Re: Acidosis and Insulin Resistance?

convicted neighbor Kumar wrote:
> Andrew, in the Holy Spirit, boldly wrote:
> > convicted neighbor Kumar wrote:
> > > Andrew, in the Holy Spirit, boldly wrote:
> > > > convicted neighbor Kumar wrote:
> > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > convicted neighbor Kumar wrote:
> > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > convicted neighbor Kumar wrote:
> >
> > > > > > > > > Hello,
> >
> > > > > > > > > "Various disease states make the body tissues more resistant to the
> > > > > > > > > actions of insulin. Examples include infection (mediated by the
> > > > > > > > > cytokine TNFα) and **acidosis. Recent research is investigating the
> > > > > > > > > roles of adipokines (the cytokines produced by adipose tissue) in
> > > > > > > > > insulin resistance.
> > > > > > > > >http://en.wikipedia.org/wiki/Insulin_sensitivity"
> >
> > > > > > > > > Reasons for acidosis can be many as indicated on floowinglink:-
> >
> > > > > > > > > "Type 4 RTA is a metabolic acidosis that results from aldosterone
> > > > > > > > > deficiency or resistance. Aldosterone normally promotes distal
> > > > > > > > > potassium (K+) and H+ secretion, as well as sodium (Na+) reabsorption.
> > > > > > > > > Hypoaldosteronism results in hyperkalemia with a concomitant metabolic
> > > > > > > > > acidosis. This type of RTA can also occur from potassium-sparing
> > > > > > > > > diuretics or collecting duct dysfunction from renal insufficiency..
> >
> > > > > > > > > Increased H+ load
> > > > > > > > > Lactic acidosis - Numerous causes, including circulatory failure,
> > > > > > > > > drugs and toxins, and **hereditary causes (see Lactic Acidosis)
> > > > > > > > > Ketoacidosis - Diabetes, alcoholism, and starvation
> > > > > > > > > Ingestions - Salicylates, methanol, ethylene glycol, isoniazid, iron,
> > > > > > > > > paraldehyde, sulfur, toluene, ammonium chloride, phenformin/metformin,
> > > > > > > > > and hyperalimentation fluids
> > > > > > > > >http://www.emedicine.com/emerg/topic312.htm#section~miscellaneous"
> >
> > > > > > > > > Pls note that Lactic acidosis is also related to hereditary causes and
> > > > > > > > > predisposition of diabetes is also indicated.
> >
> > > > > > > > > In view of above, how much we can link acidosis to getting insulin
> > > > > > > > > resistance and correcting it or alkalosis with insulin senstivity?
> >
> > > > > > > > Very rarely clinically observed in non-hospitalized patients.
> >
> > > > > > > But how acidosis can cause insulin resistance?
> >
> > > > > > By changing both the structure and function of receptor, ligand, or
> > > > > > both.
> >
> > > > > Can acidosis also change insulin structure resulting its
> > > > > inefectiveness?
> >
> > > > Yes.
> >
> > > Pls tell more details about it.
> >
> > We call in denaturation.
> >
> > > > > Can acidosis also effect extravascular movement of insulin in short
> > > > > term?
> >
> > > > Yes.
> >
> > > Pls tell more details about it.
> >
> > We call it death.
> >
> > > > > On any instabilty, say on hyperglycemia, acid base and water
> > > > > imbalance, can it deviate insulin's struture due to thermodynamics
> > > > > instabilities and thermodynamic equilibrium?
> >
> > > > No.
> >
> > > Can variation in temperature cause slight deviation in insulin's
> > > structure?
> >
> > Yes.
> >
> > This would also be called denaturation.
>
> "A protein's surroundings play an essential role in the final shape of
> the protein. An aqueous environment favors hydrophilic residues on the
> surface of the protein. A non-aqueous or non-polar environment, favors
> hydrophobic residues on the surface of the protein. The temperature
> and pH level of the protein environment also affects protein shape. A
> change in temperature or pH may cause denaturalization of the protein.
> Denaturalization is a change in the protein's three-dimensional shape.
> Frying an egg is a common example of denaturalization. The chemical
> properties of the proteins in the egg change significantly when heat
> is added. When an egg is heated, normally alpha helical protein
> segments change to beta sheet conformation. Interestingly, the process
> can be reversed with chemical denaturants. Experiments have been
> completed with chemical denaturalization that can "unboil" an egg. By
> adding chemical denaturants such as tetra-flour-ethanol, the beta
> sheet proteins in the boiled egg can be reformed into their original
> alpha helical conformation8,9.
>
> The process of transcription translation in the cell sometimes
> produces errors in the final protein product. Since a proteins
> function is dependent on its shape, the errant proteins may not work
> correctly.
> http://members.aol.com/profchm/cutler.html "
>
> I think, above don't change chemical composition/formula but just
> change the shape/structure. As such, can such change make insulin
> ineffective or antigenic?
>
> As such, can other biochemicals become dysfunctional or antigenic?

Death would ensue first.

May GOD bless you in HIS mighty way making you hungrier than ever.

Prayerfully in Jesus' awesome love,

Andrew <><
--
Andrew B. Chung, MD/PhD
http://ABChung.LiveJournal.com

"Unlike the 2PD-OMER Approach, weight loss diets can't be combined
with well-balanced diets."
http://HeartMDPhD.com/Love/TheTruth

On Jun 15, 4:02Â*pm, "Andrew B. Chung, MD/PhD" <l...@thetruth.com>
wrote:
> convicted neighbor Kumar wrote:
> > Andrew, in the Holy Spirit, boldly wrote:
> > > convicted neighbor Kumar wrote:
> > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > convicted neighbor Kumar wrote:
> > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > convicted neighbor Kumar wrote:
>
> > > > > > > > > > Hello,
>
> > > > > > > > > > "Various disease states make the body tissues more resistant to the
> > > > > > > > > > actions of insulin. Examples include infection (mediated by the
> > > > > > > > > > cytokine TNFα) and **acidosis. Recent research is investigating the
> > > > > > > > > > roles of adipokines (the cytokines produced by adipose tissue) in
> > > > > > > > > > insulin resistance.
> > > > > > > > > >http://en.wikipedia.org/wiki/Insulin_sensitivity"
>
> > > > > > > > > > Reasons for acidosis can be many as indicated on floowing link:-
>
> > > > > > > > > > "Type 4 RTA is a metabolic acidosis that results from aldosterone
> > > > > > > > > > deficiency or resistance. Aldosterone normally promotesdistal
> > > > > > > > > > potassium (K+) and H+ secretion, as well as sodium (Na+) reabsorption.
> > > > > > > > > > Hypoaldosteronism results in hyperkalemia with a concomitant metabolic
> > > > > > > > > > acidosis. This type of RTA can also occur from potassium-sparing
> > > > > > > > > > diuretics or collecting duct dysfunction from renal insufficiency..
>
> > > > > > > > > > Increased H+ load
> > > > > > > > > > Lactic acidosis - Numerous causes, including circulatory failure,
> > > > > > > > > > drugs and toxins, and **hereditary causes (see Lactic Acidosis)
> > > > > > > > > > Ketoacidosis - Diabetes, alcoholism, and starvation
> > > > > > > > > > Ingestions - Salicylates, methanol, ethylene glycol, isoniazid, iron,
> > > > > > > > > > paraldehyde, sulfur, toluene, ammonium chloride, phenformin/metformin,
> > > > > > > > > > and hyperalimentation fluids
> > > > > > > > > >http://www.emedicine.com/emerg/topic312.htm#section~miscellaneous"
>
> > > > > > > > > > Pls note that Lactic acidosis is also related to hereditary causes and
> > > > > > > > > > predisposition of diabetes is also indicated.
>
> > > > > > > > > > In view of above, how much we can link acidosis to getting insulin
> > > > > > > > > > resistance and correcting it or alkalosis with insulin senstivity?
>
> > > > > > > > > Very rarely clinically observed in non-hospitalized patients.
>
> > > > > > > > But how acidosis can cause insulin resistance?
>
> > > > > > > By changing both the structure and function of receptor, ligand, or
> > > > > > > both.
>
> > > > > > Can acidosis also change insulin structure resulting its
> > > > > > inefectiveness?
>
> > > > > Yes.
>
> > > > Pls tell more details about it.
>
> > > We call in denaturation.
>
> > > > > > Can acidosis also effect extravascular movement of insulin in short
> > > > > > term?
>
> > > > > Yes.
>
> > > > Pls tell more details about it.
>
> > > We call it death.
>
> > > > > > On any instabilty, say on hyperglycemia, acid base and water
> > > > > > imbalance, can it deviate insulin's struture due to thermodynamics
> > > > > > instabilities and thermodynamic equilibrium?
>
> > > > > No.
>
> > > > Can variation in temperature cause slight deviation in insulin's
> > > > structure?
>
> > > Yes.
>
> > > This would also be called denaturation.
>
> > "A protein's surroundings play an essential role in the final shape of
> > the protein. An aqueous environment favors hydrophilic residues on the
> > surface of the protein. A non-aqueous or non-polar environment, favors
> > hydrophobic residues on the surface of the protein. The temperature
> > and pH level of the protein environment also affects protein shape. A
> > change in temperature or pH may cause denaturalization of the protein.
> > Denaturalization is a change in the protein's three-dimensional shape.
> > Frying an egg is a common example of denaturalization. The chemical
> > properties of the proteins in the egg change significantly when heat
> > is added. When an egg is heated, normally alpha helical protein
> > segments change to beta sheet conformation. Interestingly, the process
> > can be reversed with chemical denaturants. Experiments have been
> > completed with chemical denaturalization that can "unboil" an egg. By
> > adding chemical denaturants such as tetra-flour-ethanol, the beta
> > sheet proteins in the boiled egg can be reformed into their original
> > alpha helical conformation8,9.
>
> > The process of transcription translation in the cell sometimes
> > produces errors in the final protein product. Since a proteins
> > function is dependent on its shape, the errant proteins may not work
> > correctly.
> >http://members.aol.com/profchm/cutler.html"
>
> > I think, above don't change chemical composition/formula but just
> > change the shape/structure. As such, can such change make insulin
> > ineffective or antigenic?
>
> > As such, can other biochemicals become dysfunctional or antigenic?
>
> Death would ensue first.
Can't there be conitions sub-fatal levels?

Whether insulin's normal qualities and effectiveness can be effected
due to changes in internal environment of body?
> May GOD bless you in HIS mighty way making you hungrier than ever.
>
> Prayerfully in Jesus' awesome love,
>
> Andrew <><
> --
> Andrew B. Chung, MD/PhDhttp://ABChung.LiveJournal.com
>
> "Unlike the 2PD-OMER Approach, weight loss diets can't be combined
> with well-balanced diets."http://HeartMDPhD.com/Love/TheTruth- Hide quoted text -
>
> - Show quoted text -

convicted neighbor Kumar wrote:
> Andrew, in the Holy Spirit, boldly wrote:
> > convicted neighbor Kumar wrote:
> > > Andrew, in the Holy Spirit, boldly wrote:
> > > > convicted neighbor Kumar wrote:
> > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > convicted neighbor Kumar wrote:
> > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > convicted neighbor Kumar wrote:
> >
> > > > > > > > > > > Hello,
> >
> > > > > > > > > > > "Various disease states make the body tissues more resistant to the
> > > > > > > > > > > actions of insulin. Examples include infection (mediated by the
> > > > > > > > > > > cytokine TNFα) and **acidosis. Recent research is investigating the
> > > > > > > > > > > roles of adipokines (the cytokines produced by adipose tissue) in
> > > > > > > > > > > insulin resistance.
> > > > > > > > > > >http://en.wikipedia.org/wiki/Insulin_sensitivity"
> >
> > > > > > > > > > > Reasons for acidosis can be many as indicated on floowing link:-
> >
> > > > > > > > > > > "Type 4 RTA is a metabolic acidosis that results fromaldosterone
> > > > > > > > > > > deficiency or resistance. Aldosterone normally promotes distal
> > > > > > > > > > > potassium (K+) and H+ secretion, as well as sodium (Na+) reabsorption.
> > > > > > > > > > > Hypoaldosteronism results in hyperkalemia with a concomitant metabolic
> > > > > > > > > > > acidosis. This type of RTA can also occur from potassium-sparing
> > > > > > > > > > > diuretics or collecting duct dysfunction from renal insufficiency..
> >
> > > > > > > > > > > Increased H+ load
> > > > > > > > > > > Lactic acidosis - Numerous causes, including circulatory failure,
> > > > > > > > > > > drugs and toxins, and **hereditary causes (see LacticAcidosis)
> > > > > > > > > > > Ketoacidosis - Diabetes, alcoholism, and starvation
> > > > > > > > > > > Ingestions - Salicylates, methanol, ethylene glycol, isoniazid, iron,
> > > > > > > > > > > paraldehyde, sulfur, toluene, ammonium chloride, phenformin/metformin,
> > > > > > > > > > > and hyperalimentation fluids
> > > > > > > > > > >http://www.emedicine.com/emerg/topic312.htm#section~miscellaneous"
> >
> > > > > > > > > > > Pls note that Lactic acidosis is also related to hereditary causes and
> > > > > > > > > > > predisposition of diabetes is also indicated.
> >
> > > > > > > > > > > In view of above, how much we can link acidosis to getting insulin
> > > > > > > > > > > resistance and correcting it or alkalosis with insulin senstivity?
> >
> > > > > > > > > > Very rarely clinically observed in non-hospitalized patients.
> >
> > > > > > > > > But how acidosis can cause insulin resistance?
> >
> > > > > > > > By changing both the structure and function of receptor, ligand, or
> > > > > > > > both.
> >
> > > > > > > Can acidosis also change insulin structure resulting its
> > > > > > > inefectiveness?
> >
> > > > > > Yes.
> >
> > > > > Pls tell more details about it.
> >
> > > > We call in denaturation.
> >
> > > > > > > Can acidosis also effect extravascular movement of insulin inshort
> > > > > > > term?
> >
> > > > > > Yes.
> >
> > > > > Pls tell more details about it.
> >
> > > > We call it death.
> >
> > > > > > > On any instabilty, say on hyperglycemia, acid base and water
> > > > > > > imbalance, can it deviate insulin's struture due to thermodynamics
> > > > > > > instabilities and thermodynamic equilibrium?
> >
> > > > > > No.
> >
> > > > > Can variation in temperature cause slight deviation in insulin's
> > > > > structure?
> >
> > > > Yes.
> >
> > > > This would also be called denaturation.
> >
> > > "A protein's surroundings play an essential role in the final shape of
> > > the protein. An aqueous environment favors hydrophilic residues on the
> > > surface of the protein. A non-aqueous or non-polar environment, favors
> > > hydrophobic residues on the surface of the protein. The temperature
> > > and pH level of the protein environment also affects protein shape. A
> > > change in temperature or pH may cause denaturalization of the protein.
> > > Denaturalization is a change in the protein's three-dimensional shape.
> > > Frying an egg is a common example of denaturalization. The chemical
> > > properties of the proteins in the egg change significantly when heat
> > > is added. When an egg is heated, normally alpha helical protein
> > > segments change to beta sheet conformation. Interestingly, the process
> > > can be reversed with chemical denaturants. Experiments have been
> > > completed with chemical denaturalization that can "unboil" an egg. By
> > > adding chemical denaturants such as tetra-flour-ethanol, the beta
> > > sheet proteins in the boiled egg can be reformed into their original
> > > alpha helical conformation8,9.
> >
> > > The process of transcription translation in the cell sometimes
> > > produces errors in the final protein product. Since a proteins
> > > function is dependent on its shape, the errant proteins may not work
> > > correctly.
> > >http://members.aol.com/profchm/cutler.html"
> >
> > > I think, above don't change chemical composition/formula but just
> > > change the shape/structure. As such, can such change make insulin
> > > ineffective or antigenic?
> >
> > > As such, can other biochemicals become dysfunctional or antigenic?
> >
> > Death would ensue first.
>
> Can't there be conitions sub-fatal levels?

There is not for the vast majority of structural proteins in our
bodies.

> Whether insulin's normal qualities and effectiveness can be effected
> due to changes in internal environment of body?

Not before death of the body.

May GOD bless you in HIS mighty way making you hungrier than ever.

Prayerfully in Jesus' awesome love,

Andrew <><
--
Andrew B. Chung, MD/PhD
http://ABChung.LiveJournal.com

"Unlike the 2PD-OMER Approach, weight loss diets can't be combined
with well-balanced diets."
http://HeartMDPhD.com/Love/TheTruth

On Jun 16, 2:10Â*pm, "Andrew B. Chung, MD/PhD" <l...@thetruth.com>
wrote:
> convicted neighbor Kumar wrote:
> > Andrew, in the Holy Spirit, boldly wrote:
> > > convicted neighbor Kumar wrote:
> > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > convicted neighbor Kumar wrote:
> > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > convicted neighbor Kumar wrote:
>
> > > > > > > > > > > > Hello,
>
> > > > > > > > > > > > "Various disease states make the body tissues more resistant to the
> > > > > > > > > > > > actions of insulin. Examples include infection (mediated by the
> > > > > > > > > > > > cytokine TNFα) and **acidosis. Recent researchis investigating the
> > > > > > > > > > > > roles of adipokines (the cytokines produced by adipose tissue) in
> > > > > > > > > > > > insulin resistance.
> > > > > > > > > > > >http://en.wikipedia.org/wiki/Insulin_sensitivity"
>
> > > > > > > > > > > > Reasons for acidosis can be many as indicated on floowing link:-
>
> > > > > > > > > > > > "Type 4 RTA is a metabolic acidosis that results from aldosterone
> > > > > > > > > > > > deficiency or resistance. Aldosterone normally promotes distal
> > > > > > > > > > > > potassium (K+) and H+ secretion, as well as sodium (Na+) reabsorption.
> > > > > > > > > > > > Hypoaldosteronism results in hyperkalemia with a concomitant metabolic
> > > > > > > > > > > > acidosis. This type of RTA can also occur from potassium-sparing
> > > > > > > > > > > > diuretics or collecting duct dysfunction from renalinsufficiency..
>
> > > > > > > > > > > > Increased H+ load
> > > > > > > > > > > > Lactic acidosis - Numerous causes, including circulatory failure,
> > > > > > > > > > > > drugs and toxins, and **hereditary causes (see Lactic Acidosis)
> > > > > > > > > > > > Ketoacidosis - Diabetes, alcoholism, and starvation
> > > > > > > > > > > > Ingestions - Salicylates, methanol, ethylene glycol, isoniazid, iron,
> > > > > > > > > > > > paraldehyde, sulfur, toluene, ammonium chloride, phenformin/metformin,
> > > > > > > > > > > > and hyperalimentation fluids
> > > > > > > > > > > >http://www.emedicine.com/emerg/topic312.htm#section~miscellaneous"
>
> > > > > > > > > > > > Pls note that Lactic acidosis is also related to hereditary causes and
> > > > > > > > > > > > predisposition of diabetes is also indicated.
>
> > > > > > > > > > > > In view of above, how much we can link acidosis to getting insulin
> > > > > > > > > > > > resistance and correcting it or alkalosis with insulin senstivity?
>
> > > > > > > > > > > Very rarely clinically observed in non-hospitalized patients.
>
> > > > > > > > > > But how acidosis can cause insulin resistance?
>
> > > > > > > > > By changing both the structure and function of receptor, ligand, or
> > > > > > > > > both.
>
> > > > > > > > Can acidosis also change insulin structure resulting its
> > > > > > > > inefectiveness?
>
> > > > > > > Yes.
>
> > > > > > Pls tell more details about it.
>
> > > > > We call in denaturation.
>
> > > > > > > > Can acidosis also effect extravascular movement of insulin in short
> > > > > > > > term?
>
> > > > > > > Yes.
>
> > > > > > Pls tell more details about it.
>
> > > > > We call it death.
>
> > > > > > > > On any instabilty, say on hyperglycemia, acid base and water
> > > > > > > > imbalance, can it deviate insulin's struture due to thermodynamics
> > > > > > > > instabilities and thermodynamic equilibrium?
>
> > > > > > > No.
>
> > > > > > Can variation in temperature cause slight deviation in insulin's
> > > > > > structure?
>
> > > > > Yes.
>
> > > > > This would also be called denaturation.
>
> > > > "A protein's surroundings play an essential role in the final shapeof
> > > > the protein. An aqueous environment favors hydrophilic residues on the
> > > > surface of the protein. A non-aqueous or non-polar environment, favors
> > > > hydrophobic residues on the surface of the protein. The temperature
> > > > and pH level of the protein environment also affects protein shape.A
> > > > change in temperature or pH may cause denaturalization of the protein.
> > > > Denaturalization is a change in the protein's three-dimensional shape.
> > > > Frying an egg is a common example of denaturalization. The chemical
> > > > properties of the proteins in the egg change significantly when heat
> > > > is added. When an egg is heated, normally alpha helical protein
> > > > segments change to beta sheet conformation. Interestingly, the process
> > > > can be reversed with chemical denaturants. Experiments have been
> > > > completed with chemical denaturalization that can "unboil" an egg. By
> > > > adding chemical denaturants such as tetra-flour-ethanol, the beta
> > > > sheet proteins in the boiled egg can be reformed into their original
> > > > alpha helical conformation8,9.
>
> > > > The process of transcription translation in the cell sometimes
> > > > produces errors in the final protein product. Since a proteins
> > > > function is dependent on its shape, the errant proteins may not work
> > > > correctly.
> > > >http://members.aol.com/profchm/cutler.html"
>
> > > > I think, above don't change chemical composition/formula but just
> > > > change the shape/structure. As such, can such change make insulin
> > > > ineffective or antigenic?
>
> > > > As such, can other biochemicals become dysfunctional or antigenic?
>
> > > Death would ensue first.
>
> > Can't there be conitions sub-fatal levels?
>
> There is not for the vast majority of structural proteins in our
> bodies.
>
> > Whether insulin's normal qualities and effectiveness can be effected
> > due to changes in internal environment of body?
>
> Not before death of the body.
>
> May GOD bless you in HIS mighty way making you hungrier than ever.
>
> Prayerfully in Jesus' awesome love,
>
> Andrew <><
> --
> Andrew B. Chung, MD/PhDhttp://ABChung.LiveJournal.com
>
> "Unlike the 2PD-OMER Approach, weight loss diets can't be combined
> with well-balanced diets."http://HeartMDPhD.com/Love/TheTruth- Hide quoted text -
>
> - Show quoted text -

Every substance is having its own temperature. Whether excessive bio-
substances in body can change body's temperature? Body control that is
a different aspect.

convicted neighbor Kumar wrote:
> Andrew, in the Holy Spirit, boldly wrote:
> > convicted neighbor Kumar wrote:
> > > Andrew, in the Holy Spirit, boldly wrote:
> > > > convicted neighbor Kumar wrote:
> > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > convicted neighbor Kumar wrote:
> > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > > convicted neighbor Kumar wrote:
> >
> > > > > > > > > > > > > Hello,
> >
> > > > > > > > > > > > > "Various disease states make the body tissues more resistant to the
> > > > > > > > > > > > > actions of insulin. Examples include infection (mediated by the
> > > > > > > > > > > > > cytokine TNFα) and **acidosis. Recent research is investigating the
> > > > > > > > > > > > > roles of adipokines (the cytokines produced by adipose tissue) in
> > > > > > > > > > > > > insulin resistance.
> > > > > > > > > > > > >http://en.wikipedia.org/wiki/Insulin_sensitivity"
> >
> > > > > > > > > > > > > Reasons for acidosis can be many as indicated on floowing link:-
> >
> > > > > > > > > > > > > "Type 4 RTA is a metabolic acidosis that results from aldosterone
> > > > > > > > > > > > > deficiency or resistance. Aldosterone normally promotes distal
> > > > > > > > > > > > > potassium (K+) and H+ secretion, as well as sodium (Na+) reabsorption.
> > > > > > > > > > > > > Hypoaldosteronism results in hyperkalemia with a concomitant metabolic
> > > > > > > > > > > > > acidosis. This type of RTA can also occur from potassium-sparing
> > > > > > > > > > > > > diuretics or collecting duct dysfunction from renal insufficiency..
> >
> > > > > > > > > > > > > Increased H+ load
> > > > > > > > > > > > > Lactic acidosis - Numerous causes, including circulatory failure,
> > > > > > > > > > > > > drugs and toxins, and **hereditary causes (see Lactic Acidosis)
> > > > > > > > > > > > > Ketoacidosis - Diabetes, alcoholism, and starvation
> > > > > > > > > > > > > Ingestions - Salicylates, methanol, ethylene glycol, isoniazid, iron,
> > > > > > > > > > > > > paraldehyde, sulfur, toluene, ammonium chloride, phenformin/metformin,
> > > > > > > > > > > > > and hyperalimentation fluids
> > > > > > > > > > > > >http://www.emedicine.com/emerg/topic312.htm#section~miscellaneous"
> >
> > > > > > > > > > > > > Pls note that Lactic acidosis is also related to hereditary causes and
> > > > > > > > > > > > > predisposition of diabetes is also indicated.
> >
> > > > > > > > > > > > > In view of above, how much we can link acidosis to getting insulin
> > > > > > > > > > > > > resistance and correcting it or alkalosis with insulin senstivity?
> >
> > > > > > > > > > > > Very rarely clinically observed in non-hospitalizedpatients.
> >
> > > > > > > > > > > But how acidosis can cause insulin resistance?
> >
> > > > > > > > > > By changing both the structure and function of receptor, ligand, or
> > > > > > > > > > both.
> >
> > > > > > > > > Can acidosis also change insulin structure resulting its
> > > > > > > > > inefectiveness?
> >
> > > > > > > > Yes.
> >
> > > > > > > Pls tell more details about it.
> >
> > > > > > We call in denaturation.
> >
> > > > > > > > > Can acidosis also effect extravascular movement of insulin in short
> > > > > > > > > term?
> >
> > > > > > > > Yes.
> >
> > > > > > > Pls tell more details about it.
> >
> > > > > > We call it death.
> >
> > > > > > > > > On any instabilty, say on hyperglycemia, acid base and water
> > > > > > > > > imbalance, can it deviate insulin's struture due to thermodynamics
> > > > > > > > > instabilities and thermodynamic equilibrium?
> >
> > > > > > > > No.
> >
> > > > > > > Can variation in temperature cause slight deviation in insulin's
> > > > > > > structure?
> >
> > > > > > Yes.
> >
> > > > > > This would also be called denaturation.
> >
> > > > > "A protein's surroundings play an essential role in the final shape of
> > > > > the protein. An aqueous environment favors hydrophilic residues on the
> > > > > surface of the protein. A non-aqueous or non-polar environment, favors
> > > > > hydrophobic residues on the surface of the protein. The temperature
> > > > > and pH level of the protein environment also affects protein shape. A
> > > > > change in temperature or pH may cause denaturalization of the protein.
> > > > > Denaturalization is a change in the protein's three-dimensional shape.
> > > > > Frying an egg is a common example of denaturalization. The chemical
> > > > > properties of the proteins in the egg change significantly when heat
> > > > > is added. When an egg is heated, normally alpha helical protein
> > > > > segments change to beta sheet conformation. Interestingly, the process
> > > > > can be reversed with chemical denaturants. Experiments have been
> > > > > completed with chemical denaturalization that can "unboil" an egg.. By
> > > > > adding chemical denaturants such as tetra-flour-ethanol, the beta
> > > > > sheet proteins in the boiled egg can be reformed into their original
> > > > > alpha helical conformation8,9.
> >
> > > > > The process of transcription translation in the cell sometimes
> > > > > produces errors in the final protein product. Since a proteins
> > > > > function is dependent on its shape, the errant proteins may not work
> > > > > correctly.
> > > > >http://members.aol.com/profchm/cutler.html"
> >
> > > > > I think, above don't change chemical composition/formula but just
> > > > > change the shape/structure. As such, can such change make insulin
> > > > > ineffective or antigenic?
> >
> > > > > As such, can other biochemicals become dysfunctional or antigenic?
> >
> > > > Death would ensue first.
> >
> > > Can't there be conitions sub-fatal levels?
> >
> > There is not for the vast majority of structural proteins in our
> > bodies.
> >
> > > Whether insulin's normal qualities and effectiveness can be effected
> > > due to changes in internal environment of body?
> >
> > Not before death of the body.
>
> Every substance is having its own temperature. Whether excessive bio-
> substances in body can change body's temperature? Body control that is
> a different aspect.

Body temperature is well-regulated during homeostasis.

May GOD bless you in HIS mighty way making your hungrier (healthier)
than ever.

Prayerfully in Jesus' awesome love,

Andrew <><
--
Andrew B. Chung, MD/PhD
http://ABChung.LiveJournal.com

"Unlike the 2PD-OMER Approach, weight loss diets can't be combined
with well-balanced diets."
http://HeartMDPhD.com/Love/TheTruth

On Jun 16, 2:23Â*pm, "Andrew B. Chung, MD/PhD" <l...@thetruth.com>
wrote:
> convicted neighbor Kumar wrote:
> > Andrew, in the Holy Spirit, boldly wrote:
> > > convicted neighbor Kumar wrote:
> > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > convicted neighbor Kumar wrote:
> > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > > > convicted neighbor Kumar wrote:
>
> > > > > > > > > > > > > > Hello,
>
> > > > > > > > > > > > > > "Various disease states make the body tissues more resistant to the
> > > > > > > > > > > > > > actions of insulin. Examples include infection (mediated by the
> > > > > > > > > > > > > > cytokine TNFα) and **acidosis. Recent research is investigating the
> > > > > > > > > > > > > > roles of adipokines (the cytokines produced by adipose tissue) in
> > > > > > > > > > > > > > insulin resistance.
> > > > > > > > > > > > > >http://en.wikipedia.org/wiki/Insulin_sensitivity"
>
> > > > > > > > > > > > > > Reasons for acidosis can be many as indicated on floowing link:-
>
> > > > > > > > > > > > > > "Type 4 RTA is a metabolic acidosis that results from aldosterone
> > > > > > > > > > > > > > deficiency or resistance. Aldosterone normally promotes distal
> > > > > > > > > > > > > > potassium (K+) and H+ secretion, as well as sodium (Na+) reabsorption.
> > > > > > > > > > > > > > Hypoaldosteronism results in hyperkalemia with a concomitant metabolic
> > > > > > > > > > > > > > acidosis. This type of RTA can also occur from potassium-sparing
> > > > > > > > > > > > > > diuretics or collecting duct dysfunction from renal insufficiency..
>
> > > > > > > > > > > > > > Increased H+ load
> > > > > > > > > > > > > > Lactic acidosis - Numerous causes, including circulatory failure,
> > > > > > > > > > > > > > drugs and toxins, and **hereditary causes (see Lactic Acidosis)
> > > > > > > > > > > > > > Ketoacidosis - Diabetes, alcoholism, and starvation
> > > > > > > > > > > > > > Ingestions - Salicylates, methanol, ethylene glycol, isoniazid, iron,
> > > > > > > > > > > > > > paraldehyde, sulfur, toluene, ammonium chloride, phenformin/metformin,
> > > > > > > > > > > > > > and hyperalimentation fluids
> > > > > > > > > > > > > >http://www.emedicine.com/emerg/topic312.htm#section~miscellaneous"
>
> > > > > > > > > > > > > > Pls note that Lactic acidosis is also related to hereditary causes and
> > > > > > > > > > > > > > predisposition of diabetes is also indicated.
>
> > > > > > > > > > > > > > In view of above, how much we can link acidosisto getting insulin
> > > > > > > > > > > > > > resistance and correcting it or alkalosis with insulin senstivity?
>
> > > > > > > > > > > > > Very rarely clinically observed in non-hospitalized patients.
>
> > > > > > > > > > > > But how acidosis can cause insulin resistance?
>
> > > > > > > > > > > By changing both the structure and function of receptor, ligand, or
> > > > > > > > > > > both.
>
> > > > > > > > > > Can acidosis also change insulin structure resulting its
> > > > > > > > > > inefectiveness?
>
> > > > > > > > > Yes.
>
> > > > > > > > Pls tell more details about it.
>
> > > > > > > We call in denaturation.
>
> > > > > > > > > > Can acidosis also effect extravascular movement of insulin in short
> > > > > > > > > > term?
>
> > > > > > > > > Yes.
>
> > > > > > > > Pls tell more details about it.
>
> > > > > > > We call it death.
>
> > > > > > > > > > On any instabilty, say on hyperglycemia, acid base and water
> > > > > > > > > > imbalance, can it deviate insulin's struture due to thermodynamics
> > > > > > > > > > instabilities and thermodynamic equilibrium?
>
> > > > > > > > > No.
>
> > > > > > > > Can variation in temperature cause slight deviation in insulin's
> > > > > > > > structure?
>
> > > > > > > Yes.
>
> > > > > > > This would also be called denaturation.
>
> > > > > > "A protein's surroundings play an essential role in the final shape of
> > > > > > the protein. An aqueous environment favors hydrophilic residueson the
> > > > > > surface of the protein. A non-aqueous or non-polar environment,favors
> > > > > > hydrophobic residues on the surface of the protein. The temperature
> > > > > > and pH level of the protein environment also affects protein shape. A
> > > > > > change in temperature or pH may cause denaturalization of the protein.
> > > > > > Denaturalization is a change in the protein's three-dimensionalshape.
> > > > > > Frying an egg is a common example of denaturalization. The chemical
> > > > > > properties of the proteins in the egg change significantly whenheat
> > > > > > is added. When an egg is heated, normally alpha helical protein
> > > > > > segments change to beta sheet conformation. Interestingly, the process
> > > > > > can be reversed with chemical denaturants. Experiments have been
> > > > > > completed with chemical denaturalization that can "unboil" an egg. By
> > > > > > adding chemical denaturants such as tetra-flour-ethanol, the beta
> > > > > > sheet proteins in the boiled egg can be reformed into their original
> > > > > > alpha helical conformation8,9.
>
> > > > > > The process of transcription translation in the cell sometimes
> > > > > > produces errors in the final protein product. Since a proteins
> > > > > > function is dependent on its shape, the errant proteins may notwork
> > > > > > correctly.
> > > > > >http://members.aol.com/profchm/cutler.html"
>
> > > > > > I think, above don't change chemical composition/formula but just
> > > > > > change the shape/structure. As such, can such change make insulin
> > > > > > ineffective or antigenic?
>
> > > > > > As such, can other biochemicals become dysfunctional or antigenic?
>
> > > > > Death would ensue first.
>
> > > > Can't there be conitions sub-fatal levels?
>
> > > There is not for the vast majority of structural proteins in our
> > > bodies.
>
> > > > Whether insulin's normal qualities and effectiveness can be effected
> > > > due to changes in internal environment of body?
>
> > > Not before death of the body.
>
> > Every substance is having its own temperature. Whether excessive bio-
> > substances in body can change body's temperature? Body control that is
> > a different aspect.
>
> Body temperature is well-regulated during homeostasis.
Yes but hyperglycemia or excess fats etc. may not be a homeostasis
condition?

"The underlying causes of insulin-resistant states can be categorized
as follows:

Prereceptor
Abnormal insulin (mutations)
Anti-insulin antibodies
Receptor
Decreased number of receptors (mainly, failure to activate tyrosine
kinase)
Reduced binding of insulin
Insulin receptor mutations
Insulin receptor–blocking antibodies
http://www.emedicine.com/med/topic1173.htm "

Many causes are thought for IR. What about abnormal insulin and anti-
insulin antibodies?
> May GOD bless you in HIS mighty way making your hungrier (healthier)
> than ever.
>
> Prayerfully in Jesus' awesome love,
>
> Andrew <><
> --
> Andrew B. Chung, MD/PhDhttp://ABChung.LiveJournal.com
>
> "Unlike the 2PD-OMER Approach, weight loss diets can't be combined
> with well-balanced diets."http://HeartMDPhD.com/Love/TheTruth- Hide quoted text -
>
> - Show quoted text -

convicted neighbor Kumar wrote:
> Andrew, in the Holy Spirit, boldly wrote:
> > convicted neighbor Kumar wrote:
> > > Andrew, in the Holy Spirit, boldly wrote:
> > > > convicted neighbor Kumar wrote:
> > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > convicted neighbor Kumar wrote:
> > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > > > > convicted neighbor Kumar wrote:
> >
> > > > > > > > > > > > > > > Hello,
> >
> > > > > > > > > > > > > > > "Various disease states make the body tissuesmore resistant to the
> > > > > > > > > > > > > > > actions of insulin. Examples include infection (mediated by the
> > > > > > > > > > > > > > > cytokine TNFα) and **acidosis. Recent research is investigating the
> > > > > > > > > > > > > > > roles of adipokines (the cytokines produced by adipose tissue) in
> > > > > > > > > > > > > > > insulin resistance.
> > > > > > > > > > > > > > >http://en.wikipedia.org/wiki/Insulin_sensitivity"
> >
> > > > > > > > > > > > > > > Reasons for acidosis can be many as indicatedon floowing link:-
> >
> > > > > > > > > > > > > > > "Type 4 RTA is a metabolic acidosis that results from aldosterone
> > > > > > > > > > > > > > > deficiency or resistance. Aldosterone normally promotes distal
> > > > > > > > > > > > > > > potassium (K+) and H+ secretion, as well as sodium (Na+) reabsorption.
> > > > > > > > > > > > > > > Hypoaldosteronism results in hyperkalemia with a concomitant metabolic
> > > > > > > > > > > > > > > acidosis. This type of RTA can also occur from potassium-sparing
> > > > > > > > > > > > > > > diuretics or collecting duct dysfunction fromrenal insufficiency..
> >
> > > > > > > > > > > > > > > Increased H+ load
> > > > > > > > > > > > > > > Lactic acidosis - Numerous causes, including circulatory failure,
> > > > > > > > > > > > > > > drugs and toxins, and **hereditary causes (see Lactic Acidosis)
> > > > > > > > > > > > > > > Ketoacidosis - Diabetes, alcoholism, and starvation
> > > > > > > > > > > > > > > Ingestions - Salicylates, methanol, ethylene glycol, isoniazid, iron,
> > > > > > > > > > > > > > > paraldehyde, sulfur, toluene, ammonium chloride, phenformin/metformin,
> > > > > > > > > > > > > > > and hyperalimentation fluids
> > > > > > > > > > > > > > >http://www.emedicine.com/emerg/topic312.htm#section~miscellaneous"
> >
> > > > > > > > > > > > > > > Pls note that Lactic acidosis is also relatedto hereditary causes and
> > > > > > > > > > > > > > > predisposition of diabetes is also indicated.
> >
> > > > > > > > > > > > > > > In view of above, how much we can link acidosis to getting insulin
> > > > > > > > > > > > > > > resistance and correcting it or alkalosis with insulin senstivity?
> >
> > > > > > > > > > > > > > Very rarely clinically observed in non-hospitalized patients.
> >
> > > > > > > > > > > > > But how acidosis can cause insulin resistance?
> >
> > > > > > > > > > > > By changing both the structure and function of receptor, ligand, or
> > > > > > > > > > > > both.
> >
> > > > > > > > > > > Can acidosis also change insulin structure resulting its
> > > > > > > > > > > inefectiveness?
> >
> > > > > > > > > > Yes.
> >
> > > > > > > > > Pls tell more details about it.
> >
> > > > > > > > We call in denaturation.
> >
> > > > > > > > > > > Can acidosis also effect extravascular movement of insulin in short
> > > > > > > > > > > term?
> >
> > > > > > > > > > Yes.
> >
> > > > > > > > > Pls tell more details about it.
> >
> > > > > > > > We call it death.
> >
> > > > > > > > > > > On any instabilty, say on hyperglycemia, acid base and water
> > > > > > > > > > > imbalance, can it deviate insulin's struture due to thermodynamics
> > > > > > > > > > > instabilities and thermodynamic equilibrium?
> >
> > > > > > > > > > No.
> >
> > > > > > > > > Can variation in temperature cause slight deviation in insulin's
> > > > > > > > > structure?
> >
> > > > > > > > Yes.
> >
> > > > > > > > This would also be called denaturation.
> >
> > > > > > > "A protein's surroundings play an essential role in the finalshape of
> > > > > > > the protein. An aqueous environment favors hydrophilic residues on the
> > > > > > > surface of the protein. A non-aqueous or non-polar environment, favors
> > > > > > > hydrophobic residues on the surface of the protein. The temperature
> > > > > > > and pH level of the protein environment also affects protein shape. A
> > > > > > > change in temperature or pH may cause denaturalization of theprotein.
> > > > > > > Denaturalization is a change in the protein's three-dimensional shape.
> > > > > > > Frying an egg is a common example of denaturalization. The chemical
> > > > > > > properties of the proteins in the egg change significantly when heat
> > > > > > > is added. When an egg is heated, normally alpha helical protein
> > > > > > > segments change to beta sheet conformation. Interestingly, the process
> > > > > > > can be reversed with chemical denaturants. Experiments have been
> > > > > > > completed with chemical denaturalization that can "unboil" anegg. By
> > > > > > > adding chemical denaturants such as tetra-flour-ethanol, the beta
> > > > > > > sheet proteins in the boiled egg can be reformed into their original
> > > > > > > alpha helical conformation8,9.
> >
> > > > > > > The process of transcription translation in the cell sometimes
> > > > > > > produces errors in the final protein product. Since a proteins
> > > > > > > function is dependent on its shape, the errant proteins may not work
> > > > > > > correctly.
> > > > > > >http://members.aol.com/profchm/cutler.html"
> >
> > > > > > > I think, above don't change chemical composition/formula but just
> > > > > > > change the shape/structure. As such, can such change make insulin
> > > > > > > ineffective or antigenic?
> >
> > > > > > > As such, can other biochemicals become dysfunctional or antigenic?
> >
> > > > > > Death would ensue first.
> >
> > > > > Can't there be conitions sub-fatal levels?
> >
> > > > There is not for the vast majority of structural proteins in our
> > > > bodies.
> >
> > > > > Whether insulin's normal qualities and effectiveness can be effected
> > > > > due to changes in internal environment of body?
> >
> > > > Not before death of the body.
> >
> > > Every substance is having its own temperature. Whether excessive bio-
> > > substances in body can change body's temperature? Body control that is
> > > a different aspect.
> >
> > Body temperature is well-regulated during homeostasis.
>
> Yes but hyperglycemia or excess fats etc. may not be a homeostasis
> condition?

It is if one is hungry.

> "The underlying causes of insulin-resistant states can be categorized
> as follows:
>
> Prereceptor
> Abnormal insulin (mutations)
> Anti-insulin antibodies
> Receptor
> Decreased number of receptors (mainly, failure to activate tyrosine
> kinase)
> Reduced binding of insulin
> Insulin receptor mutations
> Insulin receptor–blocking antibodies
> http://www.emedicine.com/med/topic1173.htm "
>
> Many causes are thought for IR. What about abnormal insulin and anti-
> insulin antibodies?

What is clinically seen is IR from VAT.

May GOD bless you in HIS mighty way making you hungrier than ever.

Prayerfully in Jesus' awesome love,

Andrew <><
--
Andrew B. Chung, MD/PhD
Cardiologist

On Jun 16, 11:54Â*pm, "Andrew B. Chung, MD/PhD" <l...@thetruth.com>
wrote:
> convicted neighbor Kumar wrote:
> > Andrew, in the Holy Spirit, boldly wrote:
> > > convicted neighbor Kumar wrote:
> > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > convicted neighbor Kumar wrote:
> > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > > > > > convicted neighbor Kumar wrote:
>
> > > > > > > > > > > > > > > > Hello,
>
> > > > > > > > > > > > > > > > "Various disease states make the body tissues more resistant to the
> > > > > > > > > > > > > > > > actions of insulin. Examples include infection (mediated by the
> > > > > > > > > > > > > > > > cytokine TNFα) and **acidosis. Recent research is investigating the
> > > > > > > > > > > > > > > > roles of adipokines (the cytokines producedby adipose tissue) in
> > > > > > > > > > > > > > > > insulin resistance.
> > > > > > > > > > > > > > > >http://en.wikipedia.org/wiki/Insulin_sensitivity"
>
> > > > > > > > > > > > > > > > Reasons for acidosis can be many as indicated on floowing link:-
>
> > > > > > > > > > > > > > > > "Type 4 RTA is a metabolic acidosis that results from aldosterone
> > > > > > > > > > > > > > > > deficiency or resistance. Aldosterone normally promotes distal
> > > > > > > > > > > > > > > > potassium (K+) and H+ secretion, as well assodium (Na+) reabsorption.
> > > > > > > > > > > > > > > > Hypoaldosteronism results in hyperkalemia with a concomitant metabolic
> > > > > > > > > > > > > > > > acidosis. This type of RTA can also occur from potassium-sparing
> > > > > > > > > > > > > > > > diuretics or collecting duct dysfunction from renal insufficiency..
>
> > > > > > > > > > > > > > > > Increased H+ load
> > > > > > > > > > > > > > > > Lactic acidosis - Numerous causes, including circulatory failure,
> > > > > > > > > > > > > > > > drugs and toxins, and **hereditary causes (see Lactic Acidosis)
> > > > > > > > > > > > > > > > Ketoacidosis - Diabetes, alcoholism, and starvation
> > > > > > > > > > > > > > > > Ingestions - Salicylates, methanol, ethylene glycol, isoniazid, iron,
> > > > > > > > > > > > > > > > paraldehyde, sulfur, toluene, ammonium chloride, phenformin/metformin,
> > > > > > > > > > > > > > > > and hyperalimentation fluids
> > > > > > > > > > > > > > > >http://www.emedicine.com/emerg/topic312.htm#section~miscellaneous"
>
> > > > > > > > > > > > > > > > Pls note that Lactic acidosis is also related to hereditary causes and
> > > > > > > > > > > > > > > > predisposition of diabetes is also indicated.
>
> > > > > > > > > > > > > > > > In view of above, how much we can link acidosis to getting insulin
> > > > > > > > > > > > > > > > resistance and correcting it or alkalosis with insulin senstivity?
>
> > > > > > > > > > > > > > > Very rarely clinically observed in non-hospitalized patients.
>
> > > > > > > > > > > > > > But how acidosis can cause insulin resistance?
>
> > > > > > > > > > > > > By changing both the structure and function of receptor, ligand, or
> > > > > > > > > > > > > both.
>
> > > > > > > > > > > > Can acidosis also change insulin structure resulting its
> > > > > > > > > > > > inefectiveness?
>
> > > > > > > > > > > Yes.
>
> > > > > > > > > > Pls tell more details about it.
>
> > > > > > > > > We call in denaturation.
>
> > > > > > > > > > > > Can acidosis also effect extravascular movement of insulin in short
> > > > > > > > > > > > term?
>
> > > > > > > > > > > Yes.
>
> > > > > > > > > > Pls tell more details about it.
>
> > > > > > > > > We call it death.
>
> > > > > > > > > > > > On any instabilty, say on hyperglycemia, acid base and water
> > > > > > > > > > > > imbalance, can it deviate insulin's struture due tothermodynamics
> > > > > > > > > > > > instabilities and thermodynamic equilibrium?
>
> > > > > > > > > > > No.
>
> > > > > > > > > > Can variation in temperature cause slight deviation in insulin's
> > > > > > > > > > structure?
>
> > > > > > > > > Yes.
>
> > > > > > > > > This would also be called denaturation.
>
> > > > > > > > "A protein's surroundings play an essential role in the final shape of
> > > > > > > > the protein. An aqueous environment favors hydrophilic residues on the
> > > > > > > > surface of the protein. A non-aqueous or non-polar environment, favors
> > > > > > > > hydrophobic residues on the surface of the protein. The temperature
> > > > > > > > and pH level of the protein environment also affects protein shape. A
> > > > > > > > change in temperature or pH may cause denaturalization of the protein.
> > > > > > > > Denaturalization is a change in the protein's three-dimensional shape.
> > > > > > > > Frying an egg is a common example of denaturalization. The chemical
> > > > > > > > properties of the proteins in the egg change significantly when heat
> > > > > > > > is added. When an egg is heated, normally alpha helical protein
> > > > > > > > segments change to beta sheet conformation. Interestingly, the process
> > > > > > > > can be reversed with chemical denaturants. Experiments havebeen
> > > > > > > > completed with chemical denaturalization that can "unboil" an egg. By
> > > > > > > > adding chemical denaturants such as tetra-flour-ethanol, the beta
> > > > > > > > sheet proteins in the boiled egg can be reformed into theiroriginal
> > > > > > > > alpha helical conformation8,9.
>
> > > > > > > > The process of transcription translation in the cell sometimes
> > > > > > > > produces errors in the final protein product. Since a proteins
> > > > > > > > function is dependent on its shape, the errant proteins maynot work
> > > > > > > > correctly.
> > > > > > > >http://members.aol.com/profchm/cutler.html"
>
> > > > > > > > I think, above don't change chemical composition/formula but just
> > > > > > > > change the shape/structure. As such, can such change make insulin
> > > > > > > > ineffective or antigenic?
>
> > > > > > > > As such, can other biochemicals become dysfunctional or antigenic?
>
> > > > > > > Death would ensue first.
>
> > > > > > Can't there be conitions sub-fatal levels?
>
> > > > > There is not for the vast majority of structural proteins in our
> > > > > bodies.
>
> > > > > > Whether insulin's normal qualities and effectiveness can be effected
> > > > > > due to changes in internal environment of body?
>
> > > > > Not before death of the body.
>
> > > > Every substance is having its own temperature. Whether excessive bio-
> > > > substances in body can change body's temperature? Body control thatis
> > > > a different aspect.
>
> > > Body temperature is well-regulated during homeostasis.
>
> > Yes but hyperglycemia or excess fats etc. may not be a homeostasis
> > condition?
>
> It is if one is hungry.
>
>
>
>
>
> > Â*"The underlying causes of insulin-resistant states can be categorized
> > as follows:
>
> > Prereceptor
> > Abnormal insulin (mutations)
> > Anti-insulin antibodies
> > Receptor
> > Decreased number of receptors (mainly, failure to activate tyrosine
> > kinase)
> > Reduced binding of insulin
> > Insulin receptor mutations
> > Insulin receptor–blocking antibodies
> >http://www.emedicine.com/med/topic1173.htm"
>
> > Many causes are thought for IR. What about abnormal insulin and anti-
> > insulin antibodies?
>
> What is clinically seen is IR from VAT.
What can make insulin abnormal and induce aniti-insulin antibodies?

Whether acidic conditions has vasidilatory effect and alkalosis
vasocostrictive?
> May GOD bless you in HIS mighty way making you hungrier than ever.
>
> Prayerfully in Jesus' awesome love,
>
> Andrew <><
> --
> Andrew B. Chung, MD/PhD
> Cardiologist- Hide quoted text -
>
> - Show quoted text -- Hide quoted text -
>
> - Show quoted text -

convicted neighbot Kumar wrote:
> Andrew, in the Holy Spirit, boldly wrote:
> > convicted neighbor Kumar wrote:
> > > Andrew, in the Holy Spirit, boldly wrote:
> > > > convicted neighbor Kumar wrote:
> > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > convicted neighbor Kumar wrote:
> > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > > > > convicted neighbor Kumar wrote:
> > > > > > > > > > > > > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > > > > > > > > > > > > convicted neighbor Kumar wrote:
> >
> > > > > > > > > > > > > > > > > Hello,
> >
> > > > > > > > > > > > > > > > > "Various disease states make the body tissues more resistant to the
> > > > > > > > > > > > > > > > > actions of insulin. Examples include infection (mediated by the
> > > > > > > > > > > > > > > > > cytokine TNFα) and **acidosis. Recent research is investigating the
> > > > > > > > > > > > > > > > > roles of adipokines (the cytokines produced by adipose tissue) in
> > > > > > > > > > > > > > > > > insulin resistance.
> > > > > > > > > > > > > > > > >http://en.wikipedia.org/wiki/Insulin_sensitivity"
> >
> > > > > > > > > > > > > > > > > Reasons for acidosis can be many as indicated on floowing link:-
> >
> > > > > > > > > > > > > > > > > "Type 4 RTA is a metabolic acidosis that results from aldosterone
> > > > > > > > > > > > > > > > > deficiency or resistance. Aldosterone normally promotes distal
> > > > > > > > > > > > > > > > > potassium (K+) and H+ secretion, as well as sodium (Na+) reabsorption.
> > > > > > > > > > > > > > > > > Hypoaldosteronism results in hyperkalemiawith a concomitant metabolic
> > > > > > > > > > > > > > > > > acidosis. This type of RTA can also occurfrom potassium-sparing
> > > > > > > > > > > > > > > > > diuretics or collecting duct dysfunction from renal insufficiency..
> >
> > > > > > > > > > > > > > > > > Increased H+ load
> > > > > > > > > > > > > > > > > Lactic acidosis - Numerous causes, including circulatory failure,
> > > > > > > > > > > > > > > > > drugs and toxins, and **hereditary causes(see Lactic Acidosis)
> > > > > > > > > > > > > > > > > Ketoacidosis - Diabetes, alcoholism, and starvation
> > > > > > > > > > > > > > > > > Ingestions - Salicylates, methanol, ethylene glycol, isoniazid, iron,
> > > > > > > > > > > > > > > > > paraldehyde, sulfur, toluene, ammonium chloride, phenformin/metformin,
> > > > > > > > > > > > > > > > > and hyperalimentation fluids
> > > > > > > > > > > > > > > > >http://www.emedicine.com/emerg/topic312.htm#section~miscellaneous"
> >
> > > > > > > > > > > > > > > > > Pls note that Lactic acidosis is also related to hereditary causes and
> > > > > > > > > > > > > > > > > predisposition of diabetes is also indicated.
> >
> > > > > > > > > > > > > > > > > In view of above, how much we can link acidosis to getting insulin
> > > > > > > > > > > > > > > > > resistance and correcting it or alkalosiswith insulin senstivity?
> >
> > > > > > > > > > > > > > > > Very rarely clinically observed in non-hospitalized patients.
> >
> > > > > > > > > > > > > > > But how acidosis can cause insulin resistance?
> >
> > > > > > > > > > > > > > By changing both the structure and function of receptor, ligand, or
> > > > > > > > > > > > > > both.
> >
> > > > > > > > > > > > > Can acidosis also change insulin structure resulting its
> > > > > > > > > > > > > inefectiveness?
> >
> > > > > > > > > > > > Yes.
> >
> > > > > > > > > > > Pls tell more details about it.
> >
> > > > > > > > > > We call in denaturation.
> >
> > > > > > > > > > > > > Can acidosis also effect extravascular movement of insulin in short
> > > > > > > > > > > > > term?
> >
> > > > > > > > > > > > Yes.
> >
> > > > > > > > > > > Pls tell more details about it.
> >
> > > > > > > > > > We call it death.
> >
> > > > > > > > > > > > > On any instabilty, say on hyperglycemia, acid base and water
> > > > > > > > > > > > > imbalance, can it deviate insulin's struture due to thermodynamics
> > > > > > > > > > > > > instabilities and thermodynamic equilibrium?
> >
> > > > > > > > > > > > No.
> >
> > > > > > > > > > > Can variation in temperature cause slight deviation in insulin's
> > > > > > > > > > > structure?
> >
> > > > > > > > > > Yes.
> >
> > > > > > > > > > This would also be called denaturation.
> >
> > > > > > > > > "A protein's surroundings play an essential role in the final shape of
> > > > > > > > > the protein. An aqueous environment favors hydrophilic residues on the
> > > > > > > > > surface of the protein. A non-aqueous or non-polar environment, favors
> > > > > > > > > hydrophobic residues on the surface of the protein. The temperature
> > > > > > > > > and pH level of the protein environment also affects protein shape. A
> > > > > > > > > change in temperature or pH may cause denaturalization ofthe protein.
> > > > > > > > > Denaturalization is a change in the protein's three-dimensional shape.
> > > > > > > > > Frying an egg is a common example of denaturalization. The chemical
> > > > > > > > > properties of the proteins in the egg change significantly when heat
> > > > > > > > > is added. When an egg is heated, normally alpha helical protein
> > > > > > > > > segments change to beta sheet conformation. Interestingly, the process
> > > > > > > > > can be reversed with chemical denaturants. Experiments have been
> > > > > > > > > completed with chemical denaturalization that can "unboil" an egg. By
> > > > > > > > > adding chemical denaturants such as tetra-flour-ethanol, the beta
> > > > > > > > > sheet proteins in the boiled egg can be reformed into their original
> > > > > > > > > alpha helical conformation8,9.
> >
> > > > > > > > > The process of transcription translation in the cell sometimes
> > > > > > > > > produces errors in the final protein product. Since a proteins
> > > > > > > > > function is dependent on its shape, the errant proteins may not work
> > > > > > > > > correctly.
> > > > > > > > >http://members.aol.com/profchm/cutler.html"
> >
> > > > > > > > > I think, above don't change chemical composition/formula but just
> > > > > > > > > change the shape/structure. As such, can such change makeinsulin
> > >