 12272, Jerusalem 91120, Israel
>
> Edited by Anthony Cerami, The Kenneth S. Warren Laboratories,
> Tarrytown, NY, and approved June 2, 2000 (received for review March
> 10, 2000)
> Abstract
> The therapeutic potential of cannabidiol (CBD), the major
> nonpsychoactive component of cannabis, was explored in murine collagen-
> induced arthritis (CIA). CIA was elicited by immunizing DBA/1 mice
> with type II collagen (CII) in complete Freund's adjuvant.
> The CII used was either bovine or murine, resulting in classical acute
> CIA or in chronic relapsing CIA, respectively. CBD was administered
> after onset of clinical symptoms, and in both models of arthritis the
> treatment effectively blocked progression of arthritis. CBD was
> equally effective when administered i.p. or orally.
> The dose dependency showed a bell-shaped curve, with an optimal effect
> at 5 mg/kg per day i.p. or 25 mg/kg per day orally.
> Clinical improvement was associated with protection of the joints
> against severe damage.
> Ex vivo, draining lymph node cells from CBD-treated mice showed a
> diminished CII-specific proliferation and IFN- production, as well as
> a decreased release of tumor necrosis factor by knee synovial cells.
> In vitro effects of CBD included a dose-dependent suppression of
> lymphocyte proliferation, both mitogen-stimulated and antigen-
> specific, and the blockade of the Zymosan-triggered reactive oxygen
> burst by peritoneal granulocytes.
> It also was found that CBD administration was capable of blocking the
> lipopolysaccharide-induced rise in serum tumor necrosis factor in C57/
> BL mice.
> Taken together, these data show that CBD, through its combined
> immunosuppressive and anti-inflammatory actions, has apotentanti-
> arthritic effect in CIA.
>
> Cannabidiol (CBD) is one of the major components of Cannabis sativa,
> marijuana (1). Marijuana contains approximately 80 constituents,
> termed cannabinoids (2, 3).
> CBD is not psychoactive, unlike the other major component of cannabis,
> 9-tetrahydrocannabinol (9THC) (4, 5).
> A vast literature documents the immune modulating effects of
> cannabinoids, in vivo and in vitro, mainly of 9THC and synthetic
> analogues such as CP55,940 (reviewed in ref. 6).
> A nonexhaustive list of in vitro effects includes inhibition of the
> proliferative responses of T lymphocytes (7), inhibition of cytotoxic
> T cell activity (8), suppression of macrophage function and antigen
> presentation (9, 10), and inhibition of NO production by macrophages
> (11).
> Reports on the in vitro effects of CBD on immune cells are scarce and
> include the modulation of tumor necrosis factor (TNF), IL-1, and IFN-
> by human peripheral blood mononuclear cells (12, 13) and the
> suppression of chemokine production by a human B cell line (14).
> These potentially anti-inflammatory properties of CBD, together with
> the lack of psychotropic effect and low toxicity (15), prompted us to
> test the potential of CBD as a therapeutic agent in collagen-induced
> arthritis (CIA).
>
> CIA, a murine model for rheumatoid arthritis (RA), is elicited by
> immunizing DBA/1 mice with type II collagen (CII) in complete Freund's
> adjuvant (16).
> The immune response to CII involves both humoral and cellular
> mechanisms (17, 18), and the cellular response is T helper 1-mediated
> (19). CIA is characterized by rapid onset of clinical joint
> inflammation, resulting in destruction of joint tissues and cartilage/
> bone erosions.
> Suppression of the inflammatory process by blocking TNF with mAbs has
> proven an effective treatment of CIA (20, 21), and these findings led
> to the successful use of TNF blockade in multiple phase I, II, and III
> clinical trials with RA patients (reviewed in ref. 22), thus
> validating the predictive value of CIA as a model for RA.
> In the present study, we report that CBD has a beneficial therapeutic
> action on established CIA, and we explore its mode of action.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > Cannabis may limit damage from strokes and Alzheimer's
> > Independent, The (London), Jul 6, 1998 by Steve Connor Science
> > Editor
> > CANNABIS COULD protect brain cells against the effects of a stroke and
> > may help to slow the mental deterioration associated with neurological
> > disorders such as Alzheimer's and Parkinson's diseases.
>
> > Scientists have found that a component of marijuana acts as a powerful
> > antioxidant in the brain which can prevent cells being damaged when a
> > blood vessel in the head becomes blocked during a stroke.
>
> > Experiments revealed that cannabidiol, which is a harmless constituent
> > of marijuana and does not produce a "high", is a more powerful
> > antioxidant than vitamins C and D, which are known to neutralise the
> > highly damaging free radicals released during a stroke.
> > Dr Aidan Hampson, a British-born researcher at the United States
> > National Institute of Mental Health, near Washington DC, said the
> > discovery could eventually lead to a treatment for stroke based on the
> > cannabis plant.
>
> > "We have reason to believe we are on to a good thing here. Cannabidiol
> > was given to humans in large doses in other clinical trials with no
> > significant adverse effects," Dr Hampson said. "We could synthesise it
> > and administer it to patients as a pill, in an inhaler or even as a
> > suppository, although that would not be as popular. It is non-
> > psychoactive which makes it particularly useful."
>
> > The research, which is published in the Proceedings of the National
> > Academy of Science, also found that themind-alteringingredient of
> > cannabis - tetrahyrocannabinol (THC) - also behaved as apotent
> > antioxidant which protected brain cells against the sort of oxygen
> > starvation caused by a stroke.
>
> > The US National Academy of Sciences, which publishes the proceedings,
> > said: "These findings suggest that cannabidiol may be a promising
> > treatment for stroke and other neurological disorders including
> > Parkinson's and Alzheimer's diseases, (which are) also thought to
> > involve oxidative damage."
>
> > Dr Hampson said that when a blood vessel in the brain becomes blocked
> > a complex set of reactions takes place that culminates in the power
> > houses of the cell, called mitochondria, pumping out free radicals.
>
> > When he exposed the nerve cells of laboratory animals to cannabidiol
> > he found it significantly reduced the damage resulting from the
> > release of free radicals. The dose levels were similar to those known
> > to be safe in humans.
>
> > "These are the very first results and I would be surprised if we get
> > through all the stages of drug trials for humans in less than five or
> > six years," Dr Hampson said.
>
> > However, the research findings do not explain whether people who smoke
> > cannabis are less likely to suffer ill effects following a stroke. "We
> > don't know whether smoking produces these levels of cannabidiol," he
> > said.
>
> > Copyright 1998 Newspaper Publishing PLC
> > Provided by ProQuest Information and Learning Company. All rights
> > Reserved.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> > Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -
>
> - Show quoted text -

On Mar 12, 11:26*am, ironjustice <teamtan...@hotmail.com>
wrote:cannabidiol <<

"Non- psychoactive cannabis constituent CBD inhibited the accumulation
of prion proteins"

Sunday, September 16 2007 @ 11:05 AM EDT
Edited by: Michael Hess

Cannabidiol May be Effective in Preventing Bovine Spongiforme
Enzephalopathy (Mad Cow Disease)

BBSNews 2007-09-16 -- (IACM) According to basic research of scientists
of the National Centre for Scientific Research in Valbonne, France,
cannabidiol (CBD) may prevent the development of prion diseases, the
most known being BSE (bovine spongiforme enzephalopathy), which is
often called mad cow disease. It is believed that the BSE may be
transmitted to human beings. In humans, it is known as Creutzfeldt-
Jakob disease.

The infectious agent in prion diseases is believed to be a specific
type of misfolded protein called prion. Misfolded prion proteins carry
the disease between individuals and cause deterioration of the brain.
The French researchers reported that the non- psychoactive cannabis
constituent CBD inhibited the accumulation of prion proteins in both
mouse and sheep prion- infected cells, whereas other cannabinoids were
either weak or not effective. Moreover, after infection with mouse
scrapie, a prion disease, CBD limited accumulation of the prion
protein in the brain and significantly increased the survival time of
infected mice. CBD inhibited the nerve damaging effects of prions in a
concentration-dependent manner. Researchers noted that CBD may be a
promising agent for the treatment of prion diseases.

(Source: Dirikoc S, Priola SA, Marella M, Zsuerger N, Chabry J.
Nonpsychoactive cannabidiol prevents prion accumulation and protects
neurons against prion toxicity. J Neurosci 2007;27(36):9537-44.)


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




> On Mar 11, 11:17 am, ironjustice <teamtan...@hotmail.com> wrote:
> cannabidiol <<
>
> Jeez ..
>
> Dronabinol / cannabidiol [Sativex; Bayer, GW Pharmaceuticals] has been
> approved by Health Canada for adults with moderate to severe cancer
> pain
> Source: Inpharma, Volume 1, Number 1600, 2007-08-11 , pp. 23-23(1)
>
> Publisher: Adis International
> ---------------------------http://tinyurl.com/366gow
>
> Cannabinoids: Their Role in Pain and Palliation
> Author: McCarberg, Bill H.1
>
> Source: Journal of Pain & Palliative Care Pharmacotherapy, Volume 21,
> Number 3, 24 August 2007 , pp. 19-28(10)
>
> Publisher: Haworth Press
> Abstract:
>
> Controversy is associated with the issue of cannabis and cannabinoids
> in clinical care in the United States.
> Recent research has demonstrated the underlying mechanisms of
> cannabinoid analgesia via endocannabinoids, an endogenous system of
> retrograde neuromodulatory messengers that work in tandem with
> endogenous opioids.
> Additional receptor and non-receptor mechanisms of cannabinoid drugs
> have pertinent activity, including anti-carcinogenesis and
> neuroprotection, that may be of key importance in aging and terminal
> patient populations.
> The results of clinical trials with synthetic and plant-based
> cannabinoids suggest that the role of formulation and delivery system
> is critical in optimizing the risk-benefit profile of cannabinoid
> products.
> Synergy between opioids and cannabinoids may produce opioid-sparing
> effects, as well as extend the duration of analgesia and reduce opioid
> tolerance and dependence.
> This article reviews the mechanism of action of cannabinoids, examines
> marketed agents and those in clinical trials, and addresses their role
> in treatment of chronic pain, cancer, neurodegenerative diseases, and
> HIV/ AIDS.
> The ability of cannabinoid medicines to treat pain, associated sleep
> disorders, appetite loss, muscle spasm and a wide variety of other
> symptoms suggests that such agents may in the future play an important
> role in palliative care. doi:10.1300/J354v21n03_04
> Keywords: Cannabis; cannabinoids; pain; analgesia; THC; cannabidiol;
> palliative care
>
> Document Type: Research article
>
> DOI: 10.1300/J354v21n03_04
>
> Affiliations: 1: Founder and Director, Department of Family Medicine,
> Pain Management Program, Kaiser Permanente, Escondido, CA, 92025,
> Email: Bill.H.Mccarb...@kp.org
>
> ---------------------------
> Dronabinol/cannabidiol is effective for the treatment of neuropathic
> pain
> Source: Inpharma, Volume 1, Number 1614, 2007-11-17 , pp. 20-20(1)
>
> Publisher: Adis International
> ---------------------------
>
> Health Canada has issued a Qualifying Notice for the approval of
> dronabinol/cannabidiol
> Source: Inpharma, Volume 1, Number 1594, 2007-06-30 , pp. 23-23(1)
>
> Publisher: Adis International
> ---------------------------
>
> Will Medicinal Cannabinoids Prove to be Useful Clinically?
> Author: Smith, Paul F.1
>
> Source: Current Drug Therapy, Volume 2, Number 2, May 2007 , pp.
> 143-150(8)
>
> Publisher: Bentham Science Publishers
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> < previous article | next article > | view search results
>
> * * * Key: *- Free Content *- New Content *- Subscribed Content *-
> Free Trial Content
>
> Abstract:
>
> In some parts of the world, medicinal cannabinoids have already been
> used to treat nausea and vomiting associated with chemotherapy and
> wasting in diseases such as AIDS and terminal cancer. However, over
> the last several years, currently used cannabinoids, such as
> dronabinol, as well as newly developed cannabis-based medicines such
> as Sativex(R) (narrow ratio combination of Ä9-tetrahydrocannabinol and
> cannabidiol), have been investigated for the treatment of spasticity,
> chronic pain, disruption of sleep and urinary dysfunction associated
> with multiple sclerosis and other neurological disorders. Although
> some clinical trials have yielded positive results, others have not
> and there has been controversy regarding the use of subjective rating
> scales to measure pain and spasticity. Adverse side effects have been
> generally mild and transient; however, researchers and clinicians are
> still concerned about the prospect of long-term adverse side effects.
> This review will summarise and critically evaluate the currently
> available clinical trial data.
>
> Keywords: Cannabinoids; cannabis; multiple sclerosis; pain;
> spasticity
>
> Document Type: Research article
>
> Affiliations: 1: Dept. of Pharmacology and Toxicology, School of
> Medical Sciences, University of Otago, Dunedin, New Zealand.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > On Mar 11, 10:45 am, ironjustice <teamtan...@hotmail.com>
> > wrote:cannabidiol <<
>
> > Published online on August 1, 2000, 10.1073/pnas.160105897
> > PNAS | August 15, 2000 | vol. 97 | no. 17 | 9561-9566
> > Immunology
> > The nonpsychoactive cannabis constituent cannabidiol is an oral anti-
> > arthritic therapeutic in murine collagen-induced arthritis
> > A. M. Malfait*,, R. Gallily,, P. F. Sumariwalla*, A. S. Malik*, E.
> > Andreakos*, R. Mechoulam, and M. Feldmann*,§
> > * Kennedy Institute of Rheumatology, 1 Aspenlea Road, Hammersmith,
> > London W6 8LH, United Kingdom; and *Hebrew University, Hadassah
> > Medical School, P.O.B. 12272, Jerusalem 91120, Israel
>
> > Edited by Anthony Cerami, The Kenneth S. Warren Laboratories,
> > Tarrytown, NY, and approved June 2, 2000 (received for review March
> > 10, 2000)
> > Abstract
> > The therapeutic potential of cannabidiol (CBD), the major
> > nonpsychoactive component of cannabis, was explored in murine collagen-
> > induced arthritis (CIA). CIA was elicited by immunizing DBA/1 mice
> > with type II collagen (CII) in complete Freund's adjuvant.
> > The CII used was either bovine or murine, resulting in classical acute
> > CIA or in chronic relapsing CIA, respectively. CBD was administered
> > after onset of clinical symptoms, and in both models of arthritis the
> > treatment effectively blocked progression of arthritis. CBD was
> > equally effective when administered i.p. or orally.
> > The dose dependency showed a bell-shaped curve, with an optimal effect
> > at 5 mg/kg per day i.p. or 25 mg/kg per day orally.
> > Clinical improvement was associated with protection of the joints
> > against severe damage.
> > Ex vivo, draining lymph node cells from CBD-treated mice showed a
> > diminished CII-specific proliferation and IFN- production, as well as
> > a decreased release of tumor necrosis factor by knee synovial cells.
> > In vitro effects of CBD included a dose-dependent suppression of
> > lymphocyte proliferation, both mitogen-stimulated and antigen-
> > specific, and the blockade of the Zymosan-triggered reactive oxygen
> > burst by peritoneal granulocytes.
> > It also was found that CBD administration was capable of blocking the
> > lipopolysaccharide-induced rise in serum tumor necrosis factor in C57/
> > BL mice.
> > Taken together, these data show that CBD, through its combined
> > immunosuppressive and anti-inflammatory actions, has apotentanti-
> > arthritic effect in CIA.
>
> > Cannabidiol (CBD) is one of the major components of Cannabis sativa,
> > marijuana (1). Marijuana contains approximately 80 constituents,
> > termed cannabinoids (2, 3).
> > CBD is not psychoactive, unlike the other major component of cannabis,
> > 9-tetrahydrocannabinol (9THC) (4, 5).
> > A vast literature documents the immune modulating effects of
> > cannabinoids, in vivo and in vitro, mainly of 9THC and synthetic
> > analogues such as CP55,940 (reviewed in ref. 6).
> > A nonexhaustive list of in vitro effects includes inhibition of the
> > proliferative responses of T lymphocytes (7), inhibition of cytotoxic
> > T cell activity (8), suppression of macrophage function and antigen
> > presentation (9, 10), and inhibition of NO production by macrophages
> > (11).
> > Reports on the in vitro effects of CBD on immune cells are scarce and
> > include the modulation of tumor necrosis factor (TNF), IL-1, and IFN-
> > by human peripheral blood mononuclear cells (12, 13) and the
> > suppression of chemokine production by a human B cell line (14).
> > These potentially anti-inflammatory properties of CBD, together with
> > the lack of psychotropic effect and low toxicity (15), prompted us to
> > test the potential of CBD as a therapeutic agent in collagen-induced
> > arthritis (CIA).
>
> > CIA, a murine model for rheumatoid arthritis (RA), is elicited by
> > immunizing DBA/1 mice with type II collagen (CII) in complete Freund's
> > adjuvant (16).
> > The immune response to CII involves both humoral and cellular
> > mechanisms (17, 18), and the cellular response is T helper 1-mediated
> > (19). CIA is characterized by rapid onset of clinical joint
> > inflammation, resulting in destruction of joint tissues and cartilage/
> > bone erosions.
> > Suppression of the inflammatory process by blocking TNF with mAbs has
> > proven an effective treatment of CIA (20, 21), and these findings led
> > to the successful use of TNF blockade in multiple phase I, II, and III
> > clinical trials with RA patients (reviewed in ref. 22), thus
> > validating the predictive value of CIA as a model for RA.
> > In the present study, we report that CBD has a beneficial therapeutic
> > action on established CIA, and we explore its mode of action.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> > Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> > > Cannabis may limit damage from strokes and Alzheimer's
> > > Independent, The (London), *Jul 6, 1998 *by Steve Connor Science
> > > Editor
> > > CANNABIS COULD protect brain cells against the effects of a stroke and
> > > may help to slow the mental deterioration associated with neurological
> > > disorders such as Alzheimer's and Parkinson's diseases.
>
> > > Scientists have found that a component of marijuana acts as a powerful
> > > antioxidant in the brain
>
> ...
>
> read more »- Hide quoted text -
>
> - Show quoted text -

On Mar 12, 11:38Â*am, ironjustice <teamtan...@hotmail.com>
wrote:cannabidiol <<

It kills cancer.

5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor
activity of cannabidiol, a non-psychoactive cannabinoid
Authors: Massi, P.1; Valenti, M.2; Vaccani, A.2; Gasperi, V.3;
Perletti, G.2; Marras, E.2; Fezza, F.; Maccarrone, M.; Parolaro, D.2

Source: Journal of Neurochemistry, Volume 104, Number 4, February
2008 , pp. 1091-1100(10)


Publisher: Blackwell Publishing
Abstract:


It has been recently reported that cannabidiol (CBD), a non-
psychoactive cannabinoid, is able to kill glioma cells, both in vivo
and in vitro, independently of cannabinoid receptor stimulation.
However, the underlying biochemical mechanisms were not clarified.
In the present study, we performed biochemical analysis of the effect
of CBD both in vivo, by using glioma tumor tissues excised from nude
mice, and in vitro, by using U87 glioma cells.
In vivo exposure of tumor tissues to CBD significantly decreased the
activity and content of 5-lipoxygenase (LOX, by ∼ 40%), and of its
end
product leukotriene B4 (∼ 25%).
In contrast cyclooxygenase (COX)-2 activity and content, and the
amount of its end product prostaglandin E2, were not affected by CBD.
In addition, in vivo treatment with CBD markedly stimulated (∼ 175%)
the activity of fatty acid amide hydrolase (FAAH), the main
anandamide-
degrading enzyme, while decreasing anandamide content (∼ 30%) and
binding to CB1 cannabinoid receptors (∼ 25%). In vitro pre-treatment
of U87 glioma cells with MK-886, a specific 5-LOX inhibitor,
significantly enhanced the antimitotic effect of CBD, whereas the
pre-
treatment with indomethacin (pan-COX inhibitor) or celecoxib (COX-2
inhibitor), did not alter CBD effect. The study of the
endocannabinoid
system revealed that CBD was able to induce a concentration-dependent
increase of FAAH activity in U87 cells. Moreover, a significantly
reduced growth rate was observed in FAAH-over-expressing U87 cells,
compared to wild-type controls. In conclusion, the present
investigation indicates that CBD exerts its antitumoral effects
through modulation of the LOX pathway and of the endocannabinoid
system, suggesting a possible interaction of these routes in the
control of tumor growth.
Keywords: cannabidiol; cyclooxygenase; endocannabinoid system;
glioma;
lipoxygenase


Document Type: Research article


DOI: 10.1111/j.1471-4159.2007.05073.x


Affiliations: 1: Department of Pharmacology, Chemotherapy and
Toxicology, University of Milan, Milan, Italy 2: Department of
Structural and Functional Biology, Pharmacology Section, Center of
Neuroscience, University of Insubria, Busto Arsizio, Italy 3:
Department of Biomedical Sciences, University of Teramo, Teramo,
Italy


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> On Mar 12, 11:26Â*am, ironjustice <teamtan...@hotmail.com>
> wrote:cannabidiol <<
>
> "Non- psychoactive cannabis constituent CBD inhibited the accumulation
> of prion proteins"
>
> Sunday, September 16 2007 @ 11:05 AM EDT
> Edited by: Michael Hess
>
> Cannabidiol May be Effective in Preventing Bovine Spongiforme
> Enzephalopathy (Mad Cow Disease)
>
> BBSNews 2007-09-16 -- (IACM) According to basic research of scientists
> of the National Centre for Scientific Research in Valbonne, France,
> cannabidiol (CBD) may prevent the development of prion diseases, the
> most known being BSE (bovine spongiforme enzephalopathy), which is
> often called mad cow disease. It is believed that the BSE may be
> transmitted to human beings. In humans, it is known as Creutzfeldt-
> Jakob disease.
>
> The infectious agent in prion diseases is believed to be a specific
> type of misfolded protein called prion. Misfolded prion proteins carry
> the disease between individuals and cause deterioration of the brain.
> The French researchers reported that the non- psychoactive cannabis
> constituent CBD inhibited the accumulation of prion proteins in both
> mouse and sheep prion- infected cells, whereas other cannabinoids were
> either weak or not effective. Moreover, after infection with mouse
> scrapie, a prion disease, CBD limited accumulation of the prion
> protein in the brain and significantly increased the survival time of
> infected mice. CBD inhibited the nerve damaging effects of prions in a
> concentration-dependent manner. Researchers noted that CBD may be a
> promising agent for the treatment of prion diseases.
>
> (Source: Dirikoc S, Priola SA, Marella M, Zsuerger N, Chabry J.
> Nonpsychoactive cannabidiol prevents prion accumulation and protects
> neurons against prion toxicity. J Neurosci 2007;27(36):9537-44.)
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > On Mar 11, 11:17 am, ironjustice <teamtan...@hotmail.com> wrote:
> > cannabidiol <<
>
> > Jeez ..
>
> > Dronabinol / cannabidiol [Sativex; Bayer, GW Pharmaceuticals] has been
> > approved by Health Canada for adults with moderate to severe cancer
> > pain
> > Source: Inpharma, Volume 1, Number 1600, 2007-08-11 , pp. 23-23(1)
>
> > Publisher: Adis International
> > ---------------------------http://tinyurl.com/366gow
>
> > Cannabinoids: Their Role in Pain and Palliation
> > Author: McCarberg, Bill H.1
>
> > Source: Journal of Pain & Palliative Care Pharmacotherapy, Volume 21,
> > Number 3, 24 August 2007 , pp. 19-28(10)
>
> > Publisher: Haworth Press
> > Abstract:
>
> > Controversy is associated with the issue of cannabis and cannabinoids
> > in clinical care in the United States.
> > Recent research has demonstrated the underlying mechanisms of
> > cannabinoid analgesia via endocannabinoids, an endogenous system of
> > retrograde neuromodulatory messengers that work in tandem with
> > endogenous opioids.
> > Additional receptor and non-receptor mechanisms of cannabinoid drugs
> > have pertinent activity, including anti-carcinogenesis and
> > neuroprotection, that may be of key importance in aging and terminal
> > patient populations.
> > The results of clinical trials with synthetic and plant-based
> > cannabinoids suggest that the role of formulation and delivery system
> > is critical in optimizing the risk-benefit profile of cannabinoid
> > products.
> > Synergy between opioids and cannabinoids may produce opioid-sparing
> > effects, as well as extend the duration of analgesia and reduce opioid
> > tolerance and dependence.
> > This article reviews the mechanism of action of cannabinoids, examines
> > marketed agents and those in clinical trials, and addresses their role
> > in treatment of chronic pain, cancer, neurodegenerative diseases, and
> > HIV/ AIDS.
> > The ability of cannabinoid medicines to treat pain, associated sleep
> > disorders, appetite loss, muscle spasm and a wide variety of other
> > symptoms suggests that such agents may in the future play an important
> > role in palliative care. doi:10.1300/J354v21n03_04
> > Keywords: Cannabis; cannabinoids; pain; analgesia; THC; cannabidiol;
> > palliative care
>
> > Document Type: Research article
>
> > DOI: 10.1300/J354v21n03_04
>
> > Affiliations: 1: Founder and Director, Department of Family Medicine,
> > Pain Management Program, Kaiser Permanente, Escondido, CA, 92025,
> > Email: Bill.H.Mccarb...@kp.org
>
> > ---------------------------
> > Dronabinol/cannabidiol is effective for the treatment of neuropathic
> > pain
> > Source: Inpharma, Volume 1, Number 1614, 2007-11-17 , pp. 20-20(1)
>
> > Publisher: Adis International
> > ---------------------------
>
> > Health Canada has issued a Qualifying Notice for the approval of
> > dronabinol/cannabidiol
> > Source: Inpharma, Volume 1, Number 1594, 2007-06-30 , pp. 23-23(1)
>
> > Publisher: Adis International
> > ---------------------------
>
> > Will Medicinal Cannabinoids Prove to be Useful Clinically?
> > Author: Smith, Paul F.1
>
> > Source: Current Drug Therapy, Volume 2, Number 2, May 2007 , pp.
> > 143-150(8)
>
> > Publisher: Bentham Science Publishers
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> > Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> > < previous article | next article > | view search results
>
> > Â* Â* Â* Key: Â*- Free Content Â*- New Content Â*- Subscribed Content Â*-
> > Free Trial Content
>
> > Abstract:
>
> > In some parts of the world, medicinal cannabinoids have already been
> > used to treat nausea and vomiting associated with chemotherapy and
> > wasting in diseases such as AIDS and terminal cancer. However, over
> > the last several years, currently used cannabinoids, such as
> > dronabinol, as well as newly developed cannabis-based medicines such
> > as Sativex(R) (narrow ratio combination of Ä9-tetrahydrocannabinol and
> > cannabidiol), have been investigated for the treatment of spasticity,
> > chronic pain, disruption of sleep and urinary dysfunction associated
> > with multiple sclerosis and other neurological disorders. Although
> > some clinical trials have yielded positive results, others have not
> > and there has been controversy regarding the use of subjective rating
> > scales to measure pain and spasticity. Adverse side effects have been
> > generally mild and transient; however, researchers and clinicians are
> > still concerned about the prospect of long-term adverse side effects.
> > This review will summarise and critically evaluate the currently
> > available clinical trial data.
>
> > Keywords: Cannabinoids; cannabis; multiple sclerosis; pain;
> > spasticity
>
> > Document Type: Research article
>
> > Affiliations: 1: Dept. of Pharmacology and Toxicology, School of
> > Medical Sciences, University of Otago, Dunedin, New Zealand.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> > Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> > > On Mar 11, 10:45 am, ironjustice <teamtan...@hotmail.com>
> > > wrote:cannabidiol <<
>
> > > Published online on August 1, 2000, 10.1073/pnas.160105897
> > > PNAS | August 15, 2000 | vol. 97 | no. 17 | 9561-9566
> > > Immunology
> > > The nonpsychoactive cannabis constituent cannabidiol is an oral anti-
> > > arthritic therapeutic in murine collagen-induced arthritis
> > > A. M. Malfait*,, R. Gallily,, P. F. Sumariwalla*, A. S. Malik*, E.
> > > Andreakos*, R. Mechoulam, and M. Feldmann*,§
> > > * Kennedy Institute of Rheumatology, 1 Aspenlea Road, Hammersmith,
> > > London W6 8LH, United Kingdom; and Â*Hebrew University, Hadassah
> > > Medical School, P.O.B. 12272, Jerusalem 91120, Israel
>
> > > Edited by Anthony Cerami, The Kenneth S. Warren Laboratories,
> > > Tarrytown, NY, and approved June 2, 2000 (received for review March
> > > 10, 2000)
> > > Abstract
> > > The therapeutic potential of cannabidiol (CBD), the major
> > > nonpsychoactive component of cannabis, was explored in murine collagen-
> > > induced arthritis (CIA). CIA was elicited by immunizing DBA/1 mice
> > > with type II collagen (CII) in complete Freund's adjuvant.
> > > The CII used was either bovine or murine, resulting in classical acute
> > > CIA or in chronic relapsing CIA, respectively. CBD was administered
> > > after onset of clinical symptoms, and in both models of arthritis the
> > > treatment effectively blocked progression of arthritis. CBD was
> > > equally effective when administered i.p. or orally.
> > > The dose dependency showed a bell-shaped curve, with an optimal effect
> > > at 5 mg/kg per day i.p. or 25 mg/kg per day orally.
> > > Clinical improvement was associated with protection of the joints
> > > against severe damage.
> > > Ex vivo, draining lymph node cells from CBD-treated mice showed a
> > > diminished CII-specific proliferation and IFN- production, as well as
> > > a decreased release of tumor necrosis factor by knee synovial cells.
> > > In vitro effects of CBD included a dose-dependent suppression of
> > > lymphocyte proliferation, both mitogen-stimulated and antigen-
> > > specific, and the blockade of the Zymosan-triggered reactive oxygen
> > > burst by peritoneal granulocytes.
> > > It also was found that CBD administration was capable of blocking the
> > > lipopolysaccharide-induced rise in serum tumor necrosis factor in C57/
> > > BL mice.
> > > Taken together, these data show that CBD, through its combined
> > > immunosuppressive and anti-inflammatory actions, has apotentanti-
> > > arthritic effect in CIA.
>
> > > Cannabidiol (CBD) is one of the major components of Cannabis sativa,
> > > marijuana (1). Marijuana contains approximately 80 constituents,
> > > termed cannabinoids (2, 3).
> > > CBD is not psychoactive, unlike the other major component of cannabis,
> > > 9-tetrahydrocannabinol (9THC) (4, 5).
> > > A vast literature documents the immune modulating effects of
> > > cannabinoids, in vivo and in vitro, mainly of 9THC and synthetic
> > > analogues such as CP55,940 (reviewed in ref. 6).
> > > A nonexhaustive list of in vitro effects includes inhibition of the
> > > proliferative responses of T
>
> ...
>
> read more »- Hide quoted text -
>
> - Show quoted text -

Google: Keyword: aioe.org

One post in particular talks about AIOE.org and says its a home to
cowards and terrorists

From what I figured out AIOE.org is a free server. Possibly used to
cover one's tracks when posting?

The only way AMF is going to rid AMF of its abusers is to report the
abuses.

One can contact the Clarksville, Nashville and or Memphis Tennessee
FBI or send a direct complaint to: https://tips.fbi.gov/

The US Department of Justice was notified in 2001 upon an emailed
death threat, threatening to stab to death my family members and
myself. The US DOJ put me in touch with the FBI here in Tennessee.

Death Threat Jan 20, 2001
http://groups.google.com/group/alt.m...rch+this+group

CB utilizes multiple alias's so if Queen Wakini shows up on this
thread be safe, be aware and be alert.

AMF
http://groups.google.com/group/alt.m...?lnk=srg&hl=en

Soft hugs to all the non abusers.
Diana Saba


Message from discussion Potent Mind-altering Antioxidant


View parsed - Show only message text

Path: g2news1.google.com!news4.google.com!feeder1-2.proxad.net!
proxad.net!feeder1-1.proxad.net!club-internet.fr!feedme-
small.clubint.net!aioe.org!not-for-mail
From: Queen Wakini <qu...@wakini.com>
Newsgroups: alt.med.fibromyalgia
Subject: Re: Potent Mind-altering Antioxidant
Date: Tue, 11 Mar 2008 23:41:50 -0400
Organization: Queen Wakini
Lines: 10
Message-ID: <fr7je2$b02$2@aioe.org>
References: <a1c33e7c-a752-4dfb-b237-
be1b5fbb32a3@d4g2000prg.googlegroups.com> <D4CBj.
20720$Ls6.19526@trnddc01> <2f436058-3918-48c9-
a7c1-46dcfca7679f@u10g2000prn.googlegroups.com> <9e23f0ed-0a7b-459e-
b7a0-7f6e818fd005@m3g2000hsc.googlegroups.com>
Reply-To: qu...@wakini.com
NNTP-Posting-Host: EA8nGIfDLBKJ03+jIbKxlg.user.aioe.org
Mime-Version: 1.0
Content-Type: text/plain; charset=ISO-8859-1; format=flowed
Content-Transfer-Encoding: 7bit
X-Complaints-To: abuse@aioe.org
In-Reply-To:
User-Agent: Thunderbird 2.0.0.12 (Windows/20080213)

I get muh mind altered when I read dgsaba dramas...


J666 wrote:
> On Mar 11, 5:00 pm, Father Haskell
> > We've had 10,000 years experience with weed, and not
> > one attributable death.
>
> As in Mary-Jane Magdalene
>

DGSaba wrote:
>
>
> From what I figured out AIOE.org is a free server. Possibly used to
> cover one's tracks when posting?


unlike some of the free servers, aioe specifically caches the ip
numbers of users for up to 6 months. available to legal authorrity upon
proper service.