Quaternium-15, a formaldehyde source, also causes some allergic contact
dermatitis, role of methanol from aspartame: Murray 2006.11.20
http://groups.yahoo.com/group/aspartameNM/message/1381 http://groups.yahoo.com/group/aspartameNM/message/1067
eyelid contact dermatitis by formaldehyde from aspartame,
AM Hill & DV Belsito, Nov 2003: Murray 2004.03.30 [150 KB]
http://dermnetnz.org/dermatitis/quaternium-allergy.html http://dermnetnz.org/nzds.html
New Zealand Dermatological Society Incorporated
Allergy to quaternium-15
What is quaternium-15 and where is it found?
Quaternium-15 is a formaldehyde-releasing preservative.
It is used in many cosmetics and pharmaceutical preparations.
It is also used as a preservative in many commercial and industrial
products.
The table below shows some of the products that may contain
quaternium-15.
Products containing quaternium-15
Cosmetics
Self-hygiene/pharmaceutical products
Commercial/industrial products
* Foundations, powders, concealers
* Eye makeup (liners, shadows, mascara)
* Facial makeup (blushes)
* Bronzes
* Makeup removers
* Shampoos
* Soaps
* Moisturizing lotions and creams
* Shaving products
* Body powders
* Sunscreens
* Cleansers and other skin care products
* Disinfectants
* Adhesives
* Floor wax and polish
* Paper and paperboard
* Water-based inks
* Latex paints
* Industrial cutting fluid
* Laundry starch
* Joint cement
* Printing pastes
Formaldehyde-releasing preservatives to avoid
* Imidazolidinyl urea (Germall®)
* Diazolidinyl urea (Germall II®)
* DMDM hydantoin (Glydant®)
* Bromonitropropane diol (Bronopolâ,,¢)
* Tris (hydroxymethyl) nitromethane (Tris Nitro®)
Alternative names for quaternium-15
Quaternium-15 is also known by several other names. These include:
* Azonium-adamantane chlorid
* N-(3-chloroallyl) hexaminium chloride
* Chloroallyl methenamine chloride
* 1-(3-chloroally)-3,5,7 triaza-1-azoniaadamantane chloride
* Methanamine-3-chloroallylochloride
* Hexamethylenetetramine
* Dowicil®75, Dowicil®100, Dowicil®200
Sources of Exposure to Quaternium-15
* Adhesives and glues
* Cosmetics and toiletries
* Cutting fluids
* Disinfectants and cleaning agents
* Latex paints
* Medications such as creams and lotions
* Paper products
* Polishes
* Printing/etching materials
"The reactions to formaldehyde remained low around 0.3% until 1999;
however, a considerable increase throughout the years 2000-2004 was
noted, with rates of 1.5%-1.9% (P = 0.028)."
Contact Dermatitis. 2006 Oct; 55(4): 227-9.
Preservatives sensitivity in Israel: a 10-year overview (1995-2004).
Zoller L,
l_zoller@Rambam.health.gov.il
Bergman R,
r_bergman@Rambam.health.gov.il
Weltfriend S.
Department of Dermatology, Rambam Medical Center, Haifa 31096, Israel.
This study presents a 10-year survey of 2285 patients tested to common
preservatives in northern Israel.
The demographic and clinical data were analysed using a revised MOAHLFA
index.
Patch testing was based on the International Contact Dermatitis
Research Group (ICDRG) guidelines.
411 (18%) patients were found to have positive reactions to 1 or more
preservatives.
The most frequent allergens tested positively were
thimerosal,
methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), and
formaldehyde.
The reactions to MCI/MI remained stable around 1.7% throughout the
years 1995-1998,
with a significant increase to 3.7%-4% (P = 0.029) during 1999-2004.
The reactions to formaldehyde remained low around 0.3% until 1999;
however, a considerable increase throughout the years 2000-2004 was
noted, with rates of 1.5%-1.9% (P = 0.028).
The sensitivity rates for parabens,
quaternium-15,
imidazolidinylurea, and
diazolidinylurea
were low and unchanged, mostly under 0.5%.
As for methyldibromoglutaronitrile (MDBGN),
sensitivity rates around 2% were detected for the years 1996 and
throughout 2000-2004.
Overall, this extensive survey showed a concerning increase in the
sensitivity rates for MCI/MI, formaldehyde, and MDBGN.
PMID: 16958921
"quaternium-15 (9.3%),
formaldehyde (8.4%),"
Dermatitis. 2004 Dec; 15(4): 176-83.
Erratum in: Dermatitis. 2005 Jun; 16(2): 106.
North American Contact Dermatitis Group patch-test results, 2001-2002
study period.
Pratt MD,
Belsito DV,
DeLeo VA,
Fowler JF Jr,
Fransway AF,
Maibach HI,
Marks JG,
Mathias CG,
Rietschel RL,
Sasseville D,
Sherertz EF,
Storrs FJ,
Taylor JS,
Zug K.
North American Contact Dermatitis Group.
kellypratt@sympatico.ca
BACKGROUND:
Allergic contact dermatitis is a significant cause of cutaneous disease
affecting many individuals in the home and at the workplace.
Patch testing is the most worthwhile diagnostic tool for the evaluation
of patients with suspected allergic contact dermatitis.
OBJECTIVE:
This study reports the results of patch testing from January 1, 2001,
to December 31, 2002, by the North American Contact Dermatitis Group
(NACDG).
METHODS:
Patients were tested with an extended screening series of 65 allergens.
A standardized patch-testing technique was used.
Data from these patients were recorded on a standardized computer entry
form and analyzed.
RESULTS:
Sixty-five allergens were tested on 4,913 patients.
The top 10 allergens remain the same in this study period as in the
1999-2000 study period:
nickel sulfate (16.7%),
neomycin (11.6%),
Myroxilon pereirae (balsam of Peru) (11.6%),
fragrance mix (10.4%),
thimerosal (10.2%),
sodium gold thiosulfate (10.2%),
quaternium-15 (9.3%),
formaldehyde (8.4%),
bacitracin (7.9%), and
cobalt chloride (7.4%).
Of the 4,913 patients tested,
69% had at least one positive allergic patch-test reaction.
Of all patients,
15.8% had occupation-related dermatitis;
15.4% were determined to have irritant contact dermatitis, and
11.1% of the 15.4% had a relevant reaction to an occupational irritant.
Of all patients tested,
16.7% had a relevant reaction to an allergen not in the NACDG standard
series, and
5.5% had a relevant reaction to an occupational allergen not in the
standard series.
CONCLUSION:
Our findings once again reinforce the need for a more comprehensive
group of diagnostic allergens than those found in the standard
screening kits.
The usefulness of patch testing is enhanced when a greater number of
allergens are tested, especially nonstandard allergens occupationally
encountered.
PMID: 15842061
************************************************** *****
short aspartame (methanol, formaldehyde) toxicity research summary:
Murray 2006.11.20
http://groups.yahoo.com/group/aspartameNM/message/1381
"Of course, everyone chooses, as a natural priority,
to actively find, quickly share, and positively act upon the facts
about healthy and safe food, drink, and environment."
Rich Murray, MA Room For All
rmforall@comcast.net
505-501-2298 1943 Otowi Road Santa Fe, New Mexico 87505
http://groups.yahoo.com/group/aspartameNM/messages
group with 78 members, 1,381 posts in a public, searchable archive
http://RMForAll.blogspot.com http://groups.yahoo.com/group/aspartameNM/message/1340
aspartame groups and books: updated research review of 2004.07.16:
Murray 2006.05.11
http://groups.yahoo.com/group/aspartameNM/message/1378
11 members of New Mexico legislature sign letter to ban aspartame as a
source of toxic methanol and formaldehyde, Stephen Fox, NM Senator
Gerald Ortiz y Pino: Murray 2006.10.22
http://groups.yahoo.com/group/aspartameNM/message/1374
47 UK Members of Parliament now support aspartame ban initiative of
Roger Williams, MP: Murray 2006.10.16
http://groups.yahoo.com/group/aspartameNM/message/1271
combining aspartame and quinoline yellow, or MSG and brilliant blue,
harms nerve cells, eminent C. Vyvyan Howard et al, 2005
education.guardian.co.uk, Felicity Lawrence: Murray 2005.12.21
http://groups.yahoo.com/group/aspartameNM/message/1277
50% UK baby food is now organic -- aspartame or MSG
with food dyes harm nerve cells, CV Howard 3 year study
funded by Lizzy Vann, CEO, Organix Brands,
Children's Food Advisory Service: Murray 2006.01.13
http://groups.yahoo.com/group/aspartameNM/message/1279
all three aspartame metabolites harm human erythrocyte [red blood cell]
membrane enzyme activity, KH Schulpis et al, two studies in 2005,
Athens, Greece, 2005.12.14: 2004 research review, RL Blaylock:
Murray 2006.01.14
http://groups.yahoo.com/group/aspartameNM/message/1366
toxicity in rat brains from aspartame, Vences-Mejia A, Espinosa-Aguirre
JJ et al 2006 Aug: Murray 2006.09.06
http://groups.yahoo.com/group/aspartameNM/message/1373
aspartame rat brain toxicity re cytochrome P450 enzymes, expecially
CYP2E1, Vences-Mejia A, Espinosa-Aguirre JJ et al, 2006 Aug,
Hum Exp Toxicol: relevant abstracts re formaldehyde from methanol
in alcohol drinks: Murray 2006.09.29
http://groups.yahoo.com/group/aspartameNM/message/1369
Bristol, Connecticut, schools join state program to limit artificial
sweeteners, sugar, fats for 8800 students, Johnny J Burnham,
The Bristol Press: Murray 2006.09.22
http://groups.yahoo.com/group/aspartameNM/message/1341
Connecticut bans artificial sweeteners in schools, Nancy Barnes,
New Milford Times: Murray 2006.05.25
http://groups.yahoo.com/group/aspartameNM/message/1353
carcinogenic effect of inhaled formaldehyde, Federal Institute of Risk
Assessment, Germany -- same safe level as for Canada:
Murray 2006.06.02
http://groups.yahoo.com/group/aspartameNM/message/1352
Home sickness -- indoor air often worse, as our homes seal in
pollutants
[one is formaldehyde, also from the 11% methanol part of aspartame],
Megan Gillis, WinnipegSun.com: Murray 2006.06.01
http://groups.yahoo.com/group/aspartameNM/message/1143
methanol (formaldehyde, formic acid) disposition: Bouchard M
et al, full plain text, 2001: substantial sources are
degradation of fruit pectins, liquors, aspartame, smoke:
Murray 2005.04.02
http://groups.yahoo.com/group/aspartameNM/message/1349
NIH NLM ToxNet HSDB Hazardous Substances Data Bank
inadequate re aspartame (methanol, formaldehyde, formic acid):
Murray 2006.08.19
http://toxnet.nlm.nih.gov/cgi-bin/si...temp/~HwoSfJ:1
HSDB Hazardous Substances Data Bank: Aspartame
ASPARTAME CASRN: 22839-47-0
METHANOL CASRN: 67-56-1
FORMALDEHYDE CASRN: 50-00-0
FORMIC ACID CASRN: 64-18-6
http://groups.yahoo.com/group/aspartameNM/message/1307
formaldehyde from 11% methanol part of aspartame or from red wine
causes same toxicity (hangover) harm: Murray 2006.05.24
Dark wines and liquors, as well as aspartame, provide
similar levels of methanol, above 120 mg daily, for
long-term heavy users, 2 L daily, about 6 cans.
Within hours, methanol is inevitably largely turned into formaldehyde,
and thence largely into formic acid -- the major causes of the dreaded
symptoms of "next morning" hangover.
Fully 11% of aspartame is methanol -- 1,120 mg aspartame
in 2 L diet soda, almost six 12-oz cans, gives 123 mg
methanol (wood alcohol). If 30% of the methanol is turned
into formaldehyde, the amount of formaldehyde, 37 mg,
is 18.5 times the USA EPA limit for daily formaldehyde in
drinking water, 2.0 mg in 2 L average daily drinking water.
Any unsuspected source of methanol, which the body always quickly
and largely turns into formaldehyde and then formic acid, must be
monitored, especially for high responsibility occupations, often with
night shifts, such as pilots and nuclear reactor operators.
http://groups.yahoo.com/group/aspartameNM/message/1052
DMDC: Dimethyl dicarbonate 200mg/L in drinks adds methanol 98 mg/L
( becomes formaldehyde in body ): EU Scientific Committee on Foods
2001.07.12: Murray 2004.01.22
http://www.HolisticMed.com/aspartame mgold@holisticmed.com
Aspartame Toxicity Information Center Mark D. Gold
12 East Side Drive #2-18 Concord, NH 03301 603-225-2100
http://www.holisticmed.com/aspartame.../methanol.html
"Scientific Abuse in Aspartame Research"
http://groups.yahoo.com/group/aspartameNM/message/1371
Russell L. Blaylock, MD discusses MSG, aspartame, excitotoxins
with Mike Adams: Murray 2006.09.27
http://groups.yahoo.com/group/aspartameNM/message/1372
Mike Adams interviews Randall Fitzgerald on "The Hundred Year Lie:
How Food and Medicine are Destroying Your Health" 2006.06.21:
Murray 2006.09.28
************************************************** *****
Quaternium-15, a formaldehyde source, also causes some allergic contact dermatitis, role of methanol from aspartame: Murray 2006.11.20 
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